메뉴 건너뛰기




Volumn 98, Issue 10, 2009, Pages 3839-3849

Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: Role of Mrp2 (Abcc2)

Author keywords

Biliary excretion; Hepatic clearance; Hepatic metabolism; HPLC; Multidrug resistance associated protein 2; Valerenic acid

Indexed keywords

GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG; VALERENIC ACID; VALERIAN;

EID: 70349243158     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21671     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 0033063823 scopus 로고    scopus 로고
    • The scientific basis for the reputed activity of Valerian
    • Houghton PJ. 1999. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 51:505-512.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 505-512
    • Houghton, P.J.1
  • 2
    • 34248568013 scopus 로고    scopus 로고
    • Valerian for Sleep: A Systematic Review and Meta-Analysis
    • DOI 10.1016/j.amjmed.2006.02.026, PII S0002934306002750
    • Bent S, Padula A, Moore D, Patterson M, Mehling W. 2006. Valerian for sleep: A systematic review and meta-analysis. Am J Med 119:1005-1012. (Pubitemid 44826933)
    • (2006) American Journal of Medicine , vol.119 , Issue.12 , pp. 1005-1012
    • Bent, S.1    Padula, A.2    Moore, D.3    Patterson, M.4    Mehling, W.5
  • 3
    • 70349233530 scopus 로고    scopus 로고
    • Valeriana radix
    • 2nd edition. Stuttgart: Thieme Verlag
    • Valeriana radix. ESCOP Monographs. 2003. 2nd edition. Stuttgart: Thieme Verlag. pp 539-546.
    • (2003) ESCOP Monographs , pp. 539-546
  • 4
    • 0034098748 scopus 로고    scopus 로고
    • Critical evaluation of the effect of valerian extract on sleep structure and sleep quality
    • DOI 10.1055/s-2000-7972
    • Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. 2000. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry 33:47-53. (Pubitemid 30161106)
    • (2000) Pharmacopsychiatry , vol.33 , Issue.2 , pp. 47-53
    • Donath, F.1    Quispe, S.2    Diefenbach, K.3    Maurer, A.4    Fietze, I.5    Roots, I.6
  • 5
    • 0021962440 scopus 로고
    • Central nervous depressant activity of valerenic acid in the mouse
    • Hendriks H, Bos R, Woerdenbag HJ, Koster ASj. 1984. Central nervous depressant activity of Valerenic acid in the mouse. Planta Med 51:28-31. (Pubitemid 15146408)
    • (1985) Planta Medica , vol.NO. 1 , pp. 28-31
    • Hendriks, H.1    Bos, R.2    Woerdenbag, H.J.3    Koster Sj, A.4
  • 6
    • 1642541871 scopus 로고    scopus 로고
    • The Gamma-Aminobutyric Acidergic Effects of Valerian and Valerenic Acid on Rat Brainstem Neuronal Activity
    • Yuan C, Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK. 2004. The Gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg 98:353-358. (Pubitemid 38129379)
    • (2004) Anesthesia and Analgesia , vol.98 , Issue.2 , pp. 353-358
    • Yuan, C.-S.1    Mehendale, S.2    Xiao, Y.3    Aung, H.H.4    Xie, J.-T.5    Ang-Lee, M.K.6
  • 7
    • 34547229341 scopus 로고    scopus 로고
    • a receptors: Molecular mechanism and subunit specificity
    • DOI 10.1016/j.neuropharm.2007.04.018, PII S002839080700127X
    • Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. 2007. Valerenic acid potentiates and inhibits GABA(A) receptors: Molecular mechanism and subunit specificity. Neuropharmacology 53:178-187. (Pubitemid 47125958)
    • (2007) Neuropharmacology , vol.53 , Issue.1 , pp. 178-187
    • Khom, S.1    Baburin, I.2    Timin, E.3    Hohaus, A.4    Trauner, G.5    Kopp, B.6    Hering, S.7
  • 9
    • 23744455203 scopus 로고    scopus 로고
    • Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro
    • Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res 138:191-197.
    • (2005) Brain Res Mol Brain Res , vol.138 , pp. 191-197
    • Dietz, B.M.1    Mahady, G.B.2    Pauli, G.F.3    Farnsworth, N.R.4
  • 10
    • 0242538618 scopus 로고    scopus 로고
    • The 2002 top-selling herbal supplements in food, drug and mass market retail outlets
