-
1
-
-
33750705653
-
A century of Alzheimer's disease
-
Goedert M and Spillantini MG. A century of Alzheimer's disease. Science 314(5800): 777-81(2006).
-
(2006)
Science
, vol.314
, Issue.5800
, pp. 777-781
-
-
Goedert, M.1
Spillantini, M.G.2
-
2
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner GG and Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122(3): 1131-5 (1984).
-
(1984)
Biochem Biophys Res Commun
, vol.122
, Issue.3
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
3
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG and Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120(3): 885-90 (1984).
-
(1984)
Biochem Biophys Res Commun
, vol.120
, Issue.3
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
4
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106): 733-6 (1987).
-
(1987)
Nature
, vol.325
, Issue.6106
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
-
5
-
-
0023109592
-
Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235(4791): 880-4(1987).
-
(1987)
Science
, vol.235
, Issue.4791
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
-
6
-
-
0023132387
-
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
-
Goldgaber D, Lerman MI, McBride OW, Saffiotti U and Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235(4791): 877-80 (1987).
-
(1987)
Science
, vol.235
, Issue.4791
, pp. 877-880
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, O.W.3
Saffiotti, U.4
Gajdusek, D.C.5
-
7
-
-
0023107655
-
Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome
-
Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, et al. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet 1(8529): 384-5 (1987).
-
(1987)
Lancet 1
, vol.8529
, pp. 384-385
-
-
Robakis, N.K.1
Wisniewski, H.M.2
Jenkins, E.C.3
Devine-Gage, E.A.4
Houck, G.E.5
Yao, X.L.6
-
8
-
-
42149122930
-
-
Hardy J. APP Mutations Directory. Available from: http://www.alzforum. org/res/com/mut/app/default. asp [Cited 2007 June 1] (2001).
-
Hardy J. APP Mutations Directory. Available from: http://www.alzforum. org/res/com/mut/app/default. asp [Cited 2007 June 1] (2001).
-
-
-
-
9
-
-
0025014702
-
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4 (695) mRNA is predominantly produced in rat and human brain
-
Kang J and Muller-Hill B. Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4 (695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun 166(3): 1192-200 (1990).
-
(1990)
Biochem Biophys Res Commun
, vol.166
, Issue.3
, pp. 1192-1200
-
-
Kang, J.1
Muller-Hill, B.2
-
10
-
-
33847724188
-
The amyloid precursor protein: Beyond amyloid
-
Zheng H and Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener 1: 5 (2006).
-
(2006)
Mol Neurodegener
, vol.1
, pp. 5
-
-
Zheng, H.1
Koo, E.H.2
-
11
-
-
33750151420
-
The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins
-
Anliker B and Muller U. The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins. Neurodegener Dis 3(4-5): 239-46 (2006).
-
(2006)
Neurodegener Dis
, vol.3
, Issue.4-5
, pp. 239-246
-
-
Anliker, B.1
Muller, U.2
-
12
-
-
0035816661
-
A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao XW and Sudhof TC. A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293(5527): 115-120 (2001).
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.W.1
Sudhof, T.C.2
-
13
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
De Strooper B and Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 113 (Pt 11): 1857-70 (2000).
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 11
, pp. 1857-1870
-
-
De Strooper, B.1
Annaert, W.2
-
14
-
-
0036548070
-
gamma-Secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia SS and St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 3(4): 281-90 (2002).
-
(2002)
Nat Rev Neurosci
, vol.3
, Issue.4
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
15
-
-
33750190414
-
Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers
-
Lichtenthaler SF. Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers. Neurodegener Dis 3 (4-5): 262-9 (2006).
-
(2006)
Neurodegener Dis
, vol.3
, Issue.4-5
, pp. 262-269
-
-
Lichtenthaler, S.F.1
-
16
-
-
34248169119
-
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates
-
Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ and Golde TE. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol Neurodegener 1: 3 (2006).
-
(2006)
Mol Neurodegener
, vol.1
, pp. 3
-
-
Nyborg, A.C.1
Ladd, T.B.2
Zwizinski, C.W.3
Lah, J.J.4
Golde, T.E.5
-
17
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R and Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5(6): 499-504 (2004).
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, Issue.6
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
18
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
-
Struhl G and Adachi A. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Molecular Cell 6(3): 625-636 (2000).
-
(2000)
Molecular Cell
, vol.6
, Issue.3
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
19
-
-
0041355557
-
Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
-
Selkoe D and Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 26: 565-97 (2003).
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
20
-
-
0029752755
-
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry
-
Wang R, Sweeney D, Gandy SE and Sisodia SS. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem 271(50): 31894-902 (1996).
-
(1996)
J Biol Chem
, vol.271
, Issue.50
, pp. 31894-31902
-
-
Wang, R.1
Sweeney, D.2
Gandy, S.E.3
Sisodia, S.S.4
-
21
-
-
27844441278
-
gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain
-
Zhao G, Cui MZ, Mao G, Dong Y, Tan J, Sun L, et al. gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J Biol Chem 280(45): 37689-97 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.45
, pp. 37689-37697
-
-
Zhao, G.1
Cui, M.Z.2
Mao, G.3
Dong, Y.4
Tan, J.5
Sun, L.6
-
22
-
-
34248190279
-
Abeta Oligomers - a decade of discovery
-
Walsh DM and Selkoe DJ. Abeta Oligomers - a decade of discovery. J Neurochem 101(5): 1172-84 (2007).
-
(2007)
J Neurochem
, vol.101
, Issue.5
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
23
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13(1): 45-53 (1994).
-
(1994)
Neuron
, vol.13
, Issue.1
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
24
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C and Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8(2): 101-12 (2007).
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
25
-
-
0036468772
-
Alzheimer's disease and Down's syndrome: Roles of APP, trophic factors and ACh
-
Isacson O, Seo H, Lin L, Albeck D and Granholm AC. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25(2): 79-84 (2002).
-
(2002)
Trends Neurosci
, vol.25
, Issue.2
, pp. 79-84
-
-
Isacson, O.1
Seo, H.2
Lin, L.3
Albeck, D.4
Granholm, A.C.5
-
26
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17(5): 1005-13 (1996).
-
(1996)
Neuron
, vol.17
, Issue.5
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
-
27
-
-
4143084775
-
Intramembrane proteolysis: Theme and variations
-
Wolfe MS and Kopan R. Intramembrane proteolysis: theme and variations. Science 305(5687): 1119-23 (2004).
-
(2004)
Science
, vol.305
, Issue.5687
, pp. 1119-1123
-
-
Wolfe, M.S.1
Kopan, R.2
-
29
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB and Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100(4): 391-8 (2000).
