-
1
-
-
80155142474
-
Rapamycin passes the torch: a new generation of mTOR inhibitors
-
Benjamin D., Colombi M., Moroni C., Hall M.N. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat. Rev. Drug Discov. 2011, 10:868-880.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 868-880
-
-
Benjamin, D.1
Colombi, M.2
Moroni, C.3
Hall, M.N.4
-
3
-
-
59449108595
-
Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis
-
Carobbio S., Frigerio F., Rubi B., Vetterli L., Bloksgaard M., Gjinovci A., Pournourmohammadi S., Herrera P.L., Reith W., Mandrup S., Maechler P. Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J. Biol. Chem. 2009, 284:921-929.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 921-929
-
-
Carobbio, S.1
Frigerio, F.2
Rubi, B.3
Vetterli, L.4
Bloksgaard, M.5
Gjinovci, A.6
Pournourmohammadi, S.7
Herrera, P.L.8
Reith, W.9
Mandrup, S.10
Maechler, P.11
-
4
-
-
59049100116
-
An amino acid shuffle activates mTORC1
-
Cohen A., Hall M.N. An amino acid shuffle activates mTORC1. Cell 2009, 136:399-400.
-
(2009)
Cell
, vol.136
, pp. 399-400
-
-
Cohen, A.1
Hall, M.N.2
-
5
-
-
0037076314
-
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
-
Crespo J.L., Powers T., Fowler B., Hall M.N. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. USA 2002, 99:6784-6789.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6784-6789
-
-
Crespo, J.L.1
Powers, T.2
Fowler, B.3
Hall, M.N.4
-
6
-
-
21644477132
-
Molecular mechanisms of glutamine action
-
Curi R., Lagranha C.J., Doi S.Q., Sellitti D.F., Procopio J., Pithon-Curi T.C., Corless M., Newsholme P. Molecular mechanisms of glutamine action. J. Cell. Physiol. 2005, 204:392-401.
-
(2005)
J. Cell. Physiol.
, vol.204
, pp. 392-401
-
-
Curi, R.1
Lagranha, C.J.2
Doi, S.Q.3
Sellitti, D.F.4
Procopio, J.5
Pithon-Curi, T.C.6
Corless, M.7
Newsholme, P.8
-
7
-
-
70449900928
-
TOR complex 2: a signaling pathway of its own
-
Cybulski N., Hall M.N. TOR complex 2: a signaling pathway of its own. Trends Biochem. Sci. 2009, 34:620-627.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 620-627
-
-
Cybulski, N.1
Hall, M.N.2
-
8
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis R.J., Mancuso A., Daikhin E., Nissim I., Yudkoff M., Wehrli S., Thompson C.B. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. USA 2007, 104:19345-19350.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
9
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
10
-
-
21244448694
-
The TOR and EGO protein complexes orchestrate microautophagy in yeast
-
Dubouloz F., Deloche O., Wanke V., Cameroni E., De Virgilio C. The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol. Cell 2005, 19:15-26.
-
(2005)
Mol. Cell
, vol.19
, pp. 15-26
-
-
Dubouloz, F.1
Deloche, O.2
Wanke, V.3
Cameroni, E.4
De Virgilio, C.5
-
11
-
-
84856453804
-
Regulation of TOR by small GTPases
-
Durán R.V., Hall M.N. Regulation of TOR by small GTPases. EMBO Rep. 2012, 13:121-128.
-
(2012)
EMBO Rep.
, vol.13
, pp. 121-128
-
-
Durán, R.V.1
Hall, M.N.2
-
12
-
-
80053586265
-
P62 is a key regulator of nutrient sensing in the mTORC1 pathway
-
Duran A., Amanchy R., Linares J.F., Joshi J., Abu-Baker S., Porollo A., Hansen M., Moscat J., Diaz-Meco M.T. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol. Cell 2011, 44:134-146.
-
(2011)
Mol. Cell
, vol.44
, pp. 134-146
-
-
Duran, A.1
Amanchy, R.2
Linares, J.F.3
Joshi, J.4
Abu-Baker, S.5
Porollo, A.6
Hansen, M.7
Moscat, J.8
Diaz-Meco, M.T.9
-
13
-
-
0032493658
-
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
-
Escola J.M., Kleijmeer M.J., Stoorvogel W., Griffith J.M., Yoshie O., Geuze H.J. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 1998, 273:20121-20127.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20121-20127
-
-
Escola, J.M.1
Kleijmeer, M.J.2
Stoorvogel, W.3
Griffith, J.M.4
Yoshie, O.5
Geuze, H.J.6
-
14
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
Findlay G.M., Yan L., Procter J., Mieulet V., Lamb R.F. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem. J. 2007, 403:13-20.
