Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Nature

Volumn 429, Issue 6993, 2004, Pages 771-776

  Picard, Frédéric ^a   Kurtev, Martin ^a   Chung, Namjin ^a   Topark Ngarm, Acharawan ^b   Senawong, Thanaset ^b   De Oliveira, Rita Machado ^a,c   Leid, Mark ^b   McBurney, Michael W ^d   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PORTO   (Portugal)

^d OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; OILS AND FATS; PROTEINS; REDUCTION; RNA;

ADIPOCYTES; CALORIE RESTRICTION;

GENES;

ACTIN; ADRENALIN; DEXAMETHASONE; DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INSULIN; ISOBUTYLMETHYLXANTHINE; METHIONINE; NICOTINAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; RESVERATROL; RNA; ROSIGLITAZONE; SIRT1 PROTEIN; SIRTUIN 1; SULFUR 35; UNCLASSIFIED DRUG;

BIOLOGY;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALORIC RESTRICTION; CELL CULTURE; CONTROLLED STUDY; DNA BINDING; FATTY ACID METABOLISM; GENE; HUMAN; HUMAN CELL; LIFESPAN; LIPOLYSIS; MALE; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RETROVIRUS; RNA INTERFERENCE; SIR2 GENE; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; CALORIC RESTRICTION; CELL LINE; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION; HUMANS; LIPID METABOLISM; LIPOLYSIS; LONGEVITY; MICE; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; RNA INTERFERENCE; SIRTUINS; STILBENES; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

ANIMALIA; MAMMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 3042681042     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02583     Document Type: Article

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