-
(2000)
Cell
, vol.100
, Issue.4
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
30
-
-
0042671326
-
Intramembrane proteolysis by presenilin and presenilin-like proteases
-
Xia W and Wolfe MS. Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci 116(Pt 14): 2839-44 (2003).
-
(2003)
J Cell Sci
, vol.116
, Issue.PART 14
, pp. 2839-2844
-
-
Xia, W.1
Wolfe, M.S.2
-
31
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269(5226): 973-7 (1995).
-
(1995)
Science
, vol.269
, Issue.5226
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
-
32
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, et al. A familial Alzheimer's disease locus on chromosome 1. Science 269(5226): 970-3 (1995).
-
(1995)
Science
, vol.269
, Issue.5226
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
Weber, J.L.6
-
33
-
-
0029101491
-
Familial Alzheimers-Disease in Kindreds with Missense Mutations in a Gene on Chromosome-1 Related to the Alzheimers-Disease Type-3 Gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, et al. Familial Alzheimers-Disease in Kindreds with Missense Mutations in a Gene on Chromosome-1 Related to the Alzheimers-Disease Type-3 Gene. Nature 376(6543): 775-778 (1995).
-
(1995)
Nature
, vol.376
, Issue.6543
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
-
34
-
-
0029004341
-
Cloning of a Gene Bearing Missense Mutations in Early-Onset Familial Alzheimers-Disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, et al. Cloning of a Gene Bearing Missense Mutations in Early-Onset Familial Alzheimers-Disease. Nature 375(6534): 754-760 (1995).
-
(1995)
Nature
, vol.375
, Issue.6534
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
-
35
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM. , Levesque L, et al. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 273(26): 16470-5 (1998).
-
(1998)
J Biol Chem
, vol.273
, Issue.26
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
-
36
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, et al. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 273(6): 3205-11 (1998).
-
(1998)
J Biol Chem
, vol.273
, Issue.6
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
-
37
-
-
12644290265
-
Evidence for phosphorylation and oligomeric assembly of presenilin 1
-
Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, et al. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci USA 94(10): 5090-4 (1997).
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.10
, pp. 5090-5094
-
-
Seeger, M.1
Nordstedt, C.2
Petanceska, S.3
Kovacs, D.M.4
Gouras, G.K.5
Hahne, S.6
-
38
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, et al. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 97(11): 6138-43 (2000).
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.11
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
-
39
-
-
0034282749
-
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes
-
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, et al. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. J Biol Chem 275(35): 27348-53 (2000).
-
(2000)
J Biol Chem
, vol.275
, Issue.35
, pp. 27348-27353
-
-
Yu, G.1
Chen, F.2
Nishimura, M.3
Steiner, H.4
Tandon, A.5
Kawarai, T.6
-
40
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, and Haass C. Reconstitution of gamma-secretase activity. Nature Cell Biology 5(5): 486-488 (2003).
-
(2003)
Nature Cell Biology
, vol.5
, Issue.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
41
-
-
3342993335
-
Purification and characterization of the human gammasecretase complex
-
Fraering PC, Ye WJ, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, et al. Purification and characterization of the human gammasecretase complex. Biochemistry 43(30): 9774-9789 (2004).
-
(2004)
Biochemistry
, vol.43
, Issue.30
, pp. 9774-9789
-
-
Fraering, P.C.1
Ye, W.J.2
Strub, J.M.3
Dolios, G.4
LaVoie, M.J.5
Ostaszewski, B.L.6
-
42
-
-
4444264297
-
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
-
Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, et al. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. Journal of Biological Chemistry 279(36): 38040-38046 (2004).
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.36
, pp. 38040-38046
-
-
Hayashi, I.1
Urano, Y.2
Fukuda, R.3
Isoo, N.4
Kodama, T.5
Hamakubo, T.6
-
43
-
-
23744491374
-
Nicastrin functions as a gamma-secretase-substrate receptor
-
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, et al. Nicastrin functions as a gamma-secretase-substrate receptor. Cell 122(3): 435-47 (2005).
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
Hao, Y.H.4
Yu, C.5
LaPlant, Q.6
-
44
-
-
15544378384
-
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
-
Zhang LL, Lee JL, Song LX, Sun XY, Shen J, Terracina G, et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2. Biochemistry 44(11): 4450-4457 (2005).
-
(2005)
Biochemistry
, vol.44
, Issue.11
, pp. 4450-4457
-
-
Zhang, L.L.1
Lee, J.L.2
Song, L.X.3
Sun, X.Y.4
Shen, J.5
Terracina, G.6
-
45
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, and Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 100 (11): 6382-7 (2003).
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.11
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
46
-
-
33646483640
-
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores
-
Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ and Li H. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci USA 103 (18): 6889-94 (2006).
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.18
, pp. 6889-6894
-
-
Lazarov, V.K.1
Fraering, P.C.2
Ye, W.3
Wolfe, M.S.4
Selkoe, D.J.5
Li, H.6
-
47
-
-
33645116480
-
-
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R. et al. Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun 343(2): 525-34? (2006).
-
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R. et al. Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun 343(2): 525-34? (2006).
-
-
-
-
48
-
-
33751087756
-
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines
-
Sato C, Morohashi Y, Tomita T and Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. J Neurosci 26(46): 12081-8 (2006).
-
(2006)
J Neurosci
, vol.26
, Issue.46
, pp. 12081-12088
-
-
Sato, C.1
Morohashi, Y.2
Tomita, T.3
Iwatsubo, T.4
-
49
-
-
33748743559
-
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex
-
Tolia A, Chavez-Gutierrez L and De Strooper B. Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex. J Biol Chem 281(37): 27633-42 (2006).
-
(2006)
J Biol Chem
, vol.281
, Issue.37
, pp. 27633-27642
-
-
Tolia, A.1
Chavez-Gutierrez, L.2
De Strooper, B.3
-
50
-
-
33746934183
-
Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction
-
Jozwiak K, Zekanowski C and Filipek S. Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction. J Neurochem 98(5): 1560-72 (2006).
-
(2006)
J Neurochem
, vol.98
, Issue.5
, pp. 1560-1572
-
-
Jozwiak, K.1
Zekanowski, C.2
Filipek, S.3
-
51
-
-
0025179972
-
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group
-
St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group Nature 347(6289): 194-7 (1990).
-
(1990)
Nature
, vol.347
, Issue.6289
, pp. 194-197
-
-
St George-Hyslop, P.H.1
Haines, J.L.2
Farrer, L.A.3
Polinsky, R.4
Van Broeckhoven, C.5
Goate, A.6
-
52
-
-
0023189941
-
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene
-
Tanzi RE, St George-Hyslop PH, Haines JL, Polinsky RJ, Nee L, Foncin JF, et al. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature 329(6135): 156-7 (1987).
