The coordination of nuclear and mitochondrial communication during aging and calorie restriction

Ageing Research Reviews

Volumn 8, Issue 3, 2009, Pages 173-188

  Finley, Lydia W S ^a   Haigis, Marcia C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; AMPK; Metabolism; Mitochondria; PGC 1 ; SIRT1

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1;

APOPTOSIS; CALCIUM HOMEOSTASIS; CALORIC RESTRICTION; CELL AGING; CELL FUNCTION; CELL NUCLEUS; CLINICAL RESEARCH; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY YIELD; GENE EXPRESSION REGULATION; HUMAN; MAMMAL; MITOCHONDRION; NONHUMAN; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; YEAST;

ACTIVE TRANSPORT, CELL NUCLEUS; AGING; ANIMALS; CALORIC RESTRICTION; CELL AGING; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 66049087696     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2009.03.003     Document Type: Short Survey

References (266)

1. Abu-Elheiga L., Matzuk M.M., Abo-Hashema K.A., and Wakil S.J. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291 (2001) 2613-2616
2. Abu-Elheiga L., Matzuk M.M., Kordari P., Oh W., Shaikenov T., Gu Z., and Wakil S.J. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 12011-12016
3. Abu-Erreish G.M., Neely J.R., Whitmer J.T., Whitman V., and Sanadi D.R. Fatty acid oxidation by isolated perfused working hearts of aged rats. Am. J. Physiol. 232 (1977) E258-262
4. Al-Regaiey K.A., Masternak M.M., Bonkowski M., Sun L., and Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor I/insulin signaling and caloric restriction. Endocrinology 146 (2005) 851-860
5. Allard J.S., Heilbronn L.K., Smith C., Hunt N.D., Ingram D.K., Ravussin E., and de Cabo R. In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS ONE 3 (2008) e3211
6. Amuthan G., Biswas G., Ananadatheerthavarada H.K., Vijayasarathy C., Shephard H.M., and Avadhani N.G. Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene 21 (2002) 7839-7849
7. Anbanandam A., Bieber Urbauer R.J., Bartlett R.K., Smallwood H.S., Squier T.C., and Urbauer J.L. Mediating molecular recognition by methionine oxidation: conformational switching by oxidation of methionine in the carboxyl-terminal domain of calmodulin. Biochemistry 44 (2005) 9486-9496
8. Anderson R.M., Barger J.L., Edwards M.G., Braun K.H., O'Connor C.E., Prolla T.A., and Weindruch R. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell 7 (2008) 101-111
9. Apfeld J., O'Connor G., McDonagh T., DiStefano P.S., and Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18 (2004) 3004-3009
10. Arany Z., Lebrasseur N., Morris C., Smith E., Yang W., Ma Y., Chin S., and Spiegelman B.M. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metabol. 5 (2007) 35-46
11. Arany Z., He H., Lin J., Hoyer K., Handschin C., Toka O., Ahmad F., Matsui T., Chin S., Wu P.H., Rybkin I.I., Shelton J.M., Manieri M., Cinti S., Schoen F.J., Bassel-Duby R., Rosenzweig A., Ingwall J.S., and Spiegelman B.M. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metabol. 1 (2005) 259-271
12. Arnould T., Vankoningsloo S., Renard P., Houbion A., Ninane N., Demazy C., Remacle J., and Raes M. CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation. EMBO J. 21 (2002) 53-63
13. Ashrafi K., Lin S.S., Manchester J.K., and Gordon J.I. Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev. 14 (2000) 1872-1885
14. Baar K., Wende A.R., Jones T.E., Marison M., Nolte L.A., Chen M., Kelly D.P., and Holloszy J.O. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 16 (2002) 1879-1886
15. Baker D.J., Betik A.C., Krause D.J., and Hepple R.T. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 675-684
16. Banks A.S., Kon N., Knight C., Matsumoto M., Gutierrez-Juarez R., Rossetti L., Gu W., and Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metabol. 8 (2008) 333-341
17. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., Wang Y., Raederstorff D., Morrow J.D., Leeuwenburgh C., Allison D.B., Saupe K.W., Cartee G.D., Weindruch R., and Prolla T.A. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 3 (2008) e2264
18. Barnes B.R., Marklund S., Steiler T.L., Walter M., Hjalm G., Amarger V., Mahlapuu M., Leng Y., Johansson C., Galuska D., Lindgren K., Abrink M., Stapleton D., Zierath J.R., and Andersson L. The 5′-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J. Biol. Chem. 279 (2004) 38441-38447
19. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., and Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
20. Bentzinger C.F., Romanino K., Cloetta D., Lin S., Mascarenhas J.B., Oliveri F., Xia J., Casanova E., Costa C.F., Brink M., Zorzato F., Hall M.N., and Ruegg M.A. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabol. 8 (2008) 411-424
21. Bergeron R., Ren J.M., Cadman K.S., Moore I.K., Perret P., Pypaert M., Young L.H., Semenkovich C.F., and Shulman G.I. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am. J. Physiol. Endocrinol. Metabol. 281 (2001) E1340-1346
22. Bevilacqua L., Ramsey J.J., Hagopian K., Weindruch R., and Harper M.E. Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am. J. Physiol. Endocrinol. Metabol. 286 (2004) E852-861
23. Bevilacqua L., Ramsey J.J., Hagopian K., Weindruch R., and Harper M.E. Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am. J. Physiol. Endocrinol. Metabol. 289 (2005) E429-438
