Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice

Diabetes

Volumn 55, Issue 8, 2006, Pages 2180-2191

  Zang, Mengwei ^a   Xu, Shanqin ^a   Maitland Toolan, Karlene A ^a   Zuccollo, Adriana ^a   Hou, Xiuyun ^a   Jiang, Bingbing ^a   Wierzbicki, Michel ^b   Verbeuren, Tony J ^b   Cohen, Richard A ^a,c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

ACC; Acetyl CoA carboxylase; AICAR, 5 aminoimidazole 4 carboxamide 1 D ribofuranoside; AMPK, AMP activated protein kinase; Apo, apolipoprotein; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; GFP, green fluorescent protein

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE; APIGENIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; POLYPHENOL DERIVATIVE; PROTEIN KINASE; RESVERATROL; S 17834; UNCLASSIFIED DRUG; 5' AMP ACTIVATED PROTEIN KINASE; 5'-AMP-ACTIVATED PROTEIN KINASE; 6,8 DIALLYL 5,7 DIHYDROXY 2 (2 ALLYL 3 HYDROXY 4 METHOXYPHENYL)1 H BENZO(B)PYRAN 4 ONE; 6,8-DIALLYL 5,7-DIHYDROXY 2-(2-ALLYL 3-HYDROXY 4-METHOXYPHENYL)1-H BENZO(B)PYRAN-4-ONE; ANTILIPEMIC AGENT; BENZOPYRAN DERIVATIVE; FLAVONOID; GLUCOSE; MULTIENZYME COMPLEX; PHENOL DERIVATIVE; POLYPHENOLS; PROTEIN SERINE THREONINE KINASE; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELL STRAIN HEPG2; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DYSLIPIDEMIA; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN DEPENDENT DIABETES MELLITUS; LIPID STORAGE; LIVER CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BLOOD; C57BL MOUSE; EXPERIMENTAL DIABETES MELLITUS; LIPID METABOLISM; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

ACETYL-COA CARBOXYLASE; ANIMALS; ANTILIPEMIC AGENTS; APIGENIN; ATHEROSCLEROSIS; BENZOPYRANS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; FLAVONOIDS; GLUCOSE; HUMANS; LIPID METABOLISM; LIPIDS; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIENZYME COMPLEXES; PHENOLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, LDL; STILBENES;

EID: 33749349202     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1188     Document Type: Article

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