-
(1987)
Nature
, vol.329
, Issue.6135
, pp. 156-157
-
-
Tanzi, R.E.1
St George-Hyslop, P.H.2
Haines, J.L.3
Polinsky, R.J.4
Nee, L.5
Foncin, J.F.6
-
53
-
-
4243237161
-
-
Available from:, Cited 2007 June 1, 2007
-
Hardy J. Presenilin Mutations Directory. Available from: http://www. alzforum.org/res/com/mut/pre/default. asp. [Cited 2007 June 1] (2007).
-
Presenilin Mutations Directory
-
-
Hardy, J.1
-
54
-
-
0030848149
-
-
Crook R, Ellis R, Shanks M, Thal LJ, Perez-Tur J, Baker M, et al. Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. Ann Neurol 42(1): 124-8 (1997).
-
Crook R, Ellis R, Shanks M, Thal LJ, Perez-Tur J, Baker M, et al. Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. Ann Neurol 42(1): 124-8 (1997).
-
-
-
-
55
-
-
0030250147
-
A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease
-
Perez-Tur J, Croxton R, Wright K, Phillips H, Zehr C, Crook R, et al. A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease. Neurodegeneration 5(3): 207-12 (1996).
-
(1996)
Neurodegeneration
, vol.5
, Issue.3
, pp. 207-212
-
-
Perez-Tur, J.1
Croxton, R.2
Wright, K.3
Phillips, H.4
Zehr, C.5
Crook, R.6
-
56
-
-
33748140720
-
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
-
Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, et al. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126(5): 981-93 (2006).
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
Wang, Z.4
Lee, S.F.5
Hao, Y.H.6
-
58
-
-
18844378852
-
Presenilin function and gamma-secretase activity
-
Brunkan AL and Goate AM. Presenilin function and gamma-secretase activity. J Neurochem 93(4): 769-92 (2005).
-
(2005)
J Neurochem
, vol.93
, Issue.4
, pp. 769-792
-
-
Brunkan, A.L.1
Goate, A.M.2
-
59
-
-
20944440679
-
The structure and functions of the presenilins
-
Dewji NN. The structure and functions of the presenilins. Cell Mol Life Sci 62(10): 1109-19 (2005).
-
(2005)
Cell Mol Life Sci
, vol.62
, Issue.10
, pp. 1109-1119
-
-
Dewji, N.N.1
-
60
-
-
0030293854
-
Protein topology of presenilin 1
-
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, et al. Protein topology of presenilin 1. Neuron 17(5): 1023-30(1996).
-
(1996)
Neuron
, vol.17
, Issue.5
, pp. 1023-1030
-
-
Doan, A.1
Thinakaran, G.2
Borchelt, D.R.3
Slunt, H.H.4
Ratovitsky, T.5
Podlisny, M.6
-
61
-
-
27444441308
-
A nine-transmembrane domain topology for presenilin 1
-
Laudon H, Hansson EM, Melen K, Bergman A, Farmery MR, Winblad B, et al. A nine-transmembrane domain topology for presenilin 1. J Biol Chem 280(42): 35352-60 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.42
, pp. 35352-35360
-
-
Laudon, H.1
Hansson, E.M.2
Melen, K.3
Bergman, A.4
Farmery, M.R.5
Winblad, B.6
-
62
-
-
0032499750
-
Additional evidence for an eight-transmembrane- domain topology for Caenorhabditis elegans and human presenilins
-
Li X and Greenwald I. Additional evidence for an eight-transmembrane- domain topology for Caenorhabditis elegans and human presenilins. Proc Natl Acad Sci USA 95(12): 7109-14 (1998).
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.12
, pp. 7109-7114
-
-
Li, X.1
Greenwald, I.2
-
63
-
-
24344503744
-
Topology of the C-terminal fragment of human presenilin 1
-
Oh YS and Turner RJ. Topology of the C-terminal fragment of human presenilin 1. Biochemistry 44(35): 11821-8 (2005).
-
(2005)
Biochemistry
, vol.44
, Issue.35
, pp. 11821-11828
-
-
Oh, Y.S.1
Turner, R.J.2
-
64
-
-
23944511109
-
Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space
-
Oh YS and Turner RJ. Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space. Am J Physiol Cell Physiol 289(3): C576-81 (2005).
-
(2005)
Am J Physiol Cell Physiol
, vol.289
, Issue.3
-
-
Oh, Y.S.1
Turner, R.J.2
-
65
-
-
33748746861
-
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway
-
Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, et al. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem 281(36): 26569-77 (2006).
-
(2006)
J Biol Chem
, vol.281
, Issue.36
, pp. 26569-26577
-
-
Spasic, D.1
Tolia, A.2
Dillen, K.3
Baert, V.4
De Strooper, B.5
Vrijens, S.6
-
66
-
-
0032211830
-
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe DJ. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol 8(11): 447-53 (1998).
-
(1998)
Trends Cell Biol
, vol.8
, Issue.11
, pp. 447-453
-
-
Selkoe, D.J.1
-
67
-
-
33947242870
-
When loss is gain: Reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease
-
Wolfe MS. When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep 8(2): 136-40 (2007).
-
(2007)
EMBO Rep
, vol.8
, Issue.2
, pp. 136-140
-
-
Wolfe, M.S.1
-
68
-
-
0141994826
-
Intramembrane-cleaving aspartic proteases and disease: Presenilins, signal peptide peptidase and their homologs
-
Martoglio B and Golde TE. Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Hum Mol Genet 12 Spec No 2: R201-6 (2003).
-
(2003)
Hum Mol Genet
, vol.12
, Issue.SPEC 2
-
-
Martoglio, B.1
Golde, T.E.2
-
69
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17(1): 181-190 (1996).
-
(1996)
Neuron
, vol.17
, Issue.1
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
-
70
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, et al. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J Biol Chem 272(45): 28415-22 (1997).
-
(1997)
J Biol Chem
, vol.272
, Issue.45
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
Price, D.L.6
-
71
-
-
0030854388
-
Endoproteolytic processing and stabilization of wild-type and mutant presenilin
-
Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS and Borchelt DR, Endoproteolytic processing and stabilization of wild-type and mutant presenilin. J Biol Chem 272(39): 24536-41 (1997).
