Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

European Journal of Pharmaceutical Sciences

Volumn 41, Issue 5, 2010, Pages 729-735

  Hajda, Jacek ^a,b   Rentsch, Katharina M ^c   Gubler, Christoph ^a   Steinert, Hans ^a   Stieger, Bruno ^a   Fattinger, Karin ^d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Coordination Centre for Clinical Trials ^*  (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Drug interactions; Herbal medicines; MDR1; P glycoprotein; Pravastatin; Saquinavir; Simvastatin

Indexed keywords

CYTOCHROME P450 3A4; DRUG METABOLITE; ERYTHROMYCIN; GARLIC EXTRACT; GARLIPURE; GLYCOPROTEIN P; INTESTINE ENZYME; LIVER ENZYME; PRAVASTATIN; PRAVASTATIN LACTONE; SAQUINAVIR; SELIPRAN; SIMVASTATIN; SIMVASTATIN ACID; UNCLASSIFIED DRUG; VILLIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BREATH ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG COMPETITION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DUODENOSCOPY; DUODENUM BIOPSY; GASTROSCOPY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION;

ADULT; AREA UNDER CURVE; CYTOCHROME P-450 CYP3A; DUODENUM; GARLIC; GENE EXPRESSION REGULATION; HUMANS; LIVER; MALE; P-GLYCOPROTEIN; PLANT EXTRACTS; PRAVASTATIN; SAQUINAVIR; SIMVASTATIN;

EID: 78349305570     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.09.016     Document Type: Article

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