-
(2007)
Biochem. J.
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
15
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002, 16:1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
16
-
-
0025454459
-
Total parenteral nutrition, glutamine, and tumor growth
-
Fischer J.E., Chance W.T. Total parenteral nutrition, glutamine, and tumor growth. JPEN J. Parenter. Enteral Nutr. 1990, 14(4, Suppl):86S-89S.
-
(1990)
JPEN J. Parenter. Enteral Nutr.
, vol.14
, Issue.4 SUPPL.
-
-
Fischer, J.E.1
Chance, W.T.2
-
17
-
-
46349091157
-
Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis
-
Frigerio F., Casimir M., Carobbio S., Maechler P. Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis. Biochim. Biophys. Acta 2008, 1777:965-972.
-
(2008)
Biochim. Biophys. Acta
, vol.1777
, pp. 965-972
-
-
Frigerio, F.1
Casimir, M.2
Carobbio, S.3
Maechler, P.4
-
18
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
19
-
-
80051873144
-
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
-
Gong R., Li L., Liu Y., Wang P., Yang H., Wang L., Cheng J., Guan K.L., Xu Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev. 2011, 25:1668-1673.
-
(2011)
Genes Dev.
, vol.25
, pp. 1668-1673
-
-
Gong, R.1
Li, L.2
Liu, Y.3
Wang, P.4
Yang, H.5
Wang, L.6
Cheng, J.7
Guan, K.L.8
Xu, Y.9
-
20
-
-
42649112409
-
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
-
Gulati P., Gaspers L.D., Dann S.G., Joaquin M., Nobukuni T., Natt F., Kozma S.C., Thomas A.P., Thomas G. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab. 2008, 7:456-465.
-
(2008)
Cell Metab.
, vol.7
, pp. 456-465
-
-
Gulati, P.1
Gaspers, L.D.2
Dann, S.G.3
Joaquin, M.4
Nobukuni, T.5
Natt, F.6
Kozma, S.C.7
Thomas, A.P.8
Thomas, G.9
-
21
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., Ha S.H., Ryu S.H., Kim S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149:410-424.
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
22
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 1998, 273:14484-14494.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
23
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002, 110:177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
24
-
-
77954757143
-
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
-
Heublein S., Kazi S., Ogmundsdóttir M.H., Attwood E.V., Kala S., Boyd C.A., Wilson C., Goberdhan D.C. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Oncogene 2010, 29:4068-4079.
-
(2010)
Oncogene
, vol.29
, pp. 4068-4079
-
-
Heublein, S.1
Kazi, S.2
Ogmundsdóttir, M.H.3
Attwood, E.V.4
Kala, S.5
Boyd, C.A.6
Wilson, C.7
Goberdhan, D.C.8
-
25
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E., Loewith R., Schmidt A., Lin S., Rüegg M.A., Hall A., Hall M.N. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 2004, 6:1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Rüegg, M.A.5
Hall, A.6
Hall, M.N.7
-
26
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
-
(2000)
EMBO J.
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
27
-
-
79959409830
-
Amino acid signaling in TOR activation
-
Kim J., Guan K.L. Amino acid signaling in TOR activation. Annu. Rev. Biochem. 2011, 80:1001-1032.
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 1001-1032
-
-
Kim, J.1
Guan, K.L.2
-
28
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002, 110:163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
29
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
Kim E., Goraksha-Hicks P., Li L., Neufeld T.P., Guan K.L. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 2008, 10:935-945.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
30
-
-
0037474212
-
Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets
-
Li C., Najafi H., Daikhin Y., Nissim I.B., Collins H.W., Yudkoff M., Matschinsky F.M., Stanley C.A. Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J. Biol. Chem. 2003, 278:2853-2858.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2853-2858
-
-
Li, C.1
Najafi, H.2
Daikhin, Y.3
Nissim, I.B.4
Collins, H.W.5
Yudkoff, M.6
Matschinsky, F.M.7
Stanley, C.A.8
-
31
-
-
84857804808
-
The structure and allosteric regulation of mammalian glutamate dehydrogenase
-
Li M., Li C., Allen A., Stanley C.A., Smith T.J. The structure and allosteric regulation of mammalian glutamate dehydrogenase. Arch. Biochem. Biophys. 2012, 519:69-80.
