Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux

Phytotherapy Research

Volumn 20, Issue 1, 2006, Pages 79-81

  Junyaprasert, Varaporn Buraphacheep ^a   Soonthornchareonnon, Noppamas ^a   Thongpraditchote, Suchitra ^a   Murakami, Teruo ^b   Takano, Mikihisa ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Caco 2 cells; Efflux; Inhibition; P glycoprotein; Plant extract; Rat ileum

Indexed keywords

ANDROGRAPHIS PANICULATA EXTRACT; CURCUMA LONGA EXTRACT; CURCUMIN; EMBLICA OFFICINALIS EXTRACT; GLYCOPROTEIN P; PLANT EXTRACT; PSIDIUM GUAJAVA EXTRACT; RHODAMINE 123; SOLANUM TRILOBATUM EXTRACT; UNCLASSIFIED DRUG;

ANDROGRAPHIS PANICULATA; ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; CURCUMA LONGA; EMBLICA OFFICINALIS; GUAVA; ILEUM; INTESTINE MUCOSA; MALE; MEDICINAL PLANT; NONHUMAN; PROTEIN TRANSPORT; RAT; SEROSA; SOLANUM TRILOBATUM; THAILAND;

ANDROGRAPHIS; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CURCUMA; FLAVONOIDS; HUMANS; ILEUM; MALE; MEMBRANE TRANSPORT PROTEINS; P-GLYCOPROTEIN; PHENOLS; PHYLLANTHUS EMBLICA; PLANT EXTRACTS; PLANTS, MEDICINAL; PSIDIUM; RATS; RATS, WISTAR; RHODAMINE 123; SOLANUM; THAILAND;

ANDROGRAPHIS PANICULATA; ANIMALIA; CURCUMA LONGA; PHYLLANTHUS EMBLICA; PSIDIUM GUAJAVA; SOLANUM TRILOBATUM;

EID: 31644449339     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1785     Document Type: Article

References (12)

1. Chearwae W, Anuchapreeda A, Nandigama K, Ambudkar SV, Limtrakul P. 2004. Biochemical mechanism of modulation of hum P-glycoprotein (ABCB1) by curcumin I, II, and III purified from tumeric powder. Biochem Pharmacol 68: 2043-2052.
2. Deferme S, Kamuhabwa A, Nshimo C, de Witte P, Augustijns P. 2003. Screening of Tanzanian plant extracts for their potential inhibitory effect of P-glycoprotein mediated efflux. Phytother Res 17: 459-464.
3. Kitagawa S, Nabekura T, Kamiyama S. 2004. Inhibitory of P-glycoprotein function by tea catechins in KB-C2 cells. J Pharm Pharmacol 56: 1001-1005.
4. Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S, Sakuda S, Nagasawa H, Shimizu M. 2004. Inhibitor effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Brit J Pharmacol 143: 379-387.
5. Lee JS, Paull K, Alvarez M et al. 1994. Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen. Mol Pharmacol 46: 627-638.
6. Neyfakh AA, Serpinskaya AS, Chervonsky AV, Apasov SG, Kazarov AR. 1989. Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection. Exp Cell Res 185: 496-505.
7. Plouzek CA, Ciolino R, Clarke R, Yeh GC. 1999. Inhibitory of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer 35: 1541-1545.
8. Romiti N, Tongiani R, Cervelli F, Chieli E. 1998. Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes. Life Sci 62: 2349-2358.
9. Szabo D, Keyzer H, Kaiser HE, Molnar J. 2000. Reveral of multidrug resistance of tumor cells. Anticancer Res 20: 4261-4272.
10. Teroa T, Hisanaga E, Sai Y, Tamai I, Tsuji A. 1996. Active secretion of drugs from the small intestine epithelium in rats by P-glycoprotein functioning as absorption barrier. J Pharm Pharmacol 48: 1083-1089.
11. Tsuji A, Tamai I. 1996. Carrier-mediated intestinal transport if drugs. Pharmaceut Res 13: 963-977.
12. Tsuruo T, Lida H, Tsukagoshi S, Sakurai Y. 1981. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972.