-
1
-
-
0026873446
-
Azithromycin and clarithromycin: Overview and comparison with erythromycin
-
Whitman, M. S.; Tunkel, A. R. Azithromycin and clarithromycin: overview and comparison with erythromycin. Infect. Control Hosp. Epidemiol. 1992, 13, 357-368.
-
(1992)
Infect. Control Hosp. Epidemiol.
, vol.13
, pp. 357-368
-
-
Whitman, M.S.1
Tunkel, A.R.2
-
2
-
-
0035840852
-
Anti-inflammatory effects of macrolide antibiotics
-
DOI 10.1016/S0014-2999(01)01321-8, PII S0014299901013218
-
Culic, O.; Erakovic, V.; Parnham, M. J. Anti-inflammatory effects of macrolide antibiotics. Eur. J. Pharmacol. 2001, 429, 209-229. (Pubitemid 33043997)
-
(2001)
European Journal of Pharmacology
, vol.429
, Issue.1-3
, pp. 209-229
-
-
Uli, O.1
Erakovi, V.2
Parnham, M.J.3
-
3
-
-
39549115019
-
Macrolide antibiotics as immunomodulatory medications: Proposed mechanisms of action
-
Shinkai, M.; Henke, M. O.; Rubin, B. K. Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action. Pharmacol. Ther. 2008, 117, 393-405.
-
(2008)
Pharmacol. Ther.
, vol.117
, pp. 393-405
-
-
Shinkai, M.1
Henke, M.O.2
Rubin, B.K.3
-
4
-
-
0033988530
-
Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer
-
Hamada, K.; Mikasa, K.; Yunou, Y.; Kurioka, T.; Majima, T.; Narita, N.; Kita, E. Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer. Chemotherapy 2000, 46, 49-61. (Pubitemid 30009334)
-
(2000)
Chemotherapy
, vol.46
, Issue.1
, pp. 49-61
-
-
Hamada, K.1
Mikasa, K.2
Yunou, Y.3
Kurioka, T.4
Majima, T.5
Narita, N.6
Kita, E.7
-
5
-
-
0030992340
-
Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin
-
Mikasa, K.; Sawaki, M.; Kita, E.; Hamada, K.; Teramoto, S.; Sakamoto, M.; Maeda, K.; Konishi, M.; Narita, N. Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin. Chemotherapy 1997, 43, 288-296. (Pubitemid 27230874)
-
(1997)
Chemotherapy
, vol.43
, Issue.4
, pp. 288-296
-
-
Mikasa, K.1
Sawaki, M.2
Kita, E.3
Hamada, K.4
Teramoto, S.5
Sakamoto, M.6
Maeda, K.7
Konishi, M.8
Narita, N.9
-
6
-
-
0031889731
-
Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in Western Kenya
-
Andersen, S. L.; Oloo, A. J.; Gordon, D. M.; Ragama, O. B.; Aleman, G. M.; Berman, J. D.; Tang, D. B.; Dunne, M. W.; Shanks, G. D. Successful double-blinded, randomized, placebocontrolled field trial of azithromycin and doxycycline as prophylaxis for malaria in Western Kenya. Clin. Infect. Dis. 1998, 26, 146-150. (Pubitemid 28068169)
-
(1998)
Clinical Infectious Diseases
, vol.26
, Issue.1
, pp. 146-150
-
-
Andersen, S.L.1
Oloo, A.J.2
Gordon, D.M.3
Ragama, O.B.4
Aleman, G.M.5
Berman, J.D.6
Tang, D.B.7
Dunne, R.I.W.8
Shanks, G.D.9
-
7
-
-
0033033620
-
Malaria prophylaxis using azithromycin: A double-blind, placebo- controlled trial in Irian Jaya, Indonesia
-
Taylor, W. R.; Richie, T. L.; Fryauff, D. J.; Picarima, H.; Ohrt, C.; Tang, D.; Braitman, D.; Murphy, G. S.; Widjaja, H.; Tjitra, E.; Ganjar, A.; Jones, T. R.; Basri, H.; Berman, J. Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. Clin. Infect. Dis. 1999, 28, 74-81. (Pubitemid 29246129)
-
(1999)
Clinical Infectious Diseases
, vol.28
, Issue.1
, pp. 74-81
-
-
Taylor, W.R.J.1
Richie, T.L.2
Fryauff, D.J.3
Picarima, H.4
Ohrt, C.5
Tang, D.6
Braitman, D.7
Murphy, G.S.8
Widjaja, H.9
Tjitra, E.10
Ganjar, A.11
Jones, T.R.12
Basri, H.13
Berman, J.14
-
8
-
-
58849152194
-
Long-term macrolide therapy in chronic inflammatory airway diseases
-
Crosbie, P. A.; Woodhead, M. A. Long-term macrolide therapy in chronic inflammatory airway diseases. Eur. Respir. J. 2009, 33, 171-181.
