Nicastrin is required for assembly of presenilin/γ-secretase complexes to mediate notch signaling and for processing and trafficking of β-amyloid precursor protein in mammals

Journal of Neuroscience

Volumn 23, Issue 8, 2003, Pages 3272-3277

  Li, Tong ^a   Ma, Guojun ^a   Cai, Huaibin ^a   Price, Donald L ^a   Wong, Philip C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; APP processing and trafficking; Nicastrin knock out mice; Nicastrin deficient fibroblasts; Notch signaling; Presenilin secretase complex

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE DISRUPTION; GENE INACTIVATION; INTERNALIZATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN TRANSPORT; REGULATORY MECHANISM; TRANSPORT KINETICS;

EID: 0037659067     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-08-03272.2003     Document Type: Article

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