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Volumn 33, Issue 12, 2010, Pages 1975-1984

Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats

Author keywords

Excretion; Ginsenosides Rg1; LC MS MS; Metabolism; Pharmacokinetics; Tissue distribution

Indexed keywords

BETA GLUCOSACCHARASE; GINSENOSIDE F1; GINSENOSIDE PPT; GINSENOSIDE RG 1; GINSENOSIDE RH 1; GLYCOSIDASE; SAPONIN; UNCLASSIFIED DRUG;

EID: 78751504470     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1213-2     Document Type: Article
Times cited : (41)

References (17)
  • 1
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng Pharmacology multiple constituents and multiple actions
    • 1:CAS:528:DyaK1MXntVCgtbw%3D 10.1016/S0006-2952(99)00212-9 10571242
    • A. S. Attele J. A. Wu C. S. Yuan 1999 Ginseng Pharmacology multiple constituents and multiple actions Biochem. Pharmacol. 58 1685 1693 1:CAS:528:DyaK1MXntVCgtbw%3D 10.1016/S0006-2952(99)00212-9 10571242
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 2
    • 0036370799 scopus 로고    scopus 로고
    • Metabolism of 20 (S)- and 20 (R)-Ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    • 1:CAS:528:DC%2BD38XhvVehtw%3D%3D 10.1248/bpb.25.58 11824558
    • E. A. Bae M. J. Han M. K. Choo S. Y. Park D. H. Kim 2002 Metabolism of 20 (S)- and 20 (R)-Ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities Biol. Pharm. Bull. 25 58 63 1:CAS:528:DC%2BD38XhvVehtw%3D%3D 10.1248/bpb.25.58 11824558
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 58-63
    • Bae, E.A.1    Han, M.J.2    Choo, M.K.3    Park, S.Y.4    Kim, D.H.5
  • 3
    • 34548036697 scopus 로고    scopus 로고
    • Microbial transformation of 20(S)-protopanaxatriol type saponins by Absidia eoerulea
    • 1:CAS:528:DC%2BD2sXnsF2jt7c%3D 10.1021/np070053v 17629326
    • G. T. Chen M. Yang Z. Q. Lu J. Zhang H. Huang Y. Liang S. Guan Y. Song L. Wu D. A. Guo 2007 Microbial transformation of 20(S)-protopanaxatriol type saponins by Absidia eoerulea J. Nat. Prod. 70 1203 1206 1:CAS:528: DC%2BD2sXnsF2jt7c%3D 10.1021/np070053v 17629326
    • (2007) J. Nat. Prod. , vol.70 , pp. 1203-1206
    • Chen, G.T.1    Yang, M.2    Lu, Z.Q.3    Zhang, J.4    Huang, H.5    Liang, Y.6    Guan, S.7    Song, Y.8    Wu, L.9    Guo, D.A.10
  • 4
    • 0029853361 scopus 로고    scopus 로고
    • Cardiovascular protection by ginsenosides and their nitric oxide releasing action
    • 1:CAS:528:DyaK28Xls1Omsrw%3D 10.1111/j.1440-1681.1996.tb01767.x 8886498
    • X. Chen 1996 Cardiovascular protection by ginsenosides and their nitric oxide releasing action Clin. Exp. Pharmacol. Physiol. 23 728 732 1:CAS:528:DyaK28Xls1Omsrw%3D 10.1111/j.1440-1681.1996.tb01767.x 8886498
    • (1996) Clin. Exp. Pharmacol. Physiol. , vol.23 , pp. 728-732
    • Chen, X.1
  • 5
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link
    • 1:CAS:528:DyaK2sXlsVGqtbk%3D 10.1016/S0006-2952(97)00193-7 9296344
    • C. N. Gillis 1997 Panax ginseng pharmacology: a nitric oxide link Biochem. Pharmacol. 54 1 8 1:CAS:528:DyaK2sXlsVGqtbk%3D 10.1016/S0006-2952(97) 00193-7 9296344
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 6
    • 33746824294 scopus 로고    scopus 로고
    • Mechanism of oral absorption of panax notoginseng saponins
    • 1:CAS:528:DC%2BD2sXptVGit74%3D 16927822
    • M. Han L. M. Han Q. S. Wang Z. H. Bai X. L. Fang 2006 Mechanism of oral absorption of panax notoginseng saponins Yao Xue Xue Bao 41 498 505 1:CAS:528:DC%2BD2sXptVGit74%3D 16927822
