Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra

Drug Metabolism and Disposition

Volumn 35, Issue 4, 2007, Pages 539-553

  Cao, Jie ^a   Chen, Xiao ^b   Liang, Jun ^c   Yu, Xue Qing ^b   Xu, An Long ^b   Chan, Eli ^d   Duan, Wei ^f   Huang, Min ^b   Wen, Jing Yuan ^e   Yu, Xi Yong ^g   Li, Xiao Tian ^h   Sheu, Fwu Shan ^d   Zhou, Shu Feng ^c,i  

^a GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF SYDNEY   (Australia)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

^f DEAKIN UNIVERSITY   (Australia)

^g Guangdong Provincial Cardiovascular Institute   (China)

^h FUDAN UNIVERSITY   (China)

ⁱ QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATASE; CELECOXIB; DIGOXIN; FLAVANOID; GLABRIDIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; NIFEDIPINE; PROBENECID; SODIUM AZIDE; VERAPAMIL; VERLUKAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANNULATION; CELL LINE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG TRANSPORT; ENZYME ACTIVITY; GLYCYRRHIZA GLABRA; HUMAN; HUMAN CELL; IC 50; INTESTINE ABSORPTION; LIVER MICROSOME; MALE; MESENTERIC VEIN; METABOLIC CAPACITY; MICROSOME; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FLAVONOIDS; GLUCURONIDES; GLYCYRRHIZA; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PHENOLS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRANSFECTION; URIDINE DIPHOSPHATE GLUCURONIC ACID; VERAPAMIL;

GLYCYRRHIZA GLABRA; MUS; RATTUS;

EID: 34047162392     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.010801     Document Type: Article

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