Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

Journal of Molecular Cell Biology

Volumn 6, Issue 3, 2014, Pages 255-266

  Miloslavski, Rachel ^a   Cohen, Elad ^a,g   Avraham, Adam ^a   Iluz, Yifat ^a   Hayouka, Zvi ^a   Kasir, Judith ^a   Mudhasani, Rajini ^b,h   Jones, Stephen N ^b   Cybulski, Nadine ^c,i   Rüegg, Markus A ^c   Larsson, Ola ^d   Gandin, Valentina ^e   Rajakumar, Arjuna ^e,f   Topisirovic, Ivan ^e,f   Meyuhas, Oded ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d KAROLINSKA INSTITUTE   (Sweden)

^e MCGILL UNIVERSITY   (Canada)

^f MCGILL UNIVERSITY   (Canada)

^g MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^h UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

ⁱ ADAM   (Canada)

Author keywords

4E BP; hypoxia; mTOR; TOP mRNAs; translational control

Indexed keywords

AMINO ACID; GROWTH FACTOR; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; OXYGEN; PROTEIN; PROTEIN TIA 1; PROTEIN TIAR; PROTEIN TORIN 1; RHEB PROTEIN; RNA BINDING PROTEIN; TUBEROUS SCLEROSIS COMPLEX 1; TUBEROUS SCLEROSIS COMPLEX 2; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYCLIN D3; EIF4EBP1 PROTEIN, MOUSE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOPROTEIN; RICTOR PROTEIN, MOUSE; RPTOR PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; ARTICLE; CELL STRESS; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE; GENE INACTIVATION; GENE REPRESSION; HUMAN; HUMAN CELL; HYPOXIA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAPTOR GENE; RICTOR GENE; RNA TRANSLATION; TERMINAL OLIGOPYRIMIDINE TRACT; TRANSLATION REGULATION; DEFICIENCY; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACIDS; CARRIER PROTEINS; CYCLIN D3; HEK293 CELLS; HUMANS; MONOMERIC GTP-BINDING PROTEINS; OXYGEN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84901700198     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mju008     Document Type: Article

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