메뉴 건너뛰기




Volumn 13, Issue 5, 2012, Pages 558-576

Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy

Author keywords

Cellular pharmacokinetics pharmacodynamics; Drug transporter; Herbal medicines; Metabolic enzyme; Pharmacokinetics pharmacology disconnection; Subcellular distribution

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; ANTINEOPLASTIC AGENT; ARTEMISININ; BERBERINE; CAMPTOTHECIN; CRYPTOTANSHINONE; DIHYDROTANSHINONE; DOXORUBICIN; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RD; GINSENOSIDE RG 1; GINSENOSIDE RG 3; GINSENOSIDE RH 2; PACLITAXEL; PROTOCATECHUALDEHYDE; QUININE; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE I; TANSHINONE IIA; TANSHINONE IIB; TERPENOID; UNCLASSIFIED DRUG;

EID: 84861907787     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200211209050558     Document Type: Article
Times cited : (41)

References (351)
  • 1
    • 43949115541 scopus 로고    scopus 로고
    • Herbal medicine in the united states: Review of efficacy, safety, and regulation: Grand rounds at university of california, san francisco medical center
    • Bent, S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J. Gen. Intern. Med., 2008, 23 (6),854-859.
    • (2008) J. Gen. Intern. Med. , vol.23 , Issue.6 , pp. 854-859
    • Bent, S.1
  • 3
    • 79955667458 scopus 로고    scopus 로고
    • Herbal medicines, other than St. John's Wort, in the treatment of depression: A systematic review
    • Dwyer, A.V.; Whitten, D.L.; Hawrelak, J.A. Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review. Altern. Med. Rev., 2011, 16 (1),40-49.
    • (2011) Altern. Med. Rev. , vol.16 , Issue.1 , pp. 40-49
    • Dwyer, A.V.1    Whitten, D.L.2    Hawrelak, J.A.3
  • 4
    • 79251561257 scopus 로고    scopus 로고
    • Herbal medicines in pediatric neuropsychiatry
    • Feucht, C.; Patel, D.R. Herbal medicines in pediatric neuropsychiatry. Pediatr. Clin. North. Am., 2011, 58 (1),33-54.
    • (2011) Pediatr. Clin. North. Am. , vol.58 , Issue.1 , pp. 33-54
    • Feucht, C.1    Patel, D.R.2
  • 5
    • 79551643521 scopus 로고    scopus 로고
    • Herbal medicines and nutraceuticals for diabetic vascular complications: Mechanisms of action and bioactive phytochemicals
    • Omar, E.A.; Kam. A.; Alqahtani, A.; Li, K.M.; Razmovski- Naumovski, V.; Nammi, S.; Chan, K.; Roufogalis, B.D.; Li, G.Q. Herbal medicines and nutraceuticals for diabetic vascular complications: mechanisms of action and bioactive phytochemicals. Curr. Pharm. Des., 2010, 16 (34),3776-3807.
    • (2010) Curr. Pharm. Des. , vol.16 , Issue.34 , pp. 3776-3807
    • Omar, E.A.1    Kam, A.2    Alqahtani, A.3    Li, K.M.4    Razmovski-Naumovski, V.5    Nammi, S.6    Chan, K.7    Roufogalis, B.D.8    Li, G.Q.9
  • 6
    • 0037137560 scopus 로고    scopus 로고
    • Herbal remedies
    • De Smet P.A. Herbal remedies. N. Engl. J. Med., 2002, 347 (25),2046-2056.
    • (2002) N. Engl. J. Med. , vol.347 , Issue.25 , pp. 2046-2056
    • De Smet, P.A.1
  • 7
    • 34547677792 scopus 로고    scopus 로고
    • Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: An update
    • Zhou, S.F.; Xue, C.C.; Yu, X.Q.; Wang, G. Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. Curr. Drug Metab., 2007, 8 (6),526-553.
    • (2007) Curr. Drug Metab. , vol.8 , Issue.6 , pp. 526-553
    • Zhou, S.F.1    Xue, C.C.2    Yu, X.Q.3    Wang, G.4
  • 8
    • 78751553732 scopus 로고    scopus 로고
    • Disposition pathways and pharmacokinetics of herbal medicines in humans
    • He, S.M.; Li, C.G.; Liu, J.P.; Chan, E.; Duan, W.; Zhou, S.F. Disposition pathways and pharmacokinetics of herbal medicines in humans. Curr. Med. Chem., 2010, 17 (33),4072-4113.
    • (2010) Curr. Med. Chem. , vol.17 , Issue.33 , pp. 4072-4113
    • He, S.M.1    Li, C.G.2    Liu, J.P.3    Chan, E.4    Duan, W.5    Zhou, S.F.6
  • 10
    • 0141817894 scopus 로고    scopus 로고
    • The current position of complementary/alternative medicine in cancer
    • Ernst E. The current position of complementary/alternative medicine in cancer. Eur. J. Cancer, 2003, 39 (16),2273-2277.
    • (2003) Eur. J. Cancer , vol.39 , Issue.16 , pp. 2273-2277
    • Ernst, E.1
  • 11
    • 77949368190 scopus 로고    scopus 로고
    • Assessment of herbal medicinal products: Challenges, and opportunities to increase the knowledge base for safety assessment
    • Jordan, S.A.; Cunningham, D.G.; Marles, R.J. Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment. Toxicol. Appl. Pharmacol., 2010, 243 (2),198-216.
    • (2010) Toxicol. Appl. Pharmacol. , vol.243 , Issue.2 , pp. 198-216
    • Jordan, S.A.1    Cunningham, D.G.2    Marles, R.J.3
  • 12
    • 79958290393 scopus 로고    scopus 로고
    • ADME properties of herbal medicines in humans: Evidence, challenges and strategies
    • He, S.M.; Chan, E.; Zhou, S.F. ADME properties of herbal medicines in humans: evidence, challenges and strategies. Curr. Pharm. Des., 2011, 17 (4),357-407.
    • (2011) Curr. Pharm. Des. , vol.17 , Issue.4 , pp. 357-407
    • He, S.M.1    Chan, E.2    Zhou, S.F.3
  • 13
    • 77954359970 scopus 로고    scopus 로고
    • Safety of herbal supplements: A guide for cardiologists
    • Cohen, P.A.; Ernst, E. Safety of herbal supplements: a guide for cardiologists. Cardiovasc. Ther., 2010, 28 (4),246-253.
    • (2010) Cardiovasc. Ther. , vol.28 , Issue.4 , pp. 246-253
    • Cohen, P.A.1    Ernst, E.2
  • 15
    • 80051646543 scopus 로고    scopus 로고
    • Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy
    • Kang, A.; Hao, H.; Zheng, X.; Liang, Y.; Xie, Y.; Xie, T.; Dai, C.; Zhao, Q.; Wu, X.; Xie, L.; Wang, G. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J. Neuroinflammation, 2011, 8,100.
    • (2011) J. Neuroinflammation , vol.8 , pp. 100
    • Kang, A.1    Hao, H.2    Zheng, X.3    Liang, Y.4    Xie, Y.5    Xie, T.6    Dai, C.7    Zhao, Q.8    Wu, X.9    Xie, L.10    Wang, G.11
  • 17
    • 0032900659 scopus 로고    scopus 로고
    • High-throughput pharmacokinetics: Cassette dosing
    • Bayliss, M.K.; Frick, L.W. High-throughput pharmacokinetics: cassette dosing. Curr. Opin. Drug Discov. Devel., 1999, 2 (1),20-25.
    • (1999) Curr. Opin. Drug Discov. Devel. , vol.2 , Issue.1 , pp. 20-25
    • Bayliss, M.K.1    Frick, L.W.2
  • 18
    • 0029768719 scopus 로고    scopus 로고
    • Application of metabolism and pharmacokinetic studies to the drug discovery process
    • Humphrey, M.J. Application of metabolism and pharmacokinetic studies to the drug discovery process. Drug Metab. Rev., 1996, 28 (3),473-489.
    • (1996) Drug Metab. Rev. , vol.28 , Issue.3 , pp. 473-489
    • Humphrey, M.J.1
  • 19
    • 0032901566 scopus 로고    scopus 로고
    • Emerging technologies for accelerated toxicity evaluation of potential drug candidates
    • Todd, M.D.; Ulrich, R.G. Emerging technologies for accelerated toxicity evaluation of potential drug candidates. Curr. Opin. Drug Discov. Devel., 1999, 2 (1),58-68.
    • (1999) Curr. Opin. Drug Discov. Devel. , vol.2 , Issue.1 , pp. 58-68
    • Todd, M.D.1    Ulrich, R.G.2
  • 20
    • 0032088562 scopus 로고    scopus 로고
    • High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds
    • Tarbit, M.H.; Berman, J. High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds. Curr. Opin. Chem. Biol., 1998, 2 (3),411-416.
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , Issue.3 , pp. 411-416
    • Tarbit, M.H.1    Berman, J.2
  • 21
    • 0033178249 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism in early drug discovery
    • Smith, D.A.; van de, Waterbeemd H. Pharmacokinetics and metabolism in early drug discovery. Curr. Opin. Chem. Biol., 1999, 3 (4),373-378.
    • (1999) Curr. Opin. Chem. Biol. , vol.3 , Issue.4 , pp. 373-378
    • Smith, D.A.1    Van De Waterbeemd, H.2
  • 22
    • 0032900661 scopus 로고    scopus 로고
    • Drug selection in early drug development: Screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches
    • Sinko, P.J. Drug selection in early drug development: screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches. Curr. Opin. Drug Discov. Devel., 1999, 2 (1),42-48.
    • (1999) Curr. Opin. Drug Discov. Devel. , vol.2 , Issue.1 , pp. 42-48
    • Sinko, P.J.1
  • 23
    • 79955095345 scopus 로고    scopus 로고
    • Studies on the metabolism and toxicology of emerging capsinoids
    • Watanabe, T.; Ohnuki, K.; Kobata, K. Studies on the metabolism and toxicology of emerging capsinoids. Expert. Opin. Drug Metab. Toxicol., 2011, 7 (5),533-542.
    • (2011) Expert. Opin. Drug Metab. Toxicol. , vol.7 , Issue.5 , pp. 533-542
    • Watanabe, T.1    Ohnuki, K.2    Kobata, K.3
  • 24
    • 78650018055 scopus 로고    scopus 로고
    • Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies
    • Amacher, D.E. Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies. Toxicology, 2011, 279 (1-3),10-18.
    • (2011) Toxicology , vol.279 , Issue.1-3 , pp. 10-18
    • Amacher, D.E.1
  • 25
    • 0029128834 scopus 로고
    • Success rates for new drugs entering clinical testing in the united states
    • DiMasi, J.A. Success rates for new drugs entering clinical testing in the United States. Clin. Pharmacol. Ther., 1995, 58 (1),1-14.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , Issue.1 , pp. 1-14
    • Dimasi, J.A.1
  • 26
    • 0023947965 scopus 로고
    • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies 1964-1985
    • Prentis, R.A.; Lis, Y.; Walker, S.R. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br. J. Clin. Pharmacol., 1988, 25 (3),387-396.
    • (1988) Br. J. Clin. Pharmacol. , vol.25 , Issue.3 , pp. 387-396
    • Prentis, R.A.1    Lis, Y.2    Walker, S.R.3
  • 27
    • 0030886937 scopus 로고    scopus 로고
    • Managing the drug discovery/development interface
    • Kennedy, T. Managing the drug discovery/development interface. Drug Discov. Today, 1997, 2 (10),436-444.
    • (1997) Drug Discov. Today , vol.2 , Issue.10 , pp. 436-444
    • Kennedy, T.1
  • 28
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I.; Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov., 2004, 3 (8),711-715.
    • (2004) Nat Rev. Drug Discov. , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 29
    • 0034899540 scopus 로고    scopus 로고
    • ADMET - turning chemicals into drugs
    • Hodgson, J. ADMET - turning chemicals into drugs. Nat. Biotechnol., 2001, 19 (8),722-726.
    • (2001) Nat. Biotechnol. , vol.19 , Issue.8 , pp. 722-726
    • Hodgson, J.1
  • 30
    • 4544321119 scopus 로고    scopus 로고
    • Cutting the cost of drug development?
    • Rawlins, M.D. Cutting the cost of drug development? Nat. Rev. Drug Discov., 2004, 3 (4),360-364.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.4 , pp. 360-364
    • Rawlins, M.D.1
  • 31
    • 10844227564 scopus 로고    scopus 로고
    • The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development
    • Walker, D.K. The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. Br. J. Clin. Pharmacol., 2004, 58 (6),601-608.
    • (2004) Br. J. Clin. Pharmacol. , vol.58 , Issue.6 , pp. 601-608
    • Walker, D.K.1
  • 32
    • 0032974197 scopus 로고    scopus 로고
    • Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives
    • Derendorf, H.; Meibohm, B. Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharmaceut. Res., 1999, 16 (2),176-185.
    • (1999) Pharmaceut. Res. , vol.16 , Issue.2 , pp. 176-185
    • Derendorf, H.1    Meibohm, B.2
  • 33
    • 34247234639 scopus 로고    scopus 로고
    • China plans to modernize traditional medicine
    • Qiu, J. China plans to modernize traditional medicine. Nature, 2007, 446 (7136),590-591.
    • (2007) Nature , vol.446 , Issue.7136 , pp. 590-591
    • Qiu, J.1
  • 34
    • 55549122656 scopus 로고    scopus 로고
    • Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy
    • Hao, H.; Cui, N.; Wang, G.; Xiang, B.; Liang, Y.; Xu, X.; Zhang, H.; Yang, J.; Zheng, C.; Wu, L.; Gong, P.; Wang, W. Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy. Anal. Chem., 2008, 80 (21),8187-8194.
    • (2008) Anal. Chem. , vol.80 , Issue.21 , pp. 8187-8194
    • Hao, H.1    Cui, N.2    Wang, G.3    Xiang, B.4    Liang, Y.5    Xu, X.6    Zhang, H.7    Yang, J.8    Zheng, C.9    Wu, L.10    Gong, P.11    Wang, W.12
  • 35
    • 77957164557 scopus 로고    scopus 로고
    • Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: Rats
    • Liang, Y.; Hao, H.; Xie, L.; Kang, A.; Xie, T.; Zheng, X.; Dai, C.; Hao, K.; Sheng, L.; Wang, G. Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: rats. Drug Metab. Dispos., 2010, 38 (10),1747-1759.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.10 , pp. 1747-1759
    • Liang, Y.1    Hao, H.2    Xie, L.3    Kang, A.4    Xie, T.5    Zheng, X.6    Dai, C.7    Hao, K.8    Sheng, L.9    Wang, G.10
  • 36
    • 77954175046 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of complicated herbal components by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a relative exposure approach to herbal pharmacokinetics independent of standards
    • Liang, Y.; Hao, H.; Kang, A.; Xie, L.; Xie, T.; Zheng, X.; Dai, C.; Wan, L.; Sheng, L.; Wang, G. Qualitative and quantitative determination of complicated herbal components by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a relative exposure approach to herbal pharmacokinetics independent of standards. J. Chromatogr. A., 2010, 1217 (30), 4971-4979.
    • (2010) J. Chromatogr. A. , vol.1217 , Issue.30 , pp. 4971-4979
    • Liang, Y.1    Hao, H.2    Kang, A.3    Xie, L.4    Xie, T.5    Zheng, X.6    Dai, C.7    Wan, L.8    Sheng, L.9    Wang, G.10
  • 37
    • 47949093788 scopus 로고    scopus 로고
    • Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine
    • Lu, T.; Yang, J.; Gao, X.; Chen, P.; Du, F.; Sun, Y.; Wang, F.; Xu, F.; Shang, H.; Huang, Y.; Wang, Y.; Wan, R.; Liu, C.; Zhang, B.; Li, C. Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine. Drug Metab. Dispos., 2008, 36 (8),1578-1586.
    • (2008) Drug Metab. Dispos. , vol.36 , Issue.8 , pp. 1578-1586
    • Lu, T.1    Yang, J.2    Gao, X.3    Chen, P.4    Du, F.5    Sun, Y.6    Wang, F.7    Xu, F.8    Shang, H.9    Huang, Y.10    Wang, Y.11    Wan, R.12    Liu, C.13    Zhang, B.14    Li, C.15
  • 38
    • 77955458466 scopus 로고    scopus 로고
    • Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats
    • Aa, J.Y.; Wang, G.J.; Hao, H.P.; Huang, Q.; Lu, Y.H.; Yan, B.; Zha, W.B.; Liu, L.S.; Kang, A. Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats. Acta. Pharmacol. Sin., 2010, 31 (8),930-937.
    • (2010) Acta. Pharmacol. Sin. , vol.31 , Issue.8 , pp. 930-937
    • Aa, J.Y.1    Wang, G.J.2    Hao, H.P.3    Huang, Q.4    Lu, Y.H.5    Yan, B.6    Zha, W.B.7    Liu, L.S.8    Kang, A.9
  • 39
    • 2342582660 scopus 로고    scopus 로고
    • Andrographis paniculata in the treatment of upper respiratory tract infections: A systematic review of safety and efficacy
    • Coon, J.T.; Ernst, E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med., 2004, 70 (4),293-298.
    • (2004) Planta Med. , vol.70 , Issue.4 , pp. 293-298
    • Coon, J.T.1    Ernst, E.2
  • 40
    • 80053221096 scopus 로고    scopus 로고
    • Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein
    • Ye, L.; Wang, T.; Tang, L.; Liu, W.; Yang, Z.; Zhou, J.; Zheng, Z.; Cai, Z.; Hu, M.; Liu, Z. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J. Pharm. Sci., 2011, 100(11), 5007-5017
    • (2011) J. Pharm. Sci. , vol.100 , Issue.11 , pp. 5007-5017
    • Ye, L.1    Wang, T.2    Tang, L.3    Liu, W.4    Yang, Z.5    Zhou, J.6    Zheng, Z.7    Cai, Z.8    Hu, M.9    Liu, Z.10
  • 42
    • 34848886331 scopus 로고    scopus 로고
    • Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes
    • Jaruchotikamol, A.; Jarukamjorn, K.; Sirisangtrakul, W.; Sakuma, T.; Kawasaki, Y.; Nemoto N. Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes. Toxicol. Appl. Pharmacol., 2007, 224 (2), 156-162.
