Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Cell

Volumn 130, Issue 6, 2007, Pages 1095-1107

  Yang, Hongying ^a   Yang, Tianle ^b   Baur, Joseph A ^a   Perez, Evelyn ^c   Matsui, Takashi ^d   Carmona, Juan J ^a   Lamming, Dudley W ^a   Souza Pinto, Nadja C ^c   Bohr, Vilhelm A ^c   Rosenzweig, Anthony ^d   de Cabo, Rafael ^c   Sauve, Anthony A ^b   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

CELLBIO; HUMDISEASE; SIGNALING

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN; SIRTUIN 3; SIRTUIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL NUCLEUS MEMBRANE; CELL STRAIN HEK293; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; EMBRYO; GENE; GENOTOXICITY; HUMAN; HUMAN CELL; MITOCHONDRION; NAMPT GENE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

RODENTIA;

EID: 34548627517     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2007.07.035     Document Type: Article

References (63)

1. + salvage pathway delays aging without altering steady-state NAD+ levels. J. Biol. Chem. 277 (2002) 18881-18890
2. Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., and Sinclair D.A. Nicotinamide and Pnc1 govern lifespan extension by calorie restriction in S. cerevisiae. Nature 423 (2003) 181-185
3. Andersson S.G., Karlberg O., Canback B., and Kurland C.G. On the origin of mitochondria: a genomics perspective. Philos. Trans. R. Soc. Lond. B Biol. Sci. 358 (2003) 165-177
4. Ando K., Higami Y., Tsuchiya T., Kanematsu T., and Shimokawa I. Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver. Microsc. Res. Tech. 59 (2002) 293-300
5. Araki T., Sasaki Y., and Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305 (2004) 1010-1013
6. Barile M., Cozzani E., Anonide A., Usiglio D., Burroni A., and Guarrera M. Is contact allergy rare in psoriatics?. Contact Dermatitis 35 (1996) 113-114
7. Berger F., Lau C., Dahlmann M., and Ziegler M. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J. Biol. Chem. 280 (2005) 36334-36341
8. Bieganowski P., and Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117 (2004) 495-502
9. Bitterman K.J., Medvedik O., and Sinclair D.A. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol. Mol. Biol. Rev. 67 (2003) 376-399
10. Brenner C. Evolution of NAD biosynthetic enzymes. Structure 13 (2005) 1239-1240
11. Burkle A. Poly(ADP-ribose). The most elaborate metabolite of NAD+. FEBS J. 272 (2005) 4576-4589
12. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp. Gerontol. 38 (2003) 5-11
13. Cipriani G., Rapizzi E., Vannacci A., Rizzuto R., Moroni F., and Chiarugi A. Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. J. Biol. Chem. 280 (2005) 17227-17234
14. Denu J.M. The Sir2 family of protein deacetylases. Curr. Opin. Chem. Biol. 9 (2005) 431-440
15. Di Lisa F., and Bernardi P. Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc. Res. 70 (2006) 191-199
16. Drevs J., Loser R., Rattel B., and Esser N. Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma. Anticancer Res. 23 (2003) 4853-4858
17. Du L., Zhang X., Han Y.Y., Burke N.A., Kochanek P.M., Watkins S.C., Graham S.H., Carcillo J.A., Szabo C., and Clark R.S. Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. J. Biol. Chem. 278 (2003) 18426-18433
18. Foster J.W., Park Y.K., Penfound T., Fenger T., and Spector M.P. Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon. J. Bacteriol. 172 (1990) 4187-4196
19. Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273 (2000) 793-798
20. Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., Matsuki Y., Murakami M., Ichisaka T., Murakami H., et al. Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science 307 (2004) 426-430
21. Gallo C.M., Smith Jr. D.L., and Smith J.S. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol. Cell. Biol. 24 (2004) 1301-1312
22. Gray M.W., Burger G., and Lang B.F. Mitochondrial evolution. Science 283 (1999) 1476-1481
23. Guarente L. Calorie restriction and SIR2 genes-towards a mechanism. Mech. Ageing Dev. 126 (2005) 923-928
24. Guarente L., and Picard F. Calorie restriction-the SIR2 connection. Cell 120 (2005) 473-482
25. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126 (2006) 941-954
26. Hallows W.C., Lee S., and Denu J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. USA 103 (2006) 10230-10235
27. Higami Y., and Shimokawa I. Apoptosis in the aging process. Cell Tissue Res. 301 (2000) 125-132
28. Horton J.K., Stefanick D.F., and Wilson S.H. Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death. DNA Repair (Amst.) 4 (2005) 1111-1120
29. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000) 795-800
