메뉴 건너뛰기




Volumn 7, Issue 5, 2011, Pages 533-542

Studies on the metabolism and toxicology of emerging capsinoids

Author keywords

capsinoid; CH 19 Sweet; dihydrocapsiate; human; metabolism; physiological effects; rabbit; rat; sweet pepper; teratology; toxicity; TRPV1

Indexed keywords

CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSAICINOID DERIVATIVE; CAPSIATE; CAPSICONIATE; CAPSICONINOID DERIVATIVE; CAPSINOID DERIVATIVE; CYTOCHROME P450 3A; DIHYDROCAPSAICIN; DIHYDROCAPSIATE; DIHYDROCAPSICONIATE; NORDIHYDROCAPSAICIN; NORDIHYDROCAPSIATE; UNCLASSIFIED DRUG; VANILLIC ACID; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

EID: 79955095345     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2011.562193     Document Type: Review
Times cited : (18)

References (59)
  • 1
    • 33947349535 scopus 로고
    • The constitution of capsaicin, the pungent principle of capsicum
    • Nelson E, Darson L. The constitution of capsaicin, the pungent principle of capsicum. J Am Chem Soc 1923;45:2179-81
    • (1923) J Am Chem Soc , vol.45 , pp. 2179-81
    • Nelson, E.1    Darson, L.2
  • 2
    • 0023123355 scopus 로고
    • Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats
    • DOI 10.1016/0006-291X(87)90479-7
    • Watanabe T, Kawada T, Yamamoto M, et al. Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun 1987;7(1):259-64 (Pubitemid 17000782)
    • (1987) Biochemical and Biophysical Research Communications , vol.142 , Issue.1 , pp. 259-264
    • Watanabe, T.1    Kawada, T.2    Yamamoto, M.3    Iwai, K.4
  • 3
    • 0023008170 scopus 로고
    • Capsaicin-induced β-adrenergic action on energy metabolism in rats: Influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization (42414)
    • Kawada T, Watanabe T, Takaishi T, et al. Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 1986;183(2):250-6 (Pubitemid 17183831)
    • (1986) Proceedings of the Society for Experimental Biology and Medicine , vol.183 , Issue.2 , pp. 250-256
    • Kawada, T.1    Watanabe, T.2    Takaishi, T.3
  • 4
    • 0022547292 scopus 로고
    • Effects of capsaicin on lipid metabolism in rats fed a high fat diet
    • Kawada T, Hagihara K, Iwai K. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr 1986;116(7):1272-8 (Pubitemid 16053866)
    • (1986) Journal of Nutrition , vol.116 , Issue.7 , pp. 1272-1278
    • Kawada, T.1    Hagihara, K.-I.2    Iwai, K.3
  • 5
    • 0017720392 scopus 로고
    • Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
    • Jancso G, Kiraly E, Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 1977;270(5639):741-3 (Pubitemid 8239254)
    • (1977) Nature , vol.270 , Issue.5639 , pp. 741-743
    • Jancso, G.1    Kiraly, E.2    Jancso Gabor, A.3
  • 6
    • 0000218208 scopus 로고
    • Content of capsaicinoids and capsaicinoid-like substances in fruit of pepper (Capsicum annuum L.) hybrids made with CH-19 Sweet as a parent (in Japanese)
    • Yazawa S, Suetome N, Okamoto K, et al. Content of capsaicinoids and capsaicinoid-like substances in fruit of pepper (Capsicum annuum L.) hybrids made with CH-19 Sweet as a parent (in Japanese). J Jpn Soc Hortic Sci 1989;58(3):601-7
    • (1989) J Jpn Soc Hortic Sci , vol.58 , Issue.3 , pp. 601-7
    • Yazawa, S.1    Suetome, N.2    Okamoto, K.3
  • 7
    • 0001050069 scopus 로고    scopus 로고
    • Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 sweet, of pepper (Capsicum annuum L.)