    • (2007) Toxicol. Appl. Pharmacol. , vol.224 , Issue.2 , pp. 156-162
    • Jaruchotikamol, A.1    Jarukamjorn, K.2    Sirisangtrakul, W.3    Sakuma, T.4    Kawasaki, Y.5    Nemoto, N.6
  • 44
    • 80051887433 scopus 로고    scopus 로고
    • Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin
    • Efferth, T.; Herrmann, F.; Tahrani, A.; Wink, M. Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin. Phytomedicine, 2011, 18 (11),959-969.
    • (2011) Phytomedicine , vol.18 , Issue.11 , pp. 959-969
    • Efferth, T.1    Herrmann, F.2    Tahrani, A.3    Wink, M.4
  • 46
    • 79958814964 scopus 로고    scopus 로고
    • A dyslipidemia animal model induced by poloxamer 407 in golden hamsters and pilot study on the mechanism
    • Liu, Q.; Liu, S.N.; Li, L.Y.; Chen, Z.Y.; Lei, L.; Zhang, N.; Shen, Z.F. A dyslipidemia animal model induced by poloxamer 407 in golden hamsters and pilot study on the mechanism. Yao. Xue. Xue. Bao., 2011, 46 (4),406-411.
    • (2011) Yao. Xue. Xue. Bao. , vol.46 , Issue.4 , pp. 406-411
    • Liu, Q.1    Liu, S.N.2    Li, L.Y.3    Chen, Z.Y.4    Lei, L.5    Zhang, N.6    Shen, Z.F.7
  • 47
    • 21744451835 scopus 로고    scopus 로고
    • Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor
    • Burk, O.; Arnold, K.A.; Nussler, A.K.; Schaeffeler, E.; Efimova, E.; Avery, B.A.; Avery, M.A.; Fromm M.F.; Eichelbaum M. Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol. Pharmacol., 2005, 67 (6),1954-1965.
    • (2005) Mol. Pharmacol. , vol.67 , Issue.6 , pp. 1954-1965
    • Burk, O.1    Arnold, K.A.2    Nussler, A.K.3    Schaeffeler, E.4    Efimova, E.5    Avery, B.A.6    Avery, M.A.7    Fromm, M.F.8    Eichelbaum, M.9
  • 48
    • 67650669265 scopus 로고    scopus 로고
    • Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression
    • Riganti, C.; Doublier, S.; Viarisio, D.; Miraglia, E.; Pescarmona, G.; Ghigo, D.; Bosia, A. Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression. Br. J. Pharmacol., 2009, 156 (7),1054-1066.
    • (2009) Br. J. Pharmacol. , vol.156 , Issue.7 , pp. 1054-1066
    • Riganti, C.1    Doublier, S.2    Viarisio, D.3    Miraglia, E.4    Pescarmona, G.5    Ghigo, D.6    Bosia, A.7
  • 49
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal, B.B.; Sung, B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends. Pharmacol. Sci., 2009, 30 (2),85-94.
    • (2009) Trends. Pharmacol. Sci. , vol.30 , Issue.2 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 50
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal, B.B.; Harikumar, K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol., 2009, 41 (1),40-59.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , Issue.1 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 51
    • 38749109673 scopus 로고    scopus 로고
    • Curcumin as "curecumin": From kitchen to clinic
    • Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as "Curecumin": from kitchen to clinic. Biochem. Pharmacol., 2008, 75 (4),787-809.
    • (2008) Biochem. Pharmacol. , vol.75 , Issue.4 , pp. 787-809
    • Goel, A.1    Kunnumakkara, A.B.2    Aggarwal, B.B.3
  • 55
  • 58
    • 33947233105 scopus 로고    scopus 로고
    • Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate
    • Ebert, B.; Seidel, A.; Lampen, A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol. Sci., 2007, 96 (2),227-236.
    • (2007) Toxicol. Sci. , vol.96 , Issue.2 , pp. 227-236
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 59
    • 77956227486 scopus 로고    scopus 로고
    • Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures
    • Wang, J.W.; Wu, J.Y. Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures. Appl. Microbiol. Biotechnol., 2010, 88 (2),437-449.
    • (2010) Appl. Microbiol. Biotechnol. , vol.88 , Issue.2 , pp. 437-449
    • Wang, J.W.1    Wu, J.Y.2
  • 60
    • 26844531763 scopus 로고    scopus 로고
    • Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography- electrospray ionisation-mass spectrometry
    • Li, J.; Wang, G.; Li P.; Hao, H. Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography- electrospray ionisation-mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2005, 826 (1-2),26-30.
    • (2005) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.826 , Issue.1-2 , pp. 26-30
    • Li, J.1    Wang, G.2    Li, P.3    Hao, H.4
  • 61
    • 46449109055 scopus 로고    scopus 로고
    • Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes
    • Qiu, F.; Zhang, R.; Sun, J.; Jiye, A.; Hao, H.; Peng, Y.; Ai, H.; Wang, G. Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Drug Metab. Dispos., 2008, 36 (7),1308-1314.
    • (2008) Drug Metab. Dispos. , vol.36 , Issue.7 , pp. 1308-1314
    • Qiu, F.1    Zhang, R.2    Sun, J.3    Jiye, A.4    Hao, H.5    Peng, Y.6    Ai, H.7    Wang, G.8
  • 62
    • 0344196763 scopus 로고    scopus 로고
    • Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice
    • Ueng, Y.F.; Kuo, Y.H.; Wang, S.Y.; Lin, Y.L.; Chen, C.F. Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice. Life Sci., 2004, 74 (7),885-896.
    • (2004) Life Sci. , vol.74 , Issue.7 , pp. 885-896
    • Ueng, Y.F.1    Kuo, Y.H.2    Wang, S.Y.3    Lin, Y.L.4    Chen, C.F.5
  • 63
    • 79955603019 scopus 로고    scopus 로고
    • Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoproteinand cytochrome P4503A-mediated herb-drug interactions
    • Lee, J.H.; Shin, Y.J.; Kim, H.J.; Oh, J.H.; Jang, Y.P.; Lee, Y.J. Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoproteinand cytochrome P4503A-mediated herb-drug interactions. Int. J. Pharm., 2011, 410 (1-2),68-74.
    • (2011) Int. J. Pharm. , vol.410 , Issue.1-2 , pp. 68-74
    • Lee, J.H.1    Shin, Y.J.2    Kim, H.J.3    Oh, J.H.4    Jang, Y.P.5    Lee, Y.J.6
  • 65
    • 0031823286 scopus 로고    scopus 로고
    • Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang)
    • Gurley, B.J.; Gardner, S.F.; White, L.M.; Wang, P.L. Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). Ther. Drug Monit., 1998, 20 (4),439-445.
    • (1998) Ther. Drug Monit. , vol.20 , Issue.4 , pp. 439-445
    • Gurley, B.J.1    Gardner, S.F.2    White, L.M.3    Wang, P.L.4
  • 66
    • 26444508950 scopus 로고    scopus 로고
    • The severity of toxic reactions to ephedra: Comparisons to other botanical products and national trends from 1993-2002
    • Woolf, A.D.; Watson, W.A.; Smolinske, S.; Litovitz, T. The severity of toxic reactions to ephedra: comparisons to other botanical products and national trends from 1993-2002. Clin. Toxicol. (Phila), 2005, 43 (5),347-355.
    • (2005) Clin. Toxicol. (Phila) , vol.43 , Issue.5 , pp. 347-355
    • Woolf, A.D.1    Watson, W.A.2    Smolinske, S.3    Litovitz, T.4
  • 67
    • 1242316376 scopus 로고    scopus 로고
    • Ephedra-associated cardiomyopathy
    • Naik, S.D.; Freudenberger, R.S. Ephedra-associated cardiomyopathy. Ann. Pharmacother., 2004, 38 (3),400-403.
    • (2004) Ann. Pharmacother. , vol.38 , Issue.3 , pp. 400-403
    • Naik, S.D.1    Freudenberger, R.S.2
  • 68
    • 84858002951 scopus 로고    scopus 로고
    • Effects of Ephedra Water Decoction and Cough Tablets containing Ephedra and Liquorice on CYP1A2 and the Pharmacokinetics of Theophylline in Rats
    • Tang, J.; Zhou, X.; Ji, H.; Zhu, D.; Wu, L. Effects of Ephedra Water Decoction and Cough Tablets containing Ephedra and Liquorice on CYP1A2 and the Pharmacokinetics of Theophylline in Rats. Phytother. Res., 2012, 26(3),470-474.
    • (2012) Phytother. Res. , vol.26 , Issue.3 , pp. 470-474
    • Tang, J.1    Zhou, X.2    Ji, H.3    Zhu, D.4    Wu, L.5
  • 69
    • 60349120689 scopus 로고    scopus 로고
    • Analysis of Schisandra chinensis and Schisandra sphenanthera
    • Lu, Y.; Chen, D.F. Analysis of Schisandra chinensis and Schisandra sphenanthera. J. Chromatogr. A., 2009, 1216 (11),1980-1990.
    • (2009) J. Chromatogr. A. , vol.1216 , Issue.11 , pp. 1980-1990
    • Lu, Y.1    Chen, D.F.2
  • 71
    • 77952290102 scopus 로고    scopus 로고
    • Inhibition of cytochrome p450 3a4 activity by schisandrol a and gomisin a isolated from fructus schisandrae chinensis
    • Wan, C.K.; Tse, A.K.; Yu, Z.L.; Zhu, G.Y.; Wang, H.; Fong, D.W. Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis. Phytomedicine, 2010, 17 (8-9),702-705.
    • (2010) Phytomedicine , vol.17 , Issue.8-9 , pp. 702-705
    • Wan, C.K.1    Tse, A.K.2    Yu, Z.L.3    Zhu, G.Y.4    Wang, H.5    Fong, D.W.6
  • 72
    • 34250379186 scopus 로고    scopus 로고
    • Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes
    • Fong, W.F.; Wan, C.K.; Zhu, G.Y.; Chattopadhyay, A.; Dey, S.; Zhao, Z.; Shen, X.L. Schisandrol A from Schisandra chinensis reverses P-glycoprotein- mediated multidrug resistance by affecting Pgp-substrate complexes. Planta Med., 2007, 73 (3),212-220.
    • (2007) Planta Med. , vol.73 , Issue.3 , pp. 212-220
    • Fong, W.F.1    Wan, C.K.2    Zhu, G.Y.3    Chattopadhyay, A.4    Dey, S.5    Zhao, Z.6    Shen, X.L.7
  • 73
    • 77956910771 scopus 로고    scopus 로고
    • Garlic (Allium sativum L.) and cardiovascular diseases
    • Ginter, E.; Simko V. Garlic (Allium sativum L.) and cardiovascular diseases. Bratisl. Lek. Listy., 2010, 111 (8),452-456.
    • (2010) Bratisl. Lek. Listy. , vol.111 , Issue.8 , pp. 452-456
    • Ginter, E.1    Simko, V.2
  • 74
    • 77951102768 scopus 로고    scopus 로고
    • Garlic-derived anticancer agents: Structure and biological activity of ajoene
    • Kaschula, C.H.; Hunter, R.; Parker, M.I. Garlic-derived anticancer agents: structure and biological activity of ajoene. Biofactors, 2010, 36 (1),78-85.
    • (2010) Biofactors , vol.36 , Issue.1 , pp. 78-85
    • Kaschula, C.H.1    Hunter, R.2    Parker, M.I.3
  • 75
  • 76
    • 21844451865 scopus 로고    scopus 로고
    • Health effects of garlic
    • Tattelman, E. Health effects of garlic. Am. Fam. Physician., 2005, 72 (1),103-106.
    • (2005) Am. Fam. Physician. , vol.72 , Issue.1 , pp. 103-106
    • Tattelman, E.1
  • 77
    • 77957372879 scopus 로고    scopus 로고
    • Effects of garlic on cytochromes p450 2c9- and 3a4- mediated drug metabolism in human hepatocytes
    • Ho, B.E.; Shen, D.D.; McCune, J.S.; Bui, T.; Risler, L.; Yang, Z.; Ho, R.J. Effects of Garlic on Cytochromes P450 2C9- and 3A4- Mediated Drug Metabolism in Human Hepatocytes. Sci. Pharm., 2010, 78 (3),473-481.
    • (2010) Sci. Pharm. , vol.78 , Issue.3 , pp. 473-481
    • Ho, B.E.1    Shen, D.D.2    McCune, J.S.3    Bui, T.4    Risler, L.5    Yang, Z.6    Ho, R.J.7
  • 79
    • 78349305570 scopus 로고    scopus 로고
    • Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans
    • Hajda, J.; Rentsch, K.M.; Gubler, C.; Steinert, H.; Stieger, B.; Fattinger, K. Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans. Eur. J. Pharm. Sci., 2010, 41 (5),729-735.
    • (2010) Eur. J. Pharm. Sci. , vol.41 , Issue.5 , pp. 729-735
    • Hajda, J.1    Rentsch, K.M.2    Gubler, C.3    Steinert, H.4    Stieger, B.5    Fattinger, K.6
  • 80
    • 84861843418 scopus 로고    scopus 로고
    • The mechanisms responsible for garlic - Drug interactions and their in vivo relevance
    • Epub ahead of print]
    • Berginc, K.; Kristl, A. The Mechanisms Responsible for Garlic - Drug Interactions and Their in vivo Relevance. Curr. Drug Metab., 2011. [Epub ahead of print]
    • (2011) Curr. Drug Metab.
    • Berginc, K.1    Kristl, A.2
  • 82
    • 78549261367 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
    • Chen, Z.P.; Sun, J.; Chen, H.X.; Xiao, Y.Y.; Liu, D.; Chen, J.; Cai, H.; Cai, B.C. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Fitoterapia, 2010, 81 (8),1045-1052.
    • (2010) Fitoterapia , vol.81 , Issue.8 , pp. 1045-1052
    • Chen, Z.P.1    Sun, J.2    Chen, H.X.3    Xiao, Y.Y.4    Liu, D.5    Chen, J.6    Cai, H.7    Cai, B.C.8
  • 84
    • 68649126586 scopus 로고    scopus 로고
    • Inhibition of Pglycoprotein enhances the suppressive effect of kaempferol on transformation of the aryl hydrocarbon receptor
    • Mukai, R.; Satsu, H.; Shimizu, M.; Ashida, H. Inhibition of Pglycoprotein enhances the suppressive effect of kaempferol on transformation of the aryl hydrocarbon receptor. Biosci. Biotechnol. Biochem., 2009, 73 (7),1635-1639.
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , Issue.7 , pp. 1635-1639
    • Mukai, R.1    Satsu, H.2    Shimizu, M.3    Ashida, H.4
  • 85
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen, L.P. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv. Food Nutr. Res., 2009, 55,1-99.
    • (2009) Adv. Food Nutr. Res. , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 86
    • 34548169064 scopus 로고    scopus 로고
    • Commonly used antioxidant botanicals: Active constituents and their potential role in cardiovascular illness
    • Wang, C.Z.; Mehendale, S.R.; Yuan, C.S. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am. J. Chin. Med., 2007, 35 (4),543-558.
    • (2007) Am. J. Chin. Med. , vol.35 , Issue.4 , pp. 543-558
    • Wang, C.Z.1    Mehendale, S.R.2    Yuan, C.S.3
  • 88
    • 77955586015 scopus 로고    scopus 로고
    • The tampa scale for kinesiophobia for temporomandibular disorders (tsk-tmd)
    • Visscher, C.M.; Ohrbach, R.; van Wijk, A.J.; Wilkosz M.; Naeije, M. The Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD). Pain, 2010, 150 (3),492-500.
    • (2010) Pain , vol.150 , Issue.3 , pp. 492-500
    • Visscher, C.M.1    Ohrbach, R.2    Van Wijk, A.J.3    Wilkosz, M.4    Naeije, M.5
  • 89
    • 79958055511 scopus 로고    scopus 로고
    • Pharmacokinetics study of bioadhesive tablet of Panax notoginseng saponins
    • Feng, H.; Chen, W.; Zhu, C. Pharmacokinetics study of bioadhesive tablet of Panax notoginseng saponins. Int. Arch. Med., 2011, 4 (1),18.
    • (2011) Int. Arch. Med. , vol.4 , Issue.1 , pp. 18
    • Feng, H.1    Chen, W.2    Zhu, C.3
  • 90
    • 68049127779 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs
    • Gu Y.; Wang G.J.; Sun J.G.; Jia Y.W.; Wang W.; Xu M.J.; Lv T.; Zheng Y.T.; Sai Y. Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem. Toxicol., 2009, 47 (9),2257-2268.
    • (2009) Food Chem. Toxicol. , vol.47 , Issue.9 , pp. 2257-2268
    • Gu, Y.1    Wang, G.J.2    Sun, J.G.3    Jia, Y.W.4    Wang, W.5    Xu, M.J.6    Lv, T.7    Zheng, Y.T.8    Sai, Y.9
  • 91
    • 38649129855 scopus 로고    scopus 로고
    • Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway
    • Lau, W.S.; Chan, R.Y.; Guo, D.A.; Wong, M.S. Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway. J. Steroid. Biochem. Mol. Biol., 2008, 108 (1-2),64-71.
    • (2008) J. Steroid. Biochem. Mol. Biol. , vol.108 , Issue.1-2 , pp. 64-71
    • Lau, W.S.1    Chan, R.Y.2    Guo, D.A.3    Wong, M.S.4
  • 93
    • 33744799726 scopus 로고    scopus 로고
    • Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes
    • Liu, Y.; Zhang, J.W.; Li, W.; Ma, H.; Sun, J.; Deng, M.C.; Yang, L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol. Sci., 2006, 91 (2),356-364.
    • (2006) Toxicol. Sci. , vol.91 , Issue.2 , pp. 356-364
    • Liu, Y.1    Zhang, J.W.2    Li, W.3    Ma, H.4    Sun, J.5    Deng, M.C.6    Yang, L.7
  • 95
    • 0037363620 scopus 로고    scopus 로고
    • Reversal of P-glycoproteinmediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng
    • Choi, C.H.; Kang, G.; Min, Y.D. Reversal of P-glycoproteinmediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. Planta Med., 2003, 69 (3),235-240.
    • (2003) Planta Med. , vol.69 , Issue.3 , pp. 235-240
    • Choi, C.H.1    Kang, G.2    Min, Y.D.3
  • 97
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    • Asl, M.N.; Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother. Res., 2008, 22 (6),709-724.
