메뉴 건너뛰기




Volumn 60, Issue 3, 2005, Pages 293-300

Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70; PROTEIN P85; S6 KINASE;

EID: 18244379033     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/60.3.293     Document Type: Article
Times cited : (139)

References (71)
  • 1
    • 0015040487 scopus 로고
    • Sequences of pituitary and placental lactogenic and growth hormones: Evolution from a primordial peptide by gene reduplication
    • Niall HD, Hogan ML, Sauer R, Rosenblum IY, Greenwood FC. Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc Natl Acad Sci U S A. 1971;68:866-870.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 866-870
    • Niall, H.D.1    Hogan, M.L.2    Sauer, R.3    Rosenblum, I.Y.4    Greenwood, F.C.5
  • 2
    • 0020729431 scopus 로고
    • Structure and evolution of the growth hormone gene family
    • Miller WL, Eberhardt NL. Structure and evolution of the growth hormone gene family. Endocr Rev. 1983;4:97-130.
    • (1983) Endocr Rev , vol.4 , pp. 97-130
    • Miller, W.L.1    Eberhardt, N.L.2
  • 3
    • 0024469936 scopus 로고
    • A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain
    • Bazan JF. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain. Biochem Biophys Res Commun. 1989;164:788-795.
    • (1989) Biochem Biophys Res Commun , vol.164 , pp. 788-795
    • Bazan, J.F.1
  • 4
  • 5
    • 0035043918 scopus 로고    scopus 로고
    • Control of growth by the somatropic axis: Growth hormone and the insulin-like growth factors have related and independent roles
    • Butler AA, LeRoith D. Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annu Rev Physiol. 2001;63:141-164.
    • (2001) Annu Rev Physiol , vol.63 , pp. 141-164
    • Butler, A.A.1    LeRoith, D.2
  • 6
    • 0035719947 scopus 로고    scopus 로고
    • Distinct and overlapping functions of insulin and IGF-I receptors
    • Nakae J, Kido Y, Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev. 2001;22:818-835.
    • (2001) Endocr Rev , vol.22 , pp. 818-835
    • Nakae, J.1    Kido, Y.2    Accili, D.3
  • 8
    • 0034712175 scopus 로고    scopus 로고
    • Signaling mechanisms of cytokine receptors and their perturbances in disease
    • Touw IP, De Koning JP, Ward AC, Hermans MH. Signaling mechanisms of cytokine receptors and their perturbances in disease. Mol Cell Endocrinol 2000;160:1-9.
    • (2000) Mol Cell Endocrinol , vol.160 , pp. 1-9
    • Touw, I.P.1    De Koning, J.P.2    Ward, A.C.3    Hermans, M.H.4
  • 9
    • 0032942159 scopus 로고    scopus 로고
    • Blood-brain barrier for human growth hormone and insulin-like growth factor-I
    • Coculescu M. Blood-brain barrier for human growth hormone and insulin-like growth factor-I. J Pediatr Endocrinol Metab. 1999;12:113-124.
    • (1999) J Pediatr Endocrinol Metab , vol.12 , pp. 113-124
    • Coculescu, M.1
  • 10
    • 0032717947 scopus 로고    scopus 로고
    • Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice
    • Bartke A, Chandrashekar V, Turyn D, et al. Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice. Proc Soc Exp Biol Med. 1999;222:113-123.
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 113-123
    • Bartke, A.1    Chandrashekar, V.2    Turyn, D.3
  • 12
    • 0042723693 scopus 로고    scopus 로고
    • Kostyo JL, Goodman HM, eds, New York: Oxford University Press
    • Kaplan SL. Handbook of Physiology. Kostyo JL, Goodman HM, eds, New York: Oxford University Press; 1999:V: 129-143.
    • (1999) Handbook of Physiology , vol.5 , pp. 129-143
    • Kaplan, S.L.1
  • 13
    • 0036462938 scopus 로고    scopus 로고
    • Growth hormone replacement therapy for adults: Into the new millennium
    • Simpson H, Savine R, Sonksen P, et al. Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res. 2002;12:1-33.