24. Bishop N.A., and Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447 (2007) 545-549
25. 12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J. 18 (1999) 522-533
26. Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003) 572-574
27. Boily G., Seifert E.L., Bevilacqua L., He X.H., Sabourin G., Estey C., Moffat C., Crawford S., Saliba S., Jardine K., Xuan J., Evans M., Harper M.E., and McBurney M.W. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE 3 (2008) e1759
28. Bordone L., and Guarente L. Calorie restriction. SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell. Biol. 6 (2005) 298-305
29. Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., and Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6 (2007) 759-767
30. Bordone L., Motta M.C., Picard F., Robinson A., Jhala U.S., Apfeld J., McDonagh T., Lemieux M., McBurney M., Szilvasi A., Easlon E.J., Lin S.J., and Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4 (2006) e31
31. Bremer J., and Davis E.J. Studies on the active transfer of reducing equivalents into mitochondria via the malate-aspartate shuttle. Biochim. Biophys. Acta 376 (1975) 387-397
32. Brookes P.S., Levonen A.L., Shiva S., Sarti P., and Darley-Usmar V.M. Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radic. Biol. Med. 33 (2002) 755-764
33. Brown N.F., Stefanovic-Racic M., Sipula I.J., and Perdomo G. The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes. Metabolism 56 (2007) 1500-1507
34. Bruce-Keller A.J., Umberger G., McFall R., and Mattson M.P. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 45 (1999) 8-15
35. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., and Greenberg M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
36. 2+ homeostasis in peripheral neurones: implications for changes in function. Aging Cell 6 (2007) 285-296
37. Butow R.A., and Avadhani N.G. Mitochondrial signaling: the retrograde response. Mol. Cell 14 (2004) 1-15
38. Calvo J.A., Daniels T.G., Wang X., Paul A., Lin J., Spiegelman B.M., Stevenson S.C., and Rangwala S.M. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J. Appl. Physiol. 104 (2008) 1304-1312
39. Cartwright M.J., Tchkonia T., and Kirkland J.L. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp. Gerontol. 42 (2007) 463-471
40. Chen D., Steele A.D., Lindquist S., and Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 310 (2005) 1641
41. Chen D., Pan K.Z., Palter J.E., and Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 6 (2007) 525-533
42. Chen D., Bruno J., Easlon E., Lin S.J., Cheng H.L., Alt F.W., and Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22 (2008) 1753-1757
43. Choi C.S., Befroy D.E., Codella R., Kim S., Reznick R.M., Hwang Y.J., Liu Z.X., Lee H.Y., Distefano A., Samuel V.T., Zhang D., Cline G.W., Handschin C., Lin J., Petersen K.F., Spiegelman B.M., and Shulman G.I. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 19926-19931
44. Chretien D., Gallego J., Barrientos A., Casademont J., Cardellach F., Munnich A., Rotig A., and Rustin P. Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem. J. 329 Pt 2 (1998) 249-254
45. Civitarese A.E., Carling S., Heilbronn L.K., Hulver M.H., Ukropcova B., Deutsch W.A., Smith S.R., and Ravussin E. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4 (2007) e76
46. Cleeter M.W., Cooper J.M., Darley-Usmar V.M., Moncada S., and Schapira A.H. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345 (1994) 50-54
47. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., and Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
48. Comfort A. Effect of delayed and resumed growth on the longevity of a fish (Lebistes Reticulatus, Peters) in captivity. Gerontologia 49 (1963) 150-155
49. Conley K.E., Jubrias S.A., and Esselman P.C. Oxidative capacity and ageing in human muscle. J. Physiol. 526 Pt 1 (2000) 203-210
50. Conley K.E., Jubrias S.A., Amara C.E., and Marcinek D.J. Mitochondrial dysfunction: impact on exercise performance and cellular aging. Exerc. Sport Sci. Rev. 35 (2007) 43-49
51. Cooper J.M., Mann V.M., and Schapira A.H. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J. Neurol. Sci. 113 (1992) 91-98
52. Cui L., Jeong H., Borovecki F., Parkhurst C.N., Tanese N., and Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127 (2006) 59-69
53. Cunningham J.T., Rodgers J.T., Arlow D.H., Vazquez F., Mootha V.K., and Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450 (2007) 736-740
54. Dennis P.B., Jaeschke A., Saitoh M., Fowler B., Kozma S.C., and Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science 294 (2001) 1102-1105
55. Desai B.N., Myers B.R., and Schreiber S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 4319-4324
56. Dilova I., Chen C.Y., and Powers T. Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr. Biol. 12 (2002) 389-395
57. Drew B., and Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann. N. Y. Acad. Sci. 959 (2002) 66-81
58. Drew B., and Leeuwenburgh C. Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R1259-1267
59. Drew B., Phaneuf S., Dirks A., Selman C., Gredilla R., Lezza A., Barja G., and Leeuwenburgh C. Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R474-480