    • (2008) Phytother. Res. , vol.22 , Issue.6 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 99
    • 78149484263 scopus 로고    scopus 로고
    • Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells
    • Park, S.Y.; Lim, S.S.; Kim, J.K.; Kang, I.J.; Kim, J.S.; Lee, C.; Kim, J.; Park, J.H. Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells. Br. J. Nutr., 2010, 104 (9),1272-1282.
    • (2010) Br. J. Nutr. , vol.104 , Issue.9 , pp. 1272-1282
    • Park, S.Y.1    Lim, S.S.2    Kim, J.K.3    Kang, I.J.4    Kim, J.S.5    Lee, C.6    Kim, J.7    Park, J.H.8
  • 101
    • 79959589509 scopus 로고    scopus 로고
    • Cholesterol-lowering activity of the major polyphenols in grape seed
    • Ngamukote, S.; Makynen, K.; Thilawech, T.; Adisakwattana, S. Cholesterol-lowering activity of the major polyphenols in grape seed. Molecules, 2011, 16 (6),5054-5061.
    • (2011) Molecules , vol.16 , Issue.6 , pp. 5054-5061
    • Ngamukote, S.1    Makynen, K.2    Thilawech, T.3    Adisakwattana, S.4
  • 102
    • 78851469101 scopus 로고    scopus 로고
    • Bioavailability of resveratrol
    • Walle, T. Bioavailability of resveratrol. Ann. N. Y. Acad. Sci., 2011, 1215,9-15.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1215 , pp. 9-15
    • Walle, T.1
  • 104
    • 0034634252 scopus 로고    scopus 로고
    • Resveratrol a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4
    • Chan, W.K.; Delucchi, A.B. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci., 2000, 67 (25),3103-3112.
    • (2000) Life Sci. , vol.67 , Issue.25 , pp. 3103-3112
    • Chan, W.K.1    Delucchi, A.B.2
  • 105
    • 0000023835 scopus 로고    scopus 로고
    • Mechanismbased inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine
    • Chan, W.K.; Nguyen, L.T.; Miller, V.P.; Harris, R.Z. Mechanismbased inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci., 1998, 62 (10),PL135-142.
    • (1998) Life Sci. , vol.62 , Issue.10
    • Chan, W.K.1    Nguyen, L.T.2    Miller, V.P.3    Harris, R.Z.4
  • 106
    • 0035976379 scopus 로고    scopus 로고
    • Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
    • Piver, B.; Berthou, F.; Dreano, Y.; Lucas, D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol. Lett., 2001, 125 (1-3),83-91.
    • (2001) Toxicol. Lett. , vol.125 , Issue.1-3 , pp. 83-91
    • Piver, B.1    Berthou, F.2    Dreano, Y.3    Lucas, D.4
  • 107
    • 34447542990 scopus 로고    scopus 로고
    • Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers
    • Mikstacka, R.; Przybylska, D.; Rimando, A.M.; Baer-Dubowska, W. Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers. Mol. Nutr. Food Res., 2007, 51 (5),517-524.
    • (2007) Mol. Nutr. Food Res. , vol.51 , Issue.5 , pp. 517-524
    • Mikstacka, R.1    Przybylska, D.2    Rimando, A.M.3    Baer-Dubowska, W.4
  • 108
    • 79960439315 scopus 로고    scopus 로고
    • Resveratrol inhibits genistein- induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells
    • Kim, J.H.; Chen, C.; Tony Kong, A.N. Resveratrol inhibits genistein- induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells. Arch. Biochem. Biophys., 2011, 512 (2),160-166.
    • (2011) Arch. Biochem. Biophys. , vol.512 , Issue.2 , pp. 160-166
    • Kim, J.H.1    Chen, C.2    Tony Kong, A.N.3
  • 109
    • 84996503842 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies)
    • National Toxicology Program.
    • National Toxicology Program. Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). Natl. Toxicol. Program. Tech. Rep. Ser., 2010, 8(562),1-188.
    • (2010) Natl. Toxicol. Program. Tech. Rep. Ser. , vol.8 , Issue.562 , pp. 1-188
  • 110
    • 34447640334 scopus 로고    scopus 로고
    • Determination of berberine in human plasma by liquid chromatographyelectrospray ionization-mass spectrometry
    • Hua, W.; Ding, L.; Chen, Y.; Gong, B.; He, J.; Xu, G. Determination of berberine in human plasma by liquid chromatographyelectrospray ionization-mass spectrometry. J. Pharm. Biomed. Anal., 2007, 44 (4),931-937.
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , Issue.4 , pp. 931-937
    • Hua, W.1    Ding, L.2    Chen, Y.3    Gong, B.4    He, J.5    Xu, G.6
  • 111
    • 79954549226 scopus 로고    scopus 로고
    • Investigating the potential for toxicity from longterm use of the herbal products, goldenseal and milk thistle
    • Dunnick, J.K.; Singh, B.; Nyska, A.; Peckham, J.; Kissling, G.E.; Sanders, J.M. Investigating the potential for toxicity from longterm use of the herbal products, goldenseal and milk thistle. Toxicol. Pathol., 2011, 39 (2),398-409.
    • (2011) Toxicol. Pathol. , vol.39 , Issue.2 , pp. 398-409
    • Dunnick, J.K.1    Singh, B.2    Nyska, A.3    Peckham, J.4    Kissling, G.E.5    Sanders, J.M.6
  • 112
    • 0142072045 scopus 로고    scopus 로고
    • Influence of goldenseal root on the pharmacokinetics of indinavir
    • Sandhu, R.S.; Prescilla, R.P.; Simonelli, T.M.; Edwards, D.J. Influence of goldenseal root on the pharmacokinetics of indinavir. J. Clin. Pharmacol., 2003, 43 (11),1283-1288.
    • (2003) J. Clin. Pharmacol. , vol.43 , Issue.11 , pp. 1283-1288
    • Sandhu, R.S.1    Prescilla, R.P.2    Simonelli, T.M.3    Edwards, D.J.4
  • 113
    • 53249123498 scopus 로고    scopus 로고
    • Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea
    • Gurley, B.J.; Swain, A.; Hubbard, M.A.; Williams, D.K.; Barone, G.; Hartsfield, F.; Tong, Y.; Carrier, D.J.; Cheboyina, S.; Battu, S.K. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. Mol. Nutr. Food Res., 2008, 52 (7),755-763.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.7 , pp. 755-763
    • Gurley, B.J.1    Swain, A.2    Hubbard, M.A.3    Williams, D.K.4    Barone, G.5    Hartsfield, F.6    Tong, Y.7    Carrier, D.J.8    Cheboyina, S.9    Battu, S.K.10
  • 115
    • 78650637966 scopus 로고    scopus 로고
    • Kava: A comprehensive review of efficacy, safety, and psychopharmacology
    • Sarris, J.; La Porte, E.; Schweitzer, I. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust. N. Z. J. Psychiatry., 2011, 45 (1),27-35.
    • (2011) Aust. N. Z. J. Psychiatry. , vol.45 , Issue.1 , pp. 27-35
    • Sarris, J.1    La Porte, E.2    Schweitzer, I.3
  • 116
    • 24944587145 scopus 로고    scopus 로고
    • Pharmacokinetics and disposition of the kavalactone kawain: Interaction with kava extract and kavalactones in vivo and in vitro
    • Mathews, J.M.; Etheridge, A.S.; Valentine, J.L.; Black, S.R.; Coleman, D.P.; Patel, P.; So, J.; Burka, L.T. Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro. Drug Metab. Dispos., 2005, 33 (10),1555-1563.
    • (2005) Drug Metab. Dispos. , vol.33 , Issue.10 , pp. 1555-1563
    • Mathews, J.M.1    Etheridge, A.S.2    Valentine, J.L.3    Black, S.R.4    Coleman, D.P.5    Patel, P.6    So, J.7    Burka, L.T.8
  • 117
    • 84855489838 scopus 로고    scopus 로고
    • Kava hepatotoxicity in traditional and modern use: The presumed Pacific kava paradox hypothesis revisited
    • Teschke, R.; Sarris J.; Schweitzer I. Kava hepatotoxicity in traditional and modern use: The presumed Pacific kava paradox hypothesis revisited. Br. J. Clin. Pharmacol., 2012, 73(2), 170-174.
    • (2012) Br. J. Clin. Pharmacol. , vol.73 , Issue.2 , pp. 170-174
    • Teschke, R.1    Sarris, J.2    Schweitzer, I.3
  • 118
    • 0036842023 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 activities by kava extract and kavalactones
    • Mathews, J.M.; Etheridge, A.S.; Black, S.R. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab. Dispos., 2002, 30 (11),1153-1157.
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.11 , pp. 1153-1157
    • Mathews, J.M.1    Etheridge, A.S.2    Black, S.R.3
  • 119
    • 80052073830 scopus 로고    scopus 로고
    • Chinese herbal medicine for diabetic peripheral neuropathy
    • Chen, W.; Zhang, Y.; Liu, J.P. Chinese herbal medicine for diabetic peripheral neuropathy. Cochrane. Database. Syst. Rev., 2011, 6,CD007796.
    • (2011) Cochrane. Database. Syst. Rev. , vol.6
    • Chen, W.1    Zhang, Y.2    Liu, J.P.3
  • 120
    • 80052025156 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of 2,3,5,4'- tetrahydroxystilbene-2-O-beta-dglucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats
    • Lv, G.; Lou, Z.; Chen, S.; Gu, H.; Shan, L. Pharmacokinetics and tissue distribution of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-dglucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats. J. Ethnopharmacol., 2011, 137(1): 449-456.
    • (2011) J. Ethnopharmacol. , vol.137 , Issue.1 , pp. 449-456
    • Lv, G.1    Lou, Z.2    Chen, S.3    Gu, H.4    Shan, L.5
  • 121
    • 37549005182 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract
    • Wen, Z.; Dumas, T.E.; Schrieber, S.J.; Hawke, R.L.; Fried, M.W.; Smith, P.C. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. Drug Metab. Dispos., 2008, 36 (1),65-72.
    • (2008) Drug Metab. Dispos. , vol.36 , Issue.1 , pp. 65-72
    • Wen, Z.1    Dumas, T.E.2    Schrieber, S.J.3    Hawke, R.L.4    Fried, M.W.5    Smith, P.C.6
  • 122
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: From basic research to clinical practice
    • Loguercio, C.; Festi, D. Silybin and the liver: from basic research to clinical practice. World J. Gastroenterol., 2011, 17 (18),2288-2301.
    • (2011) World J. Gastroenterol. , vol.17 , Issue.18 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 123
    • 2442649042 scopus 로고    scopus 로고
    • Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
    • Sridar, C.; Goosen, T.C.; Kent, U.M.; Williams, J.A.; Hollenberg, P.F. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab. Dispos., 2004, 32 (6),587-594.
    • (2004) Drug Metab. Dispos. , vol.32 , Issue.6 , pp. 587-594
    • Sridar, C.1    Goosen, T.C.2    Kent, U.M.3    Williams, J.A.4    Hollenberg, P.F.5
  • 124
    • 77952996831 scopus 로고    scopus 로고
    • Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats
    • Lee, C.K.; Choi, J.S. Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats. Pharmacology, 2010, 85 (6),350-356.
    • (2010) Pharmacology , vol.85 , Issue.6 , pp. 350-356
    • Lee, C.K.1    Choi, J.S.2
  • 125
    • 33646471119 scopus 로고    scopus 로고
    • New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity
    • Dzubak, P.; Hajduch, M.; Gazak, R.; Svobodova, A.; Psotova, J.; Walterova, D.; Sedmera P.; Kren V. New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity. Bioorg. Med. Chem., 2006, 14 (11),3793-3810.
    • (2006) Bioorg. Med. Chem. , vol.14 , Issue.11 , pp. 3793-3810
    • Dzubak, P.1    Hajduch, M.2    Gazak, R.3    Svobodova, A.4    Psotova, J.5    Walterova, D.6    Sedmera, P.7    Kren, V.8
  • 126
    • 75449094617 scopus 로고    scopus 로고
    • Chemical constituents and bioactivities of plants from the genus Paeonia
    • Wu, S.H.; Wu, D.G.; Chen, Y.W. Chemical constituents and bioactivities of plants from the genus Paeonia. Chem. Biodivers., 2010, 7 (1),90-104.
    • (2010) Chem. Biodivers. , vol.7 , Issue.1 , pp. 90-104
    • Wu, S.H.1    Wu, D.G.2    Chen, Y.W.3
  • 128
    • 82255180232 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine
    • He, D.Y.; Dai, S.M. Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine. Front. Pharmacol., 2011, 2,10.
    • (2011) Front. Pharmacol. , vol.2 , pp. 10
    • He, D.Y.1    Dai, S.M.2
  • 129
    • 76749121508 scopus 로고    scopus 로고
    • Paeonol the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice
    • Hu S.; Shen, G.; Zhao, W.; Wang, F.; Jiang, X.; Huang, D. Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice. J. Ethnopharmacol., 2010, 128 (1),100-106.
    • (2010) J. Ethnopharmacol. , vol.128 , Issue.1 , pp. 100-106
    • Hu, S.1    Shen, G.2    Zhao, W.3    Wang, F.4    Jiang, X.5    Huang, D.6
  • 130
    • 33845350626 scopus 로고    scopus 로고
    • Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine
    • Liu, Z.Q.; Jiang, Z.H.; Liu, L.; Hu, M. Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm. Res., 2006, 23 (12),2768-2780.
    • (2006) Pharm. Res. , vol.23 , Issue.12 , pp. 2768-2780
    • Liu, Z.Q.1    Jiang, Z.H.2    Liu, L.3    Hu, M.4
  • 131
    • 31344441408 scopus 로고    scopus 로고
    • The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model
    • Chan, K.; Liu, Z.Q.; Jiang, Z.H.; Zhou, H.; Wong, Y.F.; Xu, H.X.; Liu, L. The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. J. Ethnopharmacol., 2006, 103 (3),425-432.
    • (2006) J. Ethnopharmacol. , vol.103 , Issue.3 , pp. 425-432
    • Chan, K.1    Liu, Z.Q.2    Jiang, Z.H.3    Zhou, H.4    Wong, Y.F.5    Xu, H.X.6    Liu, L.7
  • 132
    • 79956265123 scopus 로고    scopus 로고
    • Use of Saint Johns wort against mild depression
    • Hoyland, H.K. Use of Saint Johns wort against mild depression. Tidsskr. Nor. Laegeforen., 2011, 131 (8),837-839.
    • (2011) Tidsskr. Nor. Laegeforen. , vol.131 , Issue.8 , pp. 837-839
    • Hoyland, H.K.1
  • 133
  • 135
    • 78951472564 scopus 로고    scopus 로고
    • The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: Increased platelet inhibition by enhancement of CYP3A4 metabolic activity
    • Lau, W.C.; Welch, T.D.; Shields, T.; Rubenfire, M.; Tantry, U.S.; Gurbel, P.A. The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activity. J. Cardiovasc. Pharmacol., 2011, 57 (1),86-93.
    • (2011) J. Cardiovasc. Pharmacol. , vol.57 , Issue.1 , pp. 86-93
    • Lau, W.C.1    Welch, T.D.2    Shields, T.3    Rubenfire, M.4    Tantry, U.S.5    Gurbel, P.A.6
  • 136
    • 79251598311 scopus 로고    scopus 로고
    • Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes
    • Hokkanen, J.; Tolonen, A.; Mattila, S.; Turpeinen, M. Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. Eur. J. Pharm. Sci., 2011, 42 (3),273-284.
    • (2011) Eur. J. Pharm. Sci. , vol.42 , Issue.3 , pp. 273-284
    • Hokkanen, J.1    Tolonen, A.2    Mattila, S.3    Turpeinen, M.4
  • 137
    • 77953285105 scopus 로고    scopus 로고
    • St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier
    • Ott, M.; Huls, M.; Cornelius, M.G.; Fricker, G. St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier. Pharm. Res., 2010, 27 (5),811-822.
    • (2010) Pharm. Res. , vol.27 , Issue.5 , pp. 811-822
    • Ott, M.1    Huls, M.2    Cornelius, M.G.3    Fricker, G.4
  • 138
    • 41249103765 scopus 로고    scopus 로고
    • Research and prospect on reducing the toxicity and enhancing the efficacy of Tipterygium wilfordii by combined use of Chinese medicine
    • Li, B.; Zhou, X.X.; Liang, M.X. Research and prospect on reducing the toxicity and enhancing the efficacy of Tipterygium wilfordii by combined use of Chinese medicine. Zhong. guo. Zhong. Xi. Yi. Jie. He. Za. Zhi., 2006, 26 (11),1045-1048.
    • (2006) Zhong. Guo. Zhong. Xi. Yi. Jie. He. Za. Zhi. , vol.26 , Issue.11 , pp. 1045-1048
    • Li, B.1    Zhou, X.X.2    Liang, M.X.3
  • 139
    • 84857381128 scopus 로고    scopus 로고
    • Tripterygium wilfordii bioactive compounds as anti-cancer and anti-inflammatory agents
    • Wong, K.F.; Yi Y.; Luk, J.M. Tripterygium wilfordii bioactive compounds as anti-cancer and anti-inflammatory agents. Clin. Exp. Pharmacol. Physiol., 2012, 39(3), 311-320.
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , Issue.3 , pp. 311-320
    • Wong, K.F.1    Yi, Y.2    Luk, J.M.3
  • 140
    • 34147187917 scopus 로고    scopus 로고
    • Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats
    • Shao, F.; Wang, G.; Xie, H.; Zhu, X.; Sun, J.; A J. Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats. Biol. Pharm. Bull., 2007, 30 (4),702-707.
    • (2007) Biol. Pharm. Bull. , vol.30 , Issue.4 , pp. 702-707
    • Shao, F.1    Wang, G.2    Xie, H.3    Zhu, X.4    Sun, J.5    A, J.6
  • 144
    • 77951263904 scopus 로고    scopus 로고
    • Triptolide circumvents drugresistant effect and enhances 5-fluorouracil antitumor effect on KB cells
    • Chen, Y.W.; Lin, G.J.; Chuang, Y.P.; Chia, W.T.; Hueng, D.Y.; Lin, C.K.; Nieh, S.; Sytwu, H.K. Triptolide circumvents drugresistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs, 2010, 21 (5),502-513.
