Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Nature

Volumn 450, Issue 7170, 2007, Pages 712-716

  Milne, Jill C ^a   Lambert, Philip D ^a   Schenk, Simon ^b   Carney, David P ^a   Smith, Jesse J ^a   Gagne, David J ^a   Jin, Lei ^a   Boss, Olivier ^a   Perni, Robert B ^a   Vu, Chi B ^a   Bemis, Jean E ^a   Xie, Roger ^a   Disch, Jeremy S ^a   Ng, Pui Yee ^a   Nunes, Joseph J ^a   Lynch, Amy V ^a   Yang, Hongying ^a   Galonek, Heidi ^a   Israelian, Kristine ^a   Choy, Wendy ^a   Iffland, Andre ^a   Lavu, Siva ^a   Medvedik, Oliver ^a   Sinclair, David A ^c   Olefsky, Jerrold M ^b   Jirousek, Michael R ^a   Elliott, Peter J ^a   Westphal, Christoph H ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN; RESVERATROL; ROSIGLITAZONE; SIRTUIN; SRT 1460; SRT 1720; SRT 2183; SRT 501; UNCLASSIFIED DRUG;

AGING; DIABETES; DISEASE TREATMENT; GLUCOSE; HOMEOSTASIS; METABOLISM; MITOCHONDRION; PEPTIDE; PLASMA;

ADIPOSE TISSUE; AGING; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG POTENCY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERINSULINEMIA; INSULIN SENSITIVITY; MICHAELIS CONSTANT; MITOCHONDRION; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; ZUCKER DIABETIC FATTY RAT;

MUS; RATTUS;

EID: 36749087548     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06261     Document Type: Article

References (28)

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