Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver

Experimental Gerontology

Volumn 42, Issue 11, 2007, Pages 1063-1071

  To, Kazuo ^a   Yamaza, Haruyoshi ^a   Komatsu, Toshimitsu ^a   Hayashida, Takahiro ^a   Hayashi, Hiroko ^a   Toyama, Hiroaki ^a   Chiba, Takuya ^a   Higami, Yoshikazu ^a   Shimokawa, Isao ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Acetyl CoA carboxylase; Aging; AMP activated protein kinase; Calorie restriction; Growth hormone; IGF 1; Metabolic adaptation

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; THREONINE; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; CALORIC RESTRICTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; FATTY ACID BLOOD LEVEL; FEEDING BEHAVIOR; GLUCOSE BLOOD LEVEL; IMMUNOBLOTTING; INSULIN BLOOD LEVEL; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; RAT; TRANSGENIC RAT; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

ACETYL-COA CARBOXYLASE; ANIMALS; CALORIC RESTRICTION; DOWN-REGULATION; GROWTH HORMONE; IMMUNOBLOTTING; LIVER; LONGEVITY; MALE; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; ORGANISMS, GENETICALLY MODIFIED; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 35448976050     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.07.003     Document Type: Article

References (26)

1. Al-Regaiey K.A., Masternak M.M., Bonkowski M., Sun L., and Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 146 (2005) 851-860
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Brownsey R.W., Boone A.N., Elliott J.E., Kulpa J.E., and Lee W.M. Regulation of acetyl-CoA carboxylase. Biochem. Soc. Trans. 34 (2006) 223-227
4. Carling D. The AMP-activated protein kinase cascade - a unifying system for energy control. Trends. Biochem. Sci. 29 (2004) 18-24
5. Clark H., Carling D., and Saggerson D. Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. Eur. J. Biochem. 271 (2004) 2215-2224
6. Duffy P.H., Feuers R.J., Leakey J.A., Nakamura K., Turturro A., and Hart R.W. Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. Mech. Ageing Dev. 48 (1989) 117-133
7. Fediuc S., Gaidhu M.P., and Ceddia R.B. Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. J. Lipid Res. 47 (2006) 412-420
8. Foretz M., Ancellin N., Andreelli F., Saintillan Y., Grondin P., Kahn A., Thorens B., Vaulont S., and Viollet B. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54 (2005) 1331-1339
9. Gonzalez A.A., Kumar R., Mulligan J.D., Davis A.J., Weindruch R., and Saupe K.W. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am. J. Physiol. Endocrinol. Metab. 287 (2004) E1032-E1037
10. Holliday R. Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?. Bioessays 10 (1989) 125-127
11. Hong Y.H., Varanasi U.S., Yang W., and Leff T. AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability. J. Biol. Chem. 278 (2003) 27495-27501
12. Kahn B.B., Alquier T., Carling D., and Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1 (2005) 15-25
13. Kudo N., Gillespie J.G., Kung L., Witters L.A., Schulz R., Clanachan A.S., and Lopaschuk G.D. Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim. Biophys. Acta 1301 (1996) 67-75
14. Longo V.D., and Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians?. Science 299 (2003) 1342-1346
15. Masoro E.J. Subfield history: caloric restriction, slowing aging, and extending life. Sci. Aging Knowledge Environ. 2003 (2003) RE2
16. Masoro E.J., and Austad S.N. The evolution of the antiaging action of dietary restriction: a hypothesis. J. Gerontol. A, Biol. Sci. Med. Sci. 51 (1996) B387-B391
17. Matsumoto K., Kakidani H., Takahashi A., Nakagata N., Anzai M., Matsuzaki Y., Takahashi Y., Miyata K., Utsumi K., and Iritani A. Growth retardation in rats whose growth hormone gene expression was suppressed by antisense RNA transgene. Mol. Reprod. Dev. 36 (1993) 53-58
18. McCarter R.J., and Palmer J. Energy metabolism and aging: a lifelong study of Fischer 344 rats. Am. J. Physiol. 263 (1992) E448-E452
19. Shaw R.J., Lamia K.A., Vasquez D., Koo S.H., Bardeesy N., Depinho R.A., Montminy M., and Cantley L.C. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 (2005) 1642-1646
20. Shimokawa I. Rodent models for the study of the role of GH-IGF-1 or the insulin axis in aging and longevity: special reference to a transgenic dwarf rat strain and calorie restriction. In: Nyberg F.J. (Ed). The Somatotrophic Axis in Brain Function (2006), Elsevier Academic Press, Burlington 173-184
21. Shimokawa I. A transgenic mini rat strain as a tool for studying aging and calorie restriction. In: Conn P.C. (Ed). Handbook of Models for Human Aging (2006), Elsevier Academic Press, Burlington 367-378
22. Shimokawa I., Higami Y., Tsuchiya T., Otani H., Komatsu T., Chiba T., and Yamaza H. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J. 17 (2003) 1108-1109
23. Shimokawa I., Higami Y., Utsuyama M., Tuchiya T., Komatsu T., Chiba T., and Yamaza H. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am. J. Pathol. 160 (2002) 2259-2265
24. Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A.L., Orosz L., and Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426 (2003) 620
25. Weindruch R., and Walford R.L. The Retardation of Aging and Disease by Dietary Restriction (1988), Charles C Thomas Publisher, Springfield
26. Yamaza H., Komatsu T., Chiba T., Toyama H., To K., Higami Y., and Shimokawa I. A transgenic dwarf rat model as a tool for the study of calorie restriction and aging. Exp. Gerontol. 39 (2004) 269-272