Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

Fitoterapia

Volumn 81, Issue 8, 2010, Pages 1079-1087

  Liu, Rui ^a   Zhang, Jingzhao ^b   Liu, Wencong ^a   Kimura, Yoshiyuki ^c   Zheng, Yinan ^a  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b GUIZHOU MEDICAL UNIVERSITY   (China)

^c EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

American ginseng leaves; Obese mice; Pancreatic lipase activity; PDG; Triglycerides

Indexed keywords

ANTIOBESITY AGENT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RB3; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; GINSENG; HYDROLYSIS; LIPID BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; MOUSE; NONHUMAN; OBESITY; ORGAN WEIGHT; PANAX QUINQUEFOLIUS; PANCREAS; PRIORITY JOURNAL;

ANIMALS; ANTI-OBESITY AGENTS; DIETARY FATS; FEMALE; GINSENOSIDES; MICE; MOLECULAR STRUCTURE; OBESITY; PANAX; PLANT LEAVES; SAPOGENINS;

MUS; PANAX QUINQUEFOLIUS; SUS;

EID: 78549238507     PISSN: 0367326X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fitote.2010.07.002     Document Type: Article

References (52)

1. W.S. Poston, and J.P. Foreyt Obesity is an environmental issue Atherosclerosis 146 1999 201 209
2. C. Knai, M. Suhrcke, and T. Lobstein Obesity in Eastern Europe: an overview of its health and economic implications Econ Hum Biol 5 2007 392 408
3. D. Festi, A. Colecchia, T. Sacco, M. Bondi, E. Roda, and G. Marchesini Hepatic steatosis in obese patients: clinical aspects and prognostic significance Obes Rev 5 2004 333 334
4. R.F. Kushner Medical management of obesity Semin Gastrointest Dis 13 2002 123 132
5. A.H. Goris, and K.R. Westerterp Physical activity, fat intake and body fat Physiol Behav 94 2008 164 168
6. S. Nammi, S. Koka, K.M. Chinnala, and K.M. Boini Obesity: an overview on its current perspectives and treatment Options Nutr J 3 2004 1 8
7. M. Mukherjee Human digestive and metabolic lipases-a brief review J Mol Catal B Enzym 22 2003 369 376
8. C.J. Billington, J.E. Briggs, S. Harker, M. Grace, and A.S. Levine Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism Am J Physiol 266 1994 R1765 R1770
9. M.L. Drent, I. Larsson, T. William-Olsson, F. Quaade, F. Czubayko, and K. Von Bergmann Orlistat (RO 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study Int J Obes Relat Metab Disord 19 1995 221 226
10. P. Hadváry, H. Lengsfeld, and H. Wolfer Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin Biochem J 256 1988 357 361
11. J.B. Hauptman, F.S. Jeunet, and D. Hartmann Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin) Am J Clin Nutr 55 1992 309 313
12. L. Sjöström, A. Rissanen, T. Andersen, M. Boldrin, A. Golay, and H.P. Koppeschaar Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients Labcet 352 1998 167 172
13. L.K. Han, Y. Kimura, M. Kawashima, T. Takaku, T. Taniyama, and T. Hayashi Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor Int J Obes Relat Metab Disord 25 2001 1459 1464
14. L.K. Han, T. Takaku, J. Li, Y. Kimura, and H. Okuda Anti-obesity action of oolong tea Int J Obes Relat Metab Disord 23 1999 98 105
15. L.K. Han, Y.N. Zheng, B.J. Xu, H. Okuda, and Y. Kimura Saponins from Platycodi Radix ameliorate high fat dietinduced obesity in mice J Nutr 132 2002 2241 2245
16. L.K. Han, Y.N. Zheng, M. Yoshikawa, H. Okuda, and Y. Kimura Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes BMC Complement Altern Med 5 2005 9 18
17. B.J. Xu, L.K. Han, Y.N. Zheng, J.H. Lee, and C.K. Sung In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase Arch Pharm Res 28 2005 180 185
18. H. Kimura, S. Ogawa, M. Jisaka, Y. Kimura, T. Katsube, and K. Yokota Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity J Pharm Biomed Anal 41 2006 1657 1665
19. C.S. Kwon, H.Y. Sohn, S.H. Kim, J.H. Kim, K.H. Son, and J.S. Lee Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents Biosci Biotechnol Biochem 67 2003 1451 1456
20. H. Kurihara, S. Asami, H. Shibata, H. Fukami, and T. Tanaka Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice Biol Pharm Bull 26 2003 383 385 (Pubitemid 39663631)
21. M. Nakai, Y. Fukui, S. Asami, Y. Toyoda-Ono, T. Iwashita, and H. Shibata Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro J Agric Food Chem 53 2005 4593 4598
22. K. Yoshizumi, K. Hirano, H. Ando, Y. Hirai, Y. Ida, and T. Tsuji Lupane type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase J Agric Food Chem 54 2006 335 341
