Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Molecular Biology of the Cell

Volumn 16, Issue 10, 2005, Pages 4623-4635

  Michishita, Eriko ^a   Park, Jean Y ^a   Burneskis, Jenna M ^a   Barrett, J Carl ^a,b   Horikawa, Izumi ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; HISTONE H4; MITOCHONDRIAL PROTEIN; NUCLEAR PROTEIN; PROTEIN P53; PROTEIN SIRT1; PROTEIN SIRT3; PROTEIN SIRT4; PROTEIN SIRT5; PROTEIN SIRT6; PROTEIN SIRT7; RECOMBINANT PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; CELL NUCLEUS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEACETYLATION; ENERGY METABOLISM; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; GENETIC CONSERVATION; HETEROCHROMATIN; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

CELL AGING; CELL LINE; CELL NUCLEOLUS; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; HETEROCHROMATIN; HISTONES; HUMANS; MITOCHONDRIA; ORGAN SPECIFICITY; RECOMBINANT FUSION PROTEINS; SIRTUINS; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EUKARYOTA;

EID: 26244436281     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-01-0033     Document Type: Article

References (50)

1. Baptiste, N., and Prives, C. (2004). p53 in the cytoplasm: a question of overkill? Cell 116, 487-489.
2. Barbieri, M., Bonafe, M., Franceschi, C., and Paolisso, G. (2003). Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am. J. Physiol. Endocrinol. Metab. 285, E1064-E1071.
3. Blander, G., and Guarente, L. (2004). The sir2 family of protein deacetylases. Annu. Rev. Biochem. 73, 417-435.
4. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
5. Brooks, C. L., and Gu, W. (2003). Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15, 164-171.
6. Brunet, A. et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015.
7. Campisi, J. (2001). From cells to organisms: can we learn about aging from cells in culture? Exp. Gerontol. 36, 607-618.
8. Cheng, H. L., Mostoslavsky, R., Saito, S., Manis, J. P., Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, F. W., and Chua, K. F. (2003). Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100, 10794-10799.
9. Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., De Cabo, R., and Sinclair, D. A. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392.
10. Dimri, G. P., et al. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367.
11. Frye, R. A. (1999). Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260, 273-279.
12. Frye, R. A. (2000). Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273, 793-798.
13. Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Huffman, E., Veech, R. L., and Sartorelli, V. (2003). Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12, 51-62.
14. Gotta, M., Strahl-Bolsinger, S., Renauld, H., Laroche, T., Kennedy, B. K., Grunstein, M., and Gasser, S. M. (1997). Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J. 26, 3243-3255.
15. Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., and Oda, K. (1991). Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 279, 528-534.
16. Harrington, L., and Robinson, M. O. (2002). Telomere dysfunction: multiple paths to the same end. Oncogene 21, 592-597.
17. Heilbronn, L. K., and Ravussin, E. (2003). Calorie restriction and aging: review of the literature and implications for studies in humans. Am. J. Clin. Nutr. 78, 361-369.
18. Hursting, S. D., Lavigne, J. A., Berrigan, D., Perkins, S. N., and Barrett, J. C. (2003). Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu. Rev. Med. 54, 131-152.
19. Imai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800.
20. Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580.
21. Langley, E., Pearson, M., Faretta, M., Bauer, U. M., Frye, R. A., Minucci, S., Pelicci, P. G., and Kouzarides, T. (2002). Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21, 2383-2396.
22. Liszt, G., Ford, E., Kurtev, M., and Guarente, L. (2005). Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J. Biol. Chem. 280, 21313-21320.
23. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001). Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137-148.
24. Lustig, A. J. (1998). Mechanisms of silencing in Saccharomyces cerevisiae. Curr. Opin. Genet. Dev. 8, 233-239.
25. McBurney, M. W., Yang, X., Jardine, K., Bieman, M., Th'ng, J., and Lemieux, M. (2003a). The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol. Cancer Res. 1, 402-409.
26. McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., Lansdorp, P. M., and Lemieux, M. (2003b). The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23, 38-54.
27. Merry, B. J. (2004). Oxidative stress and mitochondrial function with aging-the effects of calorie restriction. Aging Cell 3, 7-12.
28. Morris, M., Hepburn, P., and Wynford-Thomas, D. (2002). Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function. Oncogene 21, 4277-4288.
29. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M., and Guarente, L. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563.
30. Murphy, M. E., Leu, J. I., and George, D. L. (2004). p53 moves to mitochondria: a turn on the path to apoptosis. Cell Cycle 3, 836-839.
31. North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., and Verdin, E. (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11, 437-444.
32. North, B. J., and Verdin, E. (2004). Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 5, 224.
33. Oishi, S. et al. (2005). Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic. Bioorg. Med. Chem. 13, 2431-2438.
34. Onyango, P., Celic, I., McCaffery, J. M., Boeke, J. D., and Feinberg, A. P. (2002). SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc. Natl. Acad. Sci. USA 99, 13653-13658.
35. Pereira-Smith, O. M., and Smith, J. R. (1981). Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genet. 7, 411-421.
36. Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., Senawong, T., Machado De Oliveira, R., Leid, M., McBurney, M. W., and Guarente, L. (2004). Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429, 771-776.
37. Rogina, B., and Helfand, S. L. (2004). Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998-16003.
38. Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E. (1998). DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12, 2831-2841.
39. Schwer, B., North, B. J., Frye, R. A., Ott, M., and Verdin, E. (2002). The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol. 158, 647-657.
40. Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., and Barrett, J. C. (2004). Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6, 168-170.
41. Shankaranarayana, G. D., Motamedi, M. R., Moazed, D., and Grewal, S. I. (2003). Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr. Biol. 13, 1240-1246.
42. Sinha-Datta, U., Horikawa, I., Michishita, E., Datta, A., Sigler-Nicot, J.C., Brown, M., Kazanji, M., Barrett, J. C., and Nicot, C. (2004). Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood 104, 2523-2531.
43. Sugawara, O., Oshimura, M., Koi, M., Annab, L. A., and Barrett, J. C. (1990). Induction of cellular senescence in immortalized cells by human chromosome 1. Science 247, 707-710.
44. Takata, T., and Ishikawa, F. (2003). Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301, 250-257.
45. Tissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230.
46. Tissenbaum, H. A., and Guarente, L. (2002). Model organisms as a guide to mammalian aging. Dev. Cell 2, 9-19.
47. Tominaga, K., Olgun, A., Smith, J. R., and Pereira-Smith, O. M. (2002). Genetics of cellular senescence. Mech. Ageing Dev. 123, 927-936.
48. Vaquero, A., Scher, M., Lee, D., Erdjument-Brumage, H., Tempst, P., and Reinberg, D. (2004). Human SirT1 interacts with histone H1 and promotes formation of a facultative heterochromatin. Mol. Cell 16, 93-105.
49. Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L., and Weinberg, R. A. (2001). hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159.
50. Yeung, P., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., and Mayo, M. W. (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380.