-
(1997)
J Biol Chem
, vol.272
, Issue.39
, pp. 24536-24541
-
-
Ratovitski, T.1
Slunt, H.H.2
Thinakaran, G.3
Price, D.L.4
Sisodia, S.S.5
Borchelt, D.R.6
-
72
-
-
0033610863
-
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
-
Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, et al. , Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J Biol Chem 273(48): 32322-31 (1998)
-
(1998)
J Biol Chem
, vol.273
, Issue.48
, pp. 32322-32331
-
-
Steiner, H.1
Capell, A.2
Pesold, B.3
Citron, M.4
Kloetzel, P.M.5
Selkoe, D.J.6
-
73
-
-
0035834145
-
PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling
-
Levitan D, Lee J, Song L, Manning R, Wong G, Parker E, et al. PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling. Proc Natl Acad Sci U. S. A. 98(21): 12186-90 (2001).
-
(2001)
Proc Natl Acad Sci U. S. A
, vol.98
, Issue.21
, pp. 12186-12190
-
-
Levitan, D.1
Lee, J.2
Song, L.3
Manning, R.4
Wong, G.5
Parker, E.6
-
74
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, et al. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol 2(7): 428-34 (2000).
-
(2000)
Nat Cell Biol
, vol.2
, Issue.7
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
-
75
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, et al. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405(6787): 689-694 (2000).
-
(2000)
Nature
, vol.405
, Issue.6787
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
-
77
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
-
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, et al. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol 2(11): 848-51 (2000).
-
(2000)
Nat Cell Biol
, vol.2
, Issue.11
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
Hardy, J.6
-
78
-
-
33645559774
-
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase
-
Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, et al. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. J Neurosci 26(14): 3821-8 (2006).
-
(2006)
J Neurosci
, vol.26
, Issue.14
, pp. 3821-3828
-
-
Yamasaki, A.1
Eimer, S.2
Okochi, M.3
Smialowska, A.4
Kaether, C.5
Baumeister, R.6
-
79
-
-
0035980073
-
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins
-
Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, et al. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. J Biol Chem 276(35): 33273-81(2001).
-
(2001)
J Biol Chem
, vol.276
, Issue.35
, pp. 33273-33281
-
-
Tomita, T.1
Watabiki, T.2
Takikawa, R.3
Morohashi, Y.4
Takasugi, N.5
Kopan, R.6
-
80
-
-
0037147220
-
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals
-
2002
-
Takasugi N, Takahashi Y, Morohashi Y, Tomita T and Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem, 2002. 277(51): 50198-205 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.51
, pp. 50198-50205
-
-
Takasugi, N.1
Takahashi, Y.2
Morohashi, Y.3
Tomita, T.4
Iwatsubo, T.5
-
81
-
-
1842523970
-
Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes
-
Wang J, Brunkan AL, Hecimovic S, Walker E and Goate A. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes. Neurobiol Dis 15(3): 654-66. (2004).
-
(2004)
Neurobiol Dis
, vol.15
, Issue.3
, pp. 654-666
-
-
Wang, J.1
Brunkan, A.L.2
Hecimovic, S.3
Walker, E.4
Goate, A.5
-
82
-
-
11244272819
-
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
-
Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, et al. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. Embo J 23(24): 4738-48 (2004).
-
(2004)
Embo J
, vol.23
, Issue.24
, pp. 4738-4748
-
-
Kaether, C.1
Capell, A.2
Edbauer, D.3
Winkler, E.4
Novak, B.5
Steiner, H.6
-
83
-
-
24144461288
-
Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity
-
Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, et al. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. J Neurochem 94(5): 1315-28 (2005).
-
(2005)
J Neurochem
, vol.94
, Issue.5
, pp. 1315-1328
-
-
Brunkan, A.L.1
Martinez, M.2
Wang, J.3
Walker, E.S.4
Beher, D.5
Shearman, M.S.6
-
84
-
-
0035923750
-
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
-
Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32(4): 579-89 (2001).
-
(2001)
Neuron
, vol.32
, Issue.4
, pp. 579-589
-
-
Annaert, W.G.1
Esselens, C.2
Baert, V.3
Boeve, C.4
Snellings, G.5
Cupers, P.6
-
85
-
-
0038117200
-
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging
-
Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ and Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci 23(11): 4560-6 (2003).
-
(2003)
J Neurosci
, vol.23
, Issue.11
, pp. 4560-4566
-
-
Berezovska, O.1
Ramdya, P.2
Skoch, J.3
Wolfe, M.S.4
Bacskai, B.J.5
Hyman, B.T.6
-
86
-
-
0141509025
-
Designed helical peptides inhibit an intramembrane protease
-
Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, et al. Designed helical peptides inhibit an intramembrane protease. J Am Chem Soc125 (39): 11794-5 (2003).
-
(2003)
J Am Chem Soc125
, vol.39
, pp. 11794-11795
-
-
Das, C.1
Berezovska, O.2
Diehl, T.S.3
Genet, C.4
Buldyrev, I.5
Tsai, J.Y.6
-
87
-
-
0037022644
-
Activity-dependent isolation of the presenilin-gamma -secretase complex reveals nicastrin and a gamma substrate
-
Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, et al. Activity-dependent isolation of the presenilin-gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci USA 99(5): 2720-5 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.5
, pp. 2720-2725
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Ye, W.4
Diehl, T.S.5
Selkoe, D.J.6
-
88
-
-
0038607066
-
Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications
-
Kornilova AY, Das C and Wolfe MS. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem 278(19): 16470-3 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 16470-16473
-
-
Kornilova, A.Y.1
Das, C.2
Wolfe, M.S.3
-
89
-
-
14744267675
-
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
-
Kornilova AY, Bihel F, Das C and Wolfe MS. The initial substrate-binding site of gamma-secretase is located on presenilin near the active site. Proc Natl Acad Sci USA 102 (9): 3230-5 (2005).
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.9
, pp. 3230-3235
-
-
Kornilova, A.Y.1
Bihel, F.2
Das, C.3
Wolfe, M.S.4
-
90
-
-
0032972547
-
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
-
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, et al. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. J Neurochem 72(3): 999-1008 (1999).
-
(1999)
J Neurochem
, vol.72
, Issue.3
, pp. 999-1008
-
-
Levesque, G.1
Yu, G.2
Nishimura, M.3
Zhang, D.M.4
Levesque, L.5
Yu, H.6
-
91
-
-
0032905727
-
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
-
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, et al. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat Med 5(2): 164-9. (1999).
-
(1999)
Nat Med
, vol.5
, Issue.2
, pp. 164-169
-
-
Nishimura, M.1
Yu, G.2
Levesque, G.3
Zhang, D.M.4
Ruel, L.5
Chen, F.6
-
92
-
-
0030904751
-
Presenilin 1 interaction in the brain with a novel member of the Armadillo family
-
Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, et al. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8(6): 1489-94 (1999).