    • Blumenthal M. 2003. The 2002 top-selling herbal supplements in food, drug and mass market retail outlets. HerbalGram 58:71.
    • (2003) HerbalGram , vol.58 , pp. 71
    • Blumenthal, M.1
  • 11
    • 27644509061 scopus 로고    scopus 로고
    • Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects
    • DOI 10.1002/ptr.1742
    • Anderson GD, Elmer GW, Kantor ED, Templeton IE, Vitiello MV. 2005. Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. Phytotherapy Res 19:801-803. (Pubitemid 41571432)
    • (2005) Phytotherapy Research , vol.19 , Issue.9 , pp. 801-803
    • Anderson, G.D.1    Elmer, G.W.2    Kantor, E.D.3    Templeton, I.E.4    Vitiello, M.V.5
  • 12
    • 33847081268 scopus 로고    scopus 로고
    • Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro
    • Alkharfy KM, Frye RF. 2007. Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro. Xenobiotica 37:113-123.
    • (2007) Xenobiotica , vol.37 , pp. 113-123
    • Alkharfy, K.M.1    Frye, R.F.2
  • 13
    • 33845996201 scopus 로고    scopus 로고
    • The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    • DOI 10.1111/j.1742-7843.2007.00011.x
    • Hellum BH, Hu Z, Nilsen OG. 2007. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin Pharmacol Toxicol 100:23-30. (Pubitemid 46051439)
    • (2007) Basic and Clinical Pharmacology and Toxicology , vol.100 , Issue.1 , pp. 23-30
    • Hellum, B.H.1    Hu, Z.2    Nilsen, O.G.3
  • 14
    • 19144363905 scopus 로고    scopus 로고
    • In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
    • Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Khan IA, Shah A. 2005. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 77:415-426.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 415-426
    • Gurley, B.J.1    Gardner, S.F.2    Hubbard, M.A.3    Williams, D.K.4    Gentry, W.B.5    Khan, I.A.6    Shah, A.7
  • 15
    • 85031334107 scopus 로고    scopus 로고
    • Valerian Root
    • monograph 0453. 6th edition. EDQM, European Directorate for the Quality of Medicines and Health Care (Ed.) Strasbourg, France
    • Valerian Root (monograph 0453). The European Pharmacopoeia. 2007. 6th edition. EDQM, European Directorate for the Quality of Medicines and Health Care (Ed.) Strasbourg, France.
    • (2007) The European Pharmacopoeia
  • 17
    • 0031940440 scopus 로고    scopus 로고
    • Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver
    • Wang M, Dickinson RG. 1998. Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver. Drug Metab Dispos 26:98-104. (Pubitemid 28104075)
    • (1998) Drug Metabolism and Disposition , vol.26 , Issue.2 , pp. 98-104
    • Wang, M.1    Dickinson, R.G.2
  • 18
    • 0034919109 scopus 로고    scopus 로고
    • Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver
    • DOI 10.1080/00498250110052715
    • Lo A, Addison RS, Hooper WD, Dickinson RG. 2001. Disposition of naproxen, naproxen acyl glucuronide and its rearrangement isomers in the isolated perfused rat liver. Xenobiotica 31:309-319. (Pubitemid 32679310)
    • (2001) Xenobiotica , vol.31 , Issue.6 , pp. 309-319
    • Lo, A.1    Addison, R.S.2    Hooper, W.D.3    Dickinson, R.G.4
  • 19
    • 0141456201 scopus 로고    scopus 로고
    • Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: Role of multidrug resistance protein 2 (Mrp2)
    • DOI 10.1016/S0024-3205(03)00699-4
    • Jager W, Gehring E, Hagenauer B, Aust S, Senderowicz A, Thalhammer T. 2003. Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: Role of multidrug resistance protein 2 (MRP2). Life Sci 73:2841-2854. (Pubitemid 37153358)
    • (2003) Life Sciences , vol.73 , Issue.22 , pp. 2841-2854
    • Jager, W.1    Gehring, E.2    Hagenauer, B.3    Aust, S.4    Senderowicz, A.5    Thalhammer, T.6
  • 20
    • 0141456201 scopus 로고    scopus 로고
    • Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: Role of multidrug resistance protein 2 (Mrp2)
    • DOI 10.1016/S0024-3205(03)00699-4
