Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at Complex I and oxidative DNA damage in rat brain

Journal of Bioenergetics and Biomembranes

Volumn 37, Issue 2, 2005, Pages 83-90

  Sanz, Alberto ^a   Caro, Pilar ^a   Ibañez, Jorge ^a   Gómez, José ^a   Gredilla, Ricardo ^a   Barja, Gustavo ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

8 hydroxydeoxyguanosine; Aging; Brain mitochondria; Caloric restriction; Complex I; Free radical generation; Mitochondrial DNA; Old age; Oxidative DNA damage; Oxygen radicals

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DIET RESTRICTION; DNA DAMAGE; ELECTRON TRANSPORT; MALE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RAT;

AGING; ANIMALS; BRAIN; DNA DAMAGE; ELECTRON TRANSPORT COMPLEX I; MALE; MITOCHONDRIA; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

ANIMALIA; MAMMALIA;

EID: 20044384556     PISSN: 0145479X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10863-005-4131-0     Document Type: Article

References (39)

1. Asunción, J. G., Millan, A., Pla, R., Bruseghini, I., Esteras, A., Pallardo, F. V., Sastre, J., and Viña, J. (1996). FASEB J. 10, 333-338.
2. Baek, B. S., Kwon, H. J., Lee, K. H., Yoo, M. A., Kim, K. W., Ikeno, Y., Yu, B. P., and Chung, H. Y. (1999). Arch. Pharm. Res. 22, 361-366.
3. Barja, G. (1999). J. Bioenerg. Biomembr. 31, 347-366.
4. Barja, G. (2000). Aging Clin. Exp. Res. 12, 342-355.
5. Barja, G. (2002). J. Bioenerg. Biomembr. 34, 227-233.
6. Barja, G. (2004a). Trends Neurosci. 27, 595-600.
7. Barja, G. (2004b). Biol. Rev. 79, 235-251.
8. Beal, M. F. (2003). Ann. N.Y. Acad. Sci. 991, 120-131.
9. Beckman, K. B., and Ames, B. (1998). Physiol. Rev. 78, 547-581.
10. Cao, S. X., Dhabi, J. M., Mote, P. L., and Spindler, S. R. (2001). PNAS. 98, 10630-10635.
11. Edwards, M. G., Sarkar, D., Klopp, R., Morrow, J. D., Weindruch, R. D., and Prolla, T. A. (2003). Physiol. Genomics. 13, 119-127.
12. Forster, M. J., Morris, P., and Sohal, R. S. (2003). FASEB J. 17, 690-692.
13. Gredilla, R., Sanz, A., López-Torres, M., and Barja, G. (2001). FASEB J. 15, 1589-1591.
14. Greenberg, J. A., Wei, H., Ward, K., and Boozer, C. N. (2000). Mech. Ageing Dev. 115, 107-117.
15. Hamilton, M. L., Van Remmen, H. V., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., and Richardson, A. (2001). PNAS 98, 10469-10474.
16. Herrero, A., and Barja, G. (2001). J. Am. Aging Assoc. 24, 45-50.
17. Hoglinger, G. U., Carrad, G., Michel, P. P., Medja, F., Lombes, A., Ruberg, M., Friguet, B., and Hirsch, E. C. (2003). J. Neurochem. 86, 1297-1307.
18. Honda, K. (2004). Ann. N.Y. Acad. Sci. 1012, 179-182.
19. Ingram, D. K., Weindruch, R., Spangler, E. L., Freeman, J. R., and Walford, R. L. (1987). J. Gerontol. 42, 78-81.
20. Kanda, K. (2002). Micros Res. Tech. 59, 301-305.
21. Kaneko, T., Tahara, S., and Matsuo, M. (1997). Free Radical. Biol. Med. 23, 76-81.
22. Khrapko, K., Nekhaeva, E., Kraytsberg, Y., and Kunz, W. (2003). Mutat. Res. 522, 13-19.
23. Lai, C. K., and Clark, J. B. (1979). Methods Enzymol. 55, 51-60.
24. Latorre, A., Moya, A., and Ayala, A. (1986). PNAS USA 83, 8649-8653.
25. Lee, C. K., Allison, D. B., Brand, J., Weindruch, R., and Prolla, T. A. (2002). PNAS 99, 14988-14993.
26. López-Torres, M., Gredilla, R., Sanz, A., and Barja, G. (2002). Free Radical. Biol. Med. 32, 882-889.
27. Loft, S., and Poulsen, H. E. (1999). Methods Enzymol. 300, 166-184.
28. Mattson, M. P., Chan, S. L., and Duan, W. (2002). Physiol. Rev. 82, 637-672.
29. Mattson, M. P. (2003). Neurology 60, 690-695.
30. Meccoci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., and Beal, F. (1993). Ann. Neurol. 34, 609-616.
31. Moroi-Fetters, S. E. (1989). Neurobiol. Aging 10, 317-322.
32. Sanz, A., Gredilla, R., Pamplona, R., Portero-Otín, M., Vara, E., Tresguerres, J. A. F., and Barja, G. (2005). Biogerontol. 6, 15-26.
33. Sohal, R. S., Ku, H. H., Agarwal, S., Forster, M. J., and Lal, H. (1994a). Mech. Ageing Dev. 74, 121-133.
34. Sohal, R. S., Agarwal, S., Candas, M., Forster, M. J., and Lal, H. (1994b). Mech. Ageing Dev. 76, 215-224.
35. Starkov, A. A., and Fiskum, G. (2003). J. Neurochem. 86, 1101-1107.
36. Stuart, J. A., Karahalil, B., Hogue, B. A., Souza-Pinto, N. C., and Bohr, V. A. (2004). FASEB J. 18, 595-597.
37. Takahashi, R., and Goto, S. (2002). Micros Res. Tech. 59, 278-281.
38. Tyler, D. D. (1992). The Mitochondria in Health and Disease, VCH Publishers, New York.
39. Wanagat, J., Allison, D. B., and Weindruch, R. (1999). Toxicol. Sci. 52S, 35-40.