60. Duan W., Guo Z., Jiang H., Ware M., Li X.J., and Mattson M.P. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2911-2916
61. Easlon E., Tsang F., Skinner C., Wang C., and Lin S.J. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev. 22 (2008) 931-944
62. Easlon E., Tsang F., Dilova I., Wang C., Lu S.P., Skinner C., and Lin S.J. The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. J. Biol. Chem. 282 (2007) 6161-6171
63. Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., and Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metabol. 8 (2008) 347-358
64. Finck B.N., and Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116 (2006) 615-622
65. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247
66. Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273 (2000) 793-798
67. Gangloff Y.G., Mueller M., Dann S.G., Svoboda P., Sticker M., Spetz J.F., Um S.H., Brown E.J., Cereghini S., Thomas G., and Kozma S.C. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol. Cell. Biol. 24 (2004) 9508-9516
68. Garcia-Roves P.M., Osler M.E., Holmstrom M.H., and Zierath J.R. Gain-of-function R225Q mutation in AMP-activated protein kinase gamma 3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J. Biol. Chem. (2008)
69. Gerhart-Hines Z., Rodgers J.T., Bare O., Lerin C., Kim S.H., Mostoslavsky R., Alt F.W., Wu Z., and Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26 (2007) 1913-1923
70. Ghafourifar P., and Cadenas E. Mitochondrial nitric oxide synthase. Trends Pharmacol. Sci. 26 (2005) 190-195
71. Gleyzer N., Vercauteren K., and Scarpulla R.C. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol. Cell. Biol. 25 (2005) 1354-1366
72. Goffart S., and Wiesner R.J. Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. Exp. Physiol. 88 (2003) 33-40
73. Gonzalez A.A., Kumar R., Mulligan J.D., Davis A.J., Weindruch R., and Saupe K.W. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am. J. Physiol. Endocrinol. Metab. 287 (2004) E1032-1037
74. Goto M., Terada S., Kato M., Katoh M., Yokozeki T., Tabata I., and Shimokawa T. cDNA cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem. Biophys. Res. Commun. 274 (2000) 350-354
75. Gredilla R., Sanz A., Lopez-Torres M., and Barja G. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J. 15 (2001) 1589-1591
76. Greer E.L., Oskoui P.R., Banko M.R., Maniar J.M., Gygi M.P., Gygi S.P., and Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 282 (2007) 30107-30119
77. Greer E.L., Dowlatshahi D., Banko M.R., Villen J., Hoang K., Blanchard D., Gygi S.P., and Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 17 (2007) 1646-1656
78. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 444 (2006) 868-874
79. Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 (2007) 9-22
80. Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., Brown M., Fitzgerald K.J., and Sabatini D.M. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11 (2006) 859-871
81. Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., and Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 (2008) 214-226
82. Hagen T.M., Yowe D.L., Bartholomew J.C., Wehr C.M., Do K.L., Park J.Y., and Ames B.N. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 3064-3069
83. Haigis M.C., and Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20 (2006) 2913-2921
84. Hallows W.C., Lee S., and Denu J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 10230-10235
85. Handschin C., and Spiegelman B.M. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27 (2006) 728-735
86. Handschin C., Choi C.S., Chin S., Kim S., Kawamori D., Kurpad A.J., Neubauer N., Hu J., Mootha V.K., Kim Y.B., Kulkarni R.N., Shulman G.I., and Spiegelman B.M. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J. Clin. Invest. 117 (2007) 3463-3474
87. Hansen M., Taubert S., Crawford D., Libina N., Lee S.J., and Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6 (2007) 95-110
88. Hardie D.G. The AMP-activated protein kinase pathway-new players upstream and downstream. J. Cell. Sci. 117 (2004) 5479-5487
89. Hardie D.G. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett. 582 (2008) 81-89
90. Hardie D.G., and Pan D.A. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem. Soc. Trans. 30 (2002) 1064-1070
91. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
92. Hepple R.T., Baker D.J., McConkey M., Murynka T., and Norris R. Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles. Rejuvenation Res. 9 (2006) 219-222
93. Holloszy J.O., and Booth F.W. Biochemical adaptations to endurance exercise in muscle. Annu. Rev. Physiol. 38 (1976) 273-291
94. Honjoh S., Yamamoto T., Uno M., and Nishida E. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature (2008)
95. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., and Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
96. Hunt N.D., Hyun D.H., Allard J.S., Minor R.K., Mattson M.P., Ingram D.K., and de Cabo R. Bioenergetics of aging and calorie restriction. Ageing Res. Rev. 5 (2006) 125-143
97. Huss J.M., and Kelly D.P. Nuclear receptor signaling and cardiac energetics. Circ. Res. 95 (2004) 568-578
98. Huss J.M., and Kelly D.P. Mitochondrial energy metabolism in heart failure: a question of balance. J. Clin. Invest. 115 (2005) 547-555