-
(1999)
Neuroreport
, vol.8
, Issue.6
, pp. 1489-1494
-
-
Zhou, J.1
Liyanage, U.2
Medina, M.3
Ho, C.4
Simmons, A.D.5
Lovett, M.6
-
93
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407(6800): 48-54 (2000).
-
(2000)
Nature
, vol.407
, Issue.6800
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
-
94
-
-
0035312603
-
Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain
-
Fagan R, Swindells M, Overington J and Weir M. Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain. Trends Biochem Sci 26(4): 213-4 (2001).
-
(2001)
Trends Biochem Sci
, vol.26
, Issue.4
, pp. 213-214
-
-
Fagan, R.1
Swindells, M.2
Overington, J.3
Weir, M.4
-
95
-
-
0034080403
-
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM and Priess JR. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127(11): 2481-92 (2000).
-
(2000)
Development
, vol.127
, Issue.11
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
96
-
-
0035204206
-
Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila
-
Chung HM and Struhl G. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nature Cell Biology 3(12): 1129-1132 (2001).
-
(2001)
Nature Cell Biology
, vol.3
, Issue.12
, pp. 1129-1132
-
-
Chung, H.M.1
Struhl, G.2
-
97
-
-
0036007117
-
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
-
Hu Y, Ye Y and Fortini ME. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell 2(1): 69-78 (2002).
-
(2002)
Dev Cell
, vol.2
, Issue.1
, pp. 69-78
-
-
Hu, Y.1
Ye, Y.2
Fortini, M.E.3
-
98
-
-
0036007118
-
Drosophila nicastrin is essential for the intramembranous cleavage of notch
-
Lopez-Schier H and St Johnston D. Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev Cell 2(1): 79-89 (2002).
-
(2002)
Dev Cell
, vol.2
, Issue.1
, pp. 79-89
-
-
Lopez-Schier, H.1
St Johnston, D.2
-
99
-
-
0037659067
-
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
-
Li T, Ma G, Cai H, Price DL and Wong PC. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J Neurosci 23(8): 3272-7 (2003).
-
(2003)
J Neurosci
, vol.23
, Issue.8
, pp. 3272-3277
-
-
Li, T.1
Ma, G.2
Cai, H.3
Price, D.L.4
Wong, P.C.5
-
100
-
-
0346732290
-
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
-
Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, et al. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. J Biol Chem 278(52): 52519-23 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.52
, pp. 52519-52523
-
-
Capell, A.1
Kaether, C.2
Edbauer, D.3
Shirotani, K.4
Merkl, S.5
Steiner, H.6
-
101
-
-
18744371544
-
The levels of, mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein
-
Arawaka S, Hasegawa H, Tandon A, Janus C, Chen FS, Yu G, et al. The levels of, mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. Journal of Neurochemistry 83(5): 1065-1071 (2002).
-
(2002)
Journal of Neurochemistry
, vol.83
, Issue.5
, pp. 1065-1071
-
-
Arawaka, S.1
Hasegawa, H.2
Tandon, A.3
Janus, C.4
Chen, F.S.5
Yu, G.6
-
102
-
-
0037144422
-
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS and Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem 277(38): 35113-7 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.38
, pp. 35113-35117
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
103
-
-
0037008723
-
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
-
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem 277(31): 28135-42 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.31
, pp. 28135-28142
-
-
Yang, D.S.1
Tandon, A.2
Chen, F.3
Yu, G.4
Yu, H.5
Arawaka, S.6
-
104
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation
-
Edbauer D, Winkler E, Haass C and Steiner H. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc Natl Acad Sci USA 99(13): 8666-71 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.13
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
105
-
-
0037166349
-
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin
-
Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, et al. Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem 277(21): 19236-40 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.21
, pp. 19236-19240
-
-
Leem, J.Y.1
Vijayan, S.2
Han, P.3
Cai, D.4
Machura, M.5
Lopes, K.O.6
-
106
-
-
0037444574
-
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
-
Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, et al. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. J Cell Sci 116(Pt 6): 1127-36 (2003).
-
(2003)
J Cell Sci
, vol.116
, Issue.PART 6
, pp. 1127-1136
-
-
Herreman, A.1
Van Gassen, G.2
Bentahir, M.3
Nyabi, O.4
Craessaerts, K.5
Mueller, U.6
-
107
-
-
29644432040
-
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1
-
Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y and Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem 280(51): 41967-75 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.51
, pp. 41967-41975
-
-
Watanabe, N.1
Tomita, T.2
Sato, C.3
Kitamura, T.4
Morohashi, Y.5
Iwatsubo, T.6
-
108
-
-
0038607071
-
Gamma-secretase activity is associated with a conformational change of nicastrin
-
Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, and Haass C. Gamma-secretase activity is associated with a conformational change of nicastrin. J Biol Chem 278(19): 16474-7 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 16474-16477
-
-
Shirotani, K.1
Edbauer, D.2
Capell, A.3
Schmitz, J.4
Steiner, H.5
Haass, C.6
-
109
-
-
14844286856
-
Gamma-secretase complex assembly within the early secretory pathway
-
Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, et al. Gamma-secretase complex assembly within the early secretory pathway. J Biol Chem 280(8): 6471-8 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.8
, pp. 6471-6478
-
-
Capell, A.1
Beher, D.2
Prokop, S.3
Steiner, H.4
Kaether, C.5
Shearman, M.S.6
-
110
-
-
18444417998
-
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3(1): 85-97 (2002).
-
(2002)
Dev Cell
, vol.3
, Issue.1
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
-
111
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA and Priess JR. , APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 99(2): 775-9 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.2
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
112
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, et al. The role of presenilin cofactors in the gamma-secretase complex. Nature 422(6930): 438-41 (2003).
-
(2003)
Nature
, vol.422
, Issue.6930
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
-
113
-
-
0037160063
-
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
-
Lee SF, Shah S, Li H, Yu C, Han W, Yu G. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem 277(47): 45013-9 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.47
, pp. 45013-45019
-
-
Lee, S.F.1
Shah, S.2
Li, H.3
Yu, C.4
Han, W.5
Yu, G.6
-
114
-
-
0037470037
-
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin. nicastrin complexes
-
Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, et al. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin. nicastrin complexes. J Biol Chem 278(9): 7374-80 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.9
, pp. 7374-7380
-
-
Gu, Y.1
Chen, F.2
Sanjo, N.3
Kawarai, T.4
Hasegawa, H.5
Duthie, M.6
-
115
-
-
0038360879
-
Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex
-
Hu Y and Fortini ME. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol 161(4): 685-90 (2003).