23. T.K. Yun, Y.S. Lee, H.Y. Kwon, and K.J. Choi Saponin contents and anticarcinogenic effects of ginseng depending on types and ages in mice Acta Pharmacol Sin 17 1996 293 298
24. V. Vuksan, J.L. Sievenpiper, V.Y. Koo, T. Francis, U. Beljan-Zdravkovic, and Z. Xu American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus Arch Intern Med 160 2000 1009 1013
25. C.F. Chen, W.F. Chiou, and J.T. Zhang Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium Acta Pharmacol Sin 29 2008 1103 1108
26. C.Z. Wang, and C.S. Yuan Potential role of ginseng in the treatment of colorectal cancer Am J Chin Med 36 2008 1019 1028
27. W.C. Liu, Y.N. Zheng, L.K. Han, H.M. Wang, M. Saito, and M.S. Ling Saponins (ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice Phytomedicine 15 2008 1140 1145
28. J.T. Hwang, S.H. Kim, M.S. Lee, S.H. Kim, H.J. Yang, and M.J. Kim Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3 T3-L1 adipocyte Biochem Biophys Res Commun 364 2007 1002 1008
29. J.T. Xie, S.R. Mehendale, A. Wang, A.H. Han, J.A. Wu, and J. Osinski American ginseng leaf: ginsenoside analysis and hypoglycemic activity Pharmacol Res 49 2004 113 117
30. S.N. Yun, S.J. Moon, S.K. Ko, B.O. Im, and S.H. Chung Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice Arch Pham Res 27 2004 790 796
31. H.J. Zhang, Y.J. Wu, and Y.Y. Cheng Analysis of 'SHENMAI' injection by HPLC/MS/MS J Pharm Biomed Anal 31 2003 175 183
32. Y. Zhao, B. Chen, X.B. Luo, G.F. Zhan, and S.Z. Yao Study on separation and purification process of Panaxdiol type ginsenosides and panaxtriol type ginsenosides with macroporous adsorption resin Nat Prod Res Dev 16 2004 235 238
33. J. Zapf, E. Schoenle, M. Waldvoge, M. Sand, and E.R. Foresch Effects of trypsin treatment of rat adipocyte on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor Eur J Biochem 133 1981 605 609
34. T. Tsujita, and H. Okuda Carboxylestrase in rat and human sera and their relationship to serum aryl acylamidases and cholinesterase Eur J Biochem 133 1983 215 220
35. Y. Gargouri, R. Julien, G. Pieroni, R. Verger, and L. Sarda Studies on the inhibition of pancreatic and microbial lipases by soybean proteins J Lipid Res 25 1984 1214 1221
36. M.E. Lowe Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion Gastroenterology 107 1994 1524 1536
37. R.B. Birari, and K.K. Bhutani Pancreatic lipase inhibitors from natural sources: unexplored potential Drug Discov Today 12 2007 879 889
38. G.S. Sidhu, and D.G. Oakenfull A mechanism for the hypocholesterolaemic activity of saponins Br J Nutr 55 1986 643 649
39. A. Larsson, and C. Erlanson-Albertson Effect of phosphatidylcholine and free fatty acids on the activity of pancreatic lipase-colipase Biochim Biophys Acta 876 3 1986 543 550
40. J.K. Embleton, and C.W. Poutonb Structure and function of gastro-intestinal lipases Adv Drug Deliv Rev 25 1997 15 32
41. C.I. Coleman, J.H. Hebert, and P. Reddy The effects of Panax ginseng on quality of life J Clin Pharm Ther 28 2003 5 15
42. N. Karu, R. Reifen, and Z. Kerem Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor J Agric Food Chem 55 2007 2824 2828
43. J.H. Kim, D.H. Hahm, D.C. Yang, J.H. Kim, H.J. Lee, and I. Shim Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat J Pharmacol Sci 97 2005 124 131
44. J.H. Kim, S.A. Kang, S.M. Han, and I. Shim Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng Phytother Res 23 2009 78 85
45. S. Arora Anubhuti. Role of neuropeptides in appetite regulation and obesity-A review Neuropeptides 40 2006 375 401
46. D.E. Cummings Ghrelin and the short- and long-term regulation of appetite and body weight Physiol Behav 89 2006 71 84
47. M. Kojima, H. Hosoda, and K. Kangawa Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach Best Pract Res Clin Endocrinol Metab 18 2004 517 530
48. P.J. Taylor, and K.K. McClanahan Book review (Treatment of the obese patient) J Pediar Adolesc Gynecol 22 2009 e174 e182
49. L.H. Van der Ploeg Obesity: an epidemic in need of therapeutics Curr Opin Chem Biol 4 2000 452 460
50. S. Klein The case of visceral fat: argument for the defense J Clin Invest 113 2004 1530 1532
51. F. Paccaud, V. Schiuter-Fasmeyer, V. Wietlisbach, and P. Bovet Dyslipidemia and abdominal obesity: an assessment in three general populations J Clin Epid 53 2000 393 400
52. S.H. Kim, and K.S. Park Effects of Panax ginseng extract on lipid metabolism in humans Pharmacol Res 48 2003 511 513