99. Inoki K., Zhu T., and Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003) 577-590
100. Jager S., Handschin C., St-Pierre J., and Spiegelman B.M. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 12017-12022
101. Jia K., Chen D., and Riddle D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 (2004) 3897-3906
102. Johnson D.T., Harris R.A., French S., Blair P.V., You J., Bemis K.G., Wang M., and Balaban R.S. Tissue heterogeneity of the mammalian mitochondrial proteome. Am. J. Physiol. Cell. Physiol. 292 (2007) C689-C697
103. Jorgensen S.B., and Rose A.J. How is AMPK activity regulated in skeletal muscles during exercise?. Front Biosci. 13 (2008) 5589-5604
104. Jorgensen S.B., Viollet B., Andreelli F., Frosig C., Birk J.B., Schjerling P., Vaulont S., Richter E.A., and Wojtaszewski J.F. Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J. Biol. Chem. 279 (2004) 1070-1079
105. Jorgensen S.B., Wojtaszewski J.F., Viollet B., Andreelli F., Birk J.B., Hellsten Y., Schjerling P., Vaulont S., Neufer P.D., Richter E.A., and Pilegaard H. Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J. 19 (2005) 1146-1148
106. Jubrias S.A., Esselman P.C., Price L.B., Cress M.E., and Conley K.E. Large energetic adaptations of elderly muscle to resistance and endurance training. J. Appl. Physiol. 90 (2001) 1663-1670
107. Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
108. Kaeberlein M., Hu D., Kerr E.O., Tsuchiya M., Westman E.A., Dang N., Fields S., and Kennedy B.K. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet. 1 (2005) e69
109. Kaeberlein M., Powers III R.W., Steffen K.K., Westman E.A., Hu D., Dang N., Kerr E.O., Kirkland K.T., Fields S., and Kennedy B.K. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310 (2005) 1193-1196
110. Kahn B.B., Alquier T., Carling D., and Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabol. 1 (2005) 15-25
111. Kapahi P., Zid B.M., Harper T., Koslover D., Sapin V., and Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14 (2004) 885-890
112. Katic M., Kennedy A.R., Leykin I., Norris A., McGettrick A., Gesta S., Russell S.J., Bluher M., Maratos-Flier E., and Kahn C.R. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell 6 (2007) 827-839
113. Kelly D.P., and Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18 (2004) 357-368
114. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., and Sabatini D.M. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110 (2002) 163-175
115. Kirchman P.A., Kim S., Lai C.Y., and Jazwinski S.M. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152 (1999) 179-190
116. Kwong L.K., and Sohal R.S. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Arch. Biochem. Biophys. 373 (2000) 16-22
117. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., and Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (2006) 1109-1122
118. Lambert A.J., Wang B., Yardley J., Edwards J., and Merry B.J. The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp. Gerontol. 39 (2004) 289-295
119. Lanza I.R., Befroy D.E., and Kent-Braun J.A. Age-related changes in ATP-producing pathways in human skeletal muscle in vivo. J. Appl. Physiol. 99 (2005) 1736-1744
120. Le Bacquer O., Petroulakis E., Paglialunga S., Poulin F., Richard D., Cianflone K., and Sonenberg N. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Invest. 117 (2007) 387-396
121. Lee C.K., Allison D.B., Brand J., Weindruch R., and Prolla T.A. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 14988-14993
122. Lee S.S., Lee R.Y., Fraser A.G., Kamath R.S., Ahringer J., and Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33 (2003) 40-48
123. Lee W.J., Kim M., Park H.S., Kim H.S., Jeon M.J., Oh K.S., Koh E.H., Won J.C., Kim M.S., Oh G.T., Yoon M., Lee K.U., and Park J.Y. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem. Biophys. Res. Commun. 340 (2006) 291-295
124. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., and Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106 (2000) 847-856
125. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., Chen Z., Holloszy J.O., Medeiros D.M., Schmidt R.E., Saffitz J.E., Abel E.D., Semenkovich C.F., and Kelly D.P. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 3 (2005) e101
126. Li Y., Xu W., McBurney M.W., and Longo V.D. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metabol. 8 (2008) 38-48
127. Lin J., Tarr P.T., Yang R., Rhee J., Puigserver P., Newgard C.B., and Spiegelman B.M. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J. Biol. Chem. 278 (2003) 30843-30848
128. Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., Lowell B.B., Bassel-Duby R., and Spiegelman B.M. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 (2002) 797-801
129. Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., Cui L., Manieri M., Donovan M.X., Wu Z., Cooper M.P., Fan M.C., Rohas L.M., Zavacki A.M., Cinti S., Shulman G.I., Lowell B.B., Krainc D., and Spiegelman B.M. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 (2004) 121-135
130. Lin S.J., Defossez P.A., and Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 (2000) 2126-2128
131. Lin S.J., Ford E., Haigis M., Liszt G., and Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18 (2004) 12-16
132. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., and Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418 (2002) 344-348
133. Lin S.S., Manchester J.K., and Gordon J.I. Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J. Biol. Chem. 278 (2003) 13390-13397
134. Linford N.J., Beyer R.P., Gollahon K., Krajcik R.A., Malloy V.L., Demas V., Burmer G.C., and Rabinovitch P.S. Transcriptional response to aging and caloric restriction in heart and adipose tissue. Aging Cell 6 (2007) 673-688
135. Ling C., Poulsen P., Carlsson E., Ridderstrale M., Almgren P., Wojtaszewski J., Beck-Nielsen H., Groop L., and Vaag A. Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. J. Clin. Invest. 114 (2004) 1518-1526
136. Liu Z., and Butow R.A. Mitochondrial retrograde signaling. Annu. Rev. Genet. 40 (2006) 159-185
137. Loeb J., and Northrop J.H. On the influence of food and temperature upon the duration of life. J. Biol. Chem. 32 (1917) 103-121
138. Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116 (2006) 1776-1783
139. Long Y.C., Barnes B.R., Mahlapuu M., Steiler T.L., Martinsson S., Leng Y., Wallberg-Henriksson H., Andersson L., and Zierath J.R. Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle. Diabetologia 48 (2005) 2354-2364
140. Lopez-Lluch G., Hunt N., Jones B., Zhu M., Jamieson H., Hilmer S., Cascajo M.V., Allard J., Ingram D.K., Navas P., and de Cabo R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 1768-1773
141. Lowell B.B., and Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307 (2005) 384-387
142. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., Chan J., and Yankner B.A. Gene regulation and DNA damage in the ageing human brain. Nature 429 (2004) 883-891
143. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
144. Luo Y., Bond J.D., and Ingram V.M. Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 9705-9710
145. Martin M.E., Chinenov Y., Yu M., Schmidt T.K., and Yang X.Y. Redox regulation of GA-binding protein-alpha DNA binding activity. J. Biol. Chem. 271 (1996) 25617-25623
146. Maswood N., Young J., Tilmont E., Zhang Z., Gash D.M., Gerhardt G.A., Grondin R., Roth G.S., Mattison J., Lane M.A., Carson R.E., Cohen R.M., Mouton P.R., Quigley C., Mattson M.P., and Ingram D.K. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 18171-18176
147. McCarty M.F. Chronic activation of AMP-activated kinase as a strategy for slowing aging. Med. Hypotheses 63 (2004) 334-339
148. McCay C.M., Crowell M.F., and Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition 5 (1989) 155-171 discussion 172
149. McGee S.L., and Hargreaves M. AMPK and transcriptional regulation. Front Biosci. 13 (2008) 3022-3033
150. Medvedik O., Lamming D.W., Kim K.D., and Sinclair D.A. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 5 (2007) e261
151. Melanson K.J., Saltzman E., Russell R.R., and Roberts S.B. Fat oxidation in response to four graded energy challenges in younger and older women. Am. J. Clin. Nutr. 66 (1997) 860-866
152. 2+-operated transcriptional networks: molecular mechanisms and in vivo models. Physiol. Rev. 88 (2008) 421-449
153. Melov S., Tarnopolsky M.A., Beckman K., Felkey K., and Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS ONE 2 (2007) e465
154. Menshikova E.V., Ritov V.B., Fairfull L., Ferrell R.E., Kelley D.E., and Goodpaster B.H. Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 534-540
155. Merrill G.F., Kurth E.J., Hardie D.G., and Winder W.W. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273 (1997) E1107-1112
156. Merry B.J. Molecular mechanisms linking calorie restriction and longevity. Int. J. Biochem. Cell. Biol. 34 (2002) 1340-1354
157. Merry B.J. Oxidative stress and mitochondrial function with aging-the effects of calorie restriction. Aging Cell 3 (2004) 7-12
158. Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., and Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell. 16 (2005) 4623-4635
159. Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., Jin L., Boss O., Perni R.B., Vu C.B., Bemis J.E., Xie R., Disch J.S., Ng P.Y., Nunes J.J., Lynch A.V., Yang H., Galonek H., Israelian K., Choy W., Iffland A., Lavu S., Medvedik O., Sinclair D.A., Olefsky J.M., Jirousek M.R., Elliott P.J., and Westphal C.H. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450 (2007) 712-716
160. Miwa S., Lawless C., and von Zglinicki T. Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model. Aging Cell 7 (2008) 920-923
161. Mootha V.K., Handschin C., Arlow D., Xie X., St Pierre J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., Willy P.J., Schulman I.G., Heyman R.A., Lander E.S., and Spiegelman B.M. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 6570-6575
162. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., and Groop L.C. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
163. Morino K., Petersen K.F., Dufour S., Befroy D., Frattini J., Shatzkes N., Neschen S., White M.F., Bilz S., Sono S., Pypaert M., and Shulman G.I. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 115 (2005) 3587-3593
164. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., and Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 116 (2004) 551-563
165. Moynihan K.A., Grimm A.A., Plueger M.M., Bernal-Mizrachi E., Ford E., Cras-Meneur C., Permutt M.A., and Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metabol. 2 (2005) 105-117
