Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes

Hepatology

Volumn 24, Issue 5, 1996, Pages 1199-1205

  Sastre, Juan ^a   Pallardó, Federico V ^a   Plá, Rosa ^a   Pellín, Antonio ^a   Juan, Gloria ^a   O'Connor, José E ^a   Estrela, José M ^a   Miquel, Jaime ^b   Viña, José ^a,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF ALICANTE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL CELL; ARTICLE; CELL METABOLISM; ENZYME ACTIVITY; FLOW CYTOMETRY; GLUCONEOGENESIS; KETOGENESIS; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; NONHUMAN; OOCYTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

EID: 0029998087     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008903398     Document Type: Article

References (43)

1. Gibbons A. Gerontology research cornes of age. Science 1990;250:622-625.
2. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
3. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-604.
4. Miquel J, Lundgren PR, Johnson JE. Spectrophotofluorometric and electron microscopic study of lipofucsin accumulation in the testis of aging mice. J Gerontol 1978;33:5-19.
5. Miquel J, Fleming J. Theoretical and experimental support for an "oxygen radical-mitochondrial injury" hypothesis of cell aging. In: Free radicals, aging and degenerative diseases. Johnson JE Jr., Walford R, Harman D, Miquel J, eds. New York: Liss, 1986:51-74.
6. Yen TC, Chen YS, King KL, Yeh SH, Wei YH. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 1989;165: 994-1003.
7. Paradies G, Ruggiero FM. Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria. Arch Biochem Biophys 1978;284:332-337.
8. Tummino PJ, Gafni A. A comparative study of succinate-supported respiration and ATP/ADP translocation in liver mitochondrial from adult and old rats. Mech Ageing Dev 1991;59:177-188.
9. Knook DL. The isolated hepatocyte: a cellular model for aging studies. Proc Soc Exp Biol Med 1980;165:170-177.
10. Berry MN, Friend DS. High yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 1969;43: 506-520.
11. Romero FJ, Vina J. A simple procedure to prepare isolated hepatocytes. Biochem Educ 1983;11:135-136.
12. Akerboom TPM, Bookelman H, Tager JM. Control of ATP transport across the mitochondrial membrane in isolated rat-liver cells. FEBS Lett 1977; 74:50-54.
13. Rickwood D, Wilson MT, Darley-Usmar VM. Isolation and characteristics of intact mitochondria. In: Darley-Usmar VM, Rickwood D, Wilson MT, eds. Mitochondria: a practical approach. Oxford: IRL Press, 1987:1-16.
14. Bergmeyer HU. Methods of enzymatic analysis, Ed 2. New York: Academic, 1974.
15. Lowry OH, Rosenbrough NJ, Farr AE, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
16. Seubert W, Huth W. On the mechanism of gluconeogenesis and its regulation. II. The mechanism of gluconeogenesis from pyruvate and fumarate. Biochem Z 1965;343:176-191.
17. McClure WR, Lardy HA, Kneifel HP. Rat-liver pyruvate carboxylase I. Preparation, properties and cation specificity. J Biol Chem 1971;246:3569-3578.
18. Chomczynsky P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-159.
19. Nishimura H, Pallardó FV, Seidner GA, Vannucci S, Simpson IA, Birnbaum. MJ. Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes. J Biol Chem 1993;268:8514-8520.
20. Colman A. Expression of exogenous DNA in Xenopus oocytes. In: Hames BD, Higgins SJ, eds. Transcription and translation: a practical approach. Oxford: IRL Press, 1984:49-70.
21. Chen LB. Mitochondrial membrane potential in living cells. Ann Rev Cell Biol 1988;4:155-181.
22. Petit PX, O'Connor JE, Grunwald D, Brown SC. Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible implications. Eur J Biochem 1990;194:389-397.
23. Maftah A, Petit JM, Ratinaud MH, Julien R. 10-N nonyl-acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state. Biochem Biophys Res Commun 1989;164:185-190.
24. 2 in cultured endothelial cells. Arch Biochem Biophys 1993;302:348-355.
25. Siess EA, Banik E, Neugebauer S. Control of pyruvate carboxylase activity by the pyridine-nucleotide redox state in mitochondria from rat liver. Eur J Biochem 1988;173:369-374.
26. LaNoue KF, Schoolwerth AC. Metabolite transport in mitochondria. Ann Rev Biochem 1979;48:871-922.
27. Fred-Dice J. Cellular theories of aging as related to the liver. HEPATOLOGY 1985;5:508-513.
28. Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial chain function: possible factor in ageing. Lancet 1989;25:637-639.
29. Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends in Neurosciences 1993;16:125-131.
30. Gadaleta MN, Petruzzella V, Renis M, Fracasso F, Cantatore P. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. Eur J Biochem 1990;187:501-6.
31. Calleja M, Peña P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 1993;268: 18891-18897.
32. Richter C, Park JW, Ames B. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 1988;85:6465-6467.
33. Linnane A, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;25:642-645.
34. Corbisier P, Remacle J. Involvement of mitochondria in cell degeneration. Eur J Cell Biol 1990;51:173-182.
35. Scalettar BA, Abney JR, Hackenbrock CR. Dynamics, structure and function are coupled in the mitochondrial matrix. Proc Natl Acad Sci U S A 1991;88:8057-8061.
36. De la Cruz J, Buron I, Roncero I. Morphological and functional studies during aging at mitochondrial level. Action of drugs. Int J Biochem 1990; 22:729-735.
37. Corbisier P, Raes M, Michiels C, Pigeolet E, Houbion A, Delaive E, Remacle J. Respiratory activity of isolated rat liver mitochondria following in vitro exposure to oxygen species: a threshold study. Mech Ageing Dev 1990;51: 249-263.
38. D'Amore PA, Sweet E. Effects of hyperoxia on microvascular cells in vitro. In Vitro Cell Dev Biol 1987;23:123-128.
39. Sohal RS. Hydrogen peroxide production by mitochondria may be a biomarker of aging. Mech Ageing Dev 1991;60:189-198.
40. Sohal RS, Arnold LA, Sohal BH. Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species. Free Radic Biol Med 1990;9:495-500.
41. 2+-dependent inner membrane permeability transition. Biochem J 1993;294:719-25.
42. Gordillo E, Ayala A, F-Lobato F, Bautista J, Machado A. Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging. J Biol Chem 1988;263:8053-8057.
43. Hansford RG. Lipid oxidation by heart mitochondria from young adult and senescent rats. Biochem J 1978;170:285-295.