메뉴 건너뛰기




Volumn 21, Issue 5, 2010, Pages 833-841

The late endosome is essential for mTORC1 signaling

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MTORC1 PROTEIN; RAB PROTEIN; UNCLASSIFIED DRUG;

EID: 77649140362     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E09-09-0756     Document Type: Article
Times cited : (135)

References (57)
  • 1
    • 33750155593 scopus 로고    scopus 로고
    • Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
    • Avruch, J., Hara, K., Lin, Y., Liu, M., Long, X., Ortiz-Vega, S., and Yonezawa, K. (2006). Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25, 6361-6372.
    • (2006) Oncogene , vol.25 , pp. 6361-6372
    • Avruch, J.1    Hara, K.2    Lin, Y.3    Liu, M.4    Long, X.5    Ortiz-Vega, S.6    Yonezawa, K.7
  • 3
    • 0026744303 scopus 로고
    • The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
    • Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., and Zerial, M. (1992). The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70, 715-728.
    • (1992) Cell , vol.70 , pp. 715-728
    • Bucci, C.1    Parton, R.G.2    Mather, I.H.3    Stunnenberg, H.4    Simons, K.5    Hoflack, B.6    Zerial, M.7
  • 4
    • 33646143793 scopus 로고    scopus 로고
    • Localization of Rheb to the endomembrane is critical for its signaling function
    • Buerger, C., DeVries, B., and Stambolic, V. (2006). Localization of Rheb to the endomembrane is critical for its signaling function. Biochem. Biophys. Res. Commun. 344, 869-880.
    • (2006) Biochem. Biophys. Res. Commun , vol.344 , pp. 869-880
    • Buerger, C.1    DeVries, B.2    Stambolic, V.3
  • 5
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrientregulated lipid kinase required for activation of p70 S6 kinase
    • Byfield, M. P., Murray, J. T., and Backer, J. M. (2005). hVps34 is a nutrientregulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082.
    • (2005) J. Biol. Chem , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 6
    • 0037732600 scopus 로고    scopus 로고
    • LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway
    • Chen, E. J., and Kaiser, C. A. (2003). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161, 333-347.
    • (2003) J. Cell Biol , vol.161 , pp. 333-347
    • Chen, E.J.1    Kaiser, C.A.2
  • 8
    • 21244448694 scopus 로고    scopus 로고
    • The TOR and EGO protein complexes orchestrate microautophagy in yeast
    • Dubouloz, F., Deloche, O., Wanke, V., Cameroni, E., and De Virgilio, C. (2005). The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19, 15-26.
    • (2005) Mol Cell , vol.19 , pp. 15-26
    • Dubouloz, F.1    Deloche, O.2    Wanke, V.3    Cameroni, E.4    De Virgilio, C.5
  • 9
    • 0037439880 scopus 로고    scopus 로고
    • A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: Class E vps phenotype in mammalian cells
    • Fujita, H., Yamanaka, M., Imamura, K., Tanaka, Y., Nara, A., Yoshimori, T., Yokota, S., and Himeno, M. (2003). A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: class E vps phenotype in mammalian cells. J. Cell Sci. 116, 401-414.
    • (2003) J. Cell Sci , vol.116 , pp. 401-414
    • Fujita, H.1    Yamanaka, M.2    Imamura, K.3    Tanaka, Y.4    Nara, A.5    Yoshimori, T.6    Yokota, S.7    Himeno, M.8
  • 10
    • 33745745910 scopus 로고    scopus 로고
    • A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast
    • Gao, M., and Kaiser, C. A. (2006). A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat. Cell Biol 8, 657-667.
    • (2006) Nat. Cell Biol , vol.8 , pp. 657-667
    • Gao, M.1    Kaiser, C.A.2
  • 12
    • 0034678130 scopus 로고    scopus 로고
    • ARF1 regulates pH-dependent COP functions in the early endocytic pathway
    • Gu, F., and Gruenberg, J. (2000). ARF1 regulates pH-dependent COP functions in the early endocytic pathway. J. Biol. Chem. 275, 8154-8160.