    • Kobata K, Todo T, Yazawa S, et al. Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 sweet, of pepper (Capsicum annuum L.). J Agric Food Chem 1998;46(5):1695-7 (Pubitemid 128492905)
    • (1998) Journal of Agricultural and Food Chemistry , vol.46 , Issue.5 , pp. 1695-1697
    • Kobata, K.1    Todo, T.2    Yazawa, S.3    Iwai, K.4    Watanabe, T.5
  • 8
    • 0033024227 scopus 로고    scopus 로고
    • Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, Capsicum annuum
    • DOI 10.1021/np9803373
    • Kobata K, Sutoh K, Todo T, et al. Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, Capsicum annuum. J Nat Prod 1999;62(2):335-6 (Pubitemid 29137926)
    • (1999) Journal of Natural Products , vol.62 , Issue.2 , pp. 335-336
    • Kobata, K.1    Sutoh, K.2    Todo, T.3    Yazawa, S.4    Iwai, K.5    Watanabe, T.6
  • 9
    • 33846128346 scopus 로고    scopus 로고
    • Novel capsaicinoid like substances in the fruits of new non-pungent cultivar CH-19 Sweet of pepper (Capsicum annuum)
    • Yazawa S, Yoneda H, Hosokawa M, et al. Novel capsaicinoid like substances in the fruits of new non-pungent cultivar CH-19 Sweet of pepper (Capsicum annuum). Capsicum Eggplant Newslett 2004;23:17-20
    • (2004) Capsicum Eggplant Newslett , vol.23 , pp. 17-20
    • Yazawa, S.1    Yoneda, H.2    Hosokawa, M.3
  • 10
    • 39549104738 scopus 로고    scopus 로고
    • Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1
    • Kobata K, Tate H, Iwasaki Y, et al. Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Phytochemistry 2008;69(5):1179-84
    • (2008) Phytochemistry , vol.69 , Issue.5 , pp. 1179-84
    • Kobata, K.1    Tate, H.2    Iwasaki, Y.3
  • 11
    • 67649173278 scopus 로고    scopus 로고
    • Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in capsicum cultivars
    • Tanaka Y, Hosokawa M, Otsu K, et al. Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in capsicum cultivars. J Agric Food Chem 2009;57(12):5407-12
    • (2009) J Agric Food Chem , vol.57 , Issue.12 , pp. 5407-12
    • Tanaka, Y.1    Hosokawa, M.2    Otsu, K.3
  • 13
    • 33745501986 scopus 로고    scopus 로고
    • Capsinoid is biosynthesized from phenylalanine and valine in a non-pungent pepper, Capsicum annuum L. cv. CH-19 sweet
    • DOI 10.1271/bbb.50665
    • Sutoh K, Kobata K, Yazawa S, et al. Capsinoid is biosynthesized from phenylalanine and valine in a non-pungent pepper, Capsicum annuum L. cv. CH-19 Sweet. Biosci Biotechnol Biochem 2006;70(6):1513-16 (Pubitemid 43961837)
    • (2006) Bioscience, Biotechnology and Biochemistry , vol.70 , Issue.6 , pp. 1513-1516
    • Sutoh, K.1    Kobata, K.2    Yazawa, S.3    Watanabe, T.4
  • 14
    • 70349139708 scopus 로고    scopus 로고
    • Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv
    • Lang YQ, Kisaka H, Sugiyama R, et al. Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet. Plant J 2009;59:953-61
    • (2009) CH-19 Sweet. Plant J , vol.59 , pp. 953-61
    • Lang, Y.Q.1    Kisaka, H.2    Sugiyama, R.3
  • 15
    • 76449114642 scopus 로고    scopus 로고
    • Newly mutated putative-aminotransferase in nonpungent pepper (Capsicum annuum) results in biosynthesis of capsinoids, capsaicinoid analogues
    • Tanaka Y, Hosokawa M, Miwa T, et al. Newly mutated putative- aminotransferase in nonpungent pepper (Capsicum annuum) results in biosynthesis of capsinoids, capsaicinoid analogues. J Agric Food Chem 2010;58:1761-7
    • (2010) J Agric Food Chem , vol.58 , pp. 1761-7
    • Tanaka, Y.1    Hosokawa, M.2    Miwa, T.3
  • 16
    • 0037777348 scopus 로고    scopus 로고
    • Chemoselective esterification of phenolic acids and alcohols
    • Appendino G, Minassi A, Daddario N, et al. Chemoselective esterification of phenolic acids and alcohols. Org Lett 2002;4:3839-41
    • (2002) Org Lett , vol.4 , pp. 3839-41
    • Appendino, G.1    Minassi, A.2    Daddario, N.3
  • 17
    • 0036483667 scopus 로고    scopus 로고
    • Enzymatic synthesis of a capsinoid by the acylation of vanillyl alcohol with fatty acid derivatives catalyzed by lipases
    • Kobata K, Kawaguchi M, Watanabe T. Enzymatic synthesis of a capsinoid by the acylation of vanillyl alcohol with fatty acid derivatives catalyzed by lipases. Biosci Biotechnol Biochem 2002;66:319-27 (Pubitemid 39251052)
