Metabolic adaptations through the PGC-1α and SIRT1 pathways

FEBS Letters

Volumn 582, Issue 1, 2008, Pages 46-53

  Rodgers, Joseph T ^a   Lerin, Carles ^a   Gerhart Hines, Zachary ^a   Puigserver, Pere ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Glucose metabolism; Lipid metabolism; Mitochondrial oxidation; PGC 1 ; SIRT1

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1;

AGING; BRAIN METABOLISM; DIABETES MELLITUS; ENERGY BALANCE; ENERGY METABOLISM; GENE EXPRESSION; HEART MUSCLE; HORMONAL REGULATION; HUMAN; LIVER METABOLISM; METABOLIC DISORDER; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; MUSCLE METABOLISM; NONHUMAN; OBESITY; PANCREAS; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; SKELETAL MUSCLE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; GLUCOSE; LIPID METABOLISM; OXIDATION-REDUCTION; RATS; SIRTUINS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 37349110355     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.11.034     Document Type: Short Survey

References (53)

1. Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
2. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
3. Nemoto S., Fergusson M.M., and Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J. Biol. Chem. 280 (2005) 16456-16460
4. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
5. Wallberg A.E., Yamamura S., Malik S., Spiegelman B.M., and Roeder R.G. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol. Cell 12 (2003) 1137-1149
6. Lerin C., Rodgers J.T., Kalume D.E., Kim S.H., Pandey A., and Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 3 (2006) 429-438
7. Gerhart-Hines Z., et al. Metabolic control of mitochondrial function and fatty acid oxidation through PGC-1alpha/SIRT1. EMBO J. 26 (2007) 1902-1912
8. Puigserver P., et al. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol. Cell 8 (2001) 971-982
9. Fan M., et al. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 18 (2004) 278-289
10. Jager S., Handschin C., St-Pierre J., and Spiegelman B.M. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA 104 (2007) 12017-12022
11. Li X., Monks B., Ge Q., and Birnbaum M.J. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447 (2007) 1012-1016
12. Teyssier C., Ma H., Emter R., Kralli A., and Stallcup M.R. Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev. 19 (2005) 1466-1473
13. Cooper M.P., Qu L., Rohas L.M., Lin J., Yang W., Erdjument-Bromage H., Tempst P., and Spiegelman B.M. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 20 (2006) 2996-3009
14. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000) 795-800
15. Tanny J.C., Dowd G.J., Huang J., Hilz H., and Moazed D. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99 (1999) 735-745
16. Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
17. Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101 (2004) 15998-16003
18. Kuzmichev A., et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc. Natl. Acad. Sci. USA 102 (2005) 1859-1864
19. Picard F., et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004) 771-776
20. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
21. Brunet A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
22. Pagans S., et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 3 (2005) e41
23. Rodgers J.T., and Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc. Natl. Acad. Sci. USA 104 (2007) 12861-12866
24. Hallows W.C., Lee S., and Denu J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. USA 103 (2006) 10230-10235
25. Starai V.J., Celic I., Cole R.N., Boeke J.D., and Escalante-Semerena J.C. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science 298 (2002) 2390-2392
26. Lagouge M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (2006) 1109-1122
27. Lin J., et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 (2004) 121-135
28. Leone T.C., et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 3 (2005) e101
29. Dentin R., Liu Y., Koo S.H., Hedrick S., Vargas T., Heredia J., Yates III J., and Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449 (2007) 366-369
30. Matsumoto M., Pocai A., Rossetti L., Depinho R.A., and Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab. 6 (2007) 208-216
31. Brunet A., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
32. Finck B.N., Gropler M.C., Chen Z., Leone T.C., Croce M.A., Harris T.E., Lawrence Jr. J.C., and Kelly D.P. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4 (2006) 199-210
33. Krebs H.A., and Hems R. Fatty acid metabolism in the perfused rat liver. Biochem. J. 119 (1970) 525-533
34. Burgess S.C., Leone T.C., Wende A.R., Croce M.A., Chen Z., Sherry A.D., Malloy C.R., and Finck B.N. Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J. Biol. Chem. 281 (2006) 19000-19008
35. Sun C., Zhang F., Ge X., Yan T., Chen X., Shi X., and Zhai Q. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6 (2007) 307-319
36. Koo S.H., et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat. Med. 10 (2004) 530-534
37. Lin J., et al. Transcriptional co-activator PGC-1alpha drives the formation of slow-twitch muscle fibres. Nature 418 (2002) 797-801
38. Handschin C., Chin S., Li P., Liu F., Maratos-Flier E., Lebrasseur N.K., Yan Z., and Spiegelman B.M. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1{alpha} muscle-specific knock-out animals. J. Biol. Chem. 282 (2007) 30014-30021
39. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., and Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106 (2000) 847-856
40. Fulco M., et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12 (2003) 51-62
41. Baur J.A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
42. Bordone L., et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6 (2007) 759-767
43. Chen D., Steele A.D., Lindquist S., and Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 310 (2005) 1641
44. Alcendor R.R., et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100 (2007) 1512-1521
45. St-Pierre J., et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127 (2006) 397-408
46. Kim D., et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. Embo J. 26 (2007) 3169-3179
47. Yoon J.C., et al. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev. Cell 5 (2003) 73-83
48. Bordone L., et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4 (2006) e31
49. Uldry M., Yang W., St-Pierre J., Lin J., Seale P., and Spiegelman B.M. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3 (2006) 333-341
50. Seale P., et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 6 (2007) 38-54
51. Mazzucotelli A., et al. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes 56 (2007) 2467-2475
52. Timmons J.A., et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl. Acad. Sci. USA 104 (2007) 4401-4406
53. Nedergaard J., Bengtsson T., and Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293 (2007) E444-E452