After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult

Free Radical Biology and Medicine

Volumn 49, Issue 5, 2010, Pages 738-747

  Arredondo, Florencia ^a   Echeverry, Carolina ^a   Abin Carriquiry, Juan A ^a   Blasina, Fernanda ^a   Antúnez, Karina ^a   Jones, Dean P ^b   Go, Young Mi ^b   Liang, Yong Liang ^b   Dajas, Federico ^a  

^a INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bioavailability; Free radicals; Glutathione; Intrinsic fluorescence; Neuroprotection; Nrf2; Oxidative stress; Quercetin; Thioredoxin 2; Glutamate cysteine ligase

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HYDROGEN PEROXIDE; QUERCETIN; THIOREDOXIN 2; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; CELL FATE; CELL LEVEL; CEREBELLUM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG MECHANISM; GENE ACTIVATION; GENE TRANSLOCATION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERNALIZATION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 77955097118     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.05.020     Document Type: Article

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