Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures

Applied Microbiology and Biotechnology

Volumn 88, Issue 2, 2010, Pages 437-449

  Wang, Jian Wen ^a   Wu, Jian Yong ^b  

^a SOOCHOW UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Biosynthesis; Elicitation; Production processes; Salvia miltiorrhiza; Tanshinones; Tissue cultures

Indexed keywords

ADVENTITIOUS ROOT; BIOACTIVE COMPOUNDS; BIOTECHNOLOGICAL PROCESS; BIOTECHNOLOGICAL PRODUCTION; CARDIO-VASCULAR DISEASE; CELL SUSPENSION; CHINESE MEDICINES; DITERPENES; DRUG CANDIDATES; ELICITATION; FEEDING OPERATIONS; FUTURE TRENDS; HAIRY ROOT CULTURE; HUMAN DISEASE; IN-CELL; IN-VITRO; KEY ENZYMES; LAMIACEAE; MEDIUM OPTIMIZATION; MEVALONATE; MILTIORRHIZA; MODERN MEDICINE; PHARMACOLOGICAL ACTIVITY; PLANT ROOTS; PLANT TISSUE CULTURE; PRODUCTION PROCESSES; SALVIA MILTIORRHIZA; SALVIA MILTIORRHIZA BUNGE; TANSHINONES;

BIOCHEMISTRY; BIOSYNTHESIS; BIOTECHNOLOGY; DISEASES; PRODUCTION ENGINEERING; TISSUE; TISSUE CULTURE;

CELL CULTURE;

CRYPTOTANSHINONE; DIHYDROTANSHINONE I; TANSHINONE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG;

AROMATIC HYDROCARBON; CARDIOVASCULAR DISEASE; DRUG; ENZYME; GENE; HERB; MEDICINAL PLANT; PHYTOCHEMISTRY; ROOT SYSTEM;

BIOREACTOR; BIOSYNTHESIS; CALLUS CULTURE; DRUG STRUCTURE; HAIRY ROOT CULTURE; MICROPROPAGATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT TISSUE CULTURE; SALVIA MILTIORRHIZA; SHORT SURVEY;

BIOREACTORS; BIOTECHNOLOGY; CULTURE MEDIA; DITERPENES; DRUGS, CHINESE HERBAL; HUMANS; PHENANTHRENES; PLANT ROOTS; SALVIA MILTIORRHIZA; TISSUE CULTURE TECHNIQUES;

LAMIACEAE; SALVIA MILTIORRHIZA;

EID: 77956227486     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2797-7     Document Type: Short Survey

References (85)

