SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

Cell

Volumn 135, Issue 5, 2008, Pages 907-918

  Oberdoerffer, Philipp ^a   Michan, Shaday ^a   McVay, Michael ^a   Mostoslavsky, Raul ^b   Vann, James ^c   Park, Sang Kyu ^c   Hartlerode, Andrea ^a   Stegmuller, Judith ^a   Hafner, Angela ^a   Loerch, Patrick ^a   Wright, Sarah M ^d   Mills, Kevin D ^d   Bonni, Azad ^a   Yankner, Bruce A ^a   Scully, Ralph ^a   Prolla, Tomas A ^c   Alt, Frederick W ^e   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d JACKSON LABORATORY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

DNA; HUMDISEASE; SIGNALING

Indexed keywords

PROTEIN P53; REPETITIVE DNA; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN 1;

AGING; ANIMAL CELL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYONIC STEM CELL; EPIGENETICS; EUKARYOTE; GENE EXPRESSION; GENE MAPPING; GENOMIC INSTABILITY; HETEROCHROMATIN; MUTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

EUKARYOTA; MAMMALIA;

EID: 56749156405     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2008.10.025     Document Type: Article

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