    • (2010) Anticancer Drugs , vol.21 , Issue.5 , pp. 502-513
    • Chen, Y.W.1    Lin, G.J.2    Chuang, Y.P.3    Chia, W.T.4    Hueng, D.Y.5    Lin, C.K.6    Nieh, S.7    Sytwu, H.K.8
  • 145
    • 80052420265 scopus 로고    scopus 로고
    • Effect of valerian on sleep quality in postmenopausal women: A randomized placebo-controlled clinical trial
    • Taavoni, S.; Ekbatani, N.; Kashaniyan, M.; Haghani, H. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause, 2011, 18(9),951-955
    • (2011) Menopause , vol.18 , Issue.9 , pp. 951-955
    • Taavoni, S.1    Ekbatani, N.2    Kashaniyan, M.3    Haghani, H.4
  • 147
    • 27644509061 scopus 로고    scopus 로고
    • Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects
    • Anderson, G.D.; Elmer, G.W.; Kantor, E.D.; Templeton, I.E.; Vitiello, M.V. Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. Phytother. Res., 2005, 19 (9),801-803.
    • (2005) Phytother. Res. , vol.19 , Issue.9 , pp. 801-803
    • Anderson, G.D.1    Elmer, G.W.2    Kantor, E.D.3    Templeton, I.E.4    Vitiello, M.V.5
  • 148
    • 70349243158 scopus 로고    scopus 로고
    • Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: Role of Mrp2 (Abcc2)
    • Maier-Salamon, A.; Trauner, G.; Hiltscher, R.; Reznicek, G.; Kopp, B.; Thalhammer, T.; Jager, W. Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2). J. Pharm. Sci., 2009, 98 (10),3839-3849.
    • (2009) J. Pharm. Sci. , vol.98 , Issue.10 , pp. 3839-3849
    • Maier-Salamon, A.1    Trauner, G.2    Hiltscher, R.3    Reznicek, G.4    Kopp, B.5    Thalhammer, T.6    Jager, W.7
  • 150
    • 0030700627 scopus 로고    scopus 로고
    • Traditional remedies and food supplements. A 5-year toxicological study 1991-1995
    • Shaw, D.; Leon, C.; Kolev, S.; Murray, V. Traditional remedies and food supplements. A 5-year toxicological study (1991-1995). Drug Saf., 1997, 17 (5),342-356.
    • (1997) Drug Saf. , vol.17 , Issue.5 , pp. 342-356
    • Shaw, D.1    Leon, C.2    Kolev, S.3    Murray, V.4
  • 152
    • 33847081268 scopus 로고    scopus 로고
    • Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro
    • Alkharfy, K.M.; Frye, R.F. Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro. Xenobiotica, 2007, 37 (2),113-123.
    • (2007) Xenobiotica , vol.37 , Issue.2 , pp. 113-123
    • Alkharfy, K.M.1    Frye, R.F.2
  • 154
    • 84934444244 scopus 로고    scopus 로고
    • Clinical studies with curcumin
    • Hsu, C.H.; Cheng, A.L. Clinical studies with curcumin. Adv. Exp. Med. Biol., 2007, 595,471-480.
    • (2007) Adv. Exp. Med. Biol. , vol.595 , pp. 471-480
    • Hsu, C.H.1    Cheng, A.L.2
  • 157
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • Pan, M.H.; Huang, T.M.; Lin, J.K. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos., 1999, 27 (4),486-494.
    • (1999) Drug Metab. Dispos. , vol.27 , Issue.4 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 158
    • 70349986461 scopus 로고    scopus 로고
    • An approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatographyion trap-time of flight mass spectrometry analysis
    • Wang, Y.; Hao, H.; Wang, G.; Tu, P.; Jiang, Y.; Liang, Y.; Dai, L.; Yang, H.; Lai, L.; Zheng, C.; Wang, Q.; Cui, N.; Liu, Y. An approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatographyion trap-time of flight mass spectrometry analysis. Talanta., 2009, 80 (2),572-580.
    • (2009) Talanta. , vol.80 , Issue.2 , pp. 572-580
    • Wang, Y.1    Hao, H.2    Wang, G.3    Tu, P.4    Jiang, Y.5    Liang, Y.6    Dai, L.7    Yang, H.8    Lai, L.9
  • 159
    • 70349641500 scopus 로고    scopus 로고
    • Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
    • Liu, Y.; Hao, H.; Xie, H.; Lv, H.; Liu, C.; Wang, G. Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats. J. Pharm. Sci., 2009, 98 (11),4391-4401.
    • (2009) J. Pharm. Sci. , vol.98 , Issue.11 , pp. 4391-4401
    • Liu, Y.1    Hao, H.2    Xie, H.3    Lv, H.4    Liu, C.5    Wang, G.6
  • 160
    • 70349972154 scopus 로고    scopus 로고
    • Metabolism oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats
    • Barve, A.; Chen, C.; Hebbar, V.; Desiderio, J.; Saw, C.L.; Kong, A.N. Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos., 2009, 30 (7),356-365.
    • (2009) Biopharm. Drug Dispos. , vol.30 , Issue.7 , pp. 356-365
    • Barve, A.1    Chen, C.2    Hebbar, V.3    Desiderio, J.4    Saw, C.L.5    Kong, A.N.6
  • 161
    • 80054958891 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats
    • Shia, C.S.; Tsai, S.Y.; Lin, J.C.; Li, M.L.; Ko, M.H.; Chao, P.D.; Huang, Y.C.; Hou, Y.C. Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats. J. Ethnopharmacol., 2011, 137(3),1388-1394.
    • (2011) J. Ethnopharmacol. , vol.137 , Issue.3 , pp. 1388-1394
    • Shia, C.S.1    Tsai, S.Y.2    Lin, J.C.3    Li, M.L.4    Ko, M.H.5    Chao, P.D.6    Huang, Y.C.7    Hou, Y.C.8
  • 162
    • 33845254587 scopus 로고    scopus 로고
    • Pharmacokinetics absorption and tissue distribution of tanshinone IIA solid dispersion
    • Hao, H.; Wang, G.; Cui, N.; Li, J.; Xie, L.; Ding, Z. Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion. Planta Med., 2006, 72 (14),1311-1317.
    • (2006) Planta Med. , vol.72 , Issue.14 , pp. 1311-1317
    • Hao, H.1    Wang, G.2    Cui, N.3    Li, J.4    Xie, L.5    Ding, Z.6
  • 163
    • 33745663269 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs
    • Zhang, W.D.; Zhang, C.; Liu, R.H.; Li, H.L.; Zhang, J.T.; Mao, C.; Moran, S.; Chen C.L. Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs. Life Sci., 2006, 79 (8),808-815.
    • (2006) Life Sci. , vol.79 , Issue.8 , pp. 808-815
    • Zhang, W.D.1    Zhang, C.2    Liu, R.H.3    Li, H.L.4    Zhang, J.T.5    Mao, C.6    Moran, S.7    Chen, C.L.8
  • 164
    • 34447260866 scopus 로고    scopus 로고
    • Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits
    • Chen, S.M.; Fan, M.Y.; Tseng, C.C.; Ho, Y.; Hsu, K.Y. Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits. Toxicon., 2007, 50 (2),180-188.
    • (2007) Toxicon. , vol.50 , Issue.2 , pp. 180-188
    • Chen, S.M.1    Fan, M.Y.2    Tseng, C.C.3    Ho, Y.4    Hsu, K.Y.5
  • 165
    • 79955683014 scopus 로고    scopus 로고
    • Kinetics of aristolochic acid i after oral administration of Radix Aristolochiae or Guanxinsuhe preparation in canines
    • Yang, H.Y.; Zheng, X.H.; Du, Y.; Chen, Z.; Zhu, D.Y.; Lou, Y.J. Kinetics of aristolochic acid I after oral administration of Radix Aristolochiae or Guanxinsuhe preparation in canines. J. Ethnopharmacol., 2011, 135 (2),569-574.
    • (2011) J. Ethnopharmacol. , vol.135 , Issue.2 , pp. 569-574
    • Yang, H.Y.1    Zheng, X.H.2    Du, Y.3    Chen, Z.4    Zhu, D.Y.5    Lou, Y.J.6
  • 166
    • 0026504109 scopus 로고
    • Recent advances on ginseng research in China
    • Liu, C.X.; Xiao, P.G. Recent advances on ginseng research in China. J. Ethnopharmacol., 1992, 36 (1),27-38.
    • (1992) J. Ethnopharmacol. , vol.36 , Issue.1 , pp. 27-38
    • Liu, C.X.1    Xiao, P.G.2
  • 168
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: An update on their molecular mechanisms and medical applications
    • Lu, J.M.; Yao, Q.; Chen, C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr. Vasc. Pharmacol., 2009, 7 (3),293-302.
    • (2009) Curr. Vasc. Pharmacol. , vol.7 , Issue.3 , pp. 293-302
    • Lu, J.M.1    Yao, Q.2    Chen, C.3
  • 169
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • Attele A.S.; Wu, J.A.; Yuan, C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol., 1999, 58 (11),1685-1693.
    • (1999) Biochem. Pharmacol. , vol.58 , Issue.11 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 170
    • 79551666188 scopus 로고    scopus 로고
    • Targeting hypoxia inducible factor-1alpha: A novel mechanism of ginsenoside Rg1 for brain repair after hypoxia/ischemia brain damage
    • Tang, B.; Qu, Y.; Wang, D.; Mu, D. Targeting hypoxia inducible factor-1alpha: a novel mechanism of ginsenoside Rg1 for brain repair after hypoxia/ischemia brain damage. CNS. Neurol. Disord. Drug Targets, 2011, 10 (2),235-238.
    • (2011) CNS. Neurol. Disord. Drug Targets , vol.10 , Issue.2 , pp. 235-238
    • Tang, B.1    Qu, Y.2    Wang, D.3    Mu, D.4
  • 171
    • 77957673672 scopus 로고    scopus 로고
    • Ginsenoside Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein kinase A pathway
    • Lee, S.D.; Lo, M.J. Ginsenoside Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein kinase A pathway. Nutr. Res., 2010, 30 (9),660-666.
    • (2010) Nutr. Res. , vol.30 , Issue.9 , pp. 660-666
    • Lee, S.D.1    Lo, M.J.2
  • 172
    • 77957257118 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures
    • Liang, W.; Ge, S.; Yang, L.; Yang, M.; Ye, Z.; Yan, M.; Du, J.; Luo, Z. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res., 2010, 1357,19-25.
    • (2010) Brain Res. , vol.1357 , pp. 19-25
    • Liang, W.1    Ge, S.2    Yang, L.3    Yang, M.4    Ye, Z.5    Yan, M.6    Du, J.7    Luo, Z.8
  • 173
    • 78649782421 scopus 로고    scopus 로고
    • Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6- OHDA-treated MES23.5 cells
    • Xu, H.; Jiang, H.; Wang, J.; Xie, J. Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6- OHDA-treated MES23.5 cells. J. Cell Biochem., 2010, 111 (6),1537-1545.
    • (2010) J. Cell Biochem. , vol.111 , Issue.6 , pp. 1537-1545
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 174
    • 77952881045 scopus 로고    scopus 로고
    • The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart
    • Kim, T.H.; Lee, S.M. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem. Toxicol., 2010, 48 (6),1516-1520.
    • (2010) Food Chem. Toxicol. , vol.48 , Issue.6 , pp. 1516-1520
    • Kim, T.H.1    Lee, S.M.2
  • 175
    • 77957806497 scopus 로고    scopus 로고
    • Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling
    • Yi, X.Q.; Li, T.; Wang, J.R.; Wong, V.K.; Luo, P.; Wong, I.Y.; Jiang, Z.H.; Liu, L.; Zhou H. Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling. Phytomedicine, 2010, 17 (13),1006-1015.
    • (2010) Phytomedicine , vol.17 , Issue.13 , pp. 1006-1015
    • Yi, X.Q.1    Li, T.2    Wang, J.R.3    Wong, V.K.4    Luo, P.5    Wong, I.Y.6    Jiang, Z.H.7    Liu, L.8    Zhou, H.9
  • 176
    • 77954695980 scopus 로고    scopus 로고
    • Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation
    • Wang, T.; Yu, X.F.; Qu, S.C.; Xu, H.L.; Sui D.Y. Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation. Basic. Clin. Pharmacol. Toxicol., 2010, 107 (2),685-689.
    • (2010) Basic. Clin. Pharmacol. Toxicol. , vol.107 , Issue.2 , pp. 685-689
    • Wang, T.1    Yu, X.F.2    Qu, S.C.3    Xu, H.L.4    Sui, D.Y.5
  • 177
    • 78650518488 scopus 로고    scopus 로고
    • The effects of ginsenoside Rb1 on endothelial damage and ghrelin expression induced by hyperhomocysteine
    • Xu, Z.; Lan, T.; Wu, W.; Wu, Y. The effects of ginsenoside Rb1 on endothelial damage and ghrelin expression induced by hyperhomocysteine. J. Vasc. Surg., 2011, 53 (1),156-164.
    • (2011) J. Vasc. Surg. , vol.53 , Issue.1 , pp. 156-164
    • Xu, Z.1    Lan, T.2    Wu, W.3    Wu, Y.4
  • 178
    • 77949904217 scopus 로고    scopus 로고
    • Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity
    • Zhang, S.D.; Yin, Y.X.; Wei, Q. Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity. APMIS., 2010, 118 (4),288-296.
    • (2010) APMIS , vol.118 , Issue.4 , pp. 288-296
    • Zhang, S.D.1    Yin, Y.X.2    Wei, Q.3
  • 179
    • 78549238507 scopus 로고    scopus 로고
    • Anti-obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet
    • Liu, R.; Zhang, J.; Liu, W.; Kimura, Y.; Zheng, Y. Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. Fitoterapia, 2010, 81 (8),1079-1087.
    • (2010) Fitoterapia , vol.81 , Issue.8 , pp. 1079-1087
    • Liu, R.1    Zhang, J.2    Liu, W.3    Kimura, Y.4    Zheng, Y.5
  • 180
    • 78651445610 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
    • Li, B.; Zhao, J.; Wang, C.Z.; Searle, J.; He, T.C.; Yuan, C.S.; Du, W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett., 2011, 301 (2),185-192.
    • (2011) Cancer Lett. , vol.301 , Issue.2 , pp. 185-192
    • Li, B.1    Zhao, J.2    Wang, C.Z.3    Searle, J.4    He, T.C.5    Yuan, C.S.6    Du, W.7
  • 181
    • 0019149305 scopus 로고
    • American ginseng. III. Pharmacokinetics of ginsenosides in the rabbit
    • Chen, S.E.; Sawchuk, R.J.; Staba, E.J. American ginseng. III. Pharmacokinetics of ginsenosides in the rabbit. Eur. J. Drug Metab. Pharmacokinet, 1980, 5 (3),161-168.
    • (1980) Eur. J. Drug Metab. Pharmacokinet , vol.5 , Issue.3 , pp. 161-168
    • Chen, S.E.1    Sawchuk, R.J.2    Staba, E.J.3
  • 182
    • 0020375773 scopus 로고
    • Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. I. Quantitative analysis of ginsenoside Rg1 in rats
    • Takino, Y.; Odani, T.; Tanizawa, H.; Hayashi, T. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. I. Quantitative analysis of ginsenoside Rg1 in rats. Chem. Pharm. Bull. (Tokyo), 1982, 30 (6),2196-2201.
    • (1982) Chem. Pharm. Bull. (Tokyo) , vol.30 , Issue.6 , pp. 2196-2201
    • Takino, Y.1    Odani, T.2    Tanizawa, H.3    Hayashi, T.4
  • 183
    • 0020640810 scopus 로고
    • Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat
    • Odan,i T.; Tanizawa, H.; Takino, Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chem. Pharm. Bull. (Tokyo), 1983, 31 (1),292-298.
    • (1983) Chem. Pharm. Bull. (Tokyo) , vol.31 , Issue.1 , pp. 292-298
    • Odan, I.T.1    Tanizawa, H.2    Takino, Y.3
  • 184
    • 0020530970 scopus 로고
    • Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat
    • Odani, T.; Tanizawa, H.; Takino, Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat. Chem. Pharm. Bull. (Tokyo), 1983, 31 (3),1059-1066.
    • (1983) Chem. Pharm. Bull. (Tokyo) , vol.31 , Issue.3 , pp. 1059-1066
    • Odani, T.1    Tanizawa, H.2    Takino, Y.3
  • 185
    • 0037296911 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats
    • Xu, Q.F.; Fang, X.L.; Chen, D.F. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J. Ethnopharmacol., 2003, 84 (2-3), 187-192.
    • (2003) J. Ethnopharmacol. , vol.84 , Issue.2-3 , pp. 187-192
    • Xu, Q.F.1    Fang, X.L.2    Chen, D.F.3
  • 186
    • 67249119760 scopus 로고    scopus 로고
    • Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro
    • Lai, L.; Hao, H.; Liu, Y.; Zheng, C.; Wang, Q.; Wang, G.; Chen, X. Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro. Planta Med., 2009, 75 (8),797-802.
    • (2009) Planta Med. , vol.75 , Issue.8 , pp. 797-802
    • Lai, L.1    Hao, H.2    Liu, Y.3    Zheng, C.4    Wang, Q.5    Wang, G.6    Chen, X.7
  • 187
    • 33645012866 scopus 로고    scopus 로고
    • Pharmacokinetic characteristics and hepatic distribution of IH-901, a novel intestinal metabolite of ginseng saponin, in rats
    • Lee, P.S.; Song, T.W.; Sung, J.H.; Moon, D.C.; Song, S.; Chung, Y.B. Pharmacokinetic characteristics and hepatic distribution of IH-901, a novel intestinal metabolite of ginseng saponin, in rats. Planta Med., 2006, 72 (3),204-210.
    • (2006) Planta Med. , vol.72 , Issue.3 , pp. 204-210
    • Lee, P.S.1    Song, T.W.2    Sung, J.H.3    Moon, D.C.4    Song, S.5    Chung, Y.B.6
  • 188
    • 20044364935 scopus 로고    scopus 로고
    • High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
    • Xie, H.T.; Wang, G.J.; Sun, J.G.; Tucker, I.; Zhao, X.C.; Xie, Y.Y.; Li, H.; Jiang, X.L.; Wang, R.; Xu, M.J.; Wang, W. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2005, 818 (2),167-173.