1. U Bomme R Bauer G Heubl 2009 Field cultivation of Salvia miltiorrhiza Bunge as a new medicinal plant in Germany, used for the traditional Chinese medicine J Med Spice Plants 14 25 31
2. H Chen F Chen 1999 Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures Biotechnol Lett 21 803 807 10.1023/A:1005551911450
3. H Chen F Chen 2000 Effects of yeast elicitor on the growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture Proc Biochem 35 837 840 10.1016/S0032-9592(99)00146-6
4. H Chen F Chen 2000 Effect of yeast elicitor on the secondary metabolism of Ti-transformed Salvia miltiorrhiza cell suspension cultures Plant Cell Rep 19 710 717 10.1007/s002999900166
5. SQ Chen HW Luo SQ Yan 1981 Preliminary investigation of chemical constituents in callus tissue of Danshen J China Pharm Univ 16 6 8 (in Chinese)
6. H Chen JP Yuan F Chen YL Zhang JY Song 1997 Tanshinone production in Ti-transformed Salvia miltiorrhiza cell suspension cultures J Biotechnol 58 147 156 10.1016/S0168-1656(97)00144-2
7. H Chen F Chen FCK Chiu CMY Lo 2001 The effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of Salvia miltiorrhiza Enzyme Microb Technol 28 100 105 10.1016/S0141-0229(00)00284-2
8. SM Choi SH Son SR Yun OW Kwon JH Seon KY Paek 2000 Pilot-scale culture of adventitious roots of ginseng in a bioreactor system Plant Cell, Tissue Organ Cult 62 187 193 10.1023/A:1006412203197
9. RL Danheiser DS Casebier F Firooznia 1995 Aromatic annulation strategy for the synthesis of angularly-fused diterpenoid quinones. Total synthesis of (+)-neocryptotanshinone, (-)-cryptotanshinone J Org Chem 60 8341 8350 10.1021/jo00131a006
10. LL Feng MH Fang JY Zhou 2004 Effect of induction and proliferation on Salvia miltiorrhiza Bunge callus J Biol 21 25 27 (in Chinese)
11. Fujita Y (1988) Shikonin: production by plant (Lithospermum erythrorhizon) cell cultures. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry: medicinal and aromatic plants I, vol 4. Springer-Verlag, Berlin, pp 225-236
12. W Gao GH Cui JQ Kong KD Cheng W Wang Y Yuan LQ Huang 2008 Optimizing expression and purification of recombinant Salvia miltiorrhiza copalyl diphosphate synthase protein in E. coli and preparation of rabbit antiserum against SmCPS Acta Pharm Sinica 43 766 772 (in Chinese)
13. W Gao ML Hillwig LQ Huang GH Cui XY Wang JQ Kong B Yang RJ Peters 2009 Functional genomics approach to tanshinone biosynthesis provides stereochemical insights Org Lett 11 5170 5173 10.1021/ol902051v
14. + and yeast elicitor Plant Sci 168 487 491 10.1016/j.plantsci.2004.09.012
15. XC Ge JY Wu 2005 Induction and potentiation of diterpenoid tanshinone accumulation in Salvia miltiorrhiza hairy roots by β-aminobutyric acid Appl Microbiol Biotechnol 68 183 188 10.1007/s00253-004-1873-2
16. MI Georgiev J Weber A Maciuk 2009 Bioprocessing of plant cell cultures for mass production of targeted compounds Appl Microbiol Biotechnol 83 809 823 10.1007/s00253-009-2049-x
17. S Guillon J Trémouillaux-Guiller PK Pati M Rideau P Gantet 2006 Hairy root research: recent scenario and exciting prospects Curr Opin Plant Biol 9 341 346 10.1016/j.pbi.2006.03.008
18. JP Han ZS Liang Q Sun XR Wei JM Wang HS Deng 2004 Study on the characteristic of assimilating nitrogenous phosphorous fertilizer and the accumulation disciplinarian of total tanshinons of Salvia miltiorrhiza China J Chin Mater Med 29 207 211 (in Chinese)
19. GP Hao RJ Shi JM Wang B Qi 2009 Construction of full-length cDNA library of white flower Salvia miltiorrhiza bge. f. alba. root and partial EST sequence analysis African J Biotechnol 8 2027 2035
20. Hibino K, Ushiyama K (1999) Commercial production of ginseng by plant cell culture technology. In: Fu TJ, Singh G, Curtis WR (eds) Plant cell culture for the production of food ingredients. Kluwer Academic/Plenum, New York, pp 215-224