    • (2006) Yao Xue Xue Bao , vol.41 , pp. 498-505
    • Han, M.1    Han, L.M.2    Wang, Q.S.3    Bai, Z.H.4    Fang, X.L.5
  • 7
    • 0029840531 scopus 로고    scopus 로고
    • Main ginseng saponin metabolites formed by intestinal bacteria
    • 1:CAS:528:DyaK28XnsVyhsb0%3D 10.1055/s-2006-957938 8923812
    • H. Hasegawa J. H. Sung S. Matsumiya M. Uchiyama 1996 Main ginseng saponin metabolites formed by intestinal bacteria Planta Med. 62 453 457 1:CAS:528:DyaK28XnsVyhsb0%3D 10.1055/s-2006-957938 8923812
    • (1996) Planta Med. , vol.62 , pp. 453-457
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4
  • 8
    • 0025173264 scopus 로고
    • Panax ginseng as a potential immunomodulator: Studies in mice
    • 1:STN:280:DyaK3M%2Fjs1Kqtw%3D%3D 10.3109/08923979009019672 2229924
    • J. Y. Kim D. R. Germolec M. I. Luster 1990 Panax ginseng as a potential immunomodulator: studies in mice Immunopharmacol. Immunotoxicol. 12 257 276 1:STN:280:DyaK3M%2Fjs1Kqtw%3D%3D 10.3109/08923979009019672 2229924
    • (1990) Immunopharmacol. Immunotoxicol. , vol.12 , pp. 257-276
    • Kim, J.Y.1    Germolec, D.R.2    Luster, M.I.3
  • 9
    • 0030838299 scopus 로고    scopus 로고
    • 1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor
    • 1:CAS:528:DyaK2sXmsl2mt7Y%3D 10.1016/S0303-7207(97)00160-3 9406859
    • 1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor Mol. Cell. Endocrinol. 133 135 140 1:CAS:528:DyaK2sXmsl2mt7Y%3D 10.1016/S0303-7207(97) 00160-3 9406859
    • (1997) Mol. Cell. Endocrinol. , vol.133 , pp. 135-140
    • Lee, Y.J.1    Chung, E.2    Lee, K.Y.3    Lee, Y.H.4    Huh, B.5    Lee, S.K.6
  • 13
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanax saponins has the ability to induce apoptosis in tumor cells
    • 1:CAS:528:DyaK1cXjsFGmtL4%3D 10.1006/bbrc.1998.8690 9618279
    • C. Wakabayashi K. Murakami H. Hasegawa J. Murata I. Saiki 1998 An intestinal bacterial metabolite of ginseng protopanax saponins has the ability to induce apoptosis in tumor cells Biochem. Biophys. Res. Commun. 246 725 730 1:CAS:528:DyaK1cXjsFGmtL4%3D 10.1006/bbrc.1998.8690 9618279
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, J.4    Saiki, I.5
  • 14
    • 0041290817 scopus 로고    scopus 로고
    • 1 by intestinal bacterial and its absorbed metabolites in rat and human serum
    • 1:CAS:528:DC%2BD3cXjvVSgtbs%3D
    • 1 by intestinal bacterial and its absorbed metabolites in rat and human serum Acta Pharmacol. Sin. 35 284 288 1:CAS:528: DC%2BD3cXjvVSgtbs%3D
    • (2000) Acta Pharmacol. Sin. , vol.35 , pp. 284-288
    • Wang, Y.1    Liu, T.H.2    Wang, Y.P.3
  • 15
    • 0037296911 scopus 로고    scopus 로고
    • 1 from Panax notoginseng in rats
    • 1:CAS:528:DC%2BD3sXhslehtrY%3D 10.1016/S0378-8741(02)00317-3 12648814
    • 1 from Panax notoginseng in rats J. Ethnopharmacol. 84 187 192 1:CAS:528:DC%2BD3sXhslehtrY%3D 10.1016/S0378-8741(02)00317-3 12648814
    • (2003) J. Ethnopharmacol. , vol.84 , pp. 187-192
    • Xu, Q.F.1    Fang, X.L.2    Chen, D.F.3
  • 16
    • 0030512678 scopus 로고    scopus 로고
    • 1 on the performance impaired by scopolamine in rats
    • 1:CAS:528:DyaK2sXot1Kgtw%3D%3D
    • 1 on the performance impaired by scopolamine in rats Biomed. Res. 17 487 490 1:CAS:528:DyaK2sXot1Kgtw%3D%3D
    • (1996) Biomed. Res. , vol.17 , pp. 487-490
    • Yamaguchi, Y.1    Higashi, M.2    Kobayashi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.