-
(2009)
Eur. Respir. J.
, vol.33
, pp. 171-181
-
-
Crosbie, P.A.1
Woodhead, M.A.2
-
9
-
-
19544366269
-
Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin
-
DOI 10.1128/AAC.49.6.2372-2377.2005
-
Bosnar, M.; Kelneric, Z.; Munic, V.; Erakovic, V.; Parnham, M. J. Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. Antimicrob. Agents Chemother. 2005, 49, 2372-2377. (Pubitemid 40734469)
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, Issue.6
, pp. 2372-2377
-
-
Bosnar, M.1
Kelneric, Z.2
Munic, V.3
Erakovic, V.4
Parnham, M.J.5
-
10
-
-
0032841480
-
The new ketolide HMR3647 accumulates in the azurophil granules of human polymorphonuclear cells
-
Miossec-Bartoli, C.; Pilatre, L.; Peyron, P.; N'Diaye, E. N. Collart-Dutilleul, V.; Maridonneau-Parini, I.; Diu-Hercend, A. The new ketolide HMR3647 accumulates in the azurophil granules of human polymorphonuclear cells. Antimicrob. Agents Chemother. 1999, 43, 2457-2462. (Pubitemid 29471227)
-
(1999)
Antimicrobial Agents and Chemotherapy
, vol.43
, Issue.10
, pp. 2457-2462
-
-
Miossec-Bartoli, C.1
Pilatre, L.2
Peyron, P.3
N'Diaye, E.-N.4
Collart-Dutilleul, V.5
Maridonneau-Parini, I.6
Diu-Hercend, A.7
-
11
-
-
0024336748
-
Interaction of azithromycin and human phagocytic cells. Uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes
-
Wildfeuer, A.; Laufen, H.; Muller-Wening, D.; Haferkamp, O. Interaction of azithromycin and human phagocytic cells. Uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes. Arzneim.-Forsch. 1989, 39, 755-758. (Pubitemid 19176330)
-
(1989)
Arzneimittel-Forschung/Drug Research
, vol.39
, Issue.7
, pp. 755-758
-
-
Wildfeuer, A.1
Laufen, H.2
Muller-Wening, D.3
Haferkamp, O.4
-
12
-
-
0027522528
-
Uptake and subcellular distribution of azithromycin in human phagocytic cells. Demonstration of the antibiotic in neutrophil polymorphonuclear leucocytes and monocytes by autoradiography and electron microscopy
-
Wildfeuer, A.; Reisert, I.; Laufen, H. Uptake and subcellular distribution of azithromycin in human phagocytic cells. Demonstration of the antibiotic in neutrophil polymorphonuclear leucocytes and monocytes by autoradiography and electron microscopy. Arzneim.-Forsch. 1993, 43, 484-486. (Pubitemid 23112991)
-
(1993)
Arzneimittel-Forschung/Drug Research
, vol.43
, Issue.4
, pp. 484-486
-
-
Wildfeuer, A.1
Reisert, I.2
Laufen, H.3
-
13
-
-
0023481181
-
Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells
-
Carlier, M. B.; Zenebergh, A.; Tulkens, P. M. Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells. J. Antimicrob. Chemother. 1987, 20 (Suppl. B), 47-56. (Pubitemid 18003048)