    • (2002) Growth Horm IGF Res , vol.12 , pp. 1-33
    • Simpson, H.1    Savine, R.2    Sonksen, P.3
  • 15
    • 0030863133 scopus 로고    scopus 로고
    • Essential role of growth hormone in ischemia-induced retinal neovascularization
    • Smith LE, Kopchick JJ, Chen W, et al. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science. 1997;276:1706-1709.
    • (1997) Science , vol.276 , pp. 1706-1709
    • Smith, L.E.1    Kopchick, J.J.2    Chen, W.3
  • 16
    • 0036098835 scopus 로고    scopus 로고
    • Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis
    • Corbacho AM, Martinez De La Escalera G, Clapp C. Roles of prolactin and related members of the prolactin/growth hormone/placental lactogen family in angiogenesis. J Endocrinol. 2002;173:219-238.
    • (2002) J Endocrinol , vol.173 , pp. 219-238
    • Corbacho, A.M.1    Martinez De La Escalera, G.2    Clapp, C.3
  • 17
    • 0034955429 scopus 로고    scopus 로고
    • The therapeutic problem of proliferative diabetic retinopathy: Targeting somatostatin receptors
    • Davis MI, Wilson SH, Grant MB. The therapeutic problem of proliferative diabetic retinopathy: targeting somatostatin receptors. Horm Metab Res. 2001;33:295-299.
    • (2001) Horm Metab Res , vol.33 , pp. 295-299
    • Davis, M.I.1    Wilson, S.H.2    Grant, M.B.3
  • 18
    • 0034961440 scopus 로고    scopus 로고
    • Octreotide reduces vitreous hemorrhage and loss of visual acuity risk in patients with high-risk proliferative diabetic retinopathy
    • Boehm BO, Lang GK, Jehle PM, Feldman B, Lang GE. Octreotide reduces vitreous hemorrhage and loss of visual acuity risk in patients with high-risk proliferative diabetic retinopathy. Horm Metab Res. 2001;33:300-306.
    • (2001) Horm Metab Res , vol.33 , pp. 300-306
    • Boehm, B.O.1    Lang, G.K.2    Jehle, P.M.3    Feldman, B.4    Lang, G.E.5
  • 20
    • 0035434522 scopus 로고    scopus 로고
    • Signaling pathways activated by the growth hormone receptor
    • Herrington J, Carter-Su C. Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab. 2001;12:252-257.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 252-257
    • Herrington, J.1    Carter-Su, C.2
  • 21
    • 0021257065 scopus 로고
    • The effects of pituitary, thyroid, pancreatic and sexual hormones on body length and weight and organ weights of Snell dwarf mice
    • van Buul-Offers S. The effects of pituitary, thyroid, pancreatic and sexual hormones on body length and weight and organ weights of Snell dwarf mice. Growth. 1984;48:101-119.
    • (1984) Growth , vol.48 , pp. 101-119
    • Van Buul-Offers, S.1
  • 23
    • 0033594893 scopus 로고    scopus 로고
    • Normal growth and development in the absence of hepatic insulin-like growth factor I
    • Yakar S, Liu JL, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A. 1999;96:7324-7329.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7324-7329
    • Yakar, S.1    Liu, J.L.2    Stannard, B.3
  • 24
    • 13044294029 scopus 로고    scopus 로고
    • Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
    • Sjogren K, Liu JL, Blad K, et al. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A. 1999;96:7088-7092.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7088-7092
    • Sjogren, K.1    Liu, J.L.2    Blad, K.3
  • 25
    • 0034520040 scopus 로고    scopus 로고
    • Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth
    • Liu JL, Yakar S, LeRoith D. Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth. Endocrinology. 2000;141:4436-4441.
    • (2000) Endocrinology , vol.141 , pp. 4436-4441
    • Liu, J.L.1    Yakar, S.2    LeRoith, D.3
  • 26
    • 0034729710 scopus 로고    scopus 로고
    • Gigantism in mice lacking suppressor of cytokine signalling-2
    • Metcalf D, Greenhalgh CJ, Viney E, et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature. 2000;405:1069-1073.