21. ZB Hu AW Alfermann 1993 Diterpenoid production in hairy root cultures of Salvia miltiorrhiza Phytochemistry 32 699 703 10.1016/S0031-9422(00)95156-2
22. YH Hu R Zhang ZB Hu YP Wu XM Shen GY Zhang XJ Zhou 1992 Callus culture and bioactive ingredients of Salvia miltiorrhiza Plant Physiol Commu 28 424 425 (in Chinese)
23. SY Ke HL Shi ZD Ma FR Chai 2005 The optimization on cultural parameters for callus culture of S. miltiorrhiza J Chinese Med Mater 28 82 83 (in Chinese)
24. O Laule A Furholz HS Chang T Zhu X Wang PB Heifetz W Gruissem M Lange 2003 Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana Proc Natl Acad Sci USA 100 6866 6871 10.1073/pnas.1031755100
25. J Lee J Li S Oya JK Snyder 1992 Asymmetric synthesis of tanshindiol A J Org Chem 57 5301 5312 10.1021/jo00046a009
26. GJ Li SC Wang K Xia X Zhou 2003 Effect of yeast elicitor and salicylic acid on the fluctuation of phytohormone contents in Ti-transformed Salvia miltiorrhiza cell cultures Plant Growth Regul 39 27 32 10.1023/A:1021838918280
27. JT Li JE Dong ZS Liang ZM Shu GW Wan 2008 Distributional difference of fat-soluble compounds in the roots, stems and leaves of four Salvia plants J Mol Cell Biol 41 44 52 (in Chinese)
28. MH Li JM Chen Y Peng QL Wu PG Xiao 2008 Investigation of Danshen and related medicinal plants in China J Ethnopharmacol 120 419 426 10.1016/j.jep.2008.09.013
29. YG Li L Song M Liu ZB Hu ZT Wang 2009 Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen) J Charomatogr A 1216 1941 1953 10.1016/j.chroma.2008.12.032
30. J Liu HM Shen CN Ong 2000 Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells Cancer Lett 153 85 93 10.1016/S0304-3835(00)00391-8
31. WT Liu ZS Liang LL Fu XR Wei JQ Bai 2003 Effect of planting density on active constituents and output of Salvia miltiorrhiza Bunge Res Practice Chinese Med 17 14 17 (in Chinese)
32. H Miyasaka M Nasu T Yamamoto K Yoneda 1985 Production of ferruginol by cell suspension cultures of Salvia miltiorrhiza Phytochemistry 24 1931 1933 10.1016/S0031-9422(00)83094-0
33. H Miyasaka M Nasu T Yamamoto Y Endo K Yoneda 1986 Production of cryptotanshinone and ferruginol by immobilized cultured cells of Salvia miltiorrhiza Phytochemistry 25 1621 1624 10.1016/S0031-9422(00)81221-2
34. H Miyasaka M Nasu T Yamamoto Y Endo K Yoneda 1986 Regulation of ferruginol and cryptotanshinone biosynthesis in cell suspension cultures of Salvia miltiorrhiza Phytochemistry 25 637 640 10.1016/0031-9422(86)88014-1
35. H Miyasaka M Nasu T Yamamoto Y Shiomi H Ohno Y Endo K Yoneda 1987 Effect of nutritional factors on cryptotanshinone and ferruginol production by cell suspension cultures of Salvia miltiorrhiza Phytochemistry 26 1421 1424 10.1016/S0031-9422(00)81826-9
36. T Murashige FA Skoog 1962 A revised medium for rapid growth and biosynthesis with tobacco tissue cultures Physiol Plant 15 473 497 10.1111/j.1399-3054.1962.tb08052.x
37. M Nakao T Fukushima 1934 On the chemical composition of Salvia miltiorrhiza (Chinese drug Tan-shen) J Pharmac Soc Japan 54 154 162
38. YX Qi ML Cao XD Wang YS Gao ZL Xia 2006 Determination and compare of 3 active components in the cultivated and wild Salvia miltiorrhiza Bge. in Taishan Pharm Biotechnol 13 4 279 282 (in Chinese)
39. DY Qiu JY Song XJ Ma JJ Qi YL Zhang 2004 Studies on the mass culture of the hairy roots of Salvia miltiorrhiza with bioreactor Mol Plant Breeding 2 699 703 (in Chinese)
40. Y Ren PJ Houghton RC Hider MJR Howes 2004 Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza Planta Med 70 201 204 10.1055/s-2004-815535
41. SY Ryu CO Lee SU Choi 1997 In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza Planta Med 63 339 342 10.1055/s-2006-957696