    • (2005) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.818 , Issue.2 , pp. 167-173
    • Xie, H.T.1    Wang, G.J.2    Sun, J.G.3    Tucker, I.4    Zhao, X.C.5    Xie, Y.Y.6    Li, H.7    Jiang, X.L.8    Wang, R.9    Xu, M.J.10    Wang, W.11
  • 190
    • 21344433027 scopus 로고    scopus 로고
    • Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs
    • Xie, H.T.; Wang G.J.; Lv, H.; Sun, R.W.; Jiang, X.L.; Li, H.; Wang, W.; Huang, C.R.; Xu, M.J. Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs. Eur. J. Drug Metab. Pharmacokinet, 2005, 30 (1-2),63-67.
    • (2005) Eur. J. Drug Metab. Pharmacokinet , vol.30 , Issue.1-2 , pp. 63-67
    • Xie, H.T.1    Wang, G.J.2    Lv, H.3    Sun, R.W.4    Jiang, X.L.5    Li, H.6    Wang, W.7    Huang, C.R.8    Xu, M.J.9
  • 191
    • 34249681378 scopus 로고    scopus 로고
    • Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extraction and its application in dog pharmacokinetics studies
    • Wang, W.; Wang, G.J.; Xie, H.T.; Sun, J.G.; Zhao, S.; Jiang, X.L.; Li, H.; Lv, H.; Xu, M.J.; Wang, R. Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extraction and its application in dog pharmacokinetics studies. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 852 (1-2),8-14.
    • (2007) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.852 , Issue.1-2 , pp. 8-14
    • Wang, W.1    Wang, G.J.2    Xie, H.T.3    Sun, J.G.4    Zhao, S.5    Jiang, X.L.6    Li, H.7    Lv, H.8    Xu, M.J.9    Wang, R.10
  • 192
    • 70349451559 scopus 로고    scopus 로고
    • Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method
    • Joo, K.M.; Lee, J.H.; Jeon, H.Y.; Park, C.W.; Hong, D.K.; Jeong, H.J.; Lee, S.J.; Lee S.Y.; Lim, K.M. Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. J. Pharm. Biomed. Anal., 2010, 51 (1),278-283.
    • (2010) J. Pharm. Biomed. Anal. , vol.51 , Issue.1 , pp. 278-283
    • Joo, K.M.1    Lee, J.H.2    Jeon, H.Y.3    Park, C.W.4    Hong, D.K.5    Jeong, H.J.6    Lee, S.J.7    Lee, S.Y.8    Lim, K.M.9
  • 193
    • 79953787011 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors
    • Hao, M.; Wang, W.; Zhao, Y.; Zhang, R.; Wang, H. Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors. Eur. J. Drug Metab. Pharmacokinet., 2011, 35 (3-4),109-113.
    • (2011) Eur. J. Drug Metab. Pharmacokinet. , vol.35 , Issue.3-4 , pp. 109-113
    • Hao, M.1    Wang, W.2    Zhao, Y.3    Zhang, R.4    Wang, H.5
  • 194
    • 33646001775 scopus 로고    scopus 로고
    • Oral absorption of ginsenoside Rb1 using in vitro and in vivo models
    • Han, M.; Sha, X.; Wu, Y.; Fang, X. Oral absorption of ginsenoside Rb1 using in vitro and in vivo models. Planta Med., 2006, 72 (5),398-404.
    • (2006) Planta Med. , vol.72 , Issue.5 , pp. 398-404
    • Han, M.1    Sha, X.2    Wu, Y.3    Fang, X.4
  • 195
    • 77955607007 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of ginsenoside Rh2: Stereoselectivity and involvement of ABC transporters
    • Gu, Y.; Wang, G.J.; Wu, X.L.; Zheng, Y.T.; Zhang, J.W.; Ai, H.; Sun, J.G.; Jia, Y.W. Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters. Xenobiotica, 2010, 40 (9), 602-612.
    • (2010) Xenobiotica , vol.40 , Issue.9 , pp. 602-612
    • Gu, Y.1    Wang, G.J.2    Wu, X.L.3    Zheng, Y.T.4    Zhang, J.W.5    Ai, H.6    Sun, J.G.7    Jia, Y.W.8
  • 198
    • 0034113843 scopus 로고    scopus 로고
    • Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters
    • Hasegawa H.; Lee K.S.; Nagaoka T.; Tezuka Y.; Uchiyama M.; Kadota S.; Saiki I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biol. Pharm. Bull., 2000, 23 (3),298-304.
    • (2000) Biol. Pharm. Bull. , vol.23 , Issue.3 , pp. 298-304
    • Hasegawa, H.1    Lee, K.S.2    Nagaoka, T.3    Tezuka, Y.4    Uchiyama, M.5    Kadota, S.6    Saiki, I.7
  • 199
    • 79951933277 scopus 로고    scopus 로고
    • Identification of 20(S)- protopanaxadiol metabolites in human liver microsomes and human hepatocytes
    • Li L.; Chen X.; Li D.; Zhong D. Identification of 20(S)- protopanaxadiol metabolites in human liver microsomes and human hepatocytes. Drug Metab. Dispos., 2011, 39 (3),472-483.
    • (2011) Drug Metab. Dispos. , vol.39 , Issue.3 , pp. 472-483
    • Li, L.1    Chen, X.2    Li, D.3    Zhong, D.4
  • 201
    • 77956268940 scopus 로고    scopus 로고
    • The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1 Re and Rb1 after oral administration of Kai-Xin-San preparations in rats
    • Wang W.; Liao Q.P.; Quan L.H.; Liu C.Y.; Chang Q.; Liu X.M.; Liao Y.H. The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats. J. Ethnopharmacol., 2010, 131 (2),313-320.
    • (2010) J. Ethnopharmacol. , vol.131 , Issue.2 , pp. 313-320
    • Wang, W.1    Liao, Q.P.2    Quan, L.H.3    Liu, C.Y.4    Chang, Q.5    Liu, X.M.6    Liao, Y.H.7
  • 202
    • 80051646543 scopus 로고    scopus 로고
    • Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy
    • Kang A.; Hao H.; Zheng X.; Liang Y.; Xie Y.; Xie T.; Dai C.; Zhao Q.; Wu X.; Xie L.; Wang G. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J. Neuroinflammation, 2011, 8 (1),100.
    • (2011) J. Neuroinflammation , vol.8 , Issue.1 , pp. 100
    • Kang, A.1    Hao, H.2    Zheng, X.3    Liang, Y.4    Xie, Y.5    Xie, T.6    Dai, C.7    Zhao, Q.8    Wu, X.9    Xie, L.10    Wang, G.11
  • 203
    • 78751504470 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats
    • Feng L.; Wang L.; Hu C.; Jiang X. Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats. Arch. Pharm. Res., 2010, 33 (12),1975-1984.
    • (2010) Arch. Pharm. Res. , vol.33 , Issue.12 , pp. 1975-1984
    • Feng, L.1    Wang, L.2    Hu, C.3    Jiang, X.4
  • 204
    • 76649137725 scopus 로고
    • Experiments on the origin and function of berberine in Berberis Darwinii
    • Cromwell B.T. Experiments on the origin and function of berberine in Berberis Darwinii. Biochem. J., 1933, 27 (3),860-872.
    • (1933) Biochem. J. , vol.27 , Issue.3 , pp. 860-872
    • Cromwell, B.T.1
  • 205
    • 0014842302 scopus 로고
    • Berberine tannate in acute diarrhoea
    • Sharma R.; Joshi C.K.; Goyal R.K. Berberine tannate in acute diarrhoea. Indian. Pediatr., 1970, 7 (9),496-501.
    • (1970) Indian. Pediatr. , vol.7 , Issue.9 , pp. 496-501
    • Sharma, R.1    Joshi, C.K.2    Goyal, R.K.3
  • 206
    • 79961192394 scopus 로고    scopus 로고
    • Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein rad51
    • Liu, Q.; Jiang, H.; Liu, Z.; Wang, Y.; Zhao, M.; Hao, C.; Feng, S.; Guo, H.; Xu, B.; Yang, Q.; Gong, Y.; Shao, C. Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51. PLoS One, 2011, 6 (8),e23427.
    • (2011) PLoS One , vol.6 , Issue.8
    • Liu, Q.1    Jiang, H.2    Liu, Z.3    Wang, Y.4    Zhao, M.5    Hao, C.6    Feng, S.7    Guo, H.8    Xu, B.9    Yang, Q.10    Gong, Y.11    Shao, C.12
  • 208
    • 70349085370 scopus 로고    scopus 로고
    • A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs
    • Sun, Y.; Xun, K.; Wang, Y.; Chen, X. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs, 2009, 20 (9),757-769.
    • (2009) Anticancer Drugs , vol.20 , Issue.9 , pp. 757-769
    • Sun, Y.1    Xun, K.2    Wang, Y.3    Chen, X.4
  • 209
    • 50149108987 scopus 로고    scopus 로고
    • Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
    • Imanshahidi, M.; Hosseinzadeh, H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother. Res., 2008, 22 (8),999-1012.
    • (2008) Phytother. Res. , vol.22 , Issue.8 , pp. 999-1012
    • Imanshahidi, M.1    Hosseinzadeh, H.2
  • 210
    • 78149434123 scopus 로고    scopus 로고
    • Genetic evidence for inhibition of bacterial division protein FtsZ by berberine
    • Boberek, J.M.; Stach, J.; Good, L. Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS One, 2010, 5 (10),e13745.
    • (2010) PLoS One , vol.5 , Issue.10
    • Boberek, J.M.1    Stach, J.2    Good, L.3
  • 211
    • 78650261067 scopus 로고    scopus 로고
    • Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides
    • Zhang, Q.; Piao, X.L.; Piao, X.S.; Lu, T.; Wang, D.; Kim, S.W. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem. Toxicol., 2011, 49 (1),61-69.
    • (2011) Food Chem. Toxicol. , vol.49 , Issue.1 , pp. 61-69
    • Zhang, Q.1    Piao, X.L.2    Piao, X.S.3    Lu, T.4    Wang, D.5    Kim, S.W.6
  • 212
    • 67349272274 scopus 로고    scopus 로고
    • The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells
    • Gu, L.; Li, N.; Li, Q.; Zhang, Q.; Wang, C.; Zhu, W.; Li, J. The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells. Fitoterapia, 2009, 80 (4),241-248.
    • (2009) Fitoterapia , vol.80 , Issue.4 , pp. 241-248
    • Gu, L.1    Li, N.2    Li, Q.3    Zhang, Q.4    Wang, C.5    Zhu, W.6    Li, J.7
  • 213
    • 79956223990 scopus 로고    scopus 로고
    • Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia
    • Gu, L.; Li, N.; Gong, J.; Li, Q.; Zhu, W.; Li, J. Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia. J. Infect. Dis., 2011, 203 (11),1602-1612.
    • (2011) J. Infect. Dis. , vol.203 , Issue.11 , pp. 1602-1612
    • Gu, L.1    Li, N.2    Gong, J.3    Li, Q.4    Zhu, W.5    Li, J.6
  • 214
    • 77049088672 scopus 로고    scopus 로고
    • Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters
    • Wang, Y.; Jia, X.; Ghanam, K.; Beaurepaire, C.; Zidichouski, J.; Miller, L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atherosclerosis, 2010, 209 (1),111-117.
    • (2010) Atherosclerosis , vol.209 , Issue.1 , pp. 111-117
    • Wang, Y.1    Jia, X.2    Ghanam, K.3    Beaurepaire, C.4    Zidichouski, J.5    Miller, L.6
  • 215
    • 78149417658 scopus 로고    scopus 로고
    • Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL
    • Guan, S.; Wang, B.; Li, W.; Guan, J.; Fang, X. Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL. Am. J. Chin. Med., 2010, 38 (6),1161-1169.
    • (2010) Am. J. Chin. Med. , vol.38 , Issue.6 , pp. 1161-1169
    • Guan, S.1    Wang, B.2    Li, W.3    Guan, J.4    Fang, X.5
  • 216
    • 68749104337 scopus 로고    scopus 로고
    • Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage
    • Li, K.; Yao, W.; Zheng, X.; Liao, K. Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage. Cell Res., 2009, 19 (8),1006-1017.
    • (2009) Cell Res. , vol.19 , Issue.8 , pp. 1006-1017
    • Li, K.1    Yao, W.2    Zheng, X.3    Liao, K.4
  • 217
    • 78650657270 scopus 로고    scopus 로고
    • Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages
    • Huang, Z.; Wang, L.; Meng, S.; Wang, Y.; Chen, T.; Wang, C. Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. Int. J. Cardiol., 2011, 146 (2),153-158.
    • (2011) Int. J. Cardiol. , vol.146 , Issue.2 , pp. 153-158
    • Huang, Z.1    Wang, L.2    Meng, S.3    Wang, Y.4    Chen, T.5    Wang, C.6
  • 218
    • 77953231411 scopus 로고    scopus 로고
    • Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study
    • Liu, L.; Yu, Y.L.; Yang, J.S.; Li, Y.; Liu, Y.W.; Liang Y.; Liu, X.D.; Xie, L.; Wang, G.J. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn. Schmiedebergs. Arch. Pharmacol., 2010, 381 (4),371-381.
    • (2010) Naunyn. Schmiedebergs. Arch. Pharmacol. , vol.381 , Issue.4 , pp. 371-381
    • Liu, L.1    Yu, Y.L.2    Yang, J.S.3    Li, Y.4    Liu, Y.W.5    Liang, Y.6    Liu, X.D.7    Xie, L.8    Wang, G.J.9
  • 219
  • 220
    • 77449089475 scopus 로고    scopus 로고
    • Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies
    • Yu Y.; Liu L.; Wang X.; Liu X.; Xie L.; Wang G. Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. Biochem. Pharmacol., 2010, 79 (7),1000-1006.
    • (2010) Biochem. Pharmacol. , vol.79 , Issue.7 , pp. 1000-1006
    • Yu, Y.1    Liu, L.2    Wang, X.3    Liu, X.4    Xie, L.5    Wang, G.6
  • 222
    • 0007882820 scopus 로고
    • Study on the pharmacokinetics of berberine after oral administration in human being
    • Li B.; Zhang M.; Bao L. Study on the pharmacokinetics of berberine after oral administration in human being. J. Haerbin. Med. Univ., 1995, 29 (5),382-385.
    • (1995) J. Haerbin. Med. Univ. , vol.29 , Issue.5 , pp. 382-385
    • Li, B.1    Zhang, M.2    Bao, L.3
  • 223
    • 32644478813 scopus 로고    scopus 로고
    • Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method
    • Lu T.; Liang Y.; Song J.; Xie L.; Wang G.J.; Liu X.D. Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method. J. Pharm. Biomed. Anal., 2006, 40 (5),1218-1224.
    • (2006) J. Pharm. Biomed. Anal. , vol.40 , Issue.5 , pp. 1218-1224
    • Lu, T.1    Liang, Y.2    Song, J.3    Xie, L.4    Wang, G.J.5    Liu, X.D.6
  • 224
    • 0000349475 scopus 로고
    • Pharmacokinetic study of 3Hberberine in rabbits and mouse
    • Xiong C.; Shi X.; Dai Z.; Fang D. Pharmacokinetic study of 3Hberberine in rabbits and mouse. Chin. Pharmacol. Bull., 1989, 5 (5),293-296.
    • (1989) Chin. Pharmacol. Bull. , vol.5 , Issue.5 , pp. 293-296
    • Xiong, C.1    Shi, X.2    Dai, Z.3    Fang, D.4
  • 225
    • 85027931488 scopus 로고    scopus 로고
    • Bioavailability study of berberine and the enhancing effects of tpgs on intestinal absorption in rats
    • Chen, W.; Miao, Y.Q.; Fan, D.J.; Yang, S.S.; Lin, X.; Meng, L.K.; Tang, X. Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats. AAPS. Pharm- SciTech., 2011, 12 (2),705-711.
    • (2011) AAPS. Pharm- SciTech. , vol.12 , Issue.2 , pp. 705-711
    • Chen, W.1    Miao, Y.Q.2    Fan, D.J.3    Yang, S.S.4    Lin, X.5    Meng, L.K.6    Tang, X.7
  • 226
    • 78649907355 scopus 로고    scopus 로고
    • Physicochemical characterization of berberine chloride: A perspective in the development of a solution dosage form for oral delivery
    • Battu, S.K.; Repka, M.A.; Maddineni, S.; Chittiboyina, A.G.; Avery, M.A.; Majumdar, S. Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery. AAPS PharmSciTech., 2010, 11 (3),1466-1475.
    • (2010) AAPS PharmSciTech. , vol.11 , Issue.3 , pp. 1466-1475
    • Battu, S.K.1    Repka, M.A.2    Maddineni, S.3    Chittiboyina, A.G.4    Avery, M.A.5    Majumdar, S.6
  • 227
    • 79952952269 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: Involvement of P-glycoprotein
    • Zhang, X.; Qiu, F.; Jiang, J.; Gao, C.; Tan, Y. Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. Xenobiotica, 2011, 41 (4),290-296.
    • (2011) Xenobiotica , vol.41 , Issue.4 , pp. 290-296
    • Zhang, X.1    Qiu, F.2    Jiang, J.3    Gao, C.4    Tan, Y.5
  • 228
  • 229
    • 0036893418 scopus 로고    scopus 로고
    • P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers
    • Maeng, H.J.; Yoo, H.J.; Kim, I.W.; Song, I.S.; Chung, S.J.; Shim, C.K. P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. J. Pharm. Sci., 2002, 91 (12),2614-2621.
    • (2002) J. Pharm. Sci. , vol.91 , Issue.12 , pp. 2614-2621
    • Maeng, H.J.1    Yoo, H.J.2    Kim, I.W.3    Song, I.S.4    Chung, S.J.5    Shim, C.K.6
  • 230
    • 38749145110 scopus 로고    scopus 로고
    • Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons
    • Chen, Y.; Wang, X.; Sun, H.; Xing, D.; Hu, J.; Wai, Z.; Du, L. Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons. Biomed. Chromatogr., 2008, 22 (1),28-33.