-
(1987)
Journal of Antimicrobial Chemotherapy
, vol.20
, Issue.SUPPL. B
, pp. 47-56
-
-
Carlier, M.-B.1
Zenebergh, A.2
Tulkens, P.M.3
-
14
-
-
0030840528
-
Cellular accumulation of the new ketolide RU 64004 by human neutrophils: Comparison with that of azithromycin and roxithromycin
-
Vazifeh, D; Abdelghaffar, H; Labro, M. T. Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin. Antimicrob. Agents Chemother. 1997, 41, 2099-2107. (Pubitemid 27422197)
-
(1997)
Antimicrobial Agents and Chemotherapy
, vol.41
, Issue.10
, pp. 2099-2107
-
-
Vazifeh, D.1
Abdelghaffar, H.2
Labro, M.T.3
-
16
-
-
0002078065
-
Advanced-generation macrolides: Tissue-directed antibiotics
-
PII S0924857901004101
-
Amsden, G. W. Advanced-generation macrolides: tissue-directed antibiotics. Int. J. Antimicrob. Agents 2001, 18 (Suppl. 1), S11-S15. (Pubitemid 33713497)
-
(2001)
International Journal of Antimicrobial Agents
, vol.18
, Issue.SUPPL.1
-
-
Amsden, G.W.1
-
17
-
-
4544300195
-
The macrolide antibiotics: A pharmacokinetic and pharmacodynamic overview
-
DOI 10.2174/1381612043383322
-
Jain, R.; Danziger, L. H. The macrolide antibiotics: a pharmacokinetic and pharmacodynamic overview. Curr. Pharm. Des. 2004, 10, 3045-3053. (Pubitemid 39242900)
-
(2004)
Current Pharmaceutical Design
, vol.10
, Issue.25
, pp. 3045-3053
-
-
Jain, R.1
Danziger, L.H.2
-
18
-
-
44949134801
-
The impact of natural products upon modern drug discovery
-
Ganesan, A. The impact of natural products upon modern drug discovery. Curr. Opin. Chem. Biol. 2008, 12, 306-317.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 306-317
-
-
Ganesan, A.1
-
19
-
-
39749181550
-
Generation of a set of simple, interpretable ADMET rules of thumb
-
DOI 10.1021/jm701122q
-
Gleeson, M. P. Generation of a set of simple, interpretable ADMET rules of thumb. J. Med. Chem. 2008, 51, 817-834. (Pubitemid 351304691)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.4
, pp. 817-834
-
-
Gleeson, M.P.1
-
20
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
DOI 10.1038/nrd2445, PII NRD2445
-
Leeson, P. D.; Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat. Rev. Drug Discovery 2007, 6, 881-890. (Pubitemid 350042396)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.11
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
21
-
-
62849112750
-
Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds
-
Mannhold, R; Poda, G. I.; Ostermann, C; Tetko, I. V. Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds. J. Pharm. Sci. 2009, 98, 861-893.
-
(2009)