    • (2002) Bioscience, Biotechnology and Biochemistry , vol.66 , Issue.2 , pp. 319-327
    • Kobata, K.1    Kawaguchi, M.2    Watanabe, T.3
  • 18
    • 77953721405 scopus 로고    scopus 로고
    • One-procedure synthesis of capsiate from capsaicin by lipase-catalyzed dynamic transacylation
    • Ishihara K, Kwon S, Masuoka N, et al. One-procedure synthesis of capsiate from capsaicin by lipase-catalyzed dynamic transacylation. World J Microbiol Biotechnol 2010;26:1337-40
    • (2010) World J Microbiol Biotechnol , vol.26 , pp. 1337-40
    • Ishihara, K.1    Kwon, S.2    Masuoka, N.3
  • 19
    • 0035464546 scopus 로고    scopus 로고
    • CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, Increased Body Temperature and Oxygen Consumption in Humans
    • DOI 10.1271/bbb.65.2033
    • Ohnuki K, Niwa S, Maeda S, et al. CH-19 Sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 2001;65:2033-6 (Pubitemid 33667821)
    • (2001) Bioscience, Biotechnology and Biochemistry , vol.65 , Issue.9 , pp. 2033-2036
    • Ohnuki, K.1    Niwa, S.2    Maeda, S.3    Inoue, N.4    Yazawa, S.5    Fushiki, T.6
  • 20
    • 33947584106 scopus 로고    scopus 로고
    • Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans
    • DOI 10.1271/bbb.60359
    • Hachiya S, Kawabata F, Ohnuki K, et al. Effects of CH-19 sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans. Biosci Biotechnol Biochem 2007;71:671-6 (Pubitemid 46481444)
    • (2007) Bioscience, Biotechnology and Biochemistry , vol.71 , Issue.3 , pp. 671-676
    • Hachiya, S.1    Kawabata, F.2    Ohnuki, K.3    Inoue, N.4    Yoneda, H.5    Yazawa, S.6    Fushiki, T.7
  • 21
    • 0035753781 scopus 로고    scopus 로고
    • Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice
    • DOI 10.1271/bbb.65.2735
    • Ohnuki K, Haramizu S, Oki K, et al. Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 2001;65:2735-40 (Pubitemid 33617864)
    • (2001) Bioscience, Biotechnology and Biochemistry , vol.65 , Issue.12 , pp. 2735-2740
    • Ohnuki, K.1    Haramizu, S.2    Oki, K.3    Watanabe, T.4    Yazawa, S.5    Fushiki, T.6
  • 23
    • 0034765055 scopus 로고    scopus 로고
    • CH-19 Sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate
    • Ohnuki K, Haramizu S, Watanabe T, et al. CH-19 sweet, non-pungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate. J Nutr Sci Vitaminol 2001;47(4):295-8 (Pubitemid 33032419)
    • (2001) Journal of Nutritional Science and Vitaminology , vol.47 , Issue.4 , pp. 295-298
    • Ohnuki, K.1    Haramizu, S.2    Watanabe, T.3    Yazawa, S.4    Fushiki, T.5
  • 24
    • 74349091894 scopus 로고    scopus 로고
    • Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice
    • Kawabata F, Inoue N, Masamoto Y, et al. Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Biosci Biotechnol Biochem 2009;73:2690-7
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 2690-7
    • Kawabata, F.1    Inoue, N.2    Masamoto, Y.3
  • 25
    • 0021737076 scopus 로고
    • Capsaicin and central control of thermoregulation
    • DOI 10.1016/0163-7258(84)90041-X
    • Hori T. Capsaicin and central control of thermoregulation. Pharmacol Ther 1984;26:389-416 (Pubitemid 15143740)
    • (1984) Pharmacology and Therapeutics , vol.26 , Issue.3 , pp. 389-416
    • Hori, T.1
  • 27
    • 0024501543 scopus 로고
    • Thermoregulatory effects of resiniferatoxin in the mouse: Comparison with capsaicin
    • DOI 10.1016/0024-3205(89)90382-2
    • de Vries DJ, Blumberg PM. Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin. Life Sci 1989;44:711-15 (Pubitemid 19065971)
    • (1989) Life Sciences , vol.44 , Issue.11 , pp. 711-715
    • De Vries, D.J.1    Blumberg, P.M.2
  • 29
    • 70349659983 scopus 로고    scopus 로고
    • The transient receptor potential vanilloid-1 channel in thermoregulation: A thermosensor it is not
    • Romanovsky AA, Almeida MC, Garami A, et al. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 2009;61:228-61
    • (2009) Pharmacol Rev , vol.61 , pp. 228-61
    • Romanovsky, A.A.1    Almeida, M.C.2    Garami, A.3
  • 30
    • 58149394253 scopus 로고    scopus 로고
    • Effects of novel capsinoid treatment on fatness and energy metabolism in humans: Possible pharmacogenetic implications
