The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Cell

Volumn 153, Issue 4, 2013, Pages 840-854

  Csibi, Alfred ^a   Fendt, Sarah Maria ^b   Li, Chenggang ^c   Poulogiannis, George ^a   Choo, Andrew Y ^a   Chapski, Douglas J ^a   Jeong, Seung Min ^a   Dempsey, Jamie M ^a   Parkhitko, Andrey ^c   Morrison, Tasha ^c   Henske, Elizabeth P ^c   Haigis, Marcia C ^a   Cantley, Lewis C ^a   Stephanopoulos, Gregory ^b   Yu, Jane ^c   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; GLUTAMATE DEHYDROGENASE; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEASOME; SIRTUIN 4;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; UBIQUITINATION;

EID: 84877720366     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.04.023     Document Type: Article

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