42. K Saito 1993 Genetic engineering in tissue culture of medicinal plants Plant Tissue Cult Lett 10 1 8
43. CG Shan ZF Wang XH Su SL Yan HC Sun 2007 Study advance in Salvia miltiorrhiza tissue culture Res Practice Chinese Med 22 4 57
44. SJ Sheng ECK Pang CCL Xue CG Li 2009 Seasonal variations in bioactive marker contents in Australian-grown Salvia miltiorrhiza roots Chem Biodivers 6 551 560 10.1002/cbdv.200800090
45. M Shi KW Kwok JY Wu 2007 Enhancement of tanshinone production in Salvia miltiorrhiza Bunge (red or Chinese sage) hairy-root culture by hyperosmotic stress and yeast elicitor Biotechnol Appl Biochem 46 191 196 10.1042/BA20060147
46. K Shimomura T Kitazawa 1991 Tanshinone production in adventious roots and regenerates of Salvia miltiorrhiza J Nat Prod 54 1583 1587 10.1021/np50078a014
47. JY Song YL Zhang JJ Qi 1998 Biotechnology of Salvia miltiorrhiza Nat Prod Res Dev 11 86 89 (in Chinese)
48. JY Song JJ Qi HT Lei CL Ren J Fu YL Zhang 2000 Effect of Armillaria mellea elicitor on accumulation of tanshinones in crown gall cultures of Salvia miltiorrhiza Acta Bot Sin 42 316 320
49. JY Song JJ Qi CL Ren Fu Jie YL Zhang 2000 Dynamics of growth and total tanshinones accumulation in crown gall cultures of Salvia miltiorrhiza Acta Pharm Sinica 35 929 931 (in Chinese)
50. S Srivastava AK Srivastava 2007 Hairy root culture for mass-production of high-value secondary metabolites Crit Rev Biotechnol 27 29 43 10.1080/07388550601173918
51. Taiz L, Zeiger E (2006) Plant Physiology, 4th edn. Sinauer Assoc, Sunderland
52. Takayma S (1997) Bioreactors for plant cell and organ cultures. In: Vogel HC, Todaro CL (eds) Fermentation and biochemical engineering handbook: principles, process design, and equipment, 2nd edn. Noyes, Westwood, pp 41-66
53. Tang W, Eisenbrand G (1992) Chinese drugs of plant origin: chemistry, pharmacology and use in traditional and modern medicine. Springer, Berlin, pp 891-902
54. LL Tao JM Yuan JT Xu 1990 Immobilization of callus tissue cells of Salvia miltiorrhiza and the characteristics of their products Chin J Biotechnol 6 218 223 (in Chinese)
55. AM Thayer 2000 Busting down a blockbuster drug Chem Eng News 78 20 21
56. D Tholl 2006 Terpene synthases and the regulation, diversity and biological roles of terpene metabolism Curr Opin Plant Biol 9 297 304 10.1016/j.pbi.2006.03.014
57. YH Tian ZZ Wang 2003 Tissue culture and plantlet regeneration of Salvia Miltiorrhiza Bunge J Shaanxi Normal Univ (Nat Sci) 31 99 102 (in Chinese)
58. Towers GHN, Ellis S (1993) Secondary metabolism in plant tissue cultures transformed with Agrobacterium tumefaciens and Agrobacterium rhizogenes. In: Kinghorn AD, Balandrin MF (eds) Human medicinal agents from plants. American Chemical Society, Washington, pp 56-79
59. N Tsutomu M Hitoshi N Masao H Hideko Y Kaisuke 1983 Production of cryptotanshinone and ferruginol in cultured cells of Salvia miltiorrhiza Phytochemistry 22 721 722 10.1016/S0031-9422(00)86969-1
60. JY Wang D Liu 1987 Organogenesis of Salvia miltiorrhiza Plant Physiol Commun 6 46 (in Chinese)
61. X Wang SL Morris-Natschke KH Lee 2007 New developments in the chemistry and biology of the bioactive constituents of Tanshen Med Res Rev 27 133 148 10.1002/med.20077
62. XY Wang GH Cu LQ Huang W Gao Y Yuan 2008 A full length cDNA of 4-(cytidine 5′- diphospho) -2-C-methyl-D-erythritol kinase cloning and analysis of introduced gene expression in Salvia miltiorrhiza Acta Pharm Sinica 43 1251 1257
63. KK Wong TW Ho HQ Lin KF Lau JA Rudd CK Chung KP Fung PC Shaw CC David Wan 2010 Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task Planta Med 76 228 234 10.1055/s-0029-1186084
64. JY Wu M Shi 2008 Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots Appl Microbiol Biotechnol 78 441 448 10.1007/s00253-007-1332-y
