Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk

Journal of Clinical Investigation

Volumn 117, Issue 11, 2007, Pages 3463-3474

  Handschin, Christoph ^a,b   Cheol, Soo Choi ^c   Chin, Sherry ^a   Kim, Sheene ^c   Kawamori, Dan ^a   Kurpad, Amarnath J ^a   Neubauer, Nicole ^a   Hu, Jiang ^a   Mootha, Vamsi K ^d,e   Kim, Young Bum ^a   Kulkarni, Rohit N ^a   Shulman, Gerald I ^c   Spiegelman, Bruce M ^a,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; INSULIN; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; MITOCHONDRIAL GENE; MITOCHONDRION; MOUSE; MUSCLE TISSUE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CELL COMMUNICATION; FASTING; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-6; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUSCLE, SKELETAL; TRANS-ACTIVATORS;

EID: 36048931015     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI31785     Document Type: Article

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