    • (2008) Biomed. Chromatogr. , vol.22 , Issue.1 , pp. 28-33
    • Chen, Y.1    Wang, X.2    Sun, H.3    Xing, D.4    Hu, J.5    Wai, Z.6    Du, L.7
  • 231
    • 0028923815 scopus 로고
    • Determination of berberine in plasma, urine and bile by high-performance liquid chromatography
    • Chen, C.M.; Chang, H.C. Determination of berberine in plasma, urine and bile by high-performance liquid chromatography. J. Chromatogr. B. Biomed. Appl., 1995, 665 (1),117-123.
    • (1995) J. Chromatogr. B. Biomed. Appl. , vol.665 , Issue.1 , pp. 117-123
    • Chen, C.M.1    Chang, H.C.2
  • 232
    • 1842589296 scopus 로고    scopus 로고
    • Hepatobiliary excretion of berberine
    • Tsai, P.L.; Tsai, T.H. Hepatobiliary excretion of berberine. Drug Metab. Dispos., 2004, 32 (4),405-412.
    • (2004) Drug Metab. Dispos. , vol.32 , Issue.4 , pp. 405-412
    • Tsai, P.L.1    Tsai, T.H.2
  • 234
    • 77957130129 scopus 로고    scopus 로고
    • Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats
    • Liu, Y.T.; Hao, H.P.; Xie, H.G.; Lai, L.; Wang, Q.; Liu, C.X.; Wang, G.J. Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats. Drug Metab. Dispos., 2010, 38 (10),1779-1784.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.10 , pp. 1779-1784
    • Liu, Y.T.1    Hao, H.P.2    Xie, H.G.3    Lai, L.4    Wang, Q.5    Liu, C.X.6    Wang, G.J.7
  • 235
    • 84857049257 scopus 로고    scopus 로고
    • Repeated administration of berberine inhibits cytochromes P450 in humans
    • Guo, Y.; Chen, Y.; Tan, Z.R.; Klaassen, C.D.; Zhou, H.H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur. J. Clin. Pharmacol., 2012, 68(2), 213-217.
    • (2012) Eur. J. Clin. Pharmacol. , vol.68 , Issue.2 , pp. 213-217
    • Guo, Y.1    Chen, Y.2    Tan, Z.R.3    Klaassen, C.D.4    Zhou, H.H.5
  • 237
    • 84856239112 scopus 로고    scopus 로고
    • The in vitro Inhibition of Human CYP1A2, CYP2D6 and CYP3A4 by Tetrahydropalmatine, Neferine and Berberine
    • Zhao, Y.; Hellum B.H.; Liang, A.; Nilsen, O.G. The In vitro Inhibition of Human CYP1A2, CYP2D6 and CYP3A4 by Tetrahydropalmatine, Neferine and Berberine. Phytother. Res., 2012, 26(2), 277-283.
    • (2012) Phytother. Res. , vol.26 , Issue.2 , pp. 277-283
    • Zhao, Y.1    Hellum, B.H.2    Liang, A.3    Nilsen, O.G.4
  • 238
    • 79960094037 scopus 로고    scopus 로고
    • Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine
    • Chatuphonprasert, W.; Sangkawat, T.; Nemoto, N.; Jarukamjorn, K. Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. Fitoterapia, 2011, 82 (6),889-895.
    • (2011) Fitoterapia , vol.82 , Issue.6 , pp. 889-895
    • Chatuphonprasert, W.1    Sangkawat, T.2    Nemoto, N.3    Jarukamjorn, K.4
  • 239
    • 74749103942 scopus 로고    scopus 로고
    • Berberine modulates insulin signaling transduction in insulin-resistant cells
    • Liu, L.Z.; Cheung, S.C.; Lan, L.L.; Ho, S.K.; Xu, H.X.; Chan, J.C.; Tong, P.C. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol. Cell Endocrino., 2010, 317 (1-2),148-153.
    • (2010) Mol. Cell Endocrino. , vol.317 , Issue.1-2 , pp. 148-153
    • Liu, L.Z.1    Cheung, S.C.2    Lan, L.L.3    Ho, S.K.4    Xu, H.X.5    Chan, J.C.6    Tong, P.C.7
  • 240
    • 60949108484 scopus 로고    scopus 로고
    • Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat dietinduced diabetic rats
    • Zhou, J.; Zhou, S.; Tang, J.; Zhang, K.; Guang, L.; Huang, Y.; Xu, Y.; Ying, Y.; Zhang, L.; Li, D. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat dietinduced diabetic rats. Eur. J. Pharmacol.,2009, 606 (1-3),262-268.
    • (2009) Eur. J. Pharmacol. , vol.606 , Issue.1-3 , pp. 262-268
    • Zhou, J.1    Zhou, S.2    Tang, J.3    Zhang, K.4    Guang, L.5    Huang, Y.6    Xu, Y.7    Ying, Y.8    Zhang, L.9    Li, D.10
  • 241
    • 64249131013 scopus 로고    scopus 로고
    • Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats
    • Singh, J.; Kakkar, P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J. Ethnopharmacol., 2009, 123 (1),22-26.
    • (2009) J. Ethnopharmacol. , vol.123 , Issue.1 , pp. 22-26
    • Singh, J.1    Kakkar, P.2
  • 242
    • 33645402536 scopus 로고    scopus 로고
    • Danshen: A popular chinese cardiac herbal drug
    • Cheng, T.O. Danshen: a popular chinese cardiac herbal drug. J. Am. Coll. Cardiol., 2006, 47 (7),1498.
    • (2006) J. Am. Coll. Cardiol. , vol.47 , Issue.7 , pp. 1498
    • Cheng, T.O.1
  • 243
    • 33744804557 scopus 로고    scopus 로고
    • Danshen: What every cardiologist should know about this Chinese herbal drug
    • Cheng, T.O. Danshen: what every cardiologist should know about this Chinese herbal drug. Int. J. Cardiol., 2006, 110 (3),411-412.
    • (2006) Int. J. Cardiol. , vol.110 , Issue.3 , pp. 411-412
    • Cheng, T.O.1
  • 244
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • Zhou, L.; Zuo, Z.; Chow, M.S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol., 2005, 45 (12),1345-1359.
    • (2005) J. Clin. Pharmacol. , vol.45 , Issue.12 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.3
  • 245
    • 34548079309 scopus 로고    scopus 로고
    • Cardiovascular effects of Danshen
    • Cheng, T.O. Cardiovascular effects of Danshen. Int. J. Cardiol., 2007, 121 (1),9-22.
    • (2007) Int. J. Cardiol. , vol.121 , Issue.1 , pp. 9-22
    • Cheng, T.O.1
  • 246
    • 33845768814 scopus 로고    scopus 로고
    • New developments in the chemistry and biology of the bioactive constituents of Tanshen
    • Wang, X.; Morris-Natschke, S.L.; Lee, K.H. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med. Res. Rev., 2007, 27 (1),133-148.
    • (2007) Med. Res. Rev. , vol.27 , Issue.1 , pp. 133-148
    • Wang, X.1    Morris-Natschke, S.L.2    Lee, K.H.3
  • 247
    • 77649169304 scopus 로고    scopus 로고
    • Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells
    • Pan, T.L.; Hung, Y.C.; Wang, P.W.; Chen, S.T.; Hsu, T.K.; Sintupisut, N.; Cheng, C.S.; Lyu, P.C. Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics, 2010, 10 (5),914-929.
    • (2010) Proteomics , vol.10 , Issue.5 , pp. 914-929
    • Pan, T.L.1    Hung, Y.C.2    Wang, P.W.3    Chen, S.T.4    Hsu, T.K.5    Sintupisut, N.6    Cheng, C.S.7    Lyu, P.C.8
  • 248
    • 77956945287 scopus 로고    scopus 로고
    • Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation
    • Park, I.J.; Kim, M.J.; Park, O.J.; Park, M.G.; Choe, W.; Kang, I.; Kim, S.S.; Ha, J. Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer Lett., 2010, 298 (1),88-98.
    • (2010) Cancer Lett. , vol.298 , Issue.1 , pp. 88-98
    • Park, I.J.1    Kim, M.J.2    Park, O.J.3    Park, M.G.4    Choe, W.5    Kang, I.6    Kim, S.S.7    Ha, J.8
  • 249
    • 79959767855 scopus 로고    scopus 로고
    • Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice
    • Gong, Y.; Li, Y.; Lu, Y.; Li, L.; Abdolmaleky, H.; Blackburn, G.L.; Zhou, J.R. Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int. J. Cancer, 2011, 129 (5),1042-1052.
    • (2011) Int. J. Cancer , vol.129 , Issue.5 , pp. 1042-1052
    • Gong, Y.1    Li, Y.2    Lu, Y.3    Li, L.4    Abdolmaleky, H.5    Blackburn, G.L.6    Zhou, J.R.7
  • 250
    • 77954771133 scopus 로고    scopus 로고
    • Down-regulation of telomerase activity and activation of caspase-3 are responsible for tanshinone I-induced apoptosis in monocyte leukemia cells in vitro
    • Liu, X.D.; Fan, R.F.; Zhang, Y.; Yang, H.Z.; Fang, Z.G.; Guan, W.B.; Lin, D.J.; Xiao, R.Z.; Huang, R.W.; Huang H.Q.; Liu P.Q.; Liu J.J. Down-regulation of telomerase activity and activation of caspase-3 are responsible for tanshinone I-induced apoptosis in monocyte leukemia cells in vitro. Int. J. Mol. Sci., 2010, 11 (6),2267-2280.
    • (2010) Int. J. Mol. Sci. , vol.11 , Issue.6 , pp. 2267-2280
    • Liu, X.D.1    Fan, R.F.2    Zhang, Y.3    Yang, H.Z.4    Fang, Z.G.5    Guan, W.B.6    Lin, D.J.7    Xiao, R.Z.8    Huang, R.W.9    Huang, H.Q.10    Liu, P.Q.11    Liu, J.J.12
  • 251
    • 74449089539 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells
    • Tang, C.; Xue, H.L.; Huang, H.B.; Wang, X.G. Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells. Neurosci. Lett., 2010, 470 (2),126-129.
    • (2010) Neurosci. Lett. , vol.470 , Issue.2 , pp. 126-129
    • Tang, C.1    Xue, H.L.2    Huang, H.B.3    Wang, X.G.4
  • 252
    • 77952996906 scopus 로고    scopus 로고
    • Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells
    • Lee, W.Y.; Cheung, C.C.; Liu, K.W.; Fung, K.P.; Wong, J.; Lai, P.B.; Yeung, J.H. Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. J. Nat. Prod., 2010, 73 (5),854-859.
    • (2010) J. Nat. Prod. , vol.73 , Issue.5 , pp. 854-859
    • Lee, W.Y.1    Cheung, C.C.2    Liu, K.W.3    Fung, K.P.4    Wong, J.5    Lai, P.B.6    Yeung, J.H.7
  • 253
    • 80955158725 scopus 로고    scopus 로고
    • Salvianolic acid a demonstrates cardioprotective effects in rat hearts and cardiomyocytes following ischemia/reperfusion injury
    • Pan, H.; Li, D.; Fang, F.; Chen, D.; Qi, L.; Zhang, R.; Xu, T.; Sun, H. Salvianolic acid A Demonstrates Cardioprotective Effects in Rat Hearts and Cardiomyocytes Following Ischemia/Reperfusion Injury. J. Cardiovasc. Pharmacol., 2011, 58(5), 535-542
    • (2011) J. Cardiovasc. Pharmacol. , vol.58 , Issue.5 , pp. 535-542
    • Pan, H.1    Li, D.2    Fang, F.3    Chen, D.4    Qi, L.5    Zhang, R.6    Xu, T.7    Sun, H.8
  • 254
    • 79956024633 scopus 로고    scopus 로고
    • Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways
    • Pan, C.; Lou, L.; Huo, Y.; Singh, G.; Chen, M.; Zhang, D.; Wu, A.; Zhao, M.; Wang S.; Li J. Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. Ther. Adv. Cardiovasc. Dis., 2011, 5 (2),99-111.
    • (2011) Ther. Adv. Cardiovasc. Dis. , vol.5 , Issue.2 , pp. 99-111
    • Pan, C.1    Lou, L.2    Huo, Y.3    Singh, G.4    Chen, M.5    Zhang, D.6    Wu, A.7    Zhao, M.8    Wang, S.9    Li, J.10
  • 255
    • 77953120701 scopus 로고    scopus 로고
    • Antiplatelet and antithrombotic activities of salvianolic acid A
    • Fan, H.Y.; Fu, F.H.; Yang, M.Y.; Xu, H.; Zhang, A.H.; Liu, K. Antiplatelet and antithrombotic activities of salvianolic acid A. Thromb. Res., 2010, 126 (1),e17-22.
    • (2010) Thromb. Res. , vol.126 , Issue.1
    • Fan, H.Y.1    Fu, F.H.2    Yang, M.Y.3    Xu, H.4    Zhang, A.H.5    Liu, K.6
  • 256
    • 78649408796 scopus 로고    scopus 로고
    • Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endotheliumdenuded hypercholesterolaemic rabbits
    • Yang, T.L.; Lin, F.Y.; Chen, Y.H.; Chiu, J.J.; Shiao, M.S.; Tsai, C.S.; Lin, S.J.; Chen, Y.L. Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endotheliumdenuded hypercholesterolaemic rabbits. J. Sci. Food Agric., 2011, 91 (1),134-141.
    • (2011) J. Sci. Food Agric. , vol.91 , Issue.1 , pp. 134-141
    • Yang, T.L.1    Lin, F.Y.2    Chen, Y.H.3    Chiu, J.J.4    Shiao, M.S.5    Tsai, C.S.6    Lin, S.J.7    Chen, Y.L.8
  • 257
    • 78149407580 scopus 로고    scopus 로고
    • The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats
    • Tang, C.; Xue, H.; Bai, C.; Fu, R.; Wu, A. The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. Phytomedicine, 2010, 17 (14),1145-1149.
    • (2010) Phytomedicine , vol.17 , Issue.14 , pp. 1145-1149
    • Tang, C.1    Xue, H.2    Bai, C.3    Fu, R.4    Wu, A.5
  • 258
    • 79952702058 scopus 로고    scopus 로고
    • Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide
    • Wang, W.; Zheng, L.L.; Wang, F.; Hu, Z.L.; Wu, W.N.; Gu, J.; Chen, J.G. Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide. J. Ethnopharmacol., 2011, 134 (1),147-155.
    • (2011) J. Ethnopharmacol. , vol.134 , Issue.1 , pp. 147-155
    • Wang, W.1    Zheng, L.L.2    Wang, F.3    Hu, Z.L.4    Wu, W.N.5    Gu, J.6    Chen, J.G.7
  • 260
    • 77954863532 scopus 로고    scopus 로고
    • Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone i and dihydrotanshinone i by liquid chromatographic- mass spectrometry and the application to pharmacokinetics in rats
    • Liu, Y.; Li, X.; Li, Y.; Wang, L.; Xue, M. Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic- mass spectrometry and the application to pharmacokinetics in rats. J. Pharm. Biomed. Anal., 2010, 53 (3), 698-704.
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , Issue.3 , pp. 698-704
    • Liu, Y.1    Li, X.2    Li, Y.3    Wang, L.4    Xue, M.5
  • 261
    • 44249104231 scopus 로고    scopus 로고
    • Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography- tandem mass spectrometry: Application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF
    • Park, E.J.; Ji, H.Y.; Kim, N.J.; Song, W.Y.; Kim, Y.H.; Kim, Y.C.; Sohn, D.H.; Lee, H.S. Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF. Biomed. Chromatogr., 2008, 22 (5),548-555.
    • (2008) Biomed. Chromatogr. , vol.22 , Issue.5 , pp. 548-555
    • Park, E.J.1    Ji, H.Y.2    Kim, N.J.3    Song, W.Y.4    Kim, Y.H.5    Kim, Y.C.6    Sohn, D.H.7    Lee, H.S.8
  • 262
    • 38349137338 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats
    • Wang, L.; Zhang, Q.; Li, X.; Lu, Y.; Xue, Z.; Xuan, L.; Wang, Y. Pharmacokinetics and metabolism of lithospermic acid by LC/MS/MS in rats. Int. J. Pharm., 2008, 350 (1-2),240-246.
    • (2008) Int. J. Pharm. , vol.350 , Issue.1-2 , pp. 240-246
    • Wang, L.1    Zhang, Q.2    Li, X.3    Lu, Y.4    Xue, Z.5    Xuan, L.6    Wang, Y.7
  • 263
    • 43049094104 scopus 로고    scopus 로고
    • Determination and pharmacokinetics of danshensu in rat plasma after oral administration of danshen extract using liquid chromatography/tandem mass spectrometry
    • Li, W.; Li, Z.W.; Han, J.P.; Li, X.X.; Gao, J.; Liu, C.X. Determination and pharmacokinetics of danshensu in rat plasma after oral administration of danshen extract using liquid chromatography/tandem mass spectrometry. Eur. J. Drug Metab. Pharmacokinet., 2008, 33 (1),9-16.
    • (2008) Eur. J. Drug Metab. Pharmacokinet. , vol.33 , Issue.1 , pp. 9-16
    • Li, W.1    Li, Z.W.2    Han, J.P.3    Li, X.X.4    Gao, J.5    Liu, C.X.6
  • 264
    • 68749116199 scopus 로고    scopus 로고
    • Effect of sodium caprate on the oral absorptions of danshensu and salvianolic acid B
    • Zhou, L.; Chow, M.S.; Zuo, Z. Effect of sodium caprate on the oral absorptions of danshensu and salvianolic acid B. Int. J. Pharm., 2009, 379 (1),109-118.
    • (2009) Int. J. Pharm. , vol.379 , Issue.1 , pp. 109-118
    • Zhou, L.1    Chow, M.S.2    Zuo, Z.3
  • 265
    • 33750470777 scopus 로고    scopus 로고
    • Bioavailability of salvianolic acid B in conscious and freely moving rats
    • Wu, Y.T.; Chen, Y.F.; Hsieh, Y.J.; Jaw, I.; Shiao, M.S.; Tsai, T.H. Bioavailability of salvianolic acid B in conscious and freely moving rats. Int. J. Pharm., 2006, 326 (1-2),25-31.