30. James S.J., Muskhelishvili L., Gaylor D.W., Turturro A., and Hart R. Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ. Health Perspect. 106 Suppl 1 (1998) 307-312
31. Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
32. Kitani T., Okuno S., and Fujisawa H. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. FEBS Lett. 544 (2003) 74-78
33. Kun E., Zimber P.H., Chang A.C., Puschendorf B., and Grunicke H. Macromolecular enzymatic product of NAD+ in liver mitochondria. Proc. Natl. Acad. Sci. USA 72 (1975) 1436-1440
34. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1 (2005) 361-370
35. Lin S.J., Defossez P.A., and Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 (2000) 2126-2128
36. Matsui T., Li L., del Monte F., Fukui Y., Franke T.F., Hajjar R.J., and Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100 (1999) 2373-2379
37. Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., Lanfrancone L., and Pelicci P.G. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 (1999) 309-313
38. Noack H., Kunz W.S., and Augustin W. Evaluation of a procedure for the simultaneous determination of oxidized and reduced pyridine nucleotides and adenylates in organic phenol extracts from mitochondria. Anal. Biochem. 202 (1992) 162-165
39. North B.J., and Sinclair D.A. Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem. Sci. 32 (2007) 1-4
40. Pillai J.B., Isbatan A., Imai S., and Gupta M.P. Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J. Biol. Chem. 280 (2005) 43121-43130
41. Porcu M., and Chiarugi A. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol. Sci. 26 (2005) 94-103
42. Revollo J.R., Grimm A.A., and Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279 (2004) 50754-50763
43. Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101 (2004) 15998-16003
44. Rongvaux A., Shea R.J., Mulks M.H., Gigot D., Urbain J., Leo O., and Andris F. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur. J. Immunol. 32 (2002) 3225-3234
45. Samal B., Sun Y., Stearns G., Xie C., Suggs S., and McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol. Cell. Biol. 14 (1994) 1431-1437
46. Sauve A.A., and Schramm V.L. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42 (2003) 9249-9256
47. Sauve A.A., Moir R.D., Schramm V.L., and Willis I.M. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol. Cell 17 (2005) 595-601
48. Schwer B., North B.J., Frye R.A., Ott M., and Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol. 158 (2002) 647-657
49. Smith J.S., Brachmann C.B., Celic I., Kenna M.A., Muhammad S., Starai V.J., Avalos J.L., Escalante-Semerena J.C., Grubmeyer C., Wolberger C., and Boeke J.D. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA 97 (2000) 6658-6663
50. Solomon J.M., Pasupuleti R., Xu L., McDonagh T., Curtis R., DiStefano P.S., and Huber L.J. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol. Cell. Biol. 26 (2006) 28-38
51. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K., Lin J., Yang W., et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127 (2006) 397-408
52. Tanny J.C., Dowd G.J., Huang J., Hilz H., and Moazed D. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99 (1999) 735-745
53. Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
54. Tobin A., Djerdjour B., Journet E., Neuburger M., and Douce R. Effect of NAD on malate oxidation in intact plant mitochondria. Plant Physiol. 66 (1980) 225-229
55. Todisco S., Agrimi G., Castegna A., and Palmieri F. Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae. J. Biol. Chem. 281 (2006) 1524-1531
56. van Roermund C.W., Elgersma Y., Singh N., Wanders R.J., and Tabak H.F. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14 (1995) 3480-3486
57. van Wijk S.J., and Hageman G.J. Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic. Biol. Med. 39 (2005) 81-90
58. Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9 (2005) 605-615
59. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., and Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430 (2004) 686-689
60. Yamada K., Hara N., Shibata T., Osago H., and Tsuchiya M. The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry. Anal. Biochem. 352 (2006) 282-285
61. Yang H., Lavu S., and Sinclair D.A. Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?. Exp. Gerontol. 41 (2006) 718-726
62. Yu S.W., Wang H., Poitras M.F., Coombs C., Bowers W.J., Federoff H.J., Poirier G.G., Dawson T.M., and Dawson V.L. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297 (2002) 259-263
63. Zhang Y., and Herman B. Ageing and apoptosis. Mech. Ageing Dev. 123 (2002) 245-260