J. Pharm. Sci.
, vol.98
, pp. 861-893
-
-
Mannhold, R.1
Poda, G.I.2
Ostermann, C.3
Tetko, I.V.4
-
22
-
-
0023493448
-
Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution
-
Girard,A. E.;Girard,D; English,A.R.;Gootz, T.D.;Cimochowski, C. R.; Faiella, J. A.; Haskell, S. L.; Retsema, J. A. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrob. Agents Chemother. 1987, 31, 1948-1954. (Pubitemid 18009567)
-
(1987)
Antimicrobial Agents and Chemotherapy
, vol.31
, Issue.12
, pp. 1948-1954
-
-
Girard, A.E.1
Girard, D.2
English, A.R.3
Gootz, T.D.4
Cimochowski, C.R.5
Faiella, J.A.6
Haskell, S.L.7
Retsema, J.A.8
-
23
-
-
0000607945
-
Chromatographic hydrophobicity index by fast-gradient RP-HPLC: A high-throughput alternative to log P/log D
-
Valko, K.; Bevan, C.; Reynolds, D. Chromatographic hydrophobicity index by fast-gradient RP-HPLC: a high-throughput alternative to logP/logD. Anal. Chem. 1997, 69, 2022-2029. (Pubitemid 127698689)
-
(1997)
Analytical Chemistry
, vol.69
, Issue.12
, pp. 2022-2029
-
-
Valko, K.1
-
24
-
-
0033818097
-
Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: Comparison with other lipophilicity measures
-
Valko, K.; Du, C. M.; Bevan, C. D.; Reynolds, D. P.; Abraham, M. H. Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures. J. Pharm. Sci. 2000, 89, 1085-1096.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 1085-1096
-
-
Valko, K.1
Du, C.M.2
Bevan, C.D.3
Reynolds, D.P.4
Abraham, M.H.5
-
25
-
-
0000591590
-
Synthesis and structure elucidation of 10-dihydro-10-deoxo-11-methyl-11- azaerythromycin A
-
Djokic, S.; Kobrehel, G.; Lopotar, N.; Kamenar, B.; Nagl, A.; Mrvos, D. Synthesis and structure elucidation of 10-dihydro-10-deoxo-11-methyl-11- azaerythromycin A. J. Chem. Res., Synop. 1988, 152-153.
-
(1988)
J. Chem. Res. Synop.
, pp. 152-153
-
-
Djokic, S.1
Kobrehel, G.2
Lopotar, N.3
Kamenar, B.4
Nagl, A.5
Mrvos, D.6
-
26
-
-
0021329213
-
Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A
-
Morimoto, S.; Takahashi, Y.; Watanabe, Y.; Omura, S. Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A. J. Antibiot. (Tokyo) 1984, 37, 187-189. (Pubitemid 14195348)
-
(1984)
Journal of Antibiotics
, vol.37
, Issue.2
, pp. 187-189
-
-
Morimoto, S.1
Takahashi, Y.2
Watanabe, Y.3
Omura, S.4
-
27
-
-
33846815536
-
Synthesis and antibacterial activity of isomeric 15-membered azalides
-
Alihodzic, S.; Fajdetic, A.; Kobrehel, G.; Lazarevski, G.; Mutak, S.; Pavlovic, D.; Stimac, V.; Cipcic, H.; Kramaric,M.D.; Erakovic, V.; Hasenohrl, A.; Marsic, N.; Schoenfeld, W. Synthesis and antibacterial activity of isomeric 15-membered azalides. J Antibiot. (Tokyo) 2006, 59, 753-769. (Pubitemid 46212493)
-
(2006)
Journal of Antibiotics
, vol.59
, Issue.12
, pp. 753-769
-
-
Alihodzic, S.1
Fajdetic, A.2
Kobrehel, G.3
Lazarevski, G.4
Mutak, S.5
Pavlovic, D.6
Stimac, V.7
Cipcic, H.8
Kramaric, M.D.9
Erakovic, V.10
Hasenohrl, A.11
Marsic, N.12
Schoenfeld, W.13
-
28
-
-
79851496989
-
-
WO 2006087644
-
Culic, O.; Bosnar, M.; Marjanovic, N.; Jelic, D.; Alihodzic, S.; Vela, V.; Marusic-Istuk, Z.; Erakovic, V.; Bosnjak, B.; Hrvacic, B.; Tomaskovic, M.; Munic, V.; Ivetic, V.; Hutinec, A.; Kragol, G.; Leljak, M. Macrolides with Anti-Inflammatory Activity. WO 2006087644, 2006.
-
(2006)
Macrolides with Anti-Inflammatory Activity
-
-
Culic, O.1
Bosnar, M.2
Marjanovic, N.3
Jelic, D.4
Alihodzic, S.5
Vela, V.6
Marusic-Istuk, Z.7
Erakovic, V.8
Bosnjak, B.9
Hrvacic, B.10
Tomaskovic, M.11
Munic, V.12
Ivetic, V.13
Hutinec, A.14
Kragol, G.15
Leljak, M.16
-
29
-
-
0029406724
-
Molecular similarity based on novel atom type electrotopological state indices
-
Hall, L. H.; Kier, L. B.; Brown, B. B. Molecular similarity based on novel atom type electrotopological state indices. J. Chem. Inf. Comput. Sci. 1995, 35, 1074-1080.