-
(2003)
J Cell Biol
, vol.161
, Issue.4
, pp. 685-690
-
-
Hu, Y.1
Fortini, M.E.2
-
116
-
-
0141483380
-
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane substrates
-
Kim SH, Ikeuchi T, Yu C and Sisodia SS. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane substrates. J Biol Chem 278(36): 33992-4002 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.36
, pp. 33992-34002
-
-
Kim, S.H.1
Ikeuchi, T.2
Yu, C.3
Sisodia, S.S.4
-
117
-
-
3042520872
-
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: Identification of nicastrin mutants that selectively interact with APH-1
-
Shirotani K, Edbauer D, Kostka M, Steiner H and Haass C. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. J Neurochem 89(6): 1520-7 (2004).
-
(2004)
J Neurochem
, vol.89
, Issue.6
, pp. 1520-1527
-
-
Shirotani, K.1
Edbauer, D.2
Kostka, M.3
Steiner, H.4
Haass, C.5
-
118
-
-
0141733241
-
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
-
LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem 278(39): 37213-22 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.39
, pp. 37213-37222
-
-
LaVoie, M.J.1
Fraering, P.C.2
Ostaszewski, B.L.3
Ye, W.4
Kimberly, W.T.5
Wolfe, M.S.6
-
119
-
-
10744223903
-
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
-
Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem 279(6): 4144-52 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.6
, pp. 4144-4152
-
-
Lee, S.F.1
Shah, S.2
Yu, C.3
Wigley, W.C.4
Li, H.5
Lim, M.6
-
120
-
-
16844364135
-
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
-
Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. J Biol Chem 280(13): 12967-75 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.13
, pp. 12967-12975
-
-
Niimura, M.1
Isoo, N.2
Takasugi, N.3
Tsuruoka, M.4
Ui-Tei, K.5
Saigo, K.6
-
121
-
-
4444221162
-
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
-
Edbauer D, Kaether C, Steiner H and Haass C. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. J Biol Chem 279(36): 37311-5 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.36
, pp. 37311-37315
-
-
Edbauer, D.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
122
-
-
0037024364
-
Complex Nglycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments
-
Tomita T, Katayama R, Takikawa R and Iwatsubo T. Complex Nglycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS Lett 520(1-3): 117-21 (2002).
-
(2002)
FEBS Lett
, vol.520
, Issue.1-3
, pp. 117-121
-
-
Tomita, T.1
Katayama, R.2
Takikawa, R.3
Iwatsubo, T.4
-
123
-
-
4744375540
-
Identification of distinct gamma-secretase complexes with different APH-1 variants
-
Shirotani K, Edbauer D, Prokop S, Haass C and Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. J Biol Chem 279(40): 41340-5 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.40
, pp. 41340-41345
-
-
Shirotani, K.1
Edbauer, D.2
Prokop, S.3
Haass, C.4
Steiner, H.5
-
124
-
-
8544219758
-
The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity
-
Bergman A, Laudon H, Winblad B, Lundkvist J and Naslund J. The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity. J Biol Chem 279(44): 45564-72 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.44
, pp. 45564-45572
-
-
Bergman, A.1
Laudon, H.2
Winblad, B.3
Lundkvist, J.4
Naslund, J.5
-
125
-
-
0347093518
-
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
-
Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 43(2): 323-33 (2004).
-
(2004)
Biochemistry
, vol.43
, Issue.2
, pp. 323-333
-
-
Fraering, P.C.1
LaVoie, M.J.2
Ye, W.3
Ostaszewski, B.L.4
Kimberly, W.T.5
Selkoe, D.J.6
-
126
-
-
0037424275
-
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
-
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, et al. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem 278(10): 7850-4 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.10
, pp. 7850-7854
-
-
Luo, W.J.1
Wang, H.2
Li, H.3
Kim, B.S.4
Shah, S.5
Lee, H.J.6
-
127
-
-
0037131218
-
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
-
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, et al. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem 277(42): 39062-5 (2002).
-
(2002)
J Biol Chem
, vol.277
, Issue.42
, pp. 39062-39065
-
-
Steiner, H.1
Winkler, E.2
Edbauer, D.3
Prokop, S.4
Basset, G.5
Yamasaki, A.6
-
128
-
-
2542454942
-
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
-
Prokop S, Shirotani K, Edbauer D, Haass C and Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. J Biol Chem 279(22): 23255-61 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.22
, pp. 23255-23261
-
-
Prokop, S.1
Shirotani, K.2
Edbauer, D.3
Haass, C.4
Steiner, H.5
-
129
-
-
4544377736
-
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
-
Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, et al. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation. J Neurochem 90(6): 1402-13 (2004).
-
(2004)
J Neurochem
, vol.90
, Issue.6
, pp. 1402-1413
-
-
Shiraishi, H.1
Sai, X.2
Wang, H.Q.3
Maeda, Y.4
Kurono, Y.5
Nishimura, M.6
-
130
-
-
12544255206
-
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
-
Kim SH and Sisodia SS. A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. J Biol Chem 280(3): 1992-2001 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.3
, pp. 1992-2001
-
-
Kim, S.H.1
Sisodia, S.S.2
-
131
-
-
8744291081
-
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
-
Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J Biol Chem 279(45): 46455-63 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.45
, pp. 46455-46463
-
-
Hasegawa, H.1
Sanjo, N.2
Chen, F.3
Gu, Y.J.4
Shier, C.5
Petit, A.6
-
132
-
-
21344463310
-
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments
-
Prokop S, Haass C and Steiner H. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. J Neurochem 94(1): 57-62 (2005).
-
(2005)
J Neurochem
, vol.94
, Issue.1
, pp. 57-62
-
-
Prokop, S.1
Haass, C.2
Steiner, H.3
-
133
-
-
29644435433
-
Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2
-
Kim SH and Sisodia SS. Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. J Biol Chem 280(51): 41953-41966 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.51
, pp. 41953-41966
-
-
Kim, S.H.1
Sisodia, S.S.2
-
134
-
-
34250336128
-
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: Common effects of Pen-2 N-terminal elongation and fenofibrate
-
Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, et al. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. J Biol Chem 282(17): 12388-96 (2007).
-
(2007)
J Biol Chem
, vol.282
, Issue.17
, pp. 12388-12396
-
-
Isoo, N.1
Sato, C.2
Miyashita, H.3
Shinohara, M.4
Takasugi, N.5
Morohashi, Y.6
-
135
-
-
10344243551
-
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
-
Kim SH, Yin YI, Li YM and Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem 279(47): p. 48615-9 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.47
, pp. 48615-48619
-
-
Kim, S.H.1
Yin, Y.I.2
Li, Y.M.3
Sisodia, S.S.4
-
136
-
-
33947609757
-
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid
-
Verily G, Gandy SE and Martins RN. The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochem Res 32(4-5): 609-23 (2007).
