P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers

Journal of Pharmaceutical Sciences

Volumn 91, Issue 12, 2002, Pages 2614-2621

  Maeng, Han Joo ^a   Yoo, Ho Jung ^a   Kim, In Wha ^a   Song, Im Sook ^a   Chung, Suk Jae ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

Author keywords

Berberine; Caco 2 cell monolayers; P gp; Transport

Indexed keywords

BERBERINE; CARRIER PROTEIN; DAUNORUBICIN; GLYCOPROTEIN P; RHODAMINE 123; TAUROCHOLIC ACID; TETRYLAMMONIUM; VERAPAMIL;

ACTIVE TRANSPORT; APICAL MEMBRANE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CELL TRANSPORT; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG COMPETITION; DRUG STRUCTURE; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MEMBRANE PERMEABILITY; MICHAELIS MENTEN KINETICS; TEMPERATURE DEPENDENCE; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

BERBERINE; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DAUNORUBICIN; HUMANS; P-GLYCOPROTEIN;

EID: 0036893418     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10268     Document Type: Conference Paper

References (31)

1. Chopra RN, Dikshit BB, Chowan JS. 1932. Pharmacological action of berberine. Indian J Med Res 19:1193-1203.
2. Tang W, Eisenbrand G. 1992. Chinese Drugs of Plant Origin. London: Springer-Verlag Press. pp 361-371.
3. Yamamoto K, Takase H, Abe K, Saito Y, Suzuki A. 1993. Pharmacological studies on antidiarrheal effects of a preparation containing berberine and geranii herba. Nippon Yakurigaku Zasshi 101:169-175.
4. Tai YH, Feser JF, Marnane WG, Desjeux JF. 1981. Anti-secretory effects of berberine in rat ileum. Am J Physiol 241:G253-G258.
5. Guandalini S, Fasano A, Migliavacca M, Marchesano G, Ferola A, Rubino A. 1987. Effects of berberine on basal and secretagogue-modified ion transport in the rabbit ileum in vitro. J Pediatr Gastroenterol Nutr 6:953-960.
6. Taylor CT, Baird AW. 1995. Berberine inhibition of electrogenic ion transport in rat ileum. Br J Pharmacol 116:2667-2672.
7. Dutta NK, Marker PH, Rao NR. 1972. Berberine in toxin induced experimental cholera. Br J Pharmacol 44:153-159.
8. Sabir M, Akhter MH, Bhide NK. 1977. Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats. Indian J Med Res 65:305-313.
9. Sack RB, Froehlich JL. 1982. Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infect Immun 35:471-475.
10. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. 2000. Synergy in medicinal plant: Anti-microbial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA 97:1433-1437.
11. Lin HL, Liu TY, Lui WY, Chi CW. 1999. Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. Cancer 85:1937-1942.
12. Gottesman MM, Pastan I. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427.
13. Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R. 1992. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther 263:840-845.
14. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R. 1992. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem 267:24248-24252.
15. Wacher VJ, Wu CY, Benet LZ. 1995. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 13:129-134.
16. Tanaka K, Hirai M, Tanigawara Y, Ueda K, Takano M, Hori R, Inui K. 1997. Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene. Biochem Pharmacol 53:741-746.
17. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I. 1987. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269.
18. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. 1987. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738.
19. Hsing S, Gatmaitan Z, Arias IM. 1992. The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 102:879-885.
20. Hunter J, Hirst BH, Simmons NL. 1993. Transepithelial secretion, cellular accumulation, and cytotoxicity of vinblastine in defined MDCK cell strains. Biochim Biophys Acta 1179:1-10.
21. Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A. 1996. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol 48:1083-1089.
22. Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DK, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O. 1997. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94:2031-2035.
23. Wils P, Phung-Ba V, Warnery A, Lechardeur D, Raeissi S, Hidalgo IJ, Scherman D. 1994. Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol 48:1528-1530.
24. Yee S. 1997. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: Fact or myth. Pharm Res 14:763-766.
25. Augustijns PF, Bradshaw TP, Gan LS, Hendren RW, Thakker DR. 1993. Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport. Biochem Biophys Res Commun 197:360-365.
26. Chen CM, Chang HC. 1995. Determination of berberine in plasma, urine, and bile by high-performance liquid chromatography. J Chromatogr B Biomed Appl 665:117-123.
27. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. 1981. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 4:879-885.
28. Ikekawa T, Ikeda Y. 1982. Antitumor activity of 13-methyl-berberine derivatives. J Pharmacobiodyn 5:469-474.
29. Zhang RX, Dougherty DV, Rosenblum ML. 1990. Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. Chin Med J 103:658-665.
30. Bellamy WT. 1996. P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol 36:161-183.
31. Lin HL, Liu TY, Wu CW, Chi CW. 1999. Berberine modulates expression of mdrl gene product and response of digestive track cancer cells to paclitaxel. Br J Cancer 81:416-422.