    • (2006) Int. J. Pharm. , vol.326 , Issue.1-2 , pp. 25-31
    • Wu, Y.T.1    Chen, Y.F.2    Hsieh, Y.J.3    Jaw, I.4    Shiao, M.S.5    Tsai, T.H.6
  • 266
    • 40749148985 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of hydroxylpropyl-beta- cyclodextrinincluded complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)
    • Pan, Y.; Bi, H.C.; Zhong, G.P.; Chen, X.; Zuo, Z.; Zhao, L.Z.; Gu, L.Q.; Liu, P.Q.; Huang, Z.Y.; Zhou, S.F.; Huang, M. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrinincluded complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica., 2008, 38 (4),382-398.
    • (2008) Xenobiotica. , vol.38 , Issue.4 , pp. 382-398
    • Pan, Y.1    Bi, H.C.2    Zhong, G.P.3    Chen, X.4    Zuo, Z.5    Zhao, L.Z.6    Gu, L.Q.7    Liu, P.Q.8    Huang, Z.Y.9    Zhou, S.F.10    Huang, M.11
  • 267
    • 67649304834 scopus 로고    scopus 로고
    • Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs
    • Gao, D.Y.; Han, L.M.; Zhang, L.H.; Fang, X.L.; Wang, J.X. Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs. Arch. Pharm. Res., 2009, 32 (5),773-779.
    • (2009) Arch. Pharm. Res. , vol.32 , Issue.5 , pp. 773-779
    • Gao, D.Y.1    Han, L.M.2    Zhang, L.H.3    Fang, X.L.4    Wang, J.X.5
  • 268
    • 1542344491 scopus 로고    scopus 로고
    • Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat
    • Zhang, Y.; Akao, T.; Nakamura, N.; Duan, C.L.; Hattori, M.; Yang, X.W.; Liu, J.X. Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat. Planta Med., 2004, 70 (2),138-142.
    • (2004) Planta Med. , vol.70 , Issue.2 , pp. 138-142
    • Zhang, Y.1    Akao, T.2    Nakamura, N.3    Duan, C.L.4    Hattori, M.5    Yang, X.W.6    Liu, J.X.7
  • 269
    • 67149107346 scopus 로고    scopus 로고
    • Characterization of metabolites in rat plasma after intravenous administration of salvianolic acid A by liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry
    • Shen, Y.; Wang, X.; Xu, L.; Liu, X.; Chao, R. Characterization of metabolites in rat plasma after intravenous administration of salvianolic acid A by liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry. Rapid. Commun. Mass. Spectrom., 2009, 23 (12),1810-1816.
    • (2009) Rapid. Commun. Mass. Spectrom. , vol.23 , Issue.12 , pp. 1810-1816
    • Shen, Y.1    Wang, X.2    Xu, L.3    Liu, X.4    Chao, R.5
  • 270
    • 34548613590 scopus 로고    scopus 로고
    • Study of the phase i and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometry
    • Liu, J.; Wu, J.; Wang, X.; Cai, Z. Study of the phase I and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometry. Rapid. Commun. Mass. Spectrom., 2007, 21 (18),2992-2998.
    • (2007) Rapid. Commun. Mass. Spectrom. , vol.21 , Issue.18 , pp. 2992-2998
    • Liu, J.1    Wu, J.2    Wang, X.3    Cai, Z.4
  • 271
    • 77953845415 scopus 로고    scopus 로고
    • Regioselective glucuronidation of tanshinone iia after quinone reduction: Identification of human UDPglucuronosyltransferases, species differences, and interaction potential
    • Wang, Q.; Hao, H.; Zhu, X.; Yu, G.; Lai, L.; Liu, Y.; Wang, Y.; Jiang, S.; Wang, G. Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDPglucuronosyltransferases, species differences, and interaction potential. Drug Metab. Dispos., 2010, 38 (7),1132-1140.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.7 , pp. 1132-1140
    • Wang, Q.1    Hao, H.2    Zhu, X.3    Yu, G.4    Lai, L.5    Liu, Y.6    Wang, Y.7    Jiang, S.8    Wang, G.9
  • 272
    • 33846864682 scopus 로고    scopus 로고
    • Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation
    • Hao, H.; Wang, G.; Cui, N.; Li, J.; Xie, L.; Ding, Z. Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. Curr. Drug Metab., 2007, 8 (2),137-149.
    • (2007) Curr. Drug Metab. , vol.8 , Issue.2 , pp. 137-149
    • Hao, H.1    Wang, G.2    Cui, N.3    Li, J.4    Xie, L.5    Ding, Z.6
  • 273
    • 34848814434 scopus 로고    scopus 로고
    • Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography- mass spectrometry
    • Xu, M.; Guo, H.; Han, J.; Sun, S.F.; Liu, A.H.; Wang, B.R.; Ma, X.C.; Liu, P.; Qiao, X.; Zhang, Z.C.; Guo, D.A. Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography- mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 858 (1-2),184-198.
    • (2007) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.858 , Issue.1-2 , pp. 184-198
    • Xu, M.1    Guo, H.2    Han, J.3    Sun, S.F.4    Liu, A.H.5    Wang, B.R.6    Ma, X.C.7    Liu, P.8    Qiao, X.9    Zhang, Z.C.10    Guo, D.A.11
  • 274
    • 42649083309 scopus 로고    scopus 로고
    • High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
    • Cui, L.; Chan, W.; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z. High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen. Talanta, 2008, 75 (4),1002-1007.
    • (2008) Talanta , vol.75 , Issue.4 , pp. 1002-1007
    • Cui, L.1    Chan, W.2    Wu, J.L.3    Jiang, Z.H.4    Chan, K.5    Cai, Z.6
  • 275
    • 33846422712 scopus 로고    scopus 로고
    • Pharmacokinetics tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats
    • Li, X.; Yu, C.; Lu, Y.; Gu, Y.; Lu, J.; Xu, W.; Xuan, L.; Wang, Y. Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats. Drug Metab. Dispos., 2007, 35 (2),234-239.
    • (2007) Drug Metab. Dispos. , vol.35 , Issue.2 , pp. 234-239
    • Li, X.1    Yu, C.2    Lu, Y.3    Gu, Y.4    Lu, J.5    Xu, W.6    Xuan, L.7    Wang, Y.8
  • 276
    • 80054910363 scopus 로고    scopus 로고
    • Effects of Salvia miltiorrhiza Extract on the Liver CYP3A Activity in Humans and Rats
    • Wang, X.; Yeung, J.H. Effects of Salvia miltiorrhiza Extract on the Liver CYP3A Activity in Humans and Rats. Phytother. Res., 2011, 25(11),1653-1659.
    • (2011) Phytother. Res. , vol.25 , Issue.11 , pp. 1653-1659
    • Wang, X.1    Yeung, J.H.2
  • 277
    • 79955473621 scopus 로고    scopus 로고
    • Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship
    • Wang, X.; Yeung, J.H. Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship. Fitoterapia, 2011, 82 (4),539-545.
    • (2011) Fitoterapia , vol.82 , Issue.4 , pp. 539-545
    • Wang, X.1    Yeung, J.H.2
  • 279
    • 77955983219 scopus 로고    scopus 로고
    • Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro
    • Wang, X.; Cheung, C.M.; Lee, W.Y.; Or, P.M.; Yeung, J.H. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine, 2010, 17 (11),868-875.
    • (2010) Phytomedicine , vol.17 , Issue.11 , pp. 868-875
    • Wang, X.1    Cheung, C.M.2    Lee, W.Y.3    Or, P.M.4    Yeung, J.H.5
  • 280
    • 0041524153 scopus 로고    scopus 로고
    • Effects of the aqueous extract from Salvia miltiorrhiza Bge on the pharmacokinetics of diazepam and on liver microsomal cytochrome P450 enzyme activity in rats
    • Jinping, Q.; Peiling, H.; Yawei, L.; Abliz, Z. Effects of the aqueous extract from Salvia miltiorrhiza Bge on the pharmacokinetics of diazepam and on liver microsomal cytochrome P450 enzyme activity in rats. J. Pharm. Pharmacol., 2003, 55 (8),1163-1167.
    • (2003) J. Pharm. Pharmacol. , vol.55 , Issue.8 , pp. 1163-1167
    • Jinping, Q.1    Peiling, H.2    Yawei, L.3    Abliz, Z.4
  • 281
    • 0025581202 scopus 로고
    • Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections
    • Tulkens, P.M. Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections. Scand. J. Infect. Dis. Suppl., 1990, 74,209-217.
    • (1990) Scand. J. Infect. Dis. Suppl. , vol.74 , pp. 209-217
    • Tulkens, P.M.1
  • 282
    • 0031463901 scopus 로고    scopus 로고
    • Drug retention, efflux, and resistance in tumor cells
    • Krishan, A.; Fitz, C.M.; Andritsch, I. Drug retention, efflux, and resistance in tumor cells. Cytometry, 1997, 29 (4),279-285.
    • (1997) Cytometry , vol.29 , Issue.4 , pp. 279-285
    • Krishan, A.1    Fitz, C.M.2    Andritsch, I.3
  • 283
    • 17244366637 scopus 로고    scopus 로고
    • Intracellular drug sequestration events associated with the emergence of multidrug resistance: A mechanistic review
    • Duvvuri, M.; Krise, J.P. Intracellular drug sequestration events associated with the emergence of multidrug resistance: a mechanistic review. Front Biosci., 2005, 10,1499-1509.
    • (2005) Front Biosci. , vol.10 , pp. 1499-1509
    • Duvvuri, M.1    Krise, J.P.2
  • 285
    • 0345866811 scopus 로고    scopus 로고
    • Ion-trapping microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs
    • Siebert, G.A.; Hung, D.Y.; Chang, P.; Roberts, M.S. Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs. J. Pharmacol. Exp. Ther., 2004, 308 (1),228-235.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , Issue.1 , pp. 228-235
    • Siebert, G.A.1    Hung, D.Y.2    Chang, P.3    Roberts, M.S.4
  • 286
    • 44449116133 scopus 로고    scopus 로고
    • Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts)
    • Barcia-Macay, M.; Mouaden, F.; Mingeot-Leclercq, M.P.; Tulkens, P.M.; Van Bambeke, F. Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts). J. Antimicrob. Chemother., 2008, 61 (6),1288-1294.
    • (2008) J. Antimicrob. Chemother. , vol.61 , Issue.6 , pp. 1288-1294
    • Barcia-Macay, M.1    Mouaden, F.2    Mingeot-Leclercq, M.P.3    Tulkens, P.M.4    Van Bambeke, F.5
  • 287
    • 0035735809 scopus 로고    scopus 로고
    • Cellular pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: Can we improve it?
    • Jung, L.L.; Zamboni, W.C. Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it? Drug Resist. Updat., 2001, 4 (4),273-288.
    • (2001) Drug Resist. Updat. , vol.4 , Issue.4 , pp. 273-288
    • Jung, L.L.1    Zamboni, W.C.2
  • 288
    • 79960745996 scopus 로고    scopus 로고
    • Toward a new age of cellular pharmacokinetics in drug discovery
    • Zhou, F.; Zhang, J.; Li, P.; Niu, F.; Wu, X.; Wang, G.; Roberts, M.S. Toward a new age of cellular pharmacokinetics in drug discovery. Drug Metab. Rev., 2011, 43 (3),335-345.
    • (2011) Drug Metab. Rev. , vol.43 , Issue.3 , pp. 335-345
    • Zhou, F.1    Zhang, J.2    Li, P.3    Niu, F.4    Wu, X.5    Wang, G.6    Roberts, M.S.7
  • 289
    • 65349163279 scopus 로고    scopus 로고
    • Plasma and cellular pharmacokinetics of doxorubicin after intravenous infusion of Caelyx/Doxil in patients with hematological tumors
    • Richly, H.; Grubert, M.; Scheulen, M.E.; Hilger, R.A. Plasma and cellular pharmacokinetics of doxorubicin after intravenous infusion of Caelyx/Doxil in patients with hematological tumors. Int. J. Clin. Pharmacol. Ther., 2009, 47 (1),55-57.
    • (2009) Int. J. Clin. Pharmacol. Ther. , vol.47 , Issue.1 , pp. 55-57
    • Richly, H.1    Grubert, M.2    Scheulen, M.E.3    Hilger, R.A.4
  • 292
    • 3342953635 scopus 로고    scopus 로고
    • Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages
    • Van Bambeke, F.; Carryn, S.; Seral, C.; Chanteux, H.; Tyteca, D.; Mingeot-Leclercq, M.P.; Tulkens, P.M. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages. Antimicrob. Agents Chemother., 2004, 48 (8),2853-2860.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , Issue.8 , pp. 2853-2860
    • Van Bambeke, F.1    Carryn, S.2    Seral, C.3    Chanteux, H.4    Tyteca, D.5    Mingeot-Leclercq, M.P.6    Tulkens, P.M.7
  • 293
    • 18744394626 scopus 로고    scopus 로고
    • Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver
    • Hung, D.Y.; Siebert, G.A.; Chang, P.; Roberts, M.S. Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver. Br. J. Pharmacol., 2005, 145 (1),57-65.
    • (2005) Br. J. Pharmacol. , vol.145 , Issue.1 , pp. 57-65
    • Hung, D.Y.1    Siebert, G.A.2    Chang, P.3    Roberts, M.S.4
  • 294
    • 33846178278 scopus 로고    scopus 로고
    • A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration
    • Zhang, X.; Shedden, K.; Rosania, G.R. A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration. Mol. Pharm., 2006, 3 (6),704-716.
    • (2006) Mol. Pharm. , vol.3 , Issue.6 , pp. 704-716
    • Zhang, X.1    Shedden, K.2    Rosania, G.R.3
  • 295
    • 38849140975 scopus 로고    scopus 로고
    • Dissecting the components of quinine accumulation in Plasmodium falciparum
    • Sanchez, C.P.; Stein, W.D.; Lanzer, M. Dissecting the components of quinine accumulation in Plasmodium falciparum. Mol. Microbiol., 2008, 67 (5),1081-1093.
    • (2008) Mol. Microbiol. , vol.67 , Issue.5 , pp. 1081-1093
    • Sanchez, C.P.1    Stein, W.D.2    Lanzer, M.3
  • 297
    • 77950201383 scopus 로고    scopus 로고
    • Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum
    • Liu, Y.; Lok, C.N.; Ko, B.C.; Shum, T.Y.; Wong, M.K.; Che, C.M. Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum. Org. Lett., 2010, 12 (7),1420-1423.
    • (2010) Org. Lett. , vol.12 , Issue.7 , pp. 1420-1423
    • Liu, Y.1    Lok, C.N.2    Ko, B.C.3    Shum, T.Y.4    Wong, M.K.5    Che, C.M.6
  • 298
    • 80052970758 scopus 로고    scopus 로고
    • Intracellular delivery of paclitaxel using oil-free, shell cross-linked HSA - Multi-armed PEG nanocapsules
    • Lee, J.Y.; Bae, K.H.; Kim, J.S.; Nam, Y.S.; Park, T.G. Intracellular delivery of paclitaxel using oil-free, shell cross-linked HSA - Multi-armed PEG nanocapsules. Biomaterials, 2011, 32(33), 8635-8644.
    • (2011) Biomaterials , vol.32 , Issue.33 , pp. 8635-8644
    • Lee, J.Y.1    Bae, K.H.2    Kim, J.S.3    Nam, Y.S.4    Park, T.G.5
  • 299
    • 67349110406 scopus 로고    scopus 로고
    • Intracellular dynamics of topoisomerase i inhibitor, CPT-11, by slit-scanning confocal Raman microscopy
    • Harada, Y.; Dai, P.; Yamaoka, Y.; Ogawa, M.; Tanaka, H.; Nosaka, K.; Akaji, K.; Takamatsu, T. Intracellular dynamics of topoisomerase I inhibitor, CPT-11, by slit-scanning confocal Raman microscopy. Histochem. Cell Biol., 2009, 132 (1),39-46.
    • (2009) Histochem. Cell Biol. , vol.132 , Issue.1 , pp. 39-46
    • Harada, Y.1    Dai, P.2    Yamaoka, Y.3    Ogawa, M.4    Tanaka, H.5    Nosaka, K.6    Akaji, K.7    Takamatsu, T.8
  • 300
    • 34247887699 scopus 로고    scopus 로고
    • Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions
    • Zhao, Y.; Gao, J.; Sun, X.; Chen, H.; Wu, L.; Liang, W. Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions. J. Pharm. Pharm. Sci., 2007, 10 (1),61-70.
    • (2007) J. Pharm. Pharm. Sci. , vol.10 , Issue.1 , pp. 61-70
    • Zhao, Y.1    Gao, J.2    Sun, X.3    Chen, H.4    Wu, L.5    Liang, W.6
  • 302
    • 70449517239 scopus 로고    scopus 로고
    • Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope
    • Mukai, R.; Shirai, Y.; Saito, N.; Yoshida, K.; Ashida, H. Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope. Cytotechnology, 2009, 59 (3),177-182.
    • (2009) Cytotechnology , vol.59 , Issue.3 , pp. 177-182
    • Mukai, R.1    Shirai, Y.2    Saito, N.3    Yoshida, K.4    Ashida, H.5
  • 303
    • 77955097118 scopus 로고    scopus 로고
    • After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    • Arredondo, F.; Echeverry, C.; Abin-Carriquiry, J.A.; Blasina, F.; Antunez, K.; Jones, D.P.; Go, Y.M.; Liang, Y.L.; Dajas, F. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic. Biol. Med., 2010, 49 (5),738-747.
    • (2010) Free Radic. Biol. Med. , vol.49 , Issue.5 , pp. 738-747
    • Arredondo, F.1    Echeverry, C.2    Abin-Carriquiry, J.A.3    Blasina, F.4    Antunez, K.5    Jones, D.P.6    Go, Y.M.7    Liang, Y.L.8    Dajas, F.9
  • 304
    • 77952633473 scopus 로고    scopus 로고
    • Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: Studies with macrophages and polymorphonuclear neutrophils
    • Lemaire, S.; Tulkens, P.M.; Van Bambeke, F. Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. Antimicrob. Agents Chemother., 2010, 54 (6),2540-2548.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.6 , pp. 2540-2548
    • Lemaire, S.1    Tulkens, P.M.2    Van Bambeke, F.3
  • 305
    • 67651024139 scopus 로고    scopus 로고
    • Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells
    • Shen, F.; Bailey, B.J.; Chu, S.; Bence, A.K.; Xue, X.; Erickson, P.; Safa, A.R.; Beck, W.T.; Erickson, L.C. Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells. J. Pharmacol. Exp. Ther., 2009, 330 (2),423-429.