-
(2007)
Neurochem Res
, vol.32
, Issue.4-5
, pp. 609-623
-
-
Verily, G.1
Gandy, S.E.2
Martins, R.N.3
-
137
-
-
33646369950
-
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
-
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 440(7088): 1208-12 (2006).
-
(2006)
Nature
, vol.440
, Issue.7088
, pp. 1208-1212
-
-
Chen, F.1
Hasegawa, H.2
Schmitt-Ulms, G.3
Kawarai, T.4
Bohm, C.5
Katayama, T.6
-
138
-
-
0035842897
-
Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus
-
Barr FA, Preisinger C, Kopajtich R and Korner R. Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. J Cell Biol 155(6): 885-91 (2001).
-
(2001)
J Cell Biol
, vol.155
, Issue.6
, pp. 885-891
-
-
Barr, F.A.1
Preisinger, C.2
Kopajtich, R.3
Korner, R.4
-
139
-
-
0030055357
-
Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking
-
Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, et al. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. J Biol Chem 271(29): 17183-9 (1996).
-
(1996)
J Biol Chem
, vol.271
, Issue.29
, pp. 17183-17189
-
-
Blum, R.1
Feick, P.2
Puype, M.3
Vandekerckhove, J.4
Klengel, R.5
Nastainczyk, W.6
-
140
-
-
8144222791
-
A system for enhancing genome-wide coexpression dynamics study
-
Li KC, Liu CT, Sun W, Yuan S and Yu T. A system for enhancing genome-wide coexpression dynamics study. Proc Natl Acad Sci USA 101(44): p. 15561-6 (2004).
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.44
, pp. 15561-15566
-
-
Li, K.C.1
Liu, C.T.2
Sun, W.3
Yuan, S.4
Yu, T.5
-
141
-
-
34247887500
-
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism
-
Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, et al. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener 2: 4 (2007).
-
(2007)
Mol Neurodegener
, vol.2
, pp. 4
-
-
Vetrivel, K.S.1
Gong, P.2
Bowen, J.W.3
Cheng, H.4
Chen, Y.5
Carter, M.6
-
142
-
-
33847389291
-
Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway
-
Spasic D, Raemaekers T, Dillen K, Declerck I, Baert V, Serneels L, et al. Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway. J Cell Biol 176(5): 629-40 (2007).
-
(2007)
J Cell Biol
, vol.176
, Issue.5
, pp. 629-640
-
-
Spasic, D.1
Raemaekers, T.2
Dillen, K.3
Declerck, I.4
Baert, V.5
Serneels, L.6
-
143
-
-
34547628712
-
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1
-
Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, et al. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. EMBO Reports Advanced Online Publication.
-
EMBO Reports Advanced Online Publication
-
-
Kaether, C.1
Scheuermann, J.2
Fassler, M.3
Zilow, S.4
Shirotani, K.5
Valkova, C.6
-
144
-
-
27644503149
-
gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity
-
Stromberg K, Hansson EM, Laudon H, Bergstedt S, Naslund J, Lundkvist J, et al. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity. J Neurochem 95(3): 880-90 (2005).
-
(2005)
J Neurochem
, vol.95
, Issue.3
, pp. 880-890
-
-
Stromberg, K.1
Hansson, E.M.2
Laudon, H.3
Bergstedt, S.4
Naslund, J.5
Lundkvist, J.6
-
145
-
-
5144224126
-
Coordinated and widespread expression of gamma-secretase in vivo: Evidence for size and molecular heterogeneity
-
Hebert SS, Serneels L, Dejaegere T, Horre K, Dabrowski M, Baert V, et al. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis 17(2): 260-72 (2004).
-
(2004)
Neurobiol Dis
, vol.17
, Issue.2
, pp. 260-272
-
-
Hebert, S.S.1
Serneels, L.2
Dejaegere, T.3
Horre, K.4
Dabrowski, M.5
Baert, V.6
-
146
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci USA 96(21): 11872-7(1999).
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.21
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
Serneels, L.6
-
147
-
-
0037590902
-
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
-
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, et al. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem 278(25): 22475-81 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.25
, pp. 22475-22481
-
-
Lai, M.T.1
Chen, E.2
Crouthamel, M.C.3
DiMuzio-Mower, J.4
Xu, M.5
Huang, Q.6
-
148
-
-
21144447065
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
-
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci USA 102(25): 8972-7 (2005).
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.25
, pp. 8972-8977
-
-
Mastrangelo, P.1
Mathews, P.M.2
Chishti, M.A.3
Schmidt, S.D.4
Gu, Y.5
Yang, J.6
-
149
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391(6665): 387-90 (1998).
-
(1998)
Nature
, vol.391
, Issue.6665
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
-
150
-
-
0033775709
-
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells
-
Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, and De Strooper B. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2(7): 461-2 (2000).
-
(2000)
Nat Cell Biol
, vol.2
, Issue.7
, pp. 461-462
-
-
Herreman, A.1
Serneels, L.2
Annaert, W.3
Collen, D.4
Schoonjans, L.5
De Strooper, B.6
-
151
-
-
0033779635
-
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1
-
Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, et al. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2(7): 463-5 (2000).
-
(2000)
Nat Cell Biol
, vol.2
, Issue.7
, pp. 463-465
-
-
Zhang, Z.1
Nadeau, P.2
Song, W.3
Donoviel, D.4
Yuan, M.5
Bernstein, A.6
-
152
-
-
0034614384
-
Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells
-
Palacino JJ, Berechid BE, Alexander P, Eckman C, Younkin S, Nye JS, et al. Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. J Biol Chem 275(1): 215-22 (2000).
-
(2000)
J Biol Chem
, vol.275
, Issue.1
, pp. 215-222
-
-
Palacino, J.J.1
Berechid, B.E.2
Alexander, P.3
Eckman, C.4
Younkin, S.5
Nye, J.S.6
-
153
-
-
13444268952
-
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo
-
Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, Tousseyn T, et al. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci USA 102(5): 1719-24 (2005).
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.5
, pp. 1719-1724
-
-
Serneels, L.1
Dejaegere, T.2
Craessaerts, K.3
Horre, K.4
Jorissen, E.5
Tousseyn, T.6
-
154
-
-
12144250683
-
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
-
Ma G, Li T, Price DL and Wong PC. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci 25(1): 192-8 (2005).
-
(2005)
J Neurosci
, vol.25
, Issue.1
, pp. 192-198
-
-
Ma, G.1
Li, T.2
Price, D.L.3
Wong, P.C.4
-
156
-
-
0033214675
-
Presenilins: Molecular switches between proteolysis and signal transduction
-
Annaert W and De Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trends Neurosci 22(10): 439-43 (1999).