-
(1995)
J. Chem. Inf. Comput. Sci.
, vol.35
, pp. 1074-1080
-
-
Hall, L.H.1
Kier, L.B.2
Brown, B.B.3
-
30
-
-
0033062152
-
Hydrogen bonding part 46: A review of the correlation and prediction of transport properties by an LFER method: Physicochemical properties, brain penetration and skin permeability
-
DOI 10.1002/(SICI)1096-9063(199901)55:1<78::AID-PS853>3.0.CO;2-7
-
Abraham, M. H.; Chadha, H. S.; Martins, F.; Mitchell, R. C.; Bradbury, M. W.; Gratton, J. A. Hydrogen bonding. Part 46: A review of the correlation and prediction of transport properties by an LFER method: physicochemical properties, brain penetration and skin permeability. Pestic. Sci. 1999, 55, 78-88. (Pubitemid 29090796)
-
(1999)
Pesticide Science
, vol.55
, Issue.1
, pp. 78-88
-
-
Abraham, M.H.1
Chadha, H.S.2
Martins, F.3
Mitchell, R.C.4
Bradbury, M.W.5
Gratton, J.A.6
-
31
-
-
0040524262
-
Estimation of molecular linear free energy relation descriptors using a group contribution approach
-
Platts, J. A.; Abraham, M. H.; Butina, D.; Hersey, A. Estimation of molecular linear free energy relation descriptors using a group contribution approach. J. Chem. Inf. Comput. Sci. 1999, 39, 835-845.
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 835-845
-
-
Platts, J.A.1
Abraham, M.H.2
Butina, D.3
Hersey, A.4
-
32
-
-
0345306239
-
Quantitative relationship between rat intestinal absorption and Abraham descriptors
-
DOI 10.1016/j.ejmech.2003.07.005
-
Zhao, Y. H.; Abraham, M. H.; Hersey, A.; Luscombe, C. N. Quantitative relationship between rat intestinal absorption and Abraham descriptors. Eur. J. Med. Chem. 2003, 38, 939-947. (Pubitemid 37452421)
-
(2003)
European Journal of Medicinal Chemistry
, vol.38
, Issue.11-12
, pp. 939-947
-
-
Zhao, Y.H.1
Abraham, M.H.2
Hersey, A.3
Luscombe, C.N.4
-
33
-
-
33845370513
-
Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning
-
DOI 10.1021/jm050957i
-
Hollosy, F.; Valko, K.; Hersey, A.; Nunhuck, S.; Keri, G.; Bevan, C. Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning. J. Med. Chem. 2006, 49, 6958-6971. (Pubitemid 44885984)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.24
, pp. 6958-6971
-
-
Hollosy, F.1
Valko, K.2
Hersey, A.3
Nunhuck, S.4
Keri, G.5
Bevan, C.6
-
34
-
-
71049189272
-
Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides
-
Lan, T; Rao, A; Haywood, J; Davis, C. B.; Han, C; Garver, E; Dawson, P. A. Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides. Drug Metab. Dispos. 2009, 37, 2375-2382.
