Andrographis paniculata in the treatment of upper respiratory tract infections: A systematic review of safety and efficacy

Planta Medica

Volumn 70, Issue 4, 2004, Pages 293-298

  Coon, Joanna Thompson ^a   Ernst, Edzard ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

Acanthaceae; Andrographis paniculata; Herbal medicine; Medicinal plants; Systematic review; Upper respiratory infections

Indexed keywords

ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; PARACETAMOL;

ALLERGIC REACTION; CLINICAL TRIAL; CONTRACEPTION; DATA BASE; DIARRHEA; DIZZINESS; DROWSINESS; DRUG EFFICACY; DRUG ERUPTION; DRUG MEGADOSE; DRUG SAFETY; EPIGASTRIC PAIN; EYE DISEASE; FATIGUE; HEADACHE; HEARTBURN; HUMAN; INFORMATION PROCESSING; LYMPHADENOPATHY; MALAISE; MEMORY DISORDER; NAUSEA; NONHUMAN; NOSE DISEASE; PLANT LEAF; PRURITUS; REVIEW; SEXUAL DYSFUNCTION; SIDE EFFECT; TASTE DISORDER; THORAX DISEASE; UPPER RESPIRATORY TRACT INFECTION; URTICARIA; VOMITING; WORLD HEALTH ORGANIZATION;

ANDROGRAPHIS; ANTI-INFECTIVE AGENTS; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RANDOMIZED CONTROLLED TRIALS; RESPIRATORY TRACT INFECTIONS;

ACANTHACEAE; ANDROGRAPHIS; ANDROGRAPHIS PANICULATA;

EID: 2342582660     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-818938     Document Type: Review

References (35)

1. Morbidity statistics from general practise; 4th National Survey 1991-1992. Office of Population Censuses and Surveys, 1995 London, HMSO:
2. Fahey T, Stocks N, Thomas T. Systematic review of the treatment of upper respiratory tract infection. Arch Dis Child 1998; 79: 225-30
3. Neu HC. The crisis in antibiotic resistance. Science 1992; 257: 1064-73
4. Kessler RC, Davis RB, Foster DF, Van Rompay M, Walters EE, Wilkey SA et al. Long term trends in the use of complementary and alternative medical therapies in the United States. Ann Intern Med 2001; 135: 262-8
5. Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism (s) involved in its anti-inflammatory effect. Br J Pharmacol 2002; 135: 399-406
6. Amroyan E, Gabrielian E, Panossian A, Wikman G, Wagner H. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999; 6: 27-31
7. Madav S, Tripathi HC, Tandan SK, Mishra S. Analgesic, antipyretic and antiulcerogenic effect of andrographolide. Indian J Pharm Sci 1995; 57: 121-5
8. Vedavathy S, Rao KN. Antipyretic activity of six indigenous medicinal plants of Tirumala Hills, Andhra Pradesh, India. J Ethnopharmacol 1991; 33: 193-6
9. Chang RS, Ding L, Chen GQ, Pan QC, Zhao ZL, Snith KM. Dehydrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus. Proc Soc Exp Biol Med 1991; 197: 59-66
10. Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993; 56: 995-9
11. Reynolds JEJ, editor. Martindale: The Extra Pharmacopoeia. London: The Royal Pharmaceutical Scoiety, 1996
12. Rote Liste® Service GmbH, Frankfurt. Rote Liste 1999. Aulendorf, Germany: Editio Cantor Verlag, 1999
13. Jadad AR, Moore A, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ et al. Assessing the quality of reports of randomised clinical trials: Is blinding necessary? Controlled Clinical Trials 1996; 17: 1-12
14. Caceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardised Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomised double blind placebo study. Phytomedicine 1999; 6: 217-23
15. Gabrielian E, Shukarian AK, Goukasova G, Chandanian GL, Panossian AG, Wikman G et al. A double blind, placebo controlled study of Andrographis paniculata in fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002; 9: 589-97
16. Hancke JL, Burgos RA, Caceres DD, Wikman G. A double blind study with a new monodrug Kan Jang: decrease of symptoms and improvement in the recovery from common colds. Phytotherapy Research 1995; 9: 559-62
17. Melchior J, Palm S, Wikman G. Controlled clinical study of standardised Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine 1996; 3: 315-8
18. Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, Wikman G. Double blind, placebo controlled pilot and Phase III study of activity of standardised Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper respiratory tact infection. Phytomedicine 2000; 7: 341-50
19. Thamlikitkul V, Dechatiwongse T, Theerapong S, Chantrakul C, Boonroj P, Punkrut W et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med AssocThai 1991; 74: 437-42
20. Calabrese C, Berman SH, Babish JG, Ma X, Shinto L, Dorr M et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytotherapy Research 2000; 14: 333-8
21. Panossian A, Hovhannisyan A, Mamikinyan G, Abrahamian H, Hambardzumyan E, Gabrielian E et al. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 2000; 7: 351-64
22. Leelarasamee A, Trakulsomboon S, Sittisomwong N. Undetectable anti-bacterial activity of Andrographis paniculata (Burma) Wall, ex Ness. J Med Assoc Thai 1990; 73: 299-304
23. Zhang Y-Z, Tang J-Z, Zhang Y-J et al. Study of Andrographis paniculata extracts on antiplatelet aggregation and release reaction and its mechanism. Chin J Int Med 1994; 14: 5
24. Muangman V, Viseshsindh V, Ratana-Olarn K, Buadilok S. The usage of Andrographis paniculata following extracorporeal shock wave lithotripsy (ESWL). J Med Assoc Thai 1995; 78: 310-2
25. Vedavathy S, Rao DN. Herbal folk medicine of Tirumala and Tirupati region of Chittoor district, Andhra Pradesh. Fitoterapia 1995; 66: 167-71
26. Kuwashima K, Kaneko H, Nakanishi K. Studies of clinical effects of ginseng: 1st report; a double blind study of unsettled complaint improving effect of ginseng. Proceedings of the 3rd International Ginseng Symposium, 1980: 187-91
27. Akbarsha MA, Manivannan B, Hamid KS, Vijayan B. Antifertility effect of Andrographis paniculata (Nees) in male albino rat. Indian J Exp Biol 1990; 28: 421-6
28. Akbarsha MA, Murugaian P. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effects on the testis and the cauda epididymidal spermatozoa. Phytotherapy Research 2000; 14: 432-5
29. Panossian A, Kochikian A, Gabrielian E, Muradian R, Stepanian H, Arsenian F et al. Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats. Phytomedicine 1999; 6: 157-62
30. Burgos RA, Caballero EE, Sanchez NS, Schroeder RA, Wikman GK, Hancke JL. Testicular toxicity assessment of Andrographis paniculata dried extract in rats. J Ethnopharmacol 1997; 58: 219-24
31. Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet 1991; 337: 867-72
32. Barnes J, Mills SY, Abbot NC, Willoughby M, Ernst E. Different standards for reporting ADRs to herbal remedies and conventional OTC medicines: face to face interviews with 515 users of herbal medicines. Br J Clin Pharmacol 1998; 45: 96-500
33. Smith CC, Bennett PM, Pearce HM et al. Adverse drug reactions to a hospital general medical unit meriting notification to the Committee on Safety of Medicines. Br J Clin Pharmacol 1996; 42: 423-9
34. Habtemariam S. Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion. Phytotherapy Research 1998; 12: 37-40
35. Caceres DD, Hancke JL, Burgos RA, Wikman GK. Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial. Phytomedicine 1997; 4: 101-4