Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

Toxicology

Volumn 271, Issue 1-2, 2010, Pages 57-63

  Liu, Li ^a,b   Jiang, Zhenzhou ^a   Liu, Jing ^a   Huang, Xin ^a   Wang, Tao ^a   Liu, Jun ^a   Zhang, Yun ^a   Zhou, Zhixing ^a   Guo, Jianlu ^a   Yang, Lina ^a   Chen, Yun ^c   Zhang, Luyong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b YANGZHOU UNIVERSITY   (China)

^c INSTITUTE OF DERMATOLOGY   (China)

Author keywords

CYP3A2; Hepatic cytochrome P450; Metabolism; Sex difference; Subacute toxicity; Triptolide

Indexed keywords

CYTOCHROME P450 2B; CYTOCHROME P450 3A; TRIPTOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIARRHEA; DRUG DOSE COMPARISON; DRUG METABOLISM; DRUG STRUCTURE; FATTY LIVER; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SEX DIFFERENCE; SPLENOMEGALY; TOXICITY TESTING;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2B1; DEXAMETHASONE; DITERPENES; ENZYME INHIBITORS; EPOXY COMPOUNDS; FEMALE; KETOCONAZOLE; LIVER; MALE; MEMBRANE PROTEINS; MICROSOMES, LIVER; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

RATTUS; TRIPTERYGIUM WILFORDII;

EID: 77951297155     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.03.004     Document Type: Article

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