166. Mu J., Brozinick Jr. J.T., Valladares O., Bucan M., and Birnbaum M.J. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell 7 (2001) 1085-1094
167. Mulligan J.D., Gonzalez A.A., Kumar R., Davis A.J., and Saupe K.W. Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 21-27
168. Nakamura Y., Ogura M., Tanaka D., and Inagaki N. Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 366 (2008) 174-179
169. Narkar V.A., Downes M., Yu R.T., Embler E., Wang Y.X., Banayo E., Mihaylova M.M., Nelson M.C., Zou Y., Juguilon H., Kang H., Shaw R.J., and Evans R.M. AMPK and PPARdelta agonists are exercise mimetics. Cell 134 (2008) 405-415
170. Navarro A., and Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell. Physiol. 292 (2007) C670-686
171. Navarro A., and Boveris A. Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants. Adv. Drug Deliv. Rev. 60 (2008) 1534-1544
172. Nilsson E.C., Long Y.C., Martinsson S., Glund S., Garcia-Roves P., Svensson L.T., Andersson L., Zierath J.R., and Mahlapuu M. Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice. J. Biol. Chem. 281 (2006) 7244-7252
173. Nisoli E., and Carruba M.O. Nitric oxide and mitochondrial biogenesis. J. Cell. Sci. 119 (2006) 2855-2862
174. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., and Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310 (2005) 314-317
175. North B.J., and Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2 (2007) e784
176. Oberdoerffer P., Michan S., McVay M., Mostoslavsky R., Vann J., Park S.K., Hartlerode A., Stegmuller J., Hafner A., Loerch P., Wright S.M., Mills K.D., Bonni A., Yankner B.A., Scully R., Prolla T.A., Alt F.W., and Sinclair D.A. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135 (2008) 907-918
177. Osler M.E., and Zierath J.R. Adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology 149 (2008) 935-941
178. Pagliarini D.J., Calvo S.E., Chang B., Sheth S.A., Vafai S.B., Ong S.E., Walford G.A., Sugiana C., Boneh A., Chen W.K., Hill D.E., Vidal M., Evans J.G., Thorburn D.R., Carr S.A., and Mootha V.K. A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 (2008) 112-123
179. Pahlavani M.A., and Vargas D.M. Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells. Mech. Ageing Dev. 112 (1999) 59-74
180. Pahlavani M.A., and Vargas D.M. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells. Proc. Soc. Exp. Biol. Med. 223 (2000) 163-169
181. Pan K.Z., Palter J.E., Rogers A.N., Olsen A., Chen D., Lithgow G.J., and Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6 (2007) 111-119
182. Park S.Y., Kim Y.W., Kim J.E., and Kim J.Y. Age-associated changes in fat metabolism in the rat and its relation to sympathetic activity. Life Sci. 79 (2006) 2228-2233
183. Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E.J., Goldfine A.B., Mun E., DeFronzo R., Finlayson J., Kahn C.R., and Mandarino L.J. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8466-8471
184. Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., Jamieson H.A., Zhang Y., Dunn S.R., Sharma K., Pleshko N., Woollett L.A., Csiszar A., Ikeno Y., Le Couteur D., Elliott P.J., Becker K.G., Navas P., Ingram D.K., Wolf N.S., Ungvari Z., Sinclair D.A., and de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabol. 8 (2008) 157-168
185. Petersen K.F., Dufour S., Befroy D., Garcia R., and Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350 (2004) 664-671
186. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., DiPietro L., Cline G.W., and Shulman G.I. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300 (2003) 1140-1142
187. Piantadosi C.A., and Suliman H.B. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J. Biol. Chem. 281 (2006) 324-333
188. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., and Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004) 771-776
189. Pilegaard H., Saltin B., and Neufer P.D. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J. Physiol. 546 (2003) 851-858
190. Powers III R.W., Kaeberlein M., Caldwell S.D., Kennedy B.K., and Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20 (2006) 174-184
191. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
192. Qiang W., Weiqiang K., Qing Z., Pengju Z., and Yi L. Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha. Exp. Mol. Med. 39 (2007) 535-543
193. Ramsey K.M., Mills K.F., Satoh A., and Imai S. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell 7 (2008) 78-88
194. Rasmussen U.F., Krustrup P., Kjaer M., and Rasmussen H.N. Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity. Pflugers Arch. 446 (2003) 270-278
195. Reznick R.M., Zong H., Li J., Morino K., Moore I.K., Yu H.J., Liu Z.X., Dong J., Mustard K.J., Hawley S.A., Befroy D., Pypaert M., Hardie D.G., Young L.H., and Shulman G.I. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metabol. 5 (2007) 151-156
196. Rodgers J.T., Lerin C., Gerhart-Hines Z., and Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 582 (2008) 46-53
197. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
198. Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 15998-16003
199. Rohas L.M., St-Pierre J., Uldry M., Jager S., Handschin C., and Spiegelman B.M. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 7933-7938
