Qualitative and quantitative determination of complicated herbal components by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a relative exposure approach to herbal pharmacokinetics independent of standards

Journal of Chromatography A

Volumn 1217, Issue 30, 2010, Pages 4971-4979

  Liang, Yan ^a   Hao, Haiping ^a   Kang, An ^a   Xie, Lin ^a   Xie, Tong ^a   Zheng, Xiao ^a   Dai, Chen ^a   Wan, Leren ^b   Sheng, Longsheng ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Shimadzu Hongkong Limited Co   (China)

Author keywords

LC IT TOF MS; LC Q MS; Lignan; Relative exposure approach; Schisandra lignans extract

Indexed keywords

ABSOLUTE QUANTIFICATION; BIOLOGICAL MATRIXES; CALIBRATION CURVES; FIGURES OF MERITS; HERBAL MEDICINES; ION TRAPS; LC-IT-TOF/MS; LIGNANS; PHARMACOKINETIC ANALYSIS; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC RESEARCH; PLASMA CONCENTRATION; QUALITATIVE ANALYSIS; QUALITATIVE AND QUANTITATIVE ANALYSIS; QUANTITATIVE DETERMINATIONS; RAT PLASMA; SCHISANDRA; TECHNICAL CHALLENGES;

ASSAYS; CHROMATOGRAPHY; DRUG PRODUCTS; ION CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MEDICINE; PHARMACOKINETICS; STANDARDIZATION; STRATEGIC PLANNING;

QUALITY CONTROL;

GOMISIN A; NIMODIPINE; PLANT MEDICINAL PRODUCT; SCHISANDRA CHINENSIS EXTRACT; SCHISANTHERIN A; SCHIZANDRIN A; SCHIZANDRIN B; SCHIZANDROL A; UNCLASSIFIED DRUG; PLANT EXTRACT;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; HERBAL MEDICINE; INTERMETHOD COMPARISON; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY; VALIDATION PROCESS; ANIMAL; BLOOD; CHEMISTRY; EVALUATION; MASS SPECTROMETRY; METHODOLOGY; QUALITY CONTROL; SCHISANDRACEAE; SPRAGUE DAWLEY RAT; STANDARD;

RATTUS; SCHISANDRA;

ANIMALS; CHROMATOGRAPHY, LIQUID; FEMALE; MASS SPECTROMETRY; PLANT EXTRACTS; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SCHISANDRA;

EID: 77954175046     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.05.056     Document Type: Article

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