    • Snitker S, Fujishima Y, Shen HQ, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009;89:45-50
    • (2009) Am J Clin Nutr , vol.89 , pp. 45-50
    • Snitker, S.1    Fujishima, Y.2    Shen, H.Q.3
  • 31
    • 75549089629 scopus 로고    scopus 로고
    • Effect of capsinoids on energy metabolism in human subjects
    • Galgani JE, Ryan DH, Ravussin E. Effect of capsinoids on energy metabolism in human subjects. Br J Nutr 2010;103:38-42
    • (2010) Br J Nutr , vol.103 , pp. 38-42
    • Galgani, J.E.1    Ryan, D.H.2    Ravussin, E.3
  • 32
    • 78149271512 scopus 로고    scopus 로고
    • Effect of dihydrocapsiate on resting metabolic rate in humans
    • Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr 2010;92:1089-93
    • (2010) Am J Clin Nutr , vol.92 , pp. 1089-93
    • Galgani, J.E.1    Ravussin, E.2
  • 35
    • 77249166565 scopus 로고    scopus 로고
    • Assessment of the biological similarity of three capsaicin Analogs (capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits
    • Sasahara I, Furuhata Y, Iwasaki Y, et al. Assessment of the biological similarity of three capsaicin Analogs (capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. Biosci Biotechnol Biochem 2010;74:274-8
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 274-8
    • Sasahara, I.1    Furuhata, Y.2    Iwasaki, Y.3
  • 36
    • 73049104171 scopus 로고    scopus 로고
    • Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia
    • Yamasaki M, Ebihara S, Ebihara T, et al. Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia. Geriatr Gerontol Int 2010;10:107-9
    • (2010) Geriatr Gerontol Int , vol.10 , pp. 107-9
    • Yamasaki, M.1    Ebihara, S.2    Ebihara, T.3
  • 37
    • 77950368454 scopus 로고    scopus 로고
    • Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling
    • Lee EJ, Jeon MS, Kim BD, et al. Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling. Free Radical Biol Med 2010;48:1133-43
    • (2010) Free Radical Biol Med , vol.48 , pp. 1133-43
    • Lee, E.J.1    Jeon, M.S.2    Kim, B.D.3
  • 41
    • 0346338136 scopus 로고    scopus 로고
    • Roles as metabolic regulators of the non nutrients, capsaicin and capsiate, supplemented to diets
    • Iwai K, Yazawa A, Watanabe T. Roles as metabolic regulators of the non nutrients, capsaicin and capsiate, supplemented to diets. Proc Jpn Acad 2003;79B:207-12
    • (2003) Proc Jpn Acad , vol.79 B , pp. 207-12
    • Iwai, K.1    Yazawa, A.2    Watanabe, T.3
  • 42
    • 77955066391 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids, XI: Pharmacokinetic and tissue distribution study of 14C-dihydrocapsiate and metabolites in rats
    • Bernard BK, Ubukata K, Mihara R, et al. Studies of the toxicological potential of capsinoids, XI: pharmacokinetic and tissue distribution study of 14C-dihydrocapsiate and metabolites in rats. Int J Toxicol 2010;29(Suppl 2):3S-14S
    • (2010) Int J Toxicol , vol.29 , Issue.SUPPL. 2
    • Bernard, B.K.1    Ubukata, K.2    Mihara, R.3
  • 43
    • 77955084654 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids, XII: Pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats
    • Shirai Y, Ueno S, Nakayama A, et al. Studies of the toxicological potential of capsinoids, XII: pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats. Int J Toxicol 2010;29(Suppl 2):15S-21S
    • (2010) Int J Toxicol , vol.29 , Issue.SUPPL. 2
    • Shirai, Y.1    Ueno, S.2    Nakayama, A.3
  • 44
    • 57049155037 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: X. Safety assessment and pharmacokinetics of capsinoids in healthy male volunteers after a single oral ingestion of CH-19 sweet extract
    • DOI 10.1080/10915810802514476, PII 906035612
    • Bernard BK, Tsubuku S, Kayahara T, et al. Studies of the toxicological potential of capsinoids: X. Safety assessment and pharmacokinetics of capsinoids in healthy male volunteers after a single oral ingestion of CH-19 Sweet extract. Int J Toxicol 2008;27(Suppl 3):137-47 (Pubitemid 352767908)
    • (2008) International Journal of Toxicology , vol.27 , Issue.SUPPL. 3 , pp. 137-147
