CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes

Xenobiotica

Volumn 40, Issue 1, 2010, Pages 38-47

  Cao, Y F ^a   Zhang, Y Y ^b,c   Li, J ^a   Ge, G B ^b   Hu, D ^a   Liu, H X ^b,c   Huang, T ^a   Wang, Y C ^a   Fang, Z Z ^b,c   Sun, D X ^a   Huo, H ^b   Yin, J ^a   Yang, L ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Cytochrome P450; Fructus schisandrae; Metabolism; Microsomes; Schizandrin

Indexed keywords

2 DEMETHYL HYDROXYL SCHIZANDRIN; 3 DEMETHYL HDYROXYL SCHIZANDRIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DRUG METABOLITE; HYDROXYL SCHIZANDRIN; SCHIZANDRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MINIPIG; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPECIES COMPARISON;

ANIMALS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; CYTOCHROME P-450 CYP3A; HUMANS; KETOCONAZOLE; LIGNANS; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; POLYCYCLIC COMPOUNDS; RATS; SWINE; SWINE, MINIATURE; TROLEANDOMYCIN;

RATTUS;

EID: 72949105314     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498250903366052     Document Type: Article

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