    • (2000) J. Biol. Chem , vol.275 , pp. 8154-8160
    • Gu, F.1    Gruenberg, J.2
  • 13
    • 77649119923 scopus 로고    scopus 로고
    • Hanker, A. B., Mitin, N., Wilder, R. S., Henske, E. P., Tamanoi, F., Cox, A. D., and Der, C. J. (2009). Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene.
    • Hanker, A. B., Mitin, N., Wilder, R. S., Henske, E. P., Tamanoi, F., Cox, A. D., and Der, C. J. (2009). Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene.
  • 15
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 16
    • 33745235142 scopus 로고    scopus 로고
    • TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth
    • Hennig, K. M., Colombani, J., and Neufeld, T. P. (2006). TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J. Cell Biol. 173, 963-974.
    • (2006) J. Cell Biol , vol.173 , pp. 963-974
    • Hennig, K.M.1    Colombani, J.2    Neufeld, T.P.3
  • 17
    • 0034646657 scopus 로고    scopus 로고
    • Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells
    • Herbert, T. P., Kilhams, G. R., Batty, I. H., and Proud, C. G. (2000). Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. J. Biol. Chem. 275, 11249-11256.
    • (2000) J. Biol. Chem , vol.275 , pp. 11249-11256
    • Herbert, T.P.1    Kilhams, G.R.2    Batty, I.H.3    Proud, C.G.4
  • 18
    • 0035854730 scopus 로고    scopus 로고
    • Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve
    • Ikonomov, O. C., Sbrissa, D., and Shisheva, A. (2001). Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve. J. Biol. Chem. 276, 26141-26147.
    • (2001) J. Biol. Chem , vol.276 , pp. 26141-26147
    • Ikonomov, O.C.1    Sbrissa, D.2    Shisheva, A.3
  • 21
    • 0034711280 scopus 로고    scopus 로고
    • HEAT repeats mediate plasma membrane localization of Tor2p in yeast
    • Kunz, J., Schneider, U., Howald, I., Schmidt, A., and Hall, M. N. (2000). HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J. Biol. Chem. 275, 37011-37020.
    • (2000) J. Biol. Chem , vol.275 , pp. 37011-37020
    • Kunz, J.1    Schneider, U.2    Howald, I.3    Schmidt, A.4    Hall, M.N.5
  • 22
    • 16844375707 scopus 로고    scopus 로고
    • Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1
    • Lin, Y., Kimpler, L. A., Naismith, T. V., Lauer, J. M., and Hanson, P. I. (2005). Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. J. Biol. Chem. 280, 12799-12809.
    • (2005) J. Biol. Chem , vol.280 , pp. 12799-12809
    • Lin, Y.1    Kimpler, L.A.2    Naismith, T.V.3    Lauer, J.M.4    Hanson, P.I.5
  • 24
    • 21244456553 scopus 로고    scopus 로고
    • Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
    • Long, X., Ortiz-Vega, S., Lin, Y., and Avruch, J. (2005b). Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436.
    • (2005) J. Biol. Chem , vol.280 , pp. 23433-23436
    • Long, X.1    Ortiz-Vega, S.2    Lin, Y.3    Avruch, J.4
  • 26
    • 0035947648 scopus 로고    scopus 로고
    • Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes
    • Maranda, B., Brown, D., Bourgoin, S., Casanova, J. E., Vinay, P., Ausiello, D. A., and Marshansky, V. (2001). Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J. Biol. Chem. 276, 18540-18550.
    • (2001) J. Biol. Chem , vol.276 , pp. 18540-18550
    • Maranda, B.1    Brown, D.2    Bourgoin, S.3    Casanova, J.E.4    Vinay, P.5    Ausiello, D.A.6    Marshansky, V.7
  • 27
    • 9144273746 scopus 로고    scopus 로고
    • Role of LBPA and Alix in multivesicular liposome formation and endosome organization
    • Matsuo, H., et al. (2004). Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303, 531-534.
