The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

Genes and Development

Volumn 18, Issue 24, 2004, Pages 3004-3009

  Apfeld, Javier ^a   O'Connor, Greg ^a   McDonagh, Tom ^a   DiStefano, Peter S ^a   Curtis, Rory ^a  

^a Elixir Pharmaceuticals Inc   (United States)

Author keywords

Aging; AMPK; C. elegans; Energy levels; FOXO; Insulin signaling

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; ISOENZYME; PROTEIN SUBUNIT;

ARTICLE; CAENORHABDITIS ELEGANS; ENERGY; ENVIRONMENTAL FACTOR; ENZYME ACTIVATION; LIFE EXPECTANCY; LIFESPAN; MUTATION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; AGE FACTORS; AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CROSSES, GENETIC; DNA PRIMERS; ENERGY METABOLISM; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; IMMUNOPRECIPITATION; INSULIN; LONGEVITY; MULTIENZYME COMPLEXES; MUTAGENESIS; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TEMPERATURE;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 10644282295     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1255404     Document Type: Article

References (36)

1. Andersson, U., Filipsson, K., Abbott, C.R., Woods, A., Smith, K., Bloom, S.R., Carling, D., and Small, C.J. 2004. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 279: 12005-12008.
2. Apfeld, J. and Kenyon, C. 1999. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402: 804-809.
3. Beauloye, C., Marsin, A.S., Bertrand, L., Krause, U., Hardie, D.G., Vanoverschelde, J.L., and Hue, L. 2001. Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides. FEBS Lett. 505: 348-352.
4. Cypser, J.R. and Johnson, T.E. 2002. Multiple Stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 57: B109-B114.
5. Davies, S.P., Carling, D., and Hardie, D.G. 1989. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur. J. Biochem. 186: 123-128.
6. Feng, J., Bussiere, F., and Hekimi, S. 2001. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1: 633-644.
7. Garigan, D., Hsu, A.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Kenyon, C. 2002. Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
8. Hardie, D.G. and Hawley, S.A. 2001. AMP-activated protein kinase: The energy charge hypothesis revisited. Bioessays 23: 1112-1119.
9. Hardie, D.G., Salt, I.P., and Davies, S.P. 2000. Analysis of the role of the AMP-activated protein kinase in the response to cellular stress. Methods Mol. Biol. 99: 63-74.
10. Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Makela, T.P., Alessi, D.R., and Hardie, D.G. 2003. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2: 28.
11. Herndon, L.A., Schmeissner, P.J., Dudaronek, J.M., Brown, P.A., Listner, K.M., Sakano, Y., Paupard, M.C., Hall, D.H., and Driscoll, M. 2002. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 808-814.
12. Hobert, O. 2002. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans. Biotechniques 32: 728-730.
13. Hsin, H. and Kenyon, C. 1999. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399: 362-366.
14. Kenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
15. Kirkwood, T.L., Kapahi, P., and Shanley, D.P. 2000. Evolution, stress, and longevity. J. Anat. 197 (Pt 4): 587-590.
16. Lakowski, B. and Hekimi, S. 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 95: 13091-13096.
17. Lin, K., Dorman, J.B., Rodan, A., and Kenyon, C. 1997. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322.
18. Lithgow, G.J., White, T.M., Hinerfeld, D.A., and Johnson, T.E. 1994. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J. Gerontol. 49: B270-B276.
19. Longo, V.D. and Finch, C.E. 2003. Evolutionary medicine: From dwarf model systems to healthy centenarians? Science 299: 1342-1346.
20. Marsin, A.S., Bertrand, L., Rider, M.H., Deprez, J., Beauloye, C., Vincent, M.F., Van den Berghe, G., Carling, D., and Hue, L. 2000. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr. Biol. 10: 1247-1255.
21. Minois, N. 2000. Longevity and aging: Beneficial effects of exposure to mild stress. Biogerontology 1: 15-29.
22. Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferre, P., Birnbaum, M.J., et al. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574.
23. Mu, J., Brozinick Jr., J.T., Valladares, O., Bucan, M., and Birnbaum, M.J. 2001. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell 7: 1085-1094.
24. Osiewacz, H.D. 2002. Genes, mitochondria and aging in filamentous fungi. Ageing Res. Rev. 1: 425-442.
25. Petersen, K.F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D.L., DiPietro, L., Cline, G.W., and Shulman, G.I. 2003. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300: 1140-1142.
26. Riddle, D.L. and Albert, P.S. 1997. Genetic and environmental regulation of dauer larva development. In C. elegans II, pp. 739-768. (eds. D.L. Riddle et al.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., De-Pinho, R.A., and Cantley, L.C. 2004. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. 101: 3329-3335.
28. Stein, S.C., Woods, A., Jones, N.A., Davison, M.D., and Carling, D. 2000. The regulation of AMP-activated protein kinase by phosphorylation. Biochem. J. 345 (Pt 3): 437-443.
29. Stocchi, V., Cucchiarini, L., Magnani, M., Chiarantini, L., Palma, P., and Crescentini, G. 1985. Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells. Anal. Biochem. 146: 118-124.
30. Tatar, M., Bartke, A., and Antebi, A. 2003. The endocrine regulation of aging by insulin-like signals. Science 299: 1346-1351.
31. Tissenbaum, H.A. and Guarente, L. 2002. Model organisms as a guide to mammalian aging. Dev. Cell 2: 9-19.
32. Tschape, J.A., Hammerschmied, C., Muhlig-Versen, M., Athenstaedt, K., Daum, G., and Kretzschmar, D. 2002. The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21: 6367-6376.
33. Wang, W., Yang, X., Lopez de Silanes, I., Carling, D., and Gorospe, M. 2003. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J. Biol. Chem. 278: 27016-28023.
34. Watts, J.L., Morton, D.G., Bestman, J., and Kemphues, K.J. 2000. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127: 1467-1475.
35. Weindruch, R. and Sohal, R.S. 1997. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. 337: 986-994.
36. Woods, A., Johnstone, S.R., Dickerson, K., Leiper, F.C., Fryer, L.G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., and Carling, D. 2003. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13: 2004-2008.