Pharmacokinetics and disposition of the kavalactone kawain: Interaction with kava extract and kavalactones in vivo and in vitro

Drug Metabolism and Disposition

Volumn 33, Issue 10, 2005, Pages 1555-1563

  Mathews, James M ^a   Etheridge, Amy S ^a   Valentine, John L ^a   Black, Sherry R ^a   Coleman, Donna P ^a   Patel, Purvi ^a   So, James ^a   Burka, Leo T ^b  

^a RTI INTERNATIONAL   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEMETHOXYYANGONIN; DIHYDROMETHYSTICIN; GLYCOPROTEIN P; KAVA EXTRACT; KAWAIN; LACTONE DERIVATIVE; LIVER ENZYME; METHYSTICIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISPOSITION; DRUG ELIMINATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; URINALYSIS;

ADENOSINE TRIPHOSPHATASES; ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INJECTIONS, INTRAVENOUS; KAVA; LACTONES; MALE; MICROSOMES, LIVER; P-GLYCOPROTEIN; PLANT EXTRACTS; PYRONES; RATS; RATS, INBRED F344;

ANIMALIA; PIPER METHYSTICUM;

EID: 24944587145     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.004317     Document Type: Article

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