-
(2012)
Arch. Biochem. Biophys.
, vol.519
, pp. 69-80
-
-
Li, M.1
Li, C.2
Allen, A.3
Stanley, C.A.4
Smith, T.J.5
-
32
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 2002, 10:457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
33
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long X., Ortiz-Vega S., Lin Y., Avruch J. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 2005, 280:23433-23436.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
Avruch, J.4
-
34
-
-
34247553146
-
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
-
MacKenzie E.D., Selak M.A., Tennant D.A., Payne L.J., Crosby S., Frederiksen C.M., Watson D.G., Gottlieb E. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 2007, 27:3282-3289.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3282-3289
-
-
MacKenzie, E.D.1
Selak, M.A.2
Tennant, D.A.3
Payne, L.J.4
Crosby, S.5
Frederiksen, C.M.6
Watson, D.G.7
Gottlieb, E.8
-
36
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
Nicklin P., Bergman P., Zhang B., Triantafellow E., Wang H., Nyfeler B., Yang H., Hild M., Kung C., Wilson C., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009, 136:521-534.
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
Triantafellow, E.4
Wang, H.5
Nyfeler, B.6
Yang, H.7
Hild, M.8
Kung, C.9
Wilson, C.10
-
37
-
-
15944391333
-
Co-expression of glutaminase K and L isoenzymes in human tumour cells
-
Pérez-Gómez C., Campos-Sandoval J.A., Alonso F.J., Segura J.A., Manzanares E., Ruiz-Sánchez P., González M.E., Márquez J., Matés J.M. Co-expression of glutaminase K and L isoenzymes in human tumour cells. Biochem. J. 2005, 386:535-542.
-
(2005)
Biochem. J.
, vol.386
, pp. 535-542
-
-
Pérez-Gómez, C.1
Campos-Sandoval, J.A.2
Alonso, F.J.3
Segura, J.A.4
Manzanares, E.5
Ruiz-Sánchez, P.6
González, M.E.7
Márquez, J.8
Matés, J.M.9
-
38
-
-
34548789512
-
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
-
Robinson M.M., McBryant S.J., Tsukamoto T., Rojas C., Ferraris D.V., Hamilton S.K., Hansen J.C., Curthoys N.P. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem. J. 2007, 406:407-414.
-
(2007)
Biochem. J.
, vol.406
, pp. 407-414
-
-
Robinson, M.M.1
McBryant, S.J.2
Tsukamoto, T.3
Rojas, C.4
Ferraris, D.V.5
Hamilton, S.K.6
Hansen, J.C.7
Curthoys, N.P.8
-
39
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y., Peterson T.R., Shaul Y.D., Lindquist R.A., Thoreen C.C., Bar-Peled L., Sabatini D.M. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
40
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
41
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 2004, 14:1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
42
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
43
-
-
0035831451
-
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
-
Sekiguchi T., Hirose E., Nakashima N., Ii M., Nishimoto T. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J. Biol. Chem. 2001, 276:7246-7257.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7246-7257
-
-
Sekiguchi, T.1
Hirose, E.2
Nakashima, N.3
Ii, M.4
Nishimoto, T.5
-
44
-
-
78549283855
-
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
-
Seltzer M.J., Bennett B.D., Joshi A.D., Gao P., Thomas A.G., Ferraris D.V., Tsukamoto T., Rojas C.J., Slusher B.S., Rabinowitz J.D., et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010, 70:8981-8987.
-
(2010)
Cancer Res.
, vol.70
, pp. 8981-8987
-
-
Seltzer, M.J.1
Bennett, B.D.2
Joshi, A.D.3
Gao, P.4
Thomas, A.G.5
Ferraris, D.V.6
Tsukamoto, T.7
Rojas, C.J.8
Slusher, B.S.9
Rabinowitz, J.D.10
-
45
-
-
0019133275
-
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
-
Sener A., Malaisse W.J. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 1980, 288:187-189.
-
(1980)
Nature
, vol.288
, pp. 187-189
-
-
Sener, A.1
Malaisse, W.J.2
-
46
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S., Peterson T.R., Sabatini D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 2010, 40:310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
47
-
-
0027145124
-
Glutamine and cancer
-
Souba W.W. Glutamine and cancer. Ann. Surg. 1993, 218:715-728.