    • (2004) Science , vol.303 , pp. 531-534
    • Matsuo, H.1
  • 29
    • 0021281777 scopus 로고
    • Endosome pH measured in single cells by dual fluorescence flow cytometry: Rapid acidification of insulin to pH 6
    • Murphy, R. F., Powers, S., and Cantor, C. R. (1984). Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6. J. Cell Biol. 98, 1757-1762.
    • (1984) J. Cell Biol , vol.98 , pp. 1757-1762
    • Murphy, R.F.1    Powers, S.2    Cantor, C.R.3
  • 30
    • 0036300306 scopus 로고    scopus 로고
    • Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
    • Murray, J. T., Panaretou, C., Stenmark, H., Miaczynska, M., and Backer, J. M. (2002). Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic 3, 416-427.
    • (2002) Traffic , vol.3 , pp. 416-427
    • Murray, J.T.1    Panaretou, C.2    Stenmark, H.3    Miaczynska, M.4    Backer, J.M.5
  • 31
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    • Nobukuni, T., et al. (2005). Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci USA 102, 14238-14243.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14238-14243
    • Nobukuni, T.1
  • 33
    • 0347626041 scopus 로고    scopus 로고
    • A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway
    • Querbes, W., Benmerah, A., Tosoni, D., Di Fiore, P. P., and Atwood, W. J. (2004). A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway. J. Virol. 78, 250-256.
    • (2004) J. Virol , vol.78 , pp. 250-256
    • Querbes, W.1    Benmerah, A.2    Tosoni, D.3    Di Fiore, P.P.4    Atwood, W.J.5
  • 34
    • 0032568657 scopus 로고    scopus 로고
    • Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes
    • Ren, M., Xu, G., Zeng, J., De Lemos-Chiarandini, C., Adesnik, M., and Sabatini, D. D. (1998). Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc. Natl. Acad. Sci. USA 95, 6187-6192.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6187-6192
    • Ren, M.1    Xu, G.2    Zeng, J.3    De Lemos-Chiarandini, C.4    Adesnik, M.5    Sabatini, D.D.6
  • 35
    • 24144442691 scopus 로고    scopus 로고
    • Rab conversion as a mechanism of progression from early to late endosomes
    • Rink, J., Ghigo, E., Kalaidzidis, Y., and Zerial, M. (2005). Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735-749.
    • (2005) Cell , vol.122 , pp. 735-749
    • Rink, J.1    Ghigo, E.2    Kalaidzidis, Y.3    Zerial, M.4
  • 36
    • 18244362311 scopus 로고    scopus 로고
    • Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
    • Saito, K., Araki, Y., Kontani, K., Nishina, H., and Katada, T. (2005). Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem. 137, 423-430.
    • (2005) J. Biochem , vol.137 , pp. 423-430
    • Saito, K.1    Araki, Y.2    Kontani, K.3    Nishina, H.4    Katada, T.5
  • 39
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003). Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5, 566-571.
    • (2003) Nat. Cell Biol , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 40
  • 41
    • 12344262762 scopus 로고    scopus 로고
    • mTOR, translational control and human disease
    • Tee, A. R., and Blenis, J. (2005). mTOR, translational control and human disease. Semin. Cell Dev. Biol. 16, 29-37.
    • (2005) Semin. Cell Dev. Biol , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 42
    • 33846260506 scopus 로고    scopus 로고
    • Targeting and localized signalling by small GTPases
    • ten Klooster, J. P., and Hordijk, P. L. (2007). Targeting and localized signalling by small GTPases. Biol. Cell 99, 1-12.
    • (2007) Biol. Cell , vol.99 , pp. 1-12
    • ten Klooster, J.P.1    Hordijk, P.L.2
  • 44
    • 0028326049 scopus 로고
    • Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange
    • Ullrich, O., Horiuchi, H., Bucci, C., and Zerial, M. (1994). Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange. Nature 368, 157-160.
    • (1994) Nature , vol.368 , pp. 157-160
    • Ullrich, O.1    Horiuchi, H.2    Bucci, C.3    Zerial, M.4
  • 45
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • Um, S. H., D́Alessio, D., and Thomas, G. (2006). Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3, 393-402.