    • Maier-Salamon A, Hagenauer B, Reznicek G, Szekeres T, Thalhammer T, Jäger W. 2008. Metabolism and disposition of resveratrol in the isolated perfused rat liver: Role of MRP2 in the biliary excretion of glucuronides. J Pharm Sci 97:1615-1628. (Pubitemid 37153358)
    • (2003) Life Sciences , vol.73 , Issue.22 , pp. 2841-2854
    • Jager, W.1    Gehring, E.2    Hagenauer, B.3    Aust, S.4    Senderowicz, A.5    Thalhammer, T.6
  • 21
    • 0037117313 scopus 로고    scopus 로고
    • Genetic defects in hepatobiliary transport
    • Elferink RO, Groen AK. 2002. Genetic defects in hepatobiliary transport. Biochem Biophys Acta 1586:129-145.
    • (2002) Biochem Biophys Acta , vol.1586 , pp. 129-145
    • Elferink, R.O.1    Groen, A.K.2
  • 22
    • 0023157406 scopus 로고
    • Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia
    • DOI 10.1002/hep.1840070116
    • Jansen P, Groothuis GMM, Peters WHM, Meijer DKF. 1987. Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia. Hepatology 7:71-76. (Pubitemid 17019854)
    • (1987) Hepatology , vol.7 , Issue.1 , pp. 71-76
    • Jansen, P.L.M.1    Groothuis, G.M.M.2    Peters, W.H.M.3    Meijer, D.F.M.4
  • 24
    • 0036707615 scopus 로고    scopus 로고
    • Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
    • DOI 10.1124/dmd.30.9.962
    • Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM, Brouwer KL. 2002. Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug Metab Dispos 30:962-969. (Pubitemid 34894647)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.9 , pp. 962-969
    • Xiong, H.1    Suzuki, H.2    Sugiyama, Y.3    Meier, P.J.4    Pollack, G.M.5    Brouwer, K.L.R.6
  • 25
    • 33644841171 scopus 로고    scopus 로고
    • Predicting the pharmacokinetics of acyl glucuronides and their parent compounds in disease states
    • Liu JH, Smith PC. 2006. Predicting the pharmacokinetics of acyl glucuronides and their parent compounds in disease states. Curr Drug Metab 7:147-163.
    • (2006) Curr Drug Metab , vol.7 , pp. 147-163
    • Liu, J.H.1    Smith, P.C.2
  • 26
    • 36448976239 scopus 로고    scopus 로고
    • NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues
    • DOI 10.1021/ac071368i
    • Johnson CH, Wilson ID, Harding JR, Stachulski AV, Iddon L, Nicholson JK, Lindon JC. 2007. NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues. Anal Chem 15:8720-8727. (Pubitemid 350171385)
    • (2007) Analytical Chemistry , vol.79 , Issue.22 , pp. 8720-8727
    • Johnson, C.H.1    Wilson, I.D.2    Harding, J.R.3    Stachulski, A.V.4    Iddon, L.5    Nicholson, J.K.6    Lindon, J.C.7
  • 27
    • 0038171249 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog
    • DOI 10.1080/0049825031000072469
    • Kajbaf M, Barnaby RJ, Bottacini M, Bertolotti L, Ismail IM, Cholerton TJ, Pellegatti M. 2003. Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog. Xenobiotica 33:415-428. (Pubitemid 36688117)
    • (2003) Xenobiotica , vol.33 , Issue.4 , pp. 415-428
    • Kajbaf, M.1    Barnaby, R.J.2    Bottacini, M.3    Bertolotti, L.4    Ismail, I.M.5    Cholerton, T.J.6    Pellegatti, M.7
  • 28
    • 0034740588 scopus 로고    scopus 로고
    • 1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide
    • DOI 10.1021/tx010015q
    • Corcoran O, Mortensen RW, Hansen SH, Troke J, Nicholson JK. 2001. HPLC/1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide. Chem Res Toxicol 14:1363-1370. (Pubitemid 32983261)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.10 , pp. 1363-1370
    • Corcoran, O.1    Mortensen, R.W.2    Hansen, S.H.3    Troke, J.4    Nicholson, J.K.5
  • 29
    • 33846418041 scopus 로고    scopus 로고
    • Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition
    • DOI 10.1517/17425255.2.3.351
    • Jedlitschky G, Hoffmann U, Kroemer HK. 2006. Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol 2:351-366. (Pubitemid 46141403)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.3 , pp. 351-366
    • Jedlitschky, G.1    Hoffmann, U.2    Kroemer, H.K.3