-
(1999)
Trends Neurosci
, vol.22
, Issue.10
, pp. 439-443
-
-
Annaert, W.1
De Strooper, B.2
-
157
-
-
0032720496
-
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons
-
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, et al. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J Cell Biol 147(2): 277-94 (1999).
-
(1999)
J Cell Biol
, vol.147
, Issue.2
, pp. 277-294
-
-
Annaert, W.G.1
Levesque, L.2
Craessaerts, K.3
Dierinck, I.4
Snellings, G.5
Westaway, D.6
-
158
-
-
14244268498
-
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
-
Chyung JH, Raper DM and Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem 280(6): 4383-92 (2005).
-
(2005)
J Biol Chem
, vol.280
, Issue.6
, pp. 4383-4392
-
-
Chyung, J.H.1
Raper, D.M.2
Selkoe, D.J.3
-
159
-
-
0036327098
-
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
-
Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, et al. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 158(3): 551-61 (2002).
-
(2002)
J Cell Biol
, vol.158
, Issue.3
, pp. 551-561
-
-
Kaether, C.1
Lammich, S.2
Edbauer, D.3
Ertl, M.4
Rietdorf, J.5
Capell, A.6
-
160
-
-
14844326290
-
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
-
Hansson EM, Stromberg K, Bergstedt S, Yu G, Naslund J, Lundkvist J, et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch. J Neurochem 92(5): 1010-20 (2005).
-
(2005)
J Neurochem
, vol.92
, Issue.5
, pp. 1010-1020
-
-
Hansson, E.M.1
Stromberg, K.2
Bergstedt, S.3
Yu, G.4
Naslund, J.5
Lundkvist, J.6
-
161
-
-
1642336602
-
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin
-
Bergman A, Hansson EM, Pursglove SE, Farmery MR, Lannfelt L, Lendahl U, et al. Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin. J Biol Chem 279(16): 16744-53 (2004).
-
(2004)
J Biol Chem
, vol.279
, Issue.16
, pp. 16744-16753
-
-
Bergman, A.1
Hansson, E.M.2
Pursglove, S.E.3
Farmery, M.R.4
Lannfelt, L.5
Lendahl, U.6
-
162
-
-
33644862462
-
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
Kaether C, Schmitt S, Willem M and Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 7(4): 408-15 (2006).
-
(2006)
Traffic
, vol.7
, Issue.4
, pp. 408-415
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
163
-
-
33746593662
-
Alzheimer's disease beta-amyloid peptides are released in association with exosomes
-
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci USA 103(30): 11172-7 (2006).
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.30
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
-
164
-
-
33750151419
-
Assembly, trafficking and function of gamma-secretase
-
Kaether C, Haass C and Steiner H. Assembly, trafficking and function of gamma-secretase. Neurodegener Dis 3(4-5): 275-83 (2006).
-
(2006)
Neurodegener Dis
, vol.3
, Issue.4-5
, pp. 275-283
-
-
Kaether, C.1
Haass, C.2
Steiner, H.3
-
165
-
-
1842532328
-
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
-
Pasternak SH, Callahan JW and Mahuran DJ. The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective. J Alzheimers Dis 6(1): 53-65 (2004).
-
(2004)
J Alzheimers Dis
, vol.6
, Issue.1
, pp. 53-65
-
-
Pasternak, S.H.1
Callahan, J.W.2
Mahuran, D.J.3
-
166
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
-
Haass C, Koo EH, Mellon A, Hung AY and Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357(6378): 500-3 (1992).
-
(1992)
Nature
, vol.357
, Issue.6378
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
167
-
-
0345803941
-
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface
-
Chyung JH and Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J Biol Chem 278(51): 51035-43 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.51
, pp. 51035-51043
-
-
Chyung, J.H.1
Selkoe, D.J.2
-
168
-
-
0028817351
-
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases
-
Knops J, Suomensaari S, Lee M, McConlogue L, Seubert P and Sinha S. Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases. J Biol Chem 270(6): 2419-22 (1995).
-
(1995)
J Biol Chem
, vol.270
, Issue.6
, pp. 2419-2422
-
-
Knops, J.1
Suomensaari, S.2
Lee, M.3
McConlogue, L.4
Seubert, P.5
Sinha, S.6
-
169
-
-
0029972129
-
Effect of alkalizing agents on the processing of the beta-amyloid precursor protein
-
Schrader-Fischer G and Paganetti PA. Effect of alkalizing agents on the processing of the beta-amyloid precursor protein. Brain Res 716(1-2): 91-100 (1996).
-
(1996)
Brain Res
, vol.716
, Issue.1-2
, pp. 91-100
-
-
Schrader-Fischer, G.1
Paganetti, P.A.2
-
170
-
-
0027250352
-
Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments
-
Siman R, Mistretta S, Durkin JT, Savage MJ, Loh T, Trusko S, et al. Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments. J Biol Chem 268(22): 16602-9 (1993).
-
(1993)
J Biol Chem
, vol.268
, Issue.22
, pp. 16602-16609
-
-
Siman, R.1
Mistretta, S.2
Durkin, J.T.3
Savage, M.J.4
Loh, T.5
Trusko, S.6
-
171
-
-
0034711207
-
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
-
Chen FS, Yang DS, Petanceska S, Yang A, Tandon A. Yu G, et al. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem 275(47): 36794-36802 (2000).
-
(2000)
J Biol Chem
, vol.275
, Issue.47
, pp. 36794-36802
-
-
Chen, F.S.1
Yang, D.S.2
Petanceska, S.3
Yang, A.4
Tandon, A.5
Yu, G.6
-
172
-
-
0037698096
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
-
Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, et al. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J Biol Chem 278(29): 26687-94 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.29
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
Zhang, S.4
Ackerley, C.A.5
Pak, B.J.6
-
173
-
-
34547110577
-
-
Tampellini D, Magrane J, Takahashi RH, Li F, Lin MT, Almeida CG, et al. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem (2007).
-
Tampellini D, Magrane J, Takahashi RH, Li F, Lin MT, Almeida CG, et al. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem (2007).
-
-
-
-
174
-
-
34250819839
-
Intracellular amyloid-beta in Alzheimer's disease
-
Laferla FM, Green KN and Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8(7): 499-509 (2007).
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.7
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
175
-
-
33645937614
-
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct
-
Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, et al. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. Biochemistry 45(15): 4907-14 (2006).
-
(2006)
Biochemistry
, vol.45
, Issue.15
, pp. 4907-4914
-
-
Fukumori, A.1
Okochi, M.2
Tagami, S.3
Jiang, J.4
Itoh, N.5
Nakayama, T.6
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