Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

Cell

Volumn 127, Issue 2, 2006, Pages 397-408

  St Pierre, Julie ^a   Drori, Stavit ^a   Uldry, Marc ^a   Silvaggi, Jessica M ^a   Rhee, James ^a   Jäger, Sibylle ^a   Handschin, Christoph ^a   Zheng, Kangni ^a   Lin, Jiandie ^a   Yang, Wenli ^a   Simon, David K ^a   Bachoo, Robert ^b,c   Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GLUTATHIONE PEROXIDASE 1; KAINIC ACID; MANGANESE SUPEROXIDE DISMUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BRAIN DEGENERATION; CELL ACTIVITY; CELL DEATH; CELL MANIPULATION; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; DETOXIFICATION; ELECTRON TRANSPORT; ENZYME INDUCTION; ENZYME MECHANISM; HIPPOCAMPUS; MALE; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN TARGETING; RNA INTERFERENCE; SEIZURE; SENSITIVITY ANALYSIS; SUBSTANTIA NIGRA;

EID: 33749999530     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.09.024     Document Type: Article

References (42)

1. Ahn S., Olive M., Aggarwal S., Krylov D., Ginty D.D., and Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 18 (1998) 967-977
2. Arany Z., He H., Lin J., Hoyer K., Handschin C., Toka O., Ahmad F., Matsui T., Chin S., Wu P.H., et al. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 1 (2005) 259-271
3. Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B.S., Miroux B., Couplan E., Alves-Guerra M.C., Goubern M., Surwit R., et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26 (2000) 435-439
4. Balaban R.S., Nemoto S., and Finkel T. Mitochondria, oxidants, and aging. Cell 120 (2005) 483-495
5. Beal M.F. Mitochondria take center stage in aging and neurodegeneration. Ann. Neurol. 58 (2005) 495-505
6. Bedogni B., Pani G., Colavitti R., Riccio A., Borrello S., Murphy M., Smith R., Eboli M.L., and Galeotti T. Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival. J. Biol. Chem. 278 (2003) 16510-16519
7. Bove J., Prou D., Perier C., and Przedborski S. Toxin-induced models of Parkinson's disease. NeuroRx. 2 (2005) 484-494
8. Brand M.D. Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Exp. Gerontol. 35 (2000) 811-820
9. Brown G.C., and Borutaite V. Nitric oxide, mitochondria, and cell death. IUBMB Life 52 (2001) 189-195
10. Echtay K.S., Roussel D., St-Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., et al. Superoxide activates mitochondrial uncoupling proteins. Nature 415 (2002) 96-99
11. Handschin C., Rhee J., Lin J., Tarr P.T., and Spiegelman B.M. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc. Natl. Acad. Sci. USA 100 (2003) 7111-7116
12. Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413 (2001) 179-183
13. Kelly D.P., and Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18 (2004) 357-368
14. Koo S.H., Satoh H., Herzig S., Lee C.H., Hedrick S., Kulkarni R., Evans R.M., Olefsky J., and Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat. Med. 10 (2004) 530-534
15. Kornhauser J.M., Cowan C.W., Shaywitz A.J., Dolmetsch R.E., Griffith E.C., Hu L.S., Haddad C., Xia Z., and Greenberg M.E. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 34 (2002) 221-233
16. Kukidome D., Nishikawa T., Sonoda K., Imoto K., Fujisawa K., Yano M., Motoshima H., Taguchi T., Matsumura T., and Araki E. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 55 (2006) 120-127
17. Lee J.M., Li J., Johnson D.A., Stein T.D., Kraft A.D., Calkins M.J., Jakel R.J., and Johnson J.A. Nrf2, a multi-organ protector?. FASEB J. 19 (2005) 1061-1066
18. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., and Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106 (2000) 847-856
19. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 3 (2005) e101
20. Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 (2002) 797-801
21. Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 (2004) 121-135
22. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1 (2005) 361-370
23. Lin J., Yang R., Tarr P.T., Wu P.H., Handschin C., Li S., Yang W., Pei L., Uldry M., Tontonoz P., et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 120 (2005) 261-273
24. Mantamadiotis T., Lemberger T., Bleckmann S.C., Kern H., Kretz H., Martin Villalba A., Tronche F., Kellendonk C., Gau D., Kapfhammer J., et al. Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31 (2002) 47-54
25. Mates J.M., Perez-Gomez C., and Nunez de Castro I. Antioxidant enzymes and human diseases. Clin. Biochem. 32 (1999) 595-603
26. Mootha V.K., Handschin C., Arlow D., Xie X., St Pierre J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA 101 (2004) 6570-6575
27. Nemoto S., and Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295 (2002) 2450-2452
28. Przedborski S., Jackson-Lewis V., Djaldetti R., Liberatore G., Vila M., Vukosavic S., and Almer G. The parkinsonian toxin MPTP: action and mechanism. Restor. Neurol. Neurosci. 16 (2000) 135-142
29. Przedborski S., Tieu K., Perier C., and Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J. Bioenerg. Biomembr. 36 (2004) 375-379
30. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
31. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., and Spiegelman B.M. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423 (2003) 550-555
32. Rhee J., Inoue Y., Yoon J.C., Puigserver P., Fan M., Gonzalez F.J., and Spiegelman B.M. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA 100 (2003) 4012-4017
33. Rolfe D.F., and Brown G.C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 77 (1997) 731-758
34. Schapira A.H. Mitochondrial dysfunction in neurodegenerative disorders. Biochim. Biophys. Acta 1366 (1998) 225-233
35. Singer T.P., and Ramsay R.R. Mechanism of the neurotoxicity of MPTP. An update. FEBS Lett. 274 (1990) 1-8
36. St-Pierre J., Lin J., Krauss S., Tarr P.T., Yang R., Newgard C.B., and Spiegelman B.M. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J. Biol. Chem. 278 (2003) 26597-26603
37. Uldry M., Yang W., St-Pierre J., Lin J., Seale P., and Spiegelman B.M. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3 (2006) 333-341
38. Valle I., Alvarez-Barrientos A., Arza E., Lamas S., and Monsalve M. PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc. Res. 66 (2005) 562-573
39. Wallace D.C. Mitochondrial diseases in man and mouse. Science 283 (1999) 1482-1488
40. Wang Q., Yu S., Simonyi A., Sun G.Y., and Sun A.Y. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol. Neurobiol. 31 (2005) 3-16
41. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., and Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
42. Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413 (2001) 131-138