Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats

Journal of Ethnopharmacology

Volumn 84, Issue 2-3, 2003, Pages 187-192

  Xu, Qing Fang ^a   Fang, Xiao Ling ^a   Chen, Dao Feng ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Bioavailability; Ginsenoside Rb1; Ginsenoside Rg1; HPLC; Panax notoginseng; Pharmacokinetics

Indexed keywords

GINSENOSIDE RB 1; GINSENOSIDE RG 1; PANAX NOTOGINSENG EXTRACT; SAPONIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; COMPARTMENT MODEL; CONTROLLED STUDY; DIGESTIVE SYSTEM; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; QUALITATIVE ANALYSIS; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; INJECTIONS, INTRAVENOUS; PANAX; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 0037296911     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00317-3     Document Type: Article

References (16)

1. Cicero A.F.G., Bandieri E., Arletti R. Orally administered Panax notoginseng influence on rat spontaneous behavior. Journal of Ethnopharmacology. 73:2000;387-391.
2. 2+, CaM in craniocerebral injury. Chinese Journal of Integrated Traditional and Western Medicine. 19:(4):1999;227-229.
3. Hasegawa H., Sung J.H., Matsumiya S., Uchiyama M. Main ginseng saponins metabolites formed by intestinal bacteria. Planta Medica. 62:1996;453-457.
4. Hasegawa H., Lee K.S., Nagaoka T., Tezuka Y., Uchiyama M., Kadota S., Saiki I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biological and Pharmaceutical Bulletin. 23:(3):2000;298-304.
5. Li X.C. Chinese herbal study on anti-ischemia-reperfusion-injury. Chinese Journal of Hospital Pharmacy. 15:(4):1998;1-4.
6. Li X.H., Li S.H. Effects of total saponins of Sanchi (Panax pseudo-ginseng notoginseng) on TNF, NO and its mechanisms. Chinese Traditional and Herbal Drugs. 30:(7):1999;514-517.
7. 1 in rats. Chinese Herbal Medicine. 18:(9):1987;405-408.
8. 2+ concentration in dissociated neurons. Chinese Pharmaceutical Journal. 33:(8):1998;467-469.
9. Ma L.Y., Xiao P.G., Liang F.Q., Wu J.H. Protective effects of Panax notoginseng saponins on primary cortical cultures of rat. Chinese Pharmaceutical Journal. 33:(3):1998;143-145.
10. 1 in the rat. Chemical and Pharmaceutical Bulletin. 31:(3):1983;1059-1066.
11. 1 in the rat. Chemical and Pharmaceutical Bulletin. 31:(1):1983;292-298.
12. Shen Y.J. Pharmacology of Traditional Chinese Medicine. 2000;Renmin Weisheng Press, Beijing, China.
13. 2 in rats. Yakugaku Zasshi. 114:(8):1994;550-564.
14. Wakabayashi C., Hasegawa H., Murata J., Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncological Research. 9:(8):1997;411-417.
15. Zhang G.Q., Ye R.G., Kong Q.Y., Yang N.S., Zhang J.L., Guan W.M., Chen Y.X. Panax notoginseng saponins induced of human renal interstitial fibroblasts and its mechanisms. Chinese Journal of Nephrology. 14:(2):1998;93-95.
16. Zhu X.X., Mao Y.W., He R.X., Yamamoto A., Shoyama Y. Determination of ginsenosides in Panax genseng by HPLC. Chinese Journal of Biochemical Pharmaceutics. 19:(1):1998;28-30.