Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake

Journal of Applied Physiology

Volumn 104, Issue 5, 2008, Pages 1304-1312

  Calvo, Jennifer A ^a   Daniels, Thomas G ^a   Wang, Xiaomei ^a   Paul, Angelika ^a   Lin, Jiandie ^b   Spiegelman, Bruce M ^b   Stevenson, Susan C ^a   Rangwala, Shamina M ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Exercise capacity; Peak oxygen uptake; Peroxisome proliferator activated receptor coactivator 1

Indexed keywords

CITRATE SYNTHASE; GLYCOGEN; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPARGC1A PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE METABOLISM; CITRIC ACID CYCLE; ENZYME ACTIVITY; EXERCISE; EXERCISE TEST; FATTY ACID OXIDATION; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; LIVER; MALE; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKELETAL MUSCLE; TIBIALIS ANTERIOR MUSCLE; TISSUE SPECIFICITY; TRANSGENIC MOUSE; ANAEROBIC THRESHOLD; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LUNG GAS EXCHANGE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RUNNING;

ANAEROBIC THRESHOLD; ANIMALS; CITRATE (SI)-SYNTHASE; DNA, MITOCHONDRIAL; GLUCOSE INTOLERANCE; GLYCOGEN; INSULIN RESISTANCE; MALE; MICE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PPAR GAMMA; PULMONARY GAS EXCHANGE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RUNNING; TRANS-ACTIVATORS;

EID: 45149108625     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01231.2007     Document Type: Article

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