    • (2006) Cell Metab , vol.3 , pp. 393-402
    • Um, S.H.1    D́Alessio, D.2    Thomas, G.3
  • 46
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity
    • Um, S. H., et al. (2004). Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity. Nature 431, 200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 47
    • 66449123730 scopus 로고    scopus 로고
    • Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration
    • Vanlandingham, P. A., and Ceresa, B. P. (2009). Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J. Biol. Chem. 284, 12110-12124.
    • (2009) J. Biol. Chem , vol.284 , pp. 12110-12124
    • Vanlandingham, P.A.1    Ceresa, B.P.2
  • 49
    • 0037345059 scopus 로고    scopus 로고
    • Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
    • Wedaman, K. P., Reinke, A., Anderson, S., Yates, J., 3rd, McCaffery, J. M., and Powers, T. (2003). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14, 1204-1220.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1204-1220
    • Wedaman, K.P.1    Reinke, A.2    Anderson, S.3    Yates 3rd, J.4    McCaffery, J.M.5    Powers, T.6
  • 50
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., and Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 51
    • 0034735539 scopus 로고    scopus 로고
    • New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion
    • Wurmser, A. E., Sato, T. K., and Emr, S. D. (2000). New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. J. Cell Biol. 151, 551-562.
    • (2000) J. Cell Biol , vol.151 , pp. 551-562
    • Wurmser, A.E.1    Sato, T.K.2    Emr, S.D.3
  • 52
    • 0030972969 scopus 로고    scopus 로고
    • The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
    • Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A., and Yeung, R. S. (1997). The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J. Biol. Chem. 272, 6097-6100.
    • (1997) J. Biol. Chem , vol.272 , pp. 6097-6100
    • Xiao, G.H.1    Shoarinejad, F.2    Jin, F.3    Golemis, E.A.4    Yeung, R.S.5
  • 53
    • 0023589188 scopus 로고
    • Acidification of morphologically distinct endosomes in mutant and wild-type Chinese hamster ovary cells
    • Yamashiro, D. J., and Maxfield, F. R. (1987a). Acidification of morphologically distinct endosomes in mutant and wild-type Chinese hamster ovary cells. J. Cell Biol. 105, 2723-2733.
    • (1987) J. Cell Biol , vol.105 , pp. 2723-2733
    • Yamashiro, D.J.1    Maxfield, F.R.2
  • 54
    • 0023603374 scopus 로고
    • Kinetics of endosome acidification in mutant and wild-type Chinese hamster ovary cells
    • Yamashiro, D. J., and Maxfield, F. R. (1987b). Kinetics of endosome acidification in mutant and wild-type Chinese hamster ovary cells. J. Cell Biol. 105, 2713-2721.
    • (1987) J. Cell Biol , vol.105 , pp. 2713-2721
    • Yamashiro, D.J.1    Maxfield, F.R.2
  • 55
    • 59849113021 scopus 로고    scopus 로고
    • +/CaM, is required for the activity and regulation of hVps34 in mammalian cells
    • +/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J 417, 747-755.
    • (2009) Biochem J , vol.417 , pp. 747-755
    • Yan, Y.1    Flinn, R.J.2    Wu, H.3    Schnur, R.S.4    Backer, J.M.5
  • 56
    • 0035257013 scopus 로고    scopus 로고
    • Rab proteins as membrane organizers
    • Zerial, M., and McBride, H. (2001). Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2, 107-117.
    • (2001) Nat. Rev. Mol. Cell Biol , vol.2 , pp. 107-117
    • Zerial, M.1    McBride, H.2
  • 57
    • 34548421080 scopus 로고    scopus 로고
    • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
    • Zurita-Martinez, S. A., Puria, R., Pan, X., Boeke, J. D., and Cardenas, M. E. (2007). Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 176, 2139-2150.
    • (2007) Genetics , vol.176 , pp. 2139-2150
    • Zurita-Martinez, S.A.1    Puria, R.2    Pan, X.3    Boeke, J.D.4    Cardenas, M.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.