Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

Journal of Clinical Investigation

Volumn 115, Issue 12, 2005, Pages 3587-3593

  Morino, Katsutaro ^a   Petersen, Kitt Falk ^a   Dufour, Sylvie ^a   Befroy, Douglas ^a   Frattini, Jared ^a   Shatzkes, Nadine ^a   Neschen, Susanne ^a   White, Morris F ^b   Bilz, Stefan ^a   Sono, Saki ^a   Pypaert, Marc ^a   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; LIPID; PROTEIN KINASE B; PROTEIN SERINE KINASE; SERINE;

ADULT; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENZYME ACTIVATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN RESISTANCE; LIPID STORAGE; MUSCLE BIOPSY; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION;

BIOPSY; BLOOD GLUCOSE; BLOTTING, WESTERN; BODY MASS INDEX; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DNA, MITOCHONDRIAL; FAMILY HEALTH; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; IMMUNOPRECIPITATION; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MUSCLES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 31044433308     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI25151     Document Type: Article

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