    • Bernard, B.K.1    Tsubuku, S.2    Kayahara, T.3    Maeda, K.4    Hamada, M.5    Nakamura, T.6    Shirai, Y.7    Nakayama, A.8    Ueno, S.9    Mihara, R.10
  • 46
    • 0029799076 scopus 로고    scopus 로고
    • Acute oral toxicity of capsaicin in mice and rats
    • Saito A, Yamamoto M. Acute oral toxicity of capsaicin in mice and rats. J Toxicol Sci 1996;21:195-200 (Pubitemid 26341645)
    • (1996) Journal of Toxicological Sciences , vol.21 , Issue.3 , pp. 195-200
    • Saito, A.1    Yamamoto, M.2
  • 47
    • 57049167686 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: VI. Single-dose toxicity study and micronucleus test of commercial-grade dihydrocapsiate
    • DOI 10.1080/10915810802513569, PII 906046942
    • Watanabe E, Kodama T, Masuyama T, et al. Studies of the toxicological potential of capsinoids: VI. Single-dose toxicity study and micronucleus test of commercial-grade dihydrocapsiate. Int J Toxicol 2008;27(Suppl 3):73-7 (Pubitemid 352767909)
    • (2008) International Journal of Toxicology , vol.27 , Issue.SUPPL. 3 , pp. 73-77
    • Watanabe, E.1    Kodama, T.2    Masuyama, T.3    Tsubuku, S.4    Nakajima, M.5    Bernard, B.K.6
  • 48
    • 57049161007 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: II. A 26-week daily gavage dosing toxicity study of CH-19 sweet extract in rats
    • DOI 10.1080/10915810802513379, PII 906039865
    • Kodama T, Watanabe E, Masuyama T, et al. Studies of the toxicological potential of capsinoids: II. A 26-week daily gavage dosing toxicity study of CH-19 Sweet extract in rats. Int J Toxicol 2008;27(Suppl 3):11-27 (Pubitemid 352767904)
    • (2008) International Journal of Toxicology , vol.27 , Issue.SUPPL. 3 , pp. 11-27
    • Kodama, T.1    Watanabe, E.2    Masuyama, T.3    Tsubuku, S.4    Otabe, A.5    Mochizuki, M.6    Bernard, B.K.7
  • 50
    • 57049154150 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: VIII. A 13-week toxicity study of commercial-grade dihydrocapsiate in rats
    • DOI 10.1080/10915810802513619, PII 906050041
    • Watanabe E, Kodama T, Masuyama T, et al. Studies of the toxicological potential of capsinoids: VIII. A 13-week toxicity study of commercial-grade dihydrocapsiate in rats. Int J Toxicol 2008;27(Suppl 3):101-18 (Pubitemid 352767911)
    • (2008) International Journal of Toxicology , vol.27 , Issue.SUPPL. 3 , pp. 101-118
    • Watanabe, E.1    Kodama, T.2    Masuyama, T.3    Tsubuku, S.4    Otabe, A.5    Mochizuki, M.6    Bernard, B.K.7
  • 51
    • 77955083572 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids XIV: A 26-week gavage toxicity study of dihydrocapsiate in rats
    • Kodama T, Masuyama T, Kayahara T, et al. Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. Int J Toxicol 2010;29:27S-54S
    • (2010) Int J Toxicol , vol.29
    • Kodama, T.1    Masuyama, T.2    Kayahara, T.3
  • 52
    • 57049137828 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids: III. A two-generation reproduction study of CH-19 sweet extract in rats
    • DOI 10.1080/10915810802513403, PII 906036279
    • Kodama T, Watanabe E, Masuyama T, et al. Studies of the toxicological potential of capsinoids: III. A two-generation reproduction study of CH-19 Sweet extract in rats. Int J Toxicol 2008;27(Suppl 3):29-39 (Pubitemid 352767903)
    • (2008) International Journal of Toxicology , vol.27 , Issue.SUPPL. 3 , pp. 29-39
    • Kodama, T.1    Watanabe, E.2    Masuyama, T.3    Tsubuku, S.4    Otabe, A.5    Katsumata, Y.6    Bernard, B.K.7
  • 53
    • 77955073658 scopus 로고    scopus 로고
    • Studies of the toxicological potential of capsinoids, XIII: Inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes
    • Takanohashi T, Isaka M, Ubukata K, et al. Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol 2010;29:22S-26S
    • (2010) Int J Toxicol , vol.29
    • Takanohashi, T.1    Isaka, M.2    Ubukata, K.3
  • 57
    • 58149520021 scopus 로고    scopus 로고
    • Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus
    • Kuramori C, Azuma M, Kume K, et al. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Biochem Biophys Res Commun 2009;379:519-25
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 519-25
    • Kuramori, C.1    Azuma, M.2    Kume, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.