-
(1993)
Ann. Surg.
, vol.218
, pp. 715-728
-
-
Souba, W.W.1
-
49
-
-
67650165225
-
Metabolic transformation in cancer
-
Tennant D.A., Durán R.V., Boulahbel H., Gottlieb E. Metabolic transformation in cancer. Carcinogenesis 2009, 30:1269-1280.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1269-1280
-
-
Tennant, D.A.1
Durán, R.V.2
Boulahbel, H.3
Gottlieb, E.4
-
50
-
-
70449624093
-
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
-
Tennant D.A., Frezza C., MacKenzie E.D., Nguyen Q.D., Zheng L., Selak M.A., Roberts D.L., Dive C., Watson D.G., Aboagye E.O., Gottlieb E. Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. Oncogene 2009, 28:4009-4021.
-
(2009)
Oncogene
, vol.28
, pp. 4009-4021
-
-
Tennant, D.A.1
Frezza, C.2
MacKenzie, E.D.3
Nguyen, Q.D.4
Zheng, L.5
Selak, M.A.6
Roberts, D.L.7
Dive, C.8
Watson, D.G.9
Aboagye, E.O.10
Gottlieb, E.11
-
51
-
-
79953802503
-
Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake
-
Todorova V.K., Kaufmann Y., Luo S., Klimberg V.S. Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011, 67:285-291.
-
(2011)
Cancer Chemother. Pharmacol.
, vol.67
, pp. 285-291
-
-
Todorova, V.K.1
Kaufmann, Y.2
Luo, S.3
Klimberg, V.S.4
-
52
-
-
33847651745
-
Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
-
Urano J., Sato T., Matsuo T., Otsubo Y., Yamamoto M., Tamanoi F. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc. Natl. Acad. Sci. USA 2007, 104:3514-3519.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3514-3519
-
-
Urano, J.1
Sato, T.2
Matsuo, T.3
Otsubo, Y.4
Yamamoto, M.5
Tamanoi, F.6
-
53
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
Wang J.B., Erickson J.W., Fuji R., Ramachandran S., Gao P., Dinavahi R., Wilson K.F., Ambrosio A.L., Dias S.M., Dang C.V., Cerione R.A. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010, 18:207-219.
-
(2010)
Cancer Cell
, vol.18
, pp. 207-219
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
Wilson, K.F.7
Ambrosio, A.L.8
Dias, S.M.9
Dang, C.V.10
Cerione, R.A.11
-
54
-
-
0017758581
-
The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast
-
Willis R.C., Seegmiller J.E. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J. Cell. Physiol. 1977, 93:375-382.
-
(1977)
J. Cell. Physiol.
, vol.93
, pp. 375-382
-
-
Willis, R.C.1
Seegmiller, J.E.2
-
55
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B., Thompson C.B. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl. Acad. Sci. USA 2008, 105:18782-18787.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
56
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
57
-
-
77649269312
-
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR
-
Yan L., Mieulet V., Burgess D., Findlay G.M., Sully K., Procter J., Goris J., Janssens V., Morrice N.A., Lamb R.F. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol. Cell 2010, 37:633-642.
-
(2010)
Mol. Cell
, vol.37
, pp. 633-642
-
-
Yan, L.1
Mieulet, V.2
Burgess, D.3
Findlay, G.M.4
Sully, K.5
Procter, J.6
Goris, J.7
Janssens, V.8
Morrice, N.A.9
Lamb, R.F.10
-
58
-
-
80052736325
-
Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
-
Yoshida S., Hong S., Suzuki T., Nada S., Mannan A.M., Wang J., Okada M., Guan K.L., Inoki K. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. J. Biol. Chem. 2011, 286:32651-32660.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 32651-32660
-
-
Yoshida, S.1
Hong, S.2
Suzuki, T.3
Nada, S.4
Mannan, A.M.5
Wang, J.6
Okada, M.7
Guan, K.L.8
Inoki, K.9
-
59
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla V., Stracka D., Oppliger W., Hall M.N. Activation of mTORC2 by association with the ribosome. Cell 2011, 144:757-768.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
60
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
-
Zoncu R., Bar-Peled L., Efeyan A., Wang S., Sancak Y., Sabatini D.M. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 2011, 334:678-683.
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
-
61
-
-
78650510609
-
MTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R., Efeyan A., Sabatini D.M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12:21-35.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|