A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 4144-4152

  Lee, Sheu Fen ^a   Shah, Sanjiv ^a   Yu, Cong ^a   Wigley, W Christian ^c   Li, Harry ^a   Lim, Myungsil ^a   Pedersen, Kia ^d   Han, Weiping ^a   Thomas, Philip ^c   Lundkvist, Johan ^d   Hao, Yi Heng ^a,b   Yu, Gang ^a,b  

^a Center for Basic Neuroscience   (United States)

^b Karolinska Institute ^*  (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ENZYMES;

MAMMALIAN CELLS; MUTATIONS; PRECURSORS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN PRECURSOR;

ARTICLE; CAENORHABDITIS; COMPLEX FORMATION; ENZYME ACTIVITY; GENE; GENETIC ANALYSIS; GENETIC CONSERVATION; GLP1 GENE; GLYCOSYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; HUMANS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE HYDROLASES; PRESENILIN-1; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA;

EID: 10744223903     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309745200     Document Type: Article

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