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 2375-2382
-
-
Lan, T.1
Rao, A.2
Haywood, J.3
Davis, C.B.4
Han, C.5
Garver, E.6
Dawson, P.A.7
-
35
-
-
2342635206
-
Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution
-
DOI 10.1016/j.chroma.2003.10.084, PII S0021967303019095
-
Valko, K. Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution. J. Chromatogr., A 2004, 1037, 299-310. (Pubitemid 38591346)
-
(2004)
Journal of Chromatography A
, vol.1037
, Issue.1-2
, pp. 299-310
-
-
Valko, K.1
-
36
-
-
0036227660
-
Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: A physiologically based pharmacokinetic model
-
DOI 10.1358/mf.2002.24.2.677131
-
Yokogawa, K.; Ishizaki, J.; Ohkuma, S.; Miyamoto, K. Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model. Methods Find. Exp. Clin. Pharmacol. 2002, 24, 81-93. (Pubitemid 34310988)
-
(2002)
Methods and Findings in Experimental and Clinical Pharmacology
, vol.24
, Issue.2
, pp. 81-93
-
-
Yokogawa, K.1
Ishizaki, J.2
Ohkuma, S.3
Miyamoto, K.-I.4
-
37
-
-
0016260069
-
Lysosomotropic agents
-
de Duve, C.; de Barsy, T.; Poole, B.; Trouet, A.; Tulkens, P.; Van, H. F. Commentary. Lysosomotropic agents. Biochem. Pharmacol. 1974, 23, 2495-2531.
-
(1974)
Biochem. Pharmacol.
, vol.23
, pp. 2495-2531
-
-
De Duve, C.1
De Barsy, T.2
Poole, B.3
Trouet, A.4
Tulkens, P.5
Commentary, F.V.H.6
-
38
-
-
51849153232
-
Quantitative modeling of selective lysosomal targeting for drug design
-
Trapp, S.; Rosania, G. R.; Horobin, R. W.; Kornhuber, J. Quantitative modeling of selective lysosomal targeting for drug design. Eur. Biophys. J. 2008, 37, 1317-1328.
-
(2008)
Eur. Biophys. J.
, vol.37
, pp. 1317-1328
-
-
Trapp, S.1
Rosania, G.R.2
Horobin, R.W.3
Kornhuber, J.4
-
39
-
-
28544452083
-
A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict
-
DOI 10.1021/mp050043s
-
Duvvuri, M.; Krise, J. P. A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict. Mol. Pharmaceutics 2005, 2, 440-448. (Pubitemid 43016385)
-
(2005)
Molecular Pharmaceutics
, vol.2
, Issue.6
, pp. 440-448
-
-
Duvvuri, M.1
Krise, J.P.2
-
40
-
-
0026531107
-
Adipose tissue distribution and chemical structure of basic lipophilic drugs: Desipramine N-acetyl desipramine, and haloperidol
-
Moor, M. J.; Steiner, S. H.; Jachertz, G.; Bickel, M. H. Adipose tissue distribution and chemical structure of basic lipophilic drugs: desipramine, N-acetyl desipramine, and haloperidol. Pharmacol. Toxicol. 1992, 70, 121-124.
-
(1992)
Pharmacol. Toxicol.
, vol.70
, pp. 121-124
-
-
Moor, M.J.1
Steiner, S.H.2
Jachertz, G.3
Bickel, M.H.4
-
41
-
-
34247490248
-
Lysosomal sequestration of amine-containing drugs: Analysis and therapeutic implications
-
DOI 10.1002/jps.20792
-
Kaufmann, A. M.; Krise, J. P. Lysosomal sequestration of aminecontaining drugs: analysis and therapeutic implications. J. Pharm. Sci. 2007, 96, 729-746. (Pubitemid 46657864)
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, Issue.4
, pp. 729-746
-
-
Kaufmann, A.M.1
Krise, J.P.2
-
42
-
-
0023792145
-
The potential role of lysosomes in tissue distribution of weak bases
-
MacIntyre, A. C.; Cutler, D. J. The potential role of lysosomes in tissue distribution of weak bases. Biopharm. Drug Dispos. 1988, 9, 513-526.
-
(1988)
Biopharm. Drug Dispos.
, vol.9
, pp. 513-526
-
-
MacIntyre, A.C.1
Cutler, D.J.2
-
43
-
-
0023711888
-
Synthesis in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a- homoerythromycin A derivatives; A new class of macrolide antibiotics, the azalides
-
Bright, G.M.;Nagel, A.A.; Bordner, J.;Desai, K.A.;Dibrino, J.N.; Nowakowska, J.; Vincent, L.; Watrous, R. M.; Sciavolino, F. C.; English, A. R. Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a- homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides. J. Antibiot. (Tokyo) 1988, 41, 1029-1047.