    • (2000) Nature , vol.405 , pp. 1069-1073
    • Metcalf, D.1    Greenhalgh, C.J.2    Viney, E.3
  • 27
    • 84940127984 scopus 로고
    • Effects of pituitary dwarfism in the mouse on fast and slow skeletal muscles
    • Stickland NC, Crook AR, Sutton CM. Effects of pituitary dwarfism in the mouse on fast and slow skeletal muscles. Acta Anat. 1994;151:245-249.
    • (1994) Acta Anat , vol.151 , pp. 245-249
    • Stickland, N.C.1    Crook, A.R.2    Sutton, C.M.3
  • 29
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002;16:1472-1487.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 30
    • 0036007421 scopus 로고    scopus 로고
    • Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
    • Kozma SC, Thomas G. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays. 2002;24:65-71.
    • (2002) Bioessays , vol.24 , pp. 65-71
    • Kozma, S.C.1    Thomas, G.2
  • 31
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 32
    • 0001798492 scopus 로고    scopus 로고
    • Sonenberg N, Hershey JWB, Mathews M, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Fumagalli S, Thomas G. Translational Control of Gene Expression. 2nd Ed. Sonenberg N, Hershey JWB, Mathews M, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2000:695-717.
    • (2000) Translational Control of Gene Expression. 2nd Ed. , pp. 695-717
    • Fumagalli, S.1    Thomas, G.2
  • 33
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause A, Belsham GJ, Gingras AC, et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature. 1994;371:762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3
  • 34
    • 0028126506 scopus 로고
    • PHAS-I as a link between mitogen-activated protein kinase and translation initiation
    • Lin TA, Kong X, Haystead TA, et al. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science. 1994;266:653-656.
    • (1994) Science , vol.266 , pp. 653-656
    • Lin, T.A.1    Kong, X.2    Haystead, T.A.3
  • 35
    • 0033152072 scopus 로고    scopus 로고
    • Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
    • Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell. 1999;3:707-716.
    • (1999) Mol Cell , vol.3 , pp. 707-716
    • Marcotrigiano, J.1    Gingras, A.C.2    Sonenberg, N.3    Burley, S.K.4
  • 36
    • 0032834055 scopus 로고    scopus 로고
    • eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem. 1999;68:913-963.
    • (1999) Annu Rev Biochem , vol.68 , pp. 913-963
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 37
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807-826.
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 38
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 39
    • 0032999830 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
    • Dennis PB, Fumagalli S, Thomas G. Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation. Curr Opin Genet Dev. 1999;9:49-54.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 49-54
    • Dennis, P.B.1    Fumagalli, S.2    Thomas, G.3
  • 40
    • 0035971180 scopus 로고    scopus 로고
    • The TOR kinases link nutrient sensing to cell growth
    • Rohde J, Heitman J, Cardenas ME. The TOR kinases link nutrient sensing to cell growth. J Biol Chem. 2001;276:9583-9586.
    • (2001) J Biol Chem , vol.276 , pp. 9583-9586
    • Rohde, J.1    Heitman, J.2    Cardenas, M.E.3
  • 41
    • 0034644525 scopus 로고    scopus 로고
    • TOR a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 42
    • 0003448569 scopus 로고
    • Cold Spring Harbor, New York: Cold Spring Harbor Laboratories Press
    • Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratories Press; 1988.
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 43
    • 0028175455 scopus 로고
    • Nuclear localization of p85s6k: Functional requirement for entry into S phase
    • Reinhard C, Fernandez A, Lamb NJ, Thomas G. Nuclear localization of p85s6k: functional requirement for entry into S phase. Embo J. 1994;13:1557-1565.
    • (1994) Embo J , vol.13 , pp. 1557-1565
    • Reinhard, C.1    Fernandez, A.2    Lamb, N.J.3    Thomas, G.4
  • 44
    • 0034057277 scopus 로고    scopus 로고
    • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression
    • Mothe-Satney I, Yang D, Fadden P, Haystead TA, Lawrence JC Jr. Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Mol Cell Biol. 2000;20:3558-3567.