  • 30
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • DOI 10.1124/pr.55.3.1
    • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. 2003. Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425-461. (Pubitemid 37013212)
    • (2003) Pharmacological Reviews , vol.55 , Issue.3 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 32
    • 0034928631 scopus 로고    scopus 로고
    • Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
    • DOI 10.1053/jhep.2001.26213
    • Donner MG, Keppler D. 2001. Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 34:351-359. (Pubitemid 32702348)
    • (2001) Hepatology , vol.34 , Issue.2 , pp. 351-359
    • Donner, M.G.1    Keppler, D.2
  • 33
    • 0035080391 scopus 로고    scopus 로고
    • Cellular localization and up-regulation of multidrug resistance- associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
    • DOI 10.1053/jhep.2001.23501
    • Soroka CJ, Lee JM, Azzaroli F, Boyer JL. 2001. Cellular localization and up-regulation of multi-drug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 33:783-791. (Pubitemid 32246625)
    • (2001) Hepatology , vol.33 , Issue.4 , pp. 783-791
    • Soroka, C.J.1    Lee, J.M.2    Azzaroli, F.3    Boyer, J.L.4
  • 34
    • 0032926354 scopus 로고    scopus 로고
    • Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
    • Konig J, Rost D, Cui Y, Keppler D. 1999. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29:1156-1163. (Pubitemid 29168750)
    • (1999) Hepatology , vol.29 , Issue.4 , pp. 1156-1163
    • Konig, J.1    Rost, D.2    Cui, Y.3    Keppler, D.4
  • 35
    • 3542995726 scopus 로고    scopus 로고
    • The complexities of hepatic drug transport: Current knowledge and emerging concepts
    • DOI 10.1023/B:PHAM.0000026420.79421.8f
    • Chandra P, Brouwer KL. 2004. The complexities of hepatic drug transport: Current knowledge and emerging concepts. Pharm Res 21:719-735. (Pubitemid 39011292)
    • (2004) Pharmaceutical Research , vol.21 , Issue.5 , pp. 719-735
    • Chandra, P.1    Brouwer, K.L.R.2
  • 36
    • 0347363517 scopus 로고    scopus 로고
    • Pharmacokinetic-Pharmacodynamic Modeling of Morphine-6-glucuronide- induced Analgesia in Healthy Volunteers: Absence of Sex Differences
    • DOI 10.1097/00000542-200401000-00021
    • Romberg R, Olofsen E, Sarton E, den Hartigh J, Taschner PE, Dahan A. 2004. Pharmacokineticpharmacodynamic modeling of morphine-6-glucuronide induced analgesia in healthy volunteers: Absence of sex differences. Anesthesiology 100:120-133. (Pubitemid 38031663)
    • (2004) Anesthesiology , vol.100 , Issue.1 , pp. 120-133
    • Romberg, R.1    Olofsen, E.2    Sarton, E.3    Den Hartigh, J.4    Taschner, P.E.M.5    Dahan, A.6
  • 37
    • 0021245213 scopus 로고
    • Negative inotropic effects of aldosterone antagonists in isolated human and guinea-pig ventricular heart muscle
    • Scholz H, Schmitz W. 1984. Positive inotropic effects of digitoxin- and digoxin-glucuronide in human isolated ventricular heart muscle preparations. Basic Res Cardiol 79:134-139. (Pubitemid 14092518)
    • (1984) Klinische Wochenschrift , vol.62 , Issue.15 , pp. 717-723
    • Mugge, A.1    Schmitz, W.2    Scholz, H.3
  • 39
    • 0026605427 scopus 로고
    • Enhancement of biological activity by conjugation reactions
    • Olson JA, Moon RC, Anders MW, Fenselau C, Shane B. 1992. Enhancement of biological activity by conjugation reactions. J Nutr 122:615-624.
    • (1992) J Nutr , vol.122 , pp. 615-624
    • Olson, J.A.1    Moon, R.C.2    Anders, M.W.3    Fenselau, C.4    Shane, B.5
  • 40
    • 18044372636 scopus 로고    scopus 로고
    • Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer
    • Pasqualini JR, Chetrite GS. 2005. Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer. J Steroid Biochem Mol Biol 93:221-236.
    • (2005) J Steroid Biochem Mol Biol , vol.93 , pp. 221-236
    • Pasqualini, J.R.1    Chetrite, G.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.