Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats

Phytotherapy Research

Volumn 25, Issue 11, 2011, Pages 1653-1659

  Wang, Xin ^a   Yeung, John H K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Competitive inhibition; Cytochrome P450 3A (CYP3A); Midazolam; Salvia miltiorrhiza (Danshen)

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A4; KETOCONAZOLE; MIDAZOLAM; MIDAZOLAM MALEATE; SALVIA MILTIORRHIZA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CAPSULE; DRUG CLEARANCE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SUBSTRATE; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; NONHUMAN; RAT; SALVIA MILTIORRHIZA; SINGLE DRUG DOSE; TESTOSTERONE METABOLISM;

ANIMALS; CYTOCHROME P-450 CYP3A; DRUGS, CHINESE HERBAL; HUMANS; MALE; MICROSOMES, LIVER; MIDAZOLAM; PHENANTHROLINES; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA;

RATTUS; SALVIA MILTIORRHIZA;

EID: 80054910363     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3472     Document Type: Article

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