Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons

Journal of Cell Biology

Volumn 147, Issue 2, 1999, Pages 277-294

  Annaert, Wim G ^a   Levesque, Lyne ^d   Craessaerts, Kathleen ^a   Dierinck, Inge ^a   Snellings, Greet ^a   Westaway, David ^d   St George Hyslop, Peter ^d   Cordell, Barbara ^b   Fraser, Paul ^d   De Strooper, Bart ^a,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SCIOS INC   (United States)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d NONE

Author keywords

secretase; Alzheimer's disease; APP processing; Hippocampal neuron; Presenilin 1

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MUTANT PROTEIN; PRESENILIN 1; PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; GOLGI APPARATUS; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NEURONS; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL;

ANIMALIA; MUS MUSCULUS;

EID: 0032720496     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.147.2.277     Document Type: Article

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