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , Issue.2 , pp. 423-429
    • Shen, F.1    Bailey, B.J.2    Chu, S.3    Bence, A.K.4    Xue, X.5    Erickson, P.6    Safa, A.R.7    Beck, W.T.8    Erickson, L.C.9
  • 307
    • 1642579666 scopus 로고    scopus 로고
    • A cell fractionation approach for the quantitative analysis of subcellular drug disposition
    • Duvvuri, M.; Feng, W.; Mathis, A.; Krise, J.P. A cell fractionation approach for the quantitative analysis of subcellular drug disposition. Pharm. Res., 2004, 21 (1),26-32.
    • (2004) Pharm. Res. , vol.21 , Issue.1 , pp. 26-32
    • Duvvuri, M.1    Feng, W.2    Mathis, A.3    Krise, J.P.4
  • 308
    • 77953609970 scopus 로고    scopus 로고
    • Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells
    • Dopp, E.; von Recklinghausen, U.; Diaz-Bone, R.; Hirner, A.V.; Rettenmeier, A.W. Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells. Environ. Res., 2010, 110 (5),435-442.
    • (2010) Environ. Res. , vol.110 , Issue.5 , pp. 435-442
    • Dopp, E.1    Von Recklinghausen, U.2    Diaz-Bone, R.3    Hirner, A.V.4    Rettenmeier, A.W.5
  • 310
    • 1642360726 scopus 로고    scopus 로고
    • Herbal modulation of Pglycoprotein
    • Zhou, S.; Lim L.Y.; Chowbay, B. Herbal modulation of Pglycoprotein. Drug Metab. Rev., 2004, 36 (1),57-104.
    • (2004) Drug Metab. Rev. , vol.36 , Issue.1 , pp. 57-104
    • Zhou, S.1    Lim, L.Y.2    Chowbay, B.3
  • 311
    • 34548378642 scopus 로고    scopus 로고
    • Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein)
    • Marchetti, S.; Mazzanti, R.; Beijnen, J.H.; Schellens, J.H. Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). Oncologist, 2007, 12 (8),927-941.
    • (2007) Oncologist , vol.12 , Issue.8 , pp. 927-941
    • Marchetti, S.1    Mazzanti, R.2    Beijnen, J.H.3    Schellens, J.H.4
  • 312
    • 22544450860 scopus 로고    scopus 로고
    • Herbal interactions involving cytochrome p450 enzymes: A mini review
    • Delgoda, R.; Westlake, A.C. Herbal interactions involving cytochrome p450 enzymes: a mini review. Toxicol. Rev., 2004, 23 (4),239-249.
    • (2004) Toxicol. Rev. , vol.23 , Issue.4 , pp. 239-249
    • Delgoda, R.1    Westlake, A.C.2
  • 313
    • 33751549323 scopus 로고    scopus 로고
    • Drug-herb interactions: Eliminating toxicity with hard drug design
    • Yang, X.X.; Hu, Z.P.; Duan, W.; Zhu, Y.Z.; Zhou, S.F. Drug-herb interactions: eliminating toxicity with hard drug design. Curr. Pharm. Des., 2006, 12 (35),4649-4664.
    • (2006) Curr. Pharm. Des. , vol.12 , Issue.35 , pp. 4649-4664
    • Yang, X.X.1    Hu, Z.P.2    Duan, W.3    Zhu, Y.Z.4    Zhou, S.F.5
  • 314
    • 0034104453 scopus 로고    scopus 로고
    • Resistance mechanisms associated with altered intracellular distribution of anticancer agents
    • Larsen, A.K.; Escargueil, A.E.; Skladanowski, A. Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol. Ther., 2000, 85 (3),217-229.
    • (2000) Pharmacol. Ther. , vol.85 , Issue.3 , pp. 217-229
    • Larsen, A.K.1    Escargueil, A.E.2    Skladanowski, A.3
  • 316
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel, A.H.; Jonker, J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev., 2003, 55 (1),3-29.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , Issue.1 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 318
    • 0041968944 scopus 로고    scopus 로고
    • Subcellular localization and activity of multidrug resistance proteins
    • Rajagopal, A.; Simon, S.M. Subcellular localization and activity of multidrug resistance proteins. Mol. Biol. Cell, 2003, 14 (8),3389-3399.
    • (2003) Mol. Biol. Cell , vol.14 , Issue.8 , pp. 3389-3399
    • Rajagopal, A.1    Simon, S.M.2
  • 320
    • 0028880851 scopus 로고
    • Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution
    • Baldini, N.; Scotlandi, K.; Serra, M.; Shikita, T.; Zini, N.; Ognibene, A.; Santi, S.; Ferracini, R.; Maraldi, N.M. Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution. Eur. J. Cell Biol., 1995, 68 (3),226-239.
    • (1995) Eur. J. Cell Biol. , vol.68 , Issue.3 , pp. 226-239
    • Baldini, N.1    Scotlandi, K.2    Serra, M.3    Shikita, T.4    Zini, N.5    Ognibene, A.6    Santi, S.7    Ferracini, R.8    Maraldi, N.M.9
  • 322
    • 0347379902 scopus 로고    scopus 로고
    • Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60
    • Gong, Y.; Duvvuri M.; Krise, J.P. Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. J. Biol. Chem., 2003, 278 (50),50234-50239.
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 50234-50239
    • Gong, Y.1    Duvvuri, M.2    Krise, J.P.3
  • 323
    • 0033986713 scopus 로고    scopus 로고
    • Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis
    • Bour-Dill, C.; Gramain, M.P.; Merlin, J.L.; Marchal, S.; Guillemin, F. Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis. Cytometry, 2000, 39 (1),16-25.
    • (2000) Cytometry , vol.39 , Issue.1 , pp. 16-25
    • Bour-Dill, C.1    Gramain, M.P.2    Merlin, J.L.3    Marchal, S.4    Guillemin, F.5
  • 324
    • 0035066434 scopus 로고    scopus 로고
    • Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia
    • Ferrao, P.; Sincock, P.; Cole, S.; Ashman, L. Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia. Leuk. Res., 2001, 25 (5),395-405.
    • (2001) Leuk. Res. , vol.25 , Issue.5 , pp. 395-405
    • Ferrao, P.1    Sincock, P.2    Cole, S.3    Ashman, L.4
  • 325
    • 33751520985 scopus 로고    scopus 로고
    • P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines
    • Solazzo, M.; Fantappie, O.; Lasagna, N.; Sassoli, C.; Nosi, D.; Mazzanti, R. P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines. Exp. Cell Res., 2006, 312 (20),4070-4078.
    • (2006) Exp. Cell Res. , vol.312 , Issue.20 , pp. 4070-4078
    • Solazzo, M.1    Fantappie, O.2    Lasagna, N.3    Sassoli, C.4    Nosi, D.5    Mazzanti, R.6
  • 326
    • 70349751649 scopus 로고    scopus 로고
    • Mitochondrial expression and functional activity of breast cancer resistance protein in different multiple drug-resistant cell lines
    • Solazzo, M.; Fantappie, O.; D'Amico, M.; Sassoli, C.; Tani, A.; Cipriani, G.; Bogani, C.; Formigli, L.; Mazzanti, R. Mitochondrial expression and functional activity of breast cancer resistance protein in different multiple drug-resistant cell lines. Cancer Res., 2009, 69 (18),7235-7242.
    • (2009) Cancer Res. , vol.69 , Issue.18 , pp. 7235-7242
    • Solazzo, M.1    Fantappie, O.2    D'Amico, M.3    Sassoli, C.4    Tani, A.5    Cipriani, G.6    Bogani, C.7    Formigli, L.8    Mazzanti, R.9
  • 327
    • 82955184560 scopus 로고    scopus 로고
    • Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(s)-ginsenoside rh2 in mcf-7/adr cells
    • Zhang, J.; Zhou, F.; Wu, X.; Zhang, X.; Chen, Y.; Zha, B.S.; Niu, F.; Lu, M.; Hao, G.; Sun, Y.; Sun, J.; Peng, Y.; Wang, G. Cellular Pharmacokinetic Mechanisms of Adriamycin Resistance and Its Modulation by 20(S)-Ginsenoside Rh2 in MCF-7/Adr Cells. Br. J. Pharmacol., 2012, 165 (1),120-134.
    • (2012) Br. J. Pharmacol. , vol.165 , Issue.1 , pp. 120-134
    • Zhang, J.1    Zhou, F.2    Wu, X.3    Zhang, X.4    Chen, Y.5    Zha, B.S.6    Niu, F.7    Lu, M.8    Hao, G.9    Sun, Y.10    Sun, J.11    Peng, Y.12    Wang, G.13
  • 329
    • 77952492782 scopus 로고    scopus 로고
    • Human CYPs involved in drug metabolism: Structures, substrates and binding affinities
    • Lewis, D.F.; Ito, Y. Human CYPs involved in drug metabolism: structures, substrates and binding affinities. Expert. Opin. Drug Metab. Toxicol., 2010, 6 (6),661-674.
    • (2010) Expert. Opin. Drug Metab. Toxicol. , vol.6 , Issue.6 , pp. 661-674
    • Lewis, D.F.1    Ito, Y.2
  • 330
    • 34247580788 scopus 로고    scopus 로고
    • Molecular mechanism of phase i and phase II drugmetabolizing enzymes: Implications for detoxification
    • Iyanagi, T. Molecular mechanism of phase I and phase II drugmetabolizing enzymes: implications for detoxification. Int. Rev. Cytol., 2007, 260,35-112.
    • (2007) Int. Rev. Cytol. , vol.260 , pp. 35-112
    • Iyanagi, T.1
  • 331
    • 0034973607 scopus 로고    scopus 로고
    • Cytochromes P450 and metabolism of xenobiotics
    • Anzenbacher, P.; Anzenbacherova, E. Cytochromes P450 and metabolism of xenobiotics. Cell Mol. Life Sci., 2001, 58 (5-6),737-747.
    • (2001) Cell Mol. Life Sci. , vol.58 , Issue.5-6 , pp. 737-747
    • Anzenbacher, P.1    Anzenbacherova, E.2
  • 333
    • 0011270386 scopus 로고
    • Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes
    • Sakaguchi, M.; Mihara, K.; Sato, R. Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes. Proc. Natl. Acad. Sci. U. S. A., 1984, 81 (11),3361-3364.
    • (1984) Proc. Natl. Acad. Sci. U. S. A. , vol.81 , Issue.11 , pp. 3361-3364
    • Sakaguchi, M.1    Mihara, K.2    Sato, R.3
  • 334
    • 33750010974 scopus 로고    scopus 로고
    • Mitochondrial P450s
    • Omura, T. Mitochondrial P450s. Chem. Biol. Interact., 2006, 163 (1-2),86-93.
    • (2006) Chem. Biol. Interact. , vol.163 , Issue.1-2 , pp. 86-93
    • Omura, T.1
  • 335
    • 79851481559 scopus 로고    scopus 로고
    • Molecular mechanisms regulating the mitochondrial targeting of microsomal cytochrome P450 enzymes
    • Ahn, T.; Yun, C.H. Molecular mechanisms regulating the mitochondrial targeting of microsomal cytochrome P450 enzymes. Curr. Drug Metab., 2010, 11 (10),830-838.
    • (2010) Curr. Drug Metab. , vol.11 , Issue.10 , pp. 830-838
    • Ahn, T.1    Yun, C.H.2
  • 336
    • 54949089178 scopus 로고    scopus 로고
    • Intracellular transport and localization of microsomal cytochrome P450
    • Neve E.P.; Ingelman-Sundberg M. Intracellular transport and localization of microsomal cytochrome P450. Anal. Bioanal. Chem., 2008, 392 (6),1075-1084.
    • (2008) Anal. Bioanal. Chem. , vol.392 , Issue.6 , pp. 1075-1084
    • Neve, E.P.1    Ingelman-Sundberg, M.2
  • 338
    • 0027427953 scopus 로고
    • Biosynthesis of heparin/heparan sulfate. Identification of a 70-kDa protein catalyzing both the D glucuronosyl- and the N-acetyl-D- glucosaminyltransferase reactions
    • Lind, T.; Lindahl, U.; Lidholt, K. Biosynthesis of heparin/heparan sulfate. Identification of a 70-kDa protein catalyzing both the D glucuronosyl- and the N-acetyl-D-glucosaminyltransferase reactions. J. Biol. Chem., 1993, 268 (28),20705-20708.
    • (1993) J. Biol. Chem. , vol.268 , Issue.28 , pp. 20705-20708
    • Lind, T.1    Lindahl, U.2    Lidholt, K.3
  • 341
    • 0028839833 scopus 로고
    • The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation
    • Soboll, S.; Grundel, S.; Harris, J.; Kolb-Bachofen, V.; Ketterer, B.; Sies, H. The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation. Biochem. J., 1995, 311 ,889-894.
    • (1995) Biochem. J. , vol.311 , pp. 889-894
    • Soboll, S.1    Grundel, S.2    Harris, J.3    Kolb-Bachofen, V.4    Ketterer, B.5    Sies, H.6
  • 342
    • 0037103764 scopus 로고    scopus 로고
    • Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
    • Raza, H.; Robin, M.A.; Fang, J.K.; Avadhani, N.G. Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem. J., 2002, 366 ,45-55.
    • (2002) Biochem. J. , vol.366 , pp. 45-55
    • Raza, H.1    Robin, M.A.2    Fang, J.K.3    Avadhani, N.G.4
  • 343
    • 69449097954 scopus 로고    scopus 로고
    • Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans
    • Petit, E.; Michelet, X.; Rauch, C.; Bertrand-Michel, J.; Terce, F.; Legouis, R.; Morel, F. Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans. FEBS. J., 2009, 276 (18),5030-5040.
    • (2009) FEBS. J. , vol.276 , Issue.18 , pp. 5030-5040
    • Petit, E.1    Michelet, X.2    Rauch, C.3    Bertrand-Michel, J.4    Terce, F.5    Legouis, R.6    Morel, F.7
  • 344
    • 79954588933 scopus 로고    scopus 로고
    • The glutathione transferase kappa family
    • Morel, F.; Aninat C. The glutathione transferase kappa family. Drug Metab. Rev., 2011, 43 (2),281-291.
    • (2011) Drug Metab. Rev. , vol.43 , Issue.2 , pp. 281-291
    • Morel, F.1    Aninat, C.2
  • 345
    • 0026102592 scopus 로고
    • Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo
    • Kikuchi, Y.; Sasa, H.; Kita, T.; Hirata, J.; Tode, T.; Nagata, I. Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo. Anticancer Drugs, 1991, 2 (1),63-67.
    • (1991) Anticancer Drugs , vol.2 , Issue.1 , pp. 63-67
    • Kikuchi, Y.1    Sasa, H.2    Kita, T.3    Hirata, J.4    Tode, T.5    Nagata, I.6
  • 346
    • 6344294207 scopus 로고    scopus 로고
    • Rh2 a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy
    • Jia, W.W.; Bu, X.; Philips, D.; Yan, H.; Liu, G.; Chen, X.; Bush, J.A.; Li, G. Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can. J. Physiol. Pharmacol., 2004, 82 (7),431-437.
    • (2004) Can. J. Physiol. Pharmacol. , vol.82 , Issue.7 , pp. 431-437
    • Jia, W.W.1    Bu, X.2    Philips, D.3    Yan, H.4    Liu, G.5    Chen, X.6    Bush, J.A.7    Li, G.8
  • 347
    • 33646002630 scopus 로고    scopus 로고
    • Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models
    • Xie, X.; Eberding, A.; Madera, C.; Fazli, L.; Jia, W.; Goldenberg, L.; Gleave, M.; Guns, E.S. Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models. J. Urol., 2006, 175 (5),1926-1931.
    • (2006) J. Urol. , vol.175 , Issue.5 , pp. 1926-1931
    • Xie, X.1    Eberding, A.2    Madera, C.3    Fazli, L.4    Jia, W.5    Goldenberg, L.6    Gleave, M.7    Guns, E.S.8
  • 348
    • 78649580065 scopus 로고    scopus 로고
    • 20(S)-ginsenoside rh2 noncompetitively inhibits p-glycoprotein in vitro and in vivo: A case for herb-drug interactions
    • Zhang, J.; Zhou, F.; Wu, X.; Gu, Y.; Ai, H.; Zheng, Y.; Li, Y.; Zhang, X.; Hao, G.; Sun J.; Peng Y.; Wang G. 20(S)-ginsenoside rh2 noncompetitively inhibits p-glycoprotein in vitro and in vivo: a case for herb-drug interactions. Drug Metab. Dispos., 2010, 38 (12),2179-2187.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.12 , pp. 2179-2187
    • Zhang, J.1    Zhou, F.2    Wu, X.3    Gu, Y.4    Ai, H.5    Zheng, Y.6    Li, Y.7    Zhang, X.8    Hao, G.9    Sun, J.10    Peng, Y.11    Wang, G.12
  • 349
    • 23244463302 scopus 로고    scopus 로고
    • Potential anticancer activity of tanshinone IIA against human breast cancer
    • Wang, X.; Wei, Y.; Yuan, S.; Liu, G.; Lu, Y.; Zhang, J.; Wang, W. Potential anticancer activity of tanshinone IIA against human breast cancer. Int. J. Cancer, 2005, 116 (5),799-807.
    • (2005) Int. J. Cancer , vol.116 , Issue.5 , pp. 799-807
    • Wang, X.1    Wei, Y.2    Yuan, S.3    Liu, G.4    Lu, Y.5    Zhang, J.6    Wang, W.7
  • 351
    • 84856219184 scopus 로고    scopus 로고
    • Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells
    • Dai, Z.K.; Qin, J.K.; Huang, J.E.; Luo, Y.; Xu, Q.; Zhao, H.L. Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells. J. Nat. Med., 2012, 66(1), 192-201.
    • (2012) J. Nat. Med. , vol.66 , Issue.1 , pp. 192-201
    • Dai, Z.K.1    Qin, J.K.2    Huang, J.E.3    Luo, Y.4    Xu, Q.5    Zhao, H.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.