MTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8

Molecular Cell

Volumn 48, Issue 6, 2012, Pages 875-887

  Kim, Sung Jin ^a   DeStefano, Michael A ^a   Oh, Won Jun ^a   Wu, Chang chih ^a   Vega Cotto, Nicole M ^a   Finlan, Monica ^a   Liu, Dou ^b   Su, Bing ^b   Jacinto, Estela ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; PROTEIN P85; S6 KINASE; SERINE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE FBW8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; EMBRYO; ENZYME PHOSPHORYLATION; ENZYME STABILITY; GENE OVEREXPRESSION; INSULIN RESISTANCE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; ENZYME ACTIVATION; F-BOX PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HALF-LIFE; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEINS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84871703377     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.09.029     Document Type: Article

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