The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1

Molecular Cell

Volumn 52, Issue 4, 2013, Pages 495-505

  Tsun, Zhi Yang ^a,b   Bar Peled, Liron ^a,b   Chantranupong, Lynne ^a,b   Zoncu, Roberto ^a,b   Wang, Tim ^a,b   Kim, Choah ^a,b   Spooner, Eric ^a   Sabatini, DavidM ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; FOLLICULIN PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HETERODIMER; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAG PROTEIN; RAGC PROTEIN; RAGD PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; FLCN PROTEIN, HUMAN; FNIP1 PROTEIN, HUMAN; FNIP2 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; ONCOPROTEIN; PROTEIN BINDING; RRAGC PROTEIN, HUMAN; RRAGD PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL FUNCTION; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; HEK293 CELL LINE; INTRACELLULAR MEMBRANE; LYSOSOME; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

AMINO ACIDS; CARRIER PROTEINS; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84888200442     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2013.09.016     Document Type: Article

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