Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells

British Journal of Nutrition

Volumn 104, Issue 9, 2010, Pages 1272-1282

  Park, So Young ^a   Lim, Soon Sung ^a   Kim, Jin Kyu ^a   Kang, Il Jun ^a   Kim, Jong Sang ^b   Lee, Choonghwan ^c   Kim, Jongdai ^d   Park, Jung Han Yoon ^a,d  

^a Hallym University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Konkuk University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Adhesion molecules; Glycyrrhiza uralensis; Licoricidin; Matrix metalloproteinase; Metastasis; Prostate cancer

Indexed keywords

ALPHA2 INTEGRIN; ANTIMETASTATIC AGENT; CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR; GELATINASE A; GELATINASE B; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; HEXANE ETHANOL EXTRACT OF GLYCYRRHIZA URALENSIS; INTERCELLULAR ADHESION MOLECULE 1; LICORICIDIN; PROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; UROKINASE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; ALPHA INTEGRIN; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; PEPTIDE HYDROLASE; PLANT EXTRACT; SIGNAL PEPTIDE;

ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL ADHESION; CELL LINE; CELL MIGRATION; CELL STRAIN DU145; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; METASTASIS; METASTASIS INHIBITION; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTON NUCLEAR MAGNETIC RESONANCE; CANCER INVASION; CELL MOTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GLYCYRRHIZA URALENSIS; MALE; METABOLISM; PHYTOTHERAPY; PLANT ROOT; PROSTATE TUMOR; TUMOR CELL LINE;

GLYCYRRHIZA; GLYCYRRHIZA URALENSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOPYRANS; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHIZA URALENSIS; HUMANS; INTEGRIN ALPHA CHAINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEOPLASM INVASIVENESS; PEPTIDE HYDROLASES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROSTATIC NEOPLASMS;

EID: 78149484263     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510002114     Document Type: Article

References (45)

1. Lee CK, Park KK, Lim SS, et al. (2007) Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull 30, 2191-2195.
2. Adams LS, Seeram NP, Hardy ML, et al. (2006) Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. Evid Based Complement Alternat Med 3, 117-124.
3. Jo EH, Kim SH, Ra JC, et al. (2005) Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett 230, 239-247.
4. Ma J, Peng W & Liang D (2000) Apoptosis of human gastric cancer cell line MGC-803 induced by Glycyrrhiza uralensis extract. Zhongguo Zhong Xi Yi Jie He Za Zhi 20, 928-930.
5. Wang ZY & Nixon DW (2001) Licorice and cancer. Nutr Cancer 39, 1-11.
6. Asl MN & Hosseinzadeh H (2008) Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 22, 709-724.
7. Kobayashi M, Fujita K, Katakura T, et al. (2002) Inhibitory effect of glycyrrhizin on experimental pulmonary metastasis in mice inoculated with B16 melanoma. Anticancer Res 22, 4053-4058.
8. Hibasami H, Iwase H, Yoshioka K, et al. (2005) Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int J Mol Med 16, 233-236.
9. Hibasami H, Iwase H, Yoshioka K, et al. (2006) Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells. Int J Mol Med 17, 215-219.
10. Thirugnanam S, Xu L, Ramaswamy K, et al. (2008) Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP. Oncol Rep 20, 1387-1392.
11. Hattori M, Sakamoto T, Kobashi K, et al. (1983) Metabolism of glycyrrhizin by human intestinal flora. Planta Med 48, 38-42.
12. Stormer FC, Reistad R & Alexander J (1993) Glycyrrhizic acid in liquorice - evaluation of health hazard. Food Chem Toxicol 31, 303-312.
13. van Uum SH (2005) Liquorice and hypertension. Neth J Med 63, 119-120.
14. Choi HJ, SeonMR,LimSS, et al. (2008) Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. Exp Biol Med 233, 1554-1560.
15. Jemal A, Siegel R, Ward E, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58, 71-96.
16. Steeg PS (2006) Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12, 895-904.
17. Bogenrieder T & Herlyn M (2003) Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22, 6524-6536.
18. Yoon SO, Park SJ, Yun CH, et al. (2003) Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol 36, 128-137.
19. Zhang L, Shi J, Feng J, et al. (2004) Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer. Prostate Cancer Prostatic Dis 7, 327-332.
20. Crippa MP (2007) Urokinase-type plasminogen activator. Int J Biochem Cell Biol 39, 690-694.
21. Orian-Rousseau V & Ponta H (2008) Adhesion proteins meet receptors: a common theme? Adv Cancer Res 101, 63-92.
22. Okegawa T, Pong RC, Li Y, et al. (2004) The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol 51, 445-457.
23. Moll UM, Youngleib GL, Rosinski KB, et al. (1990) Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells. Cancer Res 50, 6162-6170.
24. Azzam HS & Thompson EW (1992) Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells. Cancer Res 52, 4540-4544.
25. Cho HJ, Kim WK, Kim EJ, et al. (2003) Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. Am J Physiol Gastrointest Liver Physiol 284, G996-1005.
26. Kwon GT, Cho HJ, Chung WY, et al. (2009) Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem 20, 663-676.
27. Howard EW, Bullen EC & Banda MJ (1991) Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2. J Biol Chem 266, 13064-13069.
28. Li Y & Cozzi PJ (2007) Targeting uPA/uPAR in prostate cancer. Cancer Treat Rev 33, 521-527.
29. Fukai T, Toyono M & Nomura T (1988) On the structure of licoricidin. Heterocycles 27, 2309-2313.
30. Cho HJ, Lim SS, Lee YS, et al. (2010) Hexane/ethanol extract of Glycyrrhiza uralensis licorice exerts potent anti-inflammatory effects in murine macrophages and in mouse skin. Food Chem 121, 959-966.
31. Hawthorne S & Gallagher S (2008) Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostatespecific antigen secretion in LNCaP prostate cancer cells. J Pharm Pharmacol 60, 661-666.
32. Shibata S, Inoue H, Iwata S, et al. (1991) Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. Planta Med 57, 221-224.
33. Yamazaki S, Morita T, Endo H, et al. (2002) Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma. Cancer Lett 183, 23-30.
34. Agarwal MK, Iqbal M & Athar M (2005) Inhibitory effect of 18beta-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol- 13-acetate-induced cutaneous oxidative stress and tumor promotion in mice. Redox Rep 10, 151-157.
35. Fukai T, Marumo A, Kaitou K, et al. (2002) Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci 71, 1449-1463.
36. Hatano T, Kusuda M, Inada K, et al. (2005) Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Phytochemistry 66, 2047-2055.
37. Lambert E, Dasse E, Haye B, et al. (2004) TIMPs as multifacial proteins. Crit Rev Oncol Hematol 49, 187-198.
38. Jiang Y, Goldberg ID & Shi YE (2002) Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 21, 2245-2252.
39. Soula-Rothhut M, Coissard C, Sartelet H, et al. (2005) The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells. Exp Cell Res 304, 187-201.
40. Honkavuori M, Talvensaari-Mattila A, Puistola U, et al. (2008) High serum TIMP-1 is associated with adverse prognosis in endometrial carcinoma. Anticancer Res 28, 2715-2719.
41. Blasi F & Verde P (1990) Urokinase-dependent cell surface proteolysis and cancer. Semin Cancer Biol 1, 117-126.
42. Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29, 15-18.
43. Hicklin DJ & Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23, 1011-1027.
44. Goh PP, Sze DM & Roufogalis BD (2007) Molecular and cellular regulators of cancer angiogenesis. Curr Cancer Drug Targets 7, 743-758.
45. Christofori G (2006) New signals from the invasive front. Nature 441, 444-450.