200. Russell A.P., Feilchenfeldt J., Schreiber S., Praz M., Crettenand A., Gobelet C., Meier C.A., Bell D.R., Kralli A., Giacobino J.P., and Deriaz O. Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes 52 (2003) 2874-2881
201. Russell L.K., Mansfield C.M., Lehman J.J., Kovacs A., Courtois M., Saffitz J.E., Medeiros D.M., Valencik M.L., McDonald J.A., and Kelly D.P. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ. Res. 94 (2004) 525-533
202. Ryan M.T., and Hoogenraad N.J. Mitochondrial-nuclear communications. Annu. Rev. Biochem. 76 (2007) 701-722
203. Sanz A., Caro P., Ibanez J., Gomez J., Gredilla R., and Barja G. Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain. J. Bioenergy Biomembr. 37 (2005) 83-90
204. Sarbassov D.D., and Sabatini D.M. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J. Biol. Chem. 280 (2005) 39505-39509
205. Sasaki T., Maier B., Bartke A., and Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 5 (2006) 413-422
206. Sastre J., Pallardo F.V., Pla R., Pellin A., Juan G., O'Connor J.E., Estrela J.M., Miquel J., and Vina J. Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatology 24 (1996) 1199-1205
207. Scarpulla R.C. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta 1576 (2002) 1-14
208. Scarpulla R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 88 (2008) 611-638
209. Scher M.B., Vaquero A., and Reinberg D. SirT3 is a nuclear NAD+ -dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 21 (2007) 920-928
210. Schieke S.M., Phillips D., McCoy Jr. J.P., Aponte A.M., Shen R.F., Balaban R.S., and Finkel T. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 281 (2006) 27643-27652
211. Schon E.A., and Manfredi G. Neuronal degeneration and mitochondrial dysfunction. J. Clin. Invest. 111 (2003) 303-312
212. Schulz T.J., Zarse K., Voigt A., Urban N., Birringer M., and Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metabol. 6 (2007) 280-293
213. Schwer B., and Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metabol. 7 (2008) 104-112
214. Sharp Z.D., and Bartke A. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 293-300
215. Shaw R.J., Bardeesy N., Manning B.D., Lopez L., Kosmatka M., DePinho R.A., and Cantley L.C. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6 (2004) 91-99
216. Shi T., Wang F., Stieren E., and Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J. Biol. Chem. 280 (2005) 13560-13567
217. Shiota C., Woo J.T., Lindner J., Shelton K.D., and Magnuson M.A. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11 (2006) 583-589
218. Short K.R., Vittone J.L., Bigelow M.L., Proctor D.N., Rizza R.A., Coenen-Schimke J.M., and Nair K.S. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52 (2003) 1888-1896
219. Short K.R., Bigelow M.L., Kahl J., Singh R., Coenen-Schimke J., Raghavakaimal S., and Nair K.S. Decline in skeletal muscle mitochondrial function with aging in humans. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 5618-5623
220. Sinclair D.A., and Guarente L. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91 (1997) 1033-1042
221. Sipula I.J., Brown N.F., and Perdomo G. Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation. Metabolism 55 (2006) 1637-1644
222. Sohal R.S., and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273 (1996) 59-63
223. Sohal R.S., Ku H.H., Agarwal S., Forster M.J., and Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Dev. 74 (1994) 121-133
224. Solomon T.P., Marchetti C.M., Krishnan R.K., Gonzalez F., and Kirwan J.P. Effects of aging on basal fat oxidation in obese humans. Metabolism 57 (2008) 1141-1147
225. St-Pierre J., Lin J., Krauss S., Tarr P.T., Yang R., Newgard C.B., and Spiegelman B.M. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J. Biol. Chem. 278 (2003) 26597-26603
226. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K., Lin J., Yang W., Simon D.K., Bachoo R., and Spiegelman B.M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127 (2006) 397-408
227. Steffen K.K., MacKay V.L., Kerr E.O., Tsuchiya M., Hu D., Fox L.A., Dang N., Johnston E.D., Oakes J.A., Tchao B.N., Pak D.N., Fields S., Kennedy B.K., and Kaeberlein M. Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4. Cell 133 (2008) 292-302
228. Suliman H.B., Carraway M.S., Welty-Wolf K.E., Whorton A.R., and Piantadosi C.A. Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. J. Biol. Chem. 278 (2003) 41510-41518
229. Sun C., Zhang F., Ge X., Yan T., Chen X., Shi X., and Zhai Q. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metabol. 6 (2007) 307-319
230. Sun Y., and Oberley L.W. Redox regulation of transcriptional activators. Free Radic. Biol. Med. 21 (1996) 335-348
231. Tanno M., Sakamoto J., Miura T., Shimamoto K., and Horio Y. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282 (2007) 6823-6832
232. Terada S., Kawanaka K., Goto M., Shimokawa T., and Tabata I. Effects of high-intensity intermittent swimming on PGC-1alpha protein expression in rat skeletal muscle. Acta Physiol. Scand. 184 (2005) 59-65
233. Terman A. Catabolic insufficiency and aging. Ann. N. Y. Acad. Sci. 1067 (2006) 27-36
234. Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
