-
2
-
-
12344262762
-
-
Tee AR, Blenis J. mTOR, Lranslational control and human disease. Semin Cell Dev Biol 2005;16:29-37.
-
Tee AR, Blenis J. mTOR, Lranslational control and human disease. Semin Cell Dev Biol 2005;16:29-37.
-
-
-
-
3
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang Y, Vilella-Baeh M, Bachmann R, et al. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001;294:1942-5.
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Baeh, M.2
Bachmann, R.3
-
5
-
-
33846442940
-
-
Foster DA. Phospholipase D survival signals as a therapeutic target in cancer. Curr Signal Transduction Ther 2006;1:295-303.
-
Foster DA. Phospholipase D survival signals as a therapeutic target in cancer. Curr Signal Transduction Ther 2006;1:295-303.
-
-
-
-
6
-
-
0036776168
-
A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
-
Chen J, Fang Y. A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol 2002;64:1071-7.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1071-1077
-
-
Chen, J.1
Fang, Y.2
-
7
-
-
0038339003
-
Phospholipase D confers rapamycin resistance in human breast cancer cells
-
Chen Y, Zheng Y, Foster DA. Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 2003;22:3937-42.
-
(2003)
Oncogene
, vol.22
, pp. 3937-3942
-
-
Chen, Y.1
Zheng, Y.2
Foster, D.A.3
-
8
-
-
0037200004
-
Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin
-
Park IH, Bachmann R, Shirazi H, Chen J. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. J Biol Chem 2002;277:31423-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 31423-31429
-
-
Park, I.H.1
Bachmann, R.2
Shirazi, H.3
Chen, J.4
-
9
-
-
0141733228
-
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
-
Tee AR, Anjum R, Blenis J. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem 2003;278:37288-96.
-
(2003)
J Biol Chem
, vol.278
, pp. 37288-37296
-
-
Tee, A.R.1
Anjum, R.2
Blenis, J.3
-
10
-
-
0242496906
-
Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway
-
Lim HK, Choi YA, Park W, et al. Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem 2003;278:45117-27.
-
(2003)
J Biol Chem
, vol.278
, pp. 45117-45127
-
-
Lim, H.K.1
Choi, Y.A.2
Park, W.3
-
11
-
-
1542374743
-
Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid
-
Xu Y, Fang Y, Chen J, Prestwich GD. Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid. Bioorg Med Chem Lett 2004;14:1461-4.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1461-1464
-
-
Xu, Y.1
Fang, Y.2
Chen, J.3
Prestwich, G.D.4
-
12
-
-
0142070928
-
Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling
-
Ballon LM, Jiang YP, Du G, Frohman MA, Lin RZ. Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling. FEBS Lett 2003;550:51-6.
-
(2003)
FEBS Lett
, vol.550
, pp. 51-56
-
-
Ballon, L.M.1
Jiang, Y.P.2
Du, G.3
Frohman, M.A.4
Lin, R.Z.5
-
13
-
-
33645241260
-
The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
-
Hornberger TA, Chu WK, Mak YW, Hsiung JVV, Huang SA, Chien S. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci U S A 2006;103:4741-6.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4741-4746
-
-
Hornberger, T.A.1
Chu, W.K.2
Mak, Y.W.3
Hsiung, J.V.V.4
Huang, S.A.5
Chien, S.6
-
14
-
-
33749406921
-
Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
-
Takahara T, Hara K, Yonezawa K, Sorimachi H, Maeda T. Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem 2006;281:28605-14.
-
(2006)
J Biol Chem
, vol.281
, pp. 28605-28614
-
-
Takahara, T.1
Hara, K.2
Yonezawa, K.3
Sorimachi, H.4
Maeda, T.5
-
15
-
-
13244289821
-
Alternative phospholipase D/mTOR survival signal in human breast cancer cells
-
Chen Y, Rodrik V, Foster DA. Alternative phospholipase D/mTOR survival signal in human breast cancer cells. Oncogene 2005;24:672-9.
-
(2005)
Oncogene
, vol.24
, pp. 672-679
-
-
Chen, Y.1
Rodrik, V.2
Foster, D.A.3
-
16
-
-
2942716838
-
Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53
-
Hui L, Abbas T, Pielak R, Joseph T, Bargonetti J, Foster DA. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol 2004;24:5677-88.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5677-5688
-
-
Hui, L.1
Abbas, T.2
Pielak, R.3
Joseph, T.4
Bargonetti, J.5
Foster, D.A.6
-
17
-
-
0442309363
-
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid
-
Kam Y, Exton JH. Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J 2004;18:311-9.
-
(2004)
FASEB J
, vol.18
, pp. 311-319
-
-
Kam, Y.1
Exton, J.H.2
-
18
-
-
0344663973
-
PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1
-
Fang Y, Park IH, Wu AL, et al. PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol 2003;13:2037-44.
-
(2003)
Curr Biol
, vol.13
, pp. 2037-2044
-
-
Fang, Y.1
Park, I.H.2
Wu, A.L.3
-
19
-
-
27744493917
-
Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells
-
Ohguchi K, Banno Y, Nakagawa Y, Akao Y, Nozawa V. Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells. J Cell Physiol 2005;205:444-51.
-
(2005)
J Cell Physiol
, vol.205
, pp. 444-451
-
-
Ohguchi, K.1
Banno, Y.2
Nakagawa, Y.3
Akao, Y.4
Nozawa, V.5
-
20
-
-
27744539859
-
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
-
Hui L, Rodrik V, Pielak RM, Zheng Y, Foster DA. mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem 2005;280:35829-35.
-
(2005)
J Biol Chem
, vol.280
, pp. 35829-35835
-
-
Hui, L.1
Rodrik, V.2
Pielak, R.M.3
Zheng, Y.4
Foster, D.A.5
-
21
-
-
33750336370
-
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals
-
Epub Jun 3
-
Ha SH, Kim DH, Kim IS, et al. PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal 2006;18:2283-91. Epub 2006 Jun 3.
-
(2006)
Cell Signal 2006
, vol.18
, pp. 2283-2291
-
-
Ha, S.H.1
Kim, D.H.2
Kim, I.S.3
-
22
-
-
1542323186
-
Inhibition of lysophosphatidic acid acyltransferase-β disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells
-
Coon M, Ball A, Pound J, et al. Inhibition of lysophosphatidic acid acyltransferase-β disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. Mol Cancer Ther 2003;2:1067-78.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1067-1078
-
-
Coon, M.1
Ball, A.2
Pound, J.3
-
23
-
-
15444378732
-
Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
-
Avila-Flores A, Santos T, Rincon E, Merida I. Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid. J Biol Chem 2005;280:10091-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 10091-10099
-
-
Avila-Flores, A.1
Santos, T.2
Rincon, E.3
Merida, I.4
-
24
-
-
33744943819
-
Phospholipase D couples survival and migration signals in response to stress in human breast cancer cells
-
Zheng Y, Rodrik V, Toschi A, et al. Phospholipase D couples survival and migration signals in response to stress in human breast cancer cells. J Biol Chem 2006;281:15862-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 15862-15868
-
-
Zheng, Y.1
Rodrik, V.2
Toschi, A.3
-
25
-
-
33747819801
-
mTOR and cancer: Insights into a complex relationship
-
Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006;6:729-34.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
26
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
|