-
(1988)
J. Antibiot. (Tokyo)
, vol.41
, pp. 1029-1047
-
-
Bright, G.M.1
Nagel, A.A.2
Bordner, J.3
Desai, K.A.4
Dibrino, J.N.5
Nowakowska, J.6
Vincent, L.7
Watrous, R.M.8
Sciavolino, F.C.9
English, A.R.10
-
44
-
-
79851479941
-
-
WO 2004005310
-
Mercep, M.; Mesic, M.; Tomaskovic, L.; Markovic, S.; Makaruha, O.; Poljak, V. Preparation of Steroid-Containing Macrolide Erythromycin Analog Glycosides for Treatment of Inflammatory Diseases. WO 2004005310, 2004.
-
(2004)
Preparation of Steroid-containing Macrolide Erythromycin Analog Glycosides for Treatment of Inflammatory Diseases
-
-
Mercep, M.1
Mesic, M.2
Tomaskovic, L.3
Markovic, S.4
Makaruha, O.5
Poljak, V.6
-
45
-
-
77954761478
-
Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays
-
Munić, V; Kelnerić, Z; Mikac, L; Eraković Haber, V. Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur. J. Pharm. Sci. 2010, 41, 86-95.
-
(2010)
Eur. J. Pharm. Sci.
, vol.41
, pp. 86-95
-
-
Munić, V.1
Kelnerić, Z.2
Mikac, L.3
Eraković Haber, V.4
-
46
-
-
15444352573
-
Quantitative structure-activity relationships among macrolide antibacterial agents: In vitro and in vivo potency against Pasteurella multocida
-
DOI 10.1021/jm960436i
-
McFarland, J. W.; Berger, C. M.; Froshauer, S. A.; Hayashi, S. F.; Hecker, S. J.; Jaynes, B. H.; Jefson, M. R.; Kamicker, B. J.; Lipinski, C. A.; Lundy, K. M.; Reese, C. P.; Vu, C. B. Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. J. Med. Chem. 1997, 40, 1340-1346. (Pubitemid 27198081)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.9
, pp. 1340-1346
-
-
McFarland, J.W.1
Berger, C.M.2
Froshauer, S.A.3
Hayashi, S.F.4
Hecker, S.J.5
Jaynes, B.H.6
Jefson, M.R.7
Kamicker, B.J.8
Lipinski, C.A.9
Lundy, K.M.10
Reese, C.P.11
Vu, C.B.12
-
47
-
-
33645079631
-
Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery
-
Bhattachar, S. N.; Wesley, J. A.; Seadeek, C. Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery. J. Pharm. Biomed. Anal. 2006, 41, 152-157.
-
(2006)
J. Pharm. Biomed. Anal.
, vol.41
, pp. 152-157
-
-
Bhattachar, S.N.1
Wesley, J.A.2
Seadeek, C.3
-
48
-
-
0035069173
-
Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility
-
Pan, L.;Ho, Q.;Tsutsui, K.;Takahashi, L. Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci. 2001, 90, 521-529.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 521-529
-
-
Pan, L.1
Ho, Q.2
Tsutsui, K.3
Takahashi, L.4
-
49
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
DOI 10.1021/jm020017n
-
Veber, D. F.; Johnson, S. R.; Cheng, H. Y.; Smith, B. R.; Ward, K. W.; Kopple, K. D. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 2002, 45, 2615-2623. (Pubitemid 34595232)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.12
, pp. 2615-2623
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.-Y.3
Smith, B.R.4
Ward, K.W.5
Kopple, K.D.6
-
51
-
-
0000087715
-
Multiple regression as a general data-analytic system
-
Cohen, J. Multiple regression as a general data-analytic system. Psychol. Bull. 1968, 70, 426-443.
-
(1968)
Psychol. Bull.
, vol.70
, pp. 426-443
-
-
Cohen, J.1
|