65. WL Wu WL Chang CF Chen 1991 Cytotoxic activities of tanshinones against human carcinoma cell lines Am J Chin Med 19 207 216 10.1142/S0192415X91000284
66. JY Wu J Ng M Shi SJ Wu 2007 Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root-bacteria coculture process Appl Microbiol Biotechnol 77 543 550 10.1007/s00253-007-1192-5
67. SJ Wu M Shi JY Wu 2009 Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots Biotechnol Appl Biochem 52 89 95 10.1042/BA20080004
68. XH Xie JH Li WL Feng HE Xie L Chen HX Li CX Wu 2004 The Rapid multiplication of Salvia miltiorrhiza by tissue culture J Chinese Med Mater 27 474 475 (in Chinese)
69. M Xu ML Hillwig S Prisic RM Coates RJ Peters 2004 Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products Plant J 39 309 318 10.1111/j.1365-313X.2004.02137.x
70. Q Yan ZD Hu RX Tan JY Wu 2005 Efficient production and recovery of diterpenoid tanshinones in Salvia miltiorrhiza hairy root cultures with in situ adsorption, elicitation and semi-continuous operation J Biotechnol 119 416 424 10.1016/j.jbiotec.2005.04.020
71. Q Yan M Shi J Ng JY Wu 2006 Elicitor-induced rosmarinic acid accumulation and secondary metabolism enzyme activities in Salvia miltiorrhiza hairy roots Plant Sci 170 853 858 10.1016/j.plantsci.2005.12.004
72. WR Yan SJ Niu L Yan XE Li 2009 A study on relationship between active ingredient content of Salvia miltiorrhiza Bunge and soil factor Chinese Agric Sci Bull 8 246 249 (in Chinese)
73. XM Yan L Zhang J Wang P Liao Y Zhang R Zhang GY Kai 2009 Molecular characterization and expression of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) gene from Salvia miltiorrhiza Acta Physiol Plant 31 1015 1022 10.1007/s11738-009-0320-5
74. YF Yang S Hou GH Cui SL Chen JH Wei LQ Huang 2010 Characterization of reference genes for quantitative real-time PCR analysis in various tissues of Salvia miltiorrhiza Mol Biol Rep 37 507 513 10.1007/s11033-009-9703-3
75. YL Zhang JY Song BH Zhao HL Liu 1995 Crown gall culture and production of tanshinone in Salvia miltiorrhiza Chin J Biotechnol 11 137 141 (in Chinese)
76. + elicitation and nutrient feeding Planta Med 70 147 151 10.1055/s-2004-835854
77. L Zhang ZB Dai GH Cui YY Cheng XQ Qi ZX Gao 2009 Cloning and characterization of geranylgeranyl diphosphate synthase gene of Salvia miltiorrhia China J Chinese Mater Med 34 2704 2708 (in Chinese)
78. J Zhao ZS Chen J Wan 2004 Clonic reproduction and plant regeneration from blade of Salvia miltiorrhiza Bunge J Cent China Normal Univ (Nat Sci) 33 108 111 (in Chinese)
79. J Zhao LC Davis R Verpoorte 2005 Elicitor signal transduction leading to production of plant secondary metabolites Biotechnol Adv 23 283 333 10.1016/j.biotechadv.2005.01.003
80. JL Zhao LG Zhou JY Wu 2010 Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures Appl Microbiol Biotechnol 87 137 144 10.1007/s00253-010-2443-4
81. JL Zhao LG Zhou JY Wu 2010 Promotion of Salvia miltiorrhiza hairy root growth and tanshinone production by polysaccharide-protein fractions of plant growth-promoting rhizobacterium Bacillus cereus Proc Biochem 45 1517 1522 10.1016/j.procbio.2010.05.034
82. GX Zhong P Li LJ Zeng J Guan DQ Li SP Li 2009 Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China J Agric Food Chem 57 6879 6887 10.1021/jf901462s
83. LG Zhou JY Wu 2006 Development and application of medicinal plant tissue cultures for production of drugs and herbal medicinals in China Nat Prod Rep 23 789 810 10.1039/b610767b
84. L Zhou Z Zuo MSS Chow 2005 Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use J Clin Pharmacol 45 1345 1359 10.1177/0091270005282630
85. YZ Zhu HSH Tan SJ BKH M Whiteman YC Zhu 2004 Antioxidants in Chinese herbal medicines: a biochemical perspective Nat Prod Rep 21 478 489 10.1039/b304821g