    • (2000) Mol Cell Biol , vol.20 , pp. 3558-3567
    • Mothe-Satney, I.1    Yang, D.2    Fadden, P.3    Haystead, T.A.4    Lawrence Jr., J.C.5
  • 45
    • 0013807308 scopus 로고
    • Growth hormone effects on RNA and protein synthesis in liver
    • Korner A. Growth hormone effects on RNA and protein synthesis in liver. J Cell Physiol. 1965;66(Suppl 1):153-162.
    • (1965) J Cell Physiol , vol.66 , Issue.SUPPL. 1 , pp. 153-162
    • Korner, A.1
  • 46
    • 0015550983 scopus 로고
    • Etude de l'effectif ribosomique du foie chez la souris normale et chez la souris naine
    • Mellet J. Etude de l'effectif ribosomique du foie chez la souris normale et chez la souris naine. Biochimie. 1973;55:189-194.
    • (1973) Biochimie , vol.55 , pp. 189-194
    • Mellet, J.1
  • 47
    • 0036889291 scopus 로고    scopus 로고
    • Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
    • Stolovich M, Tang H, Hornstein E, et al. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol. 2002;22:8101-8113.
    • (2002) Mol Cell Biol , vol.22 , pp. 8101-8113
    • Stolovich, M.1    Tang, H.2    Hornstein, E.3
  • 48
    • 0023800029 scopus 로고
    • The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice
    • Bates PC, Holder AT. The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice. J Endocrinol. 1988;119:31-41.
    • (1988) J Endocrinol , vol.119 , pp. 31-41
    • Bates, P.C.1    Holder, A.T.2
  • 49
    • 0020038825 scopus 로고
    • Cellular growth in organs of dwarf mice during treatment with growth hormone, thyroxine and plasma fractions containing somatomedin activity
    • van Buul-Offers S, Van den Brande JL. Cellular growth in organs of dwarf mice during treatment with growth hormone, thyroxine and plasma fractions containing somatomedin activity. Acta Endocrinol (Copenh). 1982;99:150-160.
    • (1982) Acta Endocrinol (Copenh) , vol.99 , pp. 150-160
    • Van Buul-Offers, S.1    Van Den Brande, J.L.2
  • 50
    • 0034941774 scopus 로고    scopus 로고
    • Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth
    • Skrtic S, Wallenius K, Sjogren K, Isaksson OG, Ohlsson C, Jansson JO. Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth. Horm Res. 2001;55:1-6.
    • (2001) Horm Res , vol.55 , pp. 1-6
    • Skrtic, S.1    Wallenius, K.2    Sjogren, K.3    Isaksson, O.G.4    Ohlsson, C.5    Jansson, J.O.6
  • 51
    • 0033303497 scopus 로고    scopus 로고
    • Insulin-like growth factor I is essential for postnatal growth in response to growth hormone
    • Liu JL, LeRoith D. Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology. 1999;140:5178-5184.
    • (1999) Endocrinology , vol.140 , pp. 5178-5184
    • Liu, J.L.1    LeRoith, D.2
  • 52
    • 0026743890 scopus 로고
    • The GH-transgenic mouse as an experimental model for growth research: Clinical and pathological studies
    • Wanke R, Wolf E, Hermanns W, Folger S, Buchmuller T, Brem G. The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies. Horm Res. 1992;37(Suppl 3):74-87.
    • (1992) Horm Res , vol.37 , Issue.SUPPL. 3 , pp. 74-87
    • Wanke, R.1    Wolf, E.2    Hermanns, W.3    Folger, S.4    Buchmuller, T.5    Brem, G.6
  • 53
    • 0024507405 scopus 로고
    • Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice
    • Quaife CJ, Mathews LS, Pinkert CA, Hammer RE, Brinster RL, Palmiter RD. Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice. Endocrinology. 1989;124:40-48.
