Effects of aging on basal fat oxidation in obese humans

Metabolism: Clinical and Experimental

Volumn 57, Issue 8, 2008, Pages 1141-1147

  Solomon, Thomas P J ^a   Marchetti, Christine M ^b   Krishnan, Raj K ^b   Gonzalez, Frank ^c   Kirwan, John P ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGING; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; BODY MASS; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENERGY EXPENDITURE; FEMALE; GLUCOSE TOLERANCE; HUMAN; HYPERLIPIDEMIA; INSULIN SENSITIVITY; MALE; OBESITY; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; ADULT; AGING; ANTHROPOMETRY; BASAL METABOLISM; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CHOLESTEROL; FEMALE; HUMANS; INSULIN; LEPTIN; MALE; MIDDLE AGED; OBESITY; OXYGEN CONSUMPTION; TRIGLYCERIDES;

EID: 47149104321     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.03.021     Document Type: Article

References (41)

1. Mokdad A.H., Ford E.S., Bowman B.A., et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289 (2003) 76-79
2. Sullivan P.W., Morrato E.H., Ghushchyan V., et al. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000-2002. Diabetes Care 28 (2005) 1599-1603
3. Ryan A.S. Insulin resistance with aging: effects of diet and exercise. Sports Med 30 (2000) 327-346
4. Krebs M., and Roden M. Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature. Diabetes Obes Metab 7 (2005) 621-632
5. Kelley D.E., and Mandarino L.J. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49 (2000) 677-683
6. Melanson K.J., Saltzman E., Russell R.R., et al. Fat oxidation in response to four graded energy challenges in younger and older women. Am J Clin Nutr 66 (1997) 860-866
7. Nagy T.R., Goran M.I., Weinsier R.L., et al. Determinants of basal fat oxidation in healthy Caucasians. J Appl Physiol 80 (1996) 1743-1748
8. Horber F.F., Gruber B., Thomi F., et al. Effect of sex and age on bone mass, body composition and fuel metabolism in humans. Nutrition 13 (1997) 524-534
9. Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39 (2005) 359-407
10. Lee C.K., Allison D.B., Brand J., et al. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci U S A 99 (2002) 14988-14993
11. Kelley D.E. Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance. Ann N Y Acad Sci 967 (2002) 135-145
12. Petersen K.F., Dufour S., Befroy D., et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350 (2004) 664-671
13. Weir J.B.V. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109 (1949) 1-9
14. Brooks G.A., Butte N.F., Rand W.M., et al. Chronicle of the Institute of Medicine physical activity recommendation: how a physical activity recommendation came to be among dietary recommendations. Am J Clin Nutr 79 (2004) 921S-930S
15. Taylor H.L., Jacobs Jr. D.R., Schucker B., et al. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 31 (1978) 741-755
16. O'Leary V.B., Marchetti C.M., Krishnan R.K., et al. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 100 (2006) 1584-1589
17. Williamson D.L., and Kirwan J.P. A single bout of concentric resistance exercise increases basal metabolic rate 48 hours after exercise in healthy 59-77-year-old men. J Gerontol A Biol Sci Med Sci 52 (1997) M352-M355
18. Frayn K.N. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55 (1983) 628-634
19. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetes 28 (1985) 412-419
20. Poehlman E.T. Energy expenditure and requirements in aging humans. J Nutr 122 (1992) 2057-2065
21. Morley J.E., Baumgartner R.N., Roubenoff R., et al. Sarcopenia. J Lab Clin Med 137 (2001) 231-243
22. Calles-Escandon J., Arciero P., Gardner A.W., et al. Basal fat oxidation decreases with aging in women. J Appl Physiol 78 (1995) 266-271
23. Toth M.J., Arciero P.J., Gardner A.W., et al. Rates of free fatty acid appearance and fat oxidation in healthy younger and older men. J Appl Physiol 80 (1996) 506-511
24. Rimbert V., Boirie Y., Bedu M., et al. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB J 18 (2004) 737-739
25. Hagenfeldt L., Wahren J., Pernow B., et al. Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest 51 (1972) 2324-2330
26. de Jongh R.T., Serne E.H., Ijzerman R.G., et al. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes 53 (2004) 2873-2882
27. Gudbjornsdottir S., Sjostrand M., Strindberg L., et al. Decreased muscle capillary permeability surface area in type 2 diabetic subjects. J Clin Endocrinol Metab 90 (2005) 1078-1082
28. Conley K.E., Jubrias S.A., and Esselman P.C. Oxidative capacity and ageing in human muscle. J Physiol 526 Pt 1 (2000) 203-210
29. Boffoli D., Scacco S.C., Vergari R., et al. Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta 1226 (1994) 73-82
30. Short K.R., Bigelow M.L., Kahl J., et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A 102 (2005) 5618-5623
31. Trounce I., Byrne E., and Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1 (1989) 637-639
32. Rooyackers O.E., Adey D.B., Ades P.A., et al. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci U S A 93 (1996) 15364-15369
33. Petersen K.F., Befroy D., Dufour S., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300 (2003) 1140-1142
34. Barazzoni R., Short K.R., and Nair K.S. Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem 275 (2000) 3343-3347
35. Terjung R.L., Zarzeczny R., and Yang H.T. Muscle blood flow and mitochondrial function: influence of aging. Int J Sport Nutr Exerc Metab 12 (2002) 368-378
36. Hoppeler H., and Weibel E.R. Limits for oxygen and substrate transport in mammals. J Exp Biol 201 (1998) 1051-1064
37. Lafontan M., and Viguerie N. Role of adipokines in the control of energy metabolism: focus on adiponectin. Curr Opin Pharmacol 6 (2006) 580-585
38. Minokoshi Y., Kim Y.B., Peroni O.D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
39. Steinberg G.R., Parolin M.L., Heigenhauser G.J., et al. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283 (2002) E187-E192
40. Aberg W., Thorne A., Olivecrona T., et al. Fat oxidation and plasma removal capacity of an intravenous fat emulsion in elderly and young men. Nutrition 22 (2006) 738-743
41. Schutz Y., Tremblay A., Weinsier R.L., et al. Role of fat oxidation in the long-term stabilization of body weight in obese women. Am J Clin Nutr 55 (1992) 670-674