Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase a in vitro

Journal of Biological Chemistry

Volumn 274, Issue 48, 1999, Pages 34493-34498

  Isotani, Shuji ^a   Hara, Kenta ^a   Tokunaga, Chiharu ^a   Inoue, Hitomi ^a   Avruch, Joseph ^b   Yonezawa, Kazuyoshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN; RIBOSOME PROTEIN; S6 KINASE;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TARGETING; RNA TRANSLATION;

CELL LINE; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; HUMANS; IMMUNOBLOTTING; MITOGENS; MUTATION; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PRECIPITIN TESTS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RIBOSOMAL PROTEIN S6 KINASES;

MAMMALIA;

EID: 0033607531     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.48.34493     Document Type: Article

References (23)

1. Meyuhas, O., Avni, D., and Shama, S. (1996) Translational Control of Ribosomal Protein mRNAs in Eukaryotes (Hershey, W. B., Mathews, M. B., and Sonenberg, N., eds.) pp. 363-388, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2. Avruch, J. (1998) Mol. Cell. Biochem. 182, 31-48
3. Weng, Q. P., Andrabi, K., Kozlowski, M. T., Grove, J. R., and Avruch, J. (1995) Mol. Cell. Biol. 15, 2333-2340
4. Weng, Q. P., Andrabi, K., Klippel, A., Kozlowski, M. T., Williams, L. T., and Avruch, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5744-5748
5. Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., and Thomas, G. (1995) EMBO J. 14, 5279-5287
6. Moser, B. A., Dennis, P. B., Pullen, N., Pearson, R. B., Williamson, N. A., Wettenhall, R. E., Kozma, S. C., and Thomas, G. (1997) Mol. Cell. Biol. 17, 5648-5655
7. Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., and Avruch, J. (1998) Curr. Biol. 8, 69-81
8. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
9. Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T., Belham, C., and Avruch, J. (1998) J. Biol. Chem. 273, 14484-14494
10. Patti, M. E., Brambilla, E., Luzi, L., Landaker, E. J., and Kahn, C. R. (1998) J. Clin. Invest. 101, 1519-1529
11. Shigemitsu, K., Tsujishita, Y., Hara, K., Nanahoshi, M., Avruch, J., and Yonezawa, K. (1999) J. Biol. Chem. 274, 1058-1065
12. Price, D. J., Grove, J. R., Calvo, V., Avruch, J., and Bierer, B. E. (1992) Science 257, 973-977
13. Chung, J., Kuo, C. J., Crabtree, G. R., and Blenis, J. (1992) Cell 69, 1227-1236
14. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Nature 377, 441-446
15. Hara, K., Yonezawa, K., Kozlowski, M. T., Sugimoto, T., Andrabi, K., Weng, Q. P., Kasuga, M., Nishimoto, I., and Avruch, J. (1997) J. Biol. Chem. 272, 26457-26463
16. Peterson, R. T., Desai, B. N., Hardwick, J. S., and Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4438-4442
17. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., and Sabatini, D. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1432-1437
18. Brunn, G. J., Fadden, P., Haystead, T. A. J., and Lawrence, J. C., Jr. (1997) J. Biol. Chem. 272, 32547-32550
19. Gingras, A.-C., Gygi, S. P., Raught, B., Polakiewicz, R. D., Abraham, R. T., Hoekstra, M. F., Aebersold, R., and Sonenberg, N. (1999) Genes Dev. 13, 1422-1437
20. Nishiuma, T., Hara, K., Tsujishita, Y., Kaneko, K., Shii, K., and Yonezawa, K. (1998) Biochem. Biophys. Res. Commun. 252, 440-444
21. Weng, Q. P., Kozlowski, M., Belham, C., Zhang, A. H., Comb, M. J., and Avruch, J. (1998) J. Biol. Chem. 273, 16621-16629
22. Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A., and Lawrence, J. C., Jr. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7772-7777
23. Ziegler, W. H., Parekh, D. B., Le Good, J. A., Whelan, R. D. H., Kelly, J. J., Frech, M., Hemmings, B. A., and Parker, P. J. (1999) Curr. Biol. 9, 522-529