235. To K., Yamaza H., Komatsu T., Hayashida T., Hayashi H., Toyama H., Chiba T., Higami Y., and Shimokawa I. Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver. Exp. Gerontol. 42 (2007) 1063-1071
236. Todisco S., Agrimi G., Castegna A., and Palmieri F. Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae. J. Biol. Chem. 281 (2006) 1524-1531
237. Toescu E.C. Normal brain ageing: models and mechanisms. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360 (2005) 2347-2354
238. Tonkonogi M., Fernstrom M., Walsh B., Ji L.L., Rooyackers O., Hammarqvist F., Wernerman J., and Sahlin K. Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans. Pflugers Arch. 446 (2003) 261-269
239. Toprakci M., Ozmen D., Mutaf I., Turgan N., Parildar Z., Habif S., Guner I., and Bayindir O. Age-associated changes in nitric oxide metabolites nitrite and nitrate. Int. J. Clin. Lab Res. 30 (2000) 83-85
240. Tucker M.Z., and Turcotte L.P. Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions. Am. J. Physiol. Endocrinol. Metabol. 282 (2002) E1102-1109
241. Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., and Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
242. Vavvas D., Apazidis A., Saha A.K., Gamble J., Patel A., Kemp B.E., Witters L.A., and Ruderman N.B. Contraction-induced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal muscle. J. Biol. Chem. 272 (1997) 13255-13261
243. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
244. Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A.L., Orosz L., and Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426 (2003) 620
245. Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9 (2005) 605-615
246. Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39 (2005) 359-407
247. Wei M., Fabrizio P., Hu J., Ge H., Cheng C., Li L., and Longo V.D. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 4 (2008) e13
248. Weindruch R., and Walford R.L. The Retardation of Aging and Disease by Dietary Restriction (1988), Charles C Thomas, Springfield, Illinois
249. Wenz T., Diaz F., Spiegelman B.M., and Moraes C.T. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metabol. 8 (2008) 249-256
250. Weydt P., Pineda V.V., Torrence A.E., Libby R.T., Satterfield T.F., Lazarowski E.R., Gilbert M.L., Morton G.J., Bammler T.K., Strand A.D., Cui L., Beyer R.P., Easley C.N., Smith A.C., Krainc D., Luquet S., Sweet I.R., Schwartz M.W., and La Spada A.R. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metabol. 4 (2006) 349-362
251. Williams A.D., Carey M.F., Selig S., Hayes A., Krum H., Patterson J., Toia D., and Hare D.L. Circuit resistance training in chronic heart failure improves skeletal muscle mitochondrial ATP production rate-a randomized controlled trial. J. Cardiac Fail. 13 (2007) 79-85
252. Winder W.W., Taylor E.B., and Thomson D.M. Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise. Med. Sci. Sports Exerc. 38 (2006) 1945-1949
253. Winder W.W., Holmes B.F., Rubink D.S., Jensen E.B., Chen M., and Holloszy J.O. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J. Appl. Physiol. 88 (2000) 2219-2226
254. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., and Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430 (2004) 686-689
255. Wu H., Kanatous S.B., Thurmond F.A., Gallardo T., Isotani E., Bassel-Duby R., and Williams R.S. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296 (2002) 349-352
256. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., and Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
257. Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
258. Yang H., Yang T., Baur J.A., Perez E., Matsui T., Carmona J.J., Lamming D.W., Souza-Pinto N.C., Bohr V.A., Rosenzweig A., de Cabo R., Sauve A.A., and Sinclair D.A. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130 (2007) 1095-1107
259. Yen T.C., Chen Y.S., King K.L., Yeh S.H., and Wei Y.H. Liver mitochondrial respiratory functions decline with age. Biochem. Biophys. Res. Commun. 165 (1989) 944-1003
260. Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 11 (2006) 3129-3148
261. Zahn J.M., Sonu R., Vogel H., Crane E., Mazan-Mamczarz K., Rabkin R., Davis R.W., Becker K.G., Owen A.B., and Kim S.K. Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet. 2 (2006) e115
262. Zahn J.M., Poosala S., Owen A.B., Ingram D.K., Lustig A., Carter A., Weeraratna A.T., Taub D.D., Gorospe M., Mazan-Mamczarz K., Lakatta E.G., Boheler K.R., Xu X., Mattson M.P., Falco G., Ko M.S., Schlessinger D., Firman J., Kummerfeld S.K., Wood III W.H., Zonderman A.B., Kim S.K., and Becker K.G. AGEMAP: a gene expression database for aging in mice. PLoS Genet. 3 (2007) e201
263. Zang M., Xu S., Maitland-Toolan K.A., Zuccollo A., Hou X., Jiang B., Wierzbicki M., Verbeuren T.J., and Cohen R.A. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55 (2006) 2180-2191
264. Zhao Q., Wang J., Levichkin I.V., Stasinopoulos S., Ryan M.T., and Hoogenraad N.J. A mitochondrial specific stress response in mammalian cells. EMBO J. 21 (2002) 4411-4419
265. Zhu M., Miura J., Lu L.X., Bernier M., DeCabo R., Lane M.A., Roth G.S., and Ingram D.K. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp. Gerontol. 39 (2004) 1049-1059
266. Zong H., Ren J.M., Young L.H., Pypaert M., Mu J., Birnbaum M.J., and Shulman G.I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15983-15987