    • (1989) Endocrinology , vol.124 , pp. 40-48
    • Quaife, C.J.1    Mathews, L.S.2    Pinkert, C.A.3    Hammer, R.E.4    Brinster, R.L.5    Palmiter, R.D.6
  • 54
    • 0030802370 scopus 로고    scopus 로고
    • Hormonal regulation of human muscle protein metabolism
    • Rooyackers OE, Nair KS. Hormonal regulation of human muscle protein metabolism. Annu Rev Nutr. 1997;17:457-485.
    • (1997) Annu Rev Nutr , vol.17 , pp. 457-485
    • Rooyackers, O.E.1    Nair, K.S.2
  • 55
    • 0037047098 scopus 로고    scopus 로고
    • A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
    • Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A. 2002;99:9213-9218.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9213-9218
    • Pallafacchina, G.1    Calabria, E.2    Serrano, A.L.3    Kalhovde, J.M.4    Schiaffino, S.5
  • 56
    • 0027336392 scopus 로고
    • Simultaneous activation of p90rsk and p70s6k S6 kinases by growth hormone in 3T3-F442A preadipocytes
    • Anderson NG. Simultaneous activation of p90rsk and p70s6k S6 kinases by growth hormone in 3T3-F442A preadipocytes. Biochem Biophys Res Commun. 1993;193:284-290.
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 284-290
    • Anderson, N.G.1
  • 57
    • 0029872617 scopus 로고    scopus 로고
    • Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways
    • Kilgour E, Gout I, Anderson NG. Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways. Biochem J. 1996;315(Pt 2): 517-522.
    • (1996) Biochem J , vol.315 , Issue.PART 2 , pp. 517-522
    • Kilgour, E.1    Gout, I.2    Anderson, N.G.3
  • 58
    • 0032584089 scopus 로고    scopus 로고
    • Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes
    • MacKenzie SJ, Yarwood SJ, Peden AH, Bolger GB, Vernon RG, Houslay MD. Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes. Proc Natl Acad Sci U S A. 1998;95:3549-3554.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3549-3554
    • MacKenzie, S.J.1    Yarwood, S.J.2    Peden, A.H.3    Bolger, G.B.4    Vernon, R.G.5    Houslay, M.D.6
  • 60
    • 0442323560 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: From Drosophila to human disease
    • Pan D, Dong J, Zhang Y, Gao X. Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol. 2004;14:78-85.
    • (2004) Trends Cell Biol , vol.14 , pp. 78-85
    • Pan, D.1    Dong, J.2    Zhang, Y.3    Gao, X.4
  • 61
    • 0242580765 scopus 로고    scopus 로고
    • Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span
    • Mobbs CV, Bray GA, Atkinson RL, et al. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. J Gerontol A Biol Sci Med Sci. 2001;56(Spec No. 1):34-44.
    • (2001) J Gerontol A Biol Sci Med Sci , vol.56 , Issue.SPEC. NO. 1 , pp. 34-44
    • Mobbs, C.V.1    Bray, G.A.2    Atkinson, R.L.3
  • 62
    • 0034455827 scopus 로고    scopus 로고
    • Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    • Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 2000;141:2608-2613.
    • (2000) Endocrinology , vol.141 , pp. 2608-2613
    • Coschigano, K.T.1    Clemmons, D.2    Bellush, L.L.3    Kopchick, J.J.4
  • 64
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A. 2001;98:6736-6741.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 65
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299:572-574.
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 66
    • 0035815445 scopus 로고    scopus 로고
    • A mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. 2001;292:107-110.
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 67
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182-187.
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3
  • 69
    • 0035815414 scopus 로고    scopus 로고
    • Extension of life-span by loss of CHICO, a drosophila insulin receptor substrate protein
    • Clancy DJ, Gems D, Harshman LG, et al. Extension of life-span by loss of CHICO, a drosophila insulin receptor substrate protein. Science. 2001;292:104-106.
    • (2001) Science , vol.292 , pp. 104-106
    • Clancy, D.J.1    Gems, D.2    